LOCUS       NM_002260               1238 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens killer cell lectin like receptor C2 (KLRC2), mRNA.
ACCESSION   NM_002260 XM_001713685 XM_001713701
VERSION     NM_002260.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1238)
  AUTHORS   Sanchez-Gaona,N., Gallego-Cortes,A., Astorga-Gamaza,A., Rallon,N.,
            Benito,J.M., Ruiz-Mateos,E., Curran,A., Burgos,J., Navarro,J.,
            Suanzes,P., Falco,V., Genesca,M. and Buzon,M.J.
  TITLE     NKG2C and NKG2A coexpression defines a highly functional antiviral
            NK population in spontaneous HIV control
  JOURNAL   JCI Insight 9 (20), e182660 (2024)
   PUBMED   39288262
  REMARK    GeneRIF: NKG2C and NKG2A coexpression defines a highly functional
            antiviral NK population in spontaneous HIV control.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1238)
  AUTHORS   Siemaszko,J., Lacina,P., Szymczak,D., Szeremet,A., Majcherek,M.,
            Czyz,A., Sobczyk-Kruszelnicka,M., Fidyk,W., Solarska,I.,
            Nasilowska-Adamska,B., Skowronska,P., Bieniaszewska,M.,
            Tomaszewska,A., Basak,G.W., Giebel,S., Wrobel,T. and
            Bogunia-Kubik,K.
  TITLE     Significance of HLA-E and its two NKG2 receptors in development of
            complications after allogeneic transplantation of hematopoietic
            stem cells
  JOURNAL   Front Immunol 14, 1227897 (2023)
   PUBMED   37901227
  REMARK    GeneRIF: Significance of HLA-E and its two NKG2 receptors in
            development of complications after allogeneic transplantation of
            hematopoietic stem cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1238)
  AUTHORS   Yang,X., Wang,X., Zou,Y., Zhang,S., Xia,M., Fu,L., Vollger,M.R.,
            Chen,N.C., Taylor,D.J., Harvey,W.T., Logsdon,G.A., Meng,D., Shi,J.,
            McCoy,R.C., Schatz,M.C., Li,W., Eichler,E.E., Lu,Q. and Mao,Y.
  TITLE     Characterization of large-scale genomic differences in the first
            complete human genome
  JOURNAL   Genome Biol 24 (1), 157 (2023)
   PUBMED   37403156
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1238)
  AUTHORS   Lin,Z., Bashirova,A.A., Viard,M., Garner,L., Quastel,M.,
            Beiersdorfer,M., Kasprzak,W.K., Akdag,M., Yuki,Y., Ojeda,P.,
            Das,S., Andresson,T., Naranbhai,V., Horowitz,A., McMichael,A.J.,
            Hoelzemer,A., Gillespie,G.M., Garcia-Beltran,W.F. and Carrington,M.
  TITLE     HLA class I signal peptide polymorphism determines the level of
            CD94/NKG2-HLA-E-mediated regulation of effector cell responses
  JOURNAL   Nat Immunol 24 (7), 1087-1097 (2023)
   PUBMED   37264229
REFERENCE   5  (bases 1 to 1238)
  AUTHORS   Asenjo,J., Moraru,M., Al-Akioui-Sanz,K., Altadill,M., Muntasell,A.,
            Lopez-Botet,M. and Vilches,C.
  TITLE     Diversity of NKG2C genotypes in a European population: Conserved
            and recombinant haplotypes in the coding, promoter, and
            3'-untranslated regions
  JOURNAL   HLA 100 (5), 469-478 (2022)
   PUBMED   35802353
  REMARK    GeneRIF: Diversity of NKG2C genotypes in a European population:
            Conserved and recombinant haplotypes in the coding, promoter, and
            3'-untranslated regions.
REFERENCE   6  (bases 1 to 1238)
  AUTHORS   Plougastel,B. and Trowsdale,J.
