LOCUS       NM_002259               1436 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens killer cell lectin like receptor C1 (KLRC1),
            transcript variant 1, mRNA.
ACCESSION   NM_002259 XM_005253359
VERSION     NM_002259.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1436)
  AUTHORS   Chen,Y., Liu,J.J., Qu,M.Y., Ren,B.X., Wu,H.Y., Zhang,L., Zhou,Z.,
            Liu,L.X. and Shen,H.M.
  TITLE     DNA Methylation of KLRC1 and KLRC3 in Autoimmune Thyroiditis:
            Perspective of Different Water Iodine Exposure
  JOURNAL   Biomed Environ Sci 37 (9), 1044-1055 (2024)
   PUBMED   39401997
  REMARK    GeneRIF: DNA Methylation of KLRC1 and KLRC3 in Autoimmune
            Thyroiditis: Perspective of Different Water Iodine Exposure.
REFERENCE   2  (bases 1 to 1436)
  AUTHORS   Sanchez-Gaona,N., Gallego-Cortes,A., Astorga-Gamaza,A., Rallon,N.,
            Benito,J.M., Ruiz-Mateos,E., Curran,A., Burgos,J., Navarro,J.,
            Suanzes,P., Falco,V., Genesca,M. and Buzon,M.J.
  TITLE     NKG2C and NKG2A coexpression defines a highly functional antiviral
            NK population in spontaneous HIV control
  JOURNAL   JCI Insight 9 (20), e182660 (2024)
   PUBMED   39288262
  REMARK    GeneRIF: NKG2C and NKG2A coexpression defines a highly functional
            antiviral NK population in spontaneous HIV control.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1436)
  AUTHORS   Li,G., Liu,X., Gu,C., Ma,G., Li,S., Ma,Z., Xiong,Y., Jiang,Y.,
            Huang,Q., Wu,J., Wu,Z., Liao,W., Wu,Q. and Shi,M.
  TITLE     Mutual exclusivity and co-occurrence patterns of immune checkpoints
            indicate NKG2A relates to anti-PD-1 resistance in gastric cancer
  JOURNAL   J Transl Med 22 (1), 718 (2024)
   PUBMED   39097734
  REMARK    GeneRIF: Mutual exclusivity and co-occurrence patterns of immune
            checkpoints indicate NKG2A relates to anti-PD-1 resistance in
            gastric cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1436)
  AUTHORS   Rodriguez-Garcia,G.J., Graves,D.K., Mirza,M.B., Idrees,K.,
            Kim,Y.J., Korrer,M.J. and Rathmell,J.C.
  TITLE     Cancer Cell Small Molecule Secretome Induces the Immune Checkpoint
            NKG2A and Dysfunction of Human CD8+ T Cells
  JOURNAL   Immunohorizons 8 (6), 464-477 (2024)
   PUBMED   38922288
  REMARK    GeneRIF: Cancer Cell Small Molecule Secretome Induces the Immune
            Checkpoint NKG2A and Dysfunction of Human CD8+ T Cells.
REFERENCE   5  (bases 1 to 1436)
  AUTHORS   Jost,S., Lucar,O., Lee,E., Yoder,T., Kroll,K., Sugawara,S.,
            Smith,S., Jones,R., Tweet,G., Werner,A., Tomezsko,P.J., Dugan,H.L.,
            Ghofrani,J., Rascle,P., Altfeld,M., Muller-Trutwin,M., Goepfert,P.
            and Reeves,R.K.
  TITLE     Antigen-specific memory NK cell responses against HIV and influenza
            use the NKG2/HLA-E axis
  JOURNAL   Sci Immunol 8 (90), eadi3974 (2023)
   PUBMED   38064568
  REMARK    GeneRIF: Antigen-specific memory NK cell responses against HIV and
            influenza use the NKG2/HLA-E axis.
REFERENCE   6  (bases 1 to 1436)
  AUTHORS   Brooks,A.G., Posch,P.E., Scorzelli,C.J., Borrego,F. and
            Coligan,J.E.
  TITLE     NKG2A complexed with CD94 defines a novel inhibitory natural killer
            cell receptor
  JOURNAL   J Exp Med 185 (4), 795-800 (1997)
   PUBMED   9034158
REFERENCE   7  (bases 1 to 1436)
  AUTHORS   Lazetic,S., Chang,C., Houchins,J.P., Lanier,L.L. and Phillips,J.H.
  TITLE     Human natural killer cell receptors involved in MHC class I
            recognition are disulfide-linked heterodimers of CD94 and NKG2
            subunits
  JOURNAL   J Immunol 157 (11), 4741-4745 (1996)
   PUBMED   8943374
REFERENCE   8  (bases 1 to 1436)
  AUTHORS   Plougastel,B., Jones,T. and Trowsdale,J.
  TITLE     Genomic structure, chromosome location, and alternative splicing of
            the human NKG2A gene
  JOURNAL