  TITLE     Sequence analysis of a 62-kb region overlapping the human KLRC
            cluster of genes
  JOURNAL   Genomics 49 (2), 193-199 (1998)
   PUBMED   9598306
REFERENCE   7  (bases 1 to 1238)
  AUTHORS   Braud,V.M., Allan,D.S., O'Callaghan,C.A., Soderstrom,K.,
            D'Andrea,A., Ogg,G.S., Lazetic,S., Young,N.T., Bell,J.I.,
            Phillips,J.H., Lanier,L.L. and McMichael,A.J.
  TITLE     HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C
  JOURNAL   Nature 391 (6669), 795-799 (1998)
   PUBMED   9486650
REFERENCE   8  (bases 1 to 1238)
  AUTHORS   Houchins,J.P., Lanier,L.L., Niemi,E.C., Phillips,J.H. and Ryan,J.C.
  TITLE     Natural killer cell cytolytic activity is inhibited by NKG2-A and
            activated by NKG2-C
  JOURNAL   J Immunol 158 (8), 3603-3609 (1997)
   PUBMED   9103421
REFERENCE   9  (bases 1 to 1238)
  AUTHORS   Yabe,T., McSherry,C., Bach,F.H., Fisch,P., Schall,R.P., Sondel,P.M.
            and Houchins,J.P.
  TITLE     A multigene family on human chromosome 12 encodes natural
            killer-cell lectins
  JOURNAL   Immunogenetics 37 (6), 455-460 (1993)
   PUBMED   8436421
REFERENCE   10 (bases 1 to 1238)
  AUTHORS   Houchins,J.P., Yabe,T., McSherry,C. and Bach,F.H.
  TITLE     DNA sequence analysis of NKG2, a family of related cDNA clones
            encoding type II integral membrane proteins on human natural killer
            cells
  JOURNAL   J Exp Med 173 (4), 1017-1020 (1991)
   PUBMED   2007850
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC093644.1, X54869.1,
            AF260134.1 and AC068775.52.
            
            On Aug 3, 2020 this sequence version replaced NM_002260.3.
            
            Summary: Natural killer (NK) cells are lymphocytes that can mediate
            lysis of certain tumor cells and virus-infected cells without
            previous activation. They can also regulate specific humoral and
            cell-mediated immunity. NK cells preferentially express several
            calcium-dependent (C-type) lectins, which have been implicated in
            the regulation of NK cell function. The group, designated KLRC
            (NKG2) are expressed primarily in natural killer (NK) cells and
            encodes a family of transmembrane proteins characterized by a type
            II membrane orientation (extracellular C terminus) and the presence
            of a C-type lectin domain. The KLRC (NKG2) gene family is located
            within the NK complex, a region that contains several C-type lectin
            genes preferentially expressed on NK cells. KLRC2 alternative
            splice variants have been described but their full-length nature
            has not been determined. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X54869.1, BC106069.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000381902.7/ ENSP00000371327.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                BC093644.1         8-24
            18-24               X54869.1           1-7
            25-726              AF260134.1         1-702
            727-1139            AC068775.52        14883-15295         c
            1140-1238           X54869.1           1123-1221
FEATURES             Location/Qualifiers
     source          1..1238
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.2"
     gene            1..1238
                     /gene="KLRC2"
                     /gene_synonym="CD159c; NKG2-C; NKG2C"
                     /note="killer cell lectin like receptor C2"
                     /db_xref="GeneID:3822"
                     /db_xref="HGNC:HGNC:6375"
                     /db_xref="MIM:602891"
     exon            1..211
                     /gene="KLRC2"
                     /gene_synonym="CD159c; NKG2-C; NKG2C"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..720
                     /gene="KLRC2"
                     /gene_synonym="CD159c; NKG2-C; NKG2C"
                     /note="NK cell receptor C; NKG2-C-activating NK receptor;
                     CD159 antigen-like family member C; killer cell
                     lectin-like receptor subfamily C, member 2; natural killer
                     cell receptor G2-C"
                     /codon_start=1
                     /product="NKG2-C type II integral membrane protein"
                     /protein_id="NP_002251.2"
                     /db_xref="CCDS:CCDS31745.1"
                     /db_xref="GeneID:3822"
                     /db_xref="HGNC:HGNC:6375"
                     /db_xref="MIM:602891"
                     /translation="MNKQRGTFSEVSLAQDPKRQQRKPKGNKSSISGTEQEIFQVELN
                     LQNPSLNHQGIDKIYDCQGLLPPPEKLTAEVLGIICIVLMATVLKTIVLIPFLEQNNF
                     SPNTRTQKARHCGHCPEEWITYSNSCYYIGKERRTWEESLLACTSKNSSLLSIDNEEE
                     MKFLASILPSSWIGVFRNSSHHPWVTINGLAFKHKIKDSDNAELNCAVLQVNRLKSAQ
                     CGSSMIYHCKHKL"
     exon            212..310
                     /gene="KLRC2"
                     /gene_synonym="CD159c; NKG2-C; NKG2C"
                     /inference="alignment:Splign:2.1.0"
     exon            311..355
                     /gene="KLRC2"
                     /gene_synonym="CD159c; NKG2-C; NKG2C"
                     /inference="alignment:Splign:2.1.0"
     exon            356..507
                     /gene="KLRC2"
                     /gene_synonym="CD159c; NKG2-C; NKG2C"
                     /inference="alignment:Splign:2.1.0"
     exon            508..608
                     /gene="KLRC2"
                     /gene_synonym="CD159c; NKG2-C; NKG2C"
                     /inference="alignment:Splign:2.1.0"
     exon            609..1238
                     /gene="KLRC2"
                     /gene_synonym="CD159c; NKG2-C; NKG2C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      722..727
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLRC2"
                     /gene_synonym="CD159c; NKG2-C; NKG2C"
                     /note="hexamer: AGTAAA"
     polyA_site      750
                     /gene="KLRC2"
                     /gene_synonym="CD159c; NKG2-C; NKG2C"
                     /note="major polyA site"
ORIGIN      
        1 ccctcacatc acacagctgc agagatgaat aaacaaagag gaaccttctc agaagtgagt
       61 ctggcccagg acccaaagcg gcagcaaagg aaacctaaag gcaataaaag ctccatttca
      121 ggaaccgaac aggaaatatt ccaagtagaa ttaaatcttc aaaatccttc cctgaatcat
      181 caagggattg ataaaatata tgactgccaa ggtttactgc cacctccaga gaagctcact
      241 gccgaggtcc taggaatcat ttgcattgtc ctgatggcca ctgtgttaaa aacaatagtt
      301 cttattcctt tcctggagca gaacaatttt tccccgaata caagaacgca gaaagcacgt
      361 cattgtggcc attgtcctga ggagtggatt acatattcca acagttgtta ttacattggt
      421 aaggaaagaa gaacttggga agagagtttg ctggcctgta cttcgaagaa ctccagtctg
      481 ctttctatag ataatgaaga agaaatgaaa tttctggcca gcattttacc ttcctcatgg
      541 attggtgtgt ttcgtaacag cagtcatcat ccatgggtga caataaatgg tttggctttc
      601 aaacataaga taaaagactc agataatgct gaacttaact gtgcagtgct acaagtaaat
      661 cgacttaaat cagcccagtg tggatcttca atgatatatc attgtaagca taagctttag
      721 aagtaaagca tttgcgtttg cagtgcatca gatacatttt atatttctta aaatagaaat
      781 attatgattg cataaatctg aaaatgaatt atgttatttg ctctgataca aaaattctaa
      841 atcaattatt gaaataggat gcacacaatt actaaagtac agacatccta gcatttgtgt
      901 cgggctcatt ttgctcaaca tggtatttgt ggttttcagc ctttctaaaa gttgcatgtt
      961 atgtgagtca gcttatagga agtaccaaga acagtcaaac ccatggagac agaaagtaga
     1021 atagtggttg ccaatgtctc agggaggttg aaataggaga tgaccactaa ttgatagaac
     1081 gtttctttgt gtcgtgatga aaactttcta aatttcagta gtggtgatgg ttgtaactct
     1141 gcgaatatac taaacatcat tgatttttaa tcattttaag tgcatgaaat gtatgctttg
     1201 tacatgacac ttcaataaag ctatccagaa aaaaaaaa
//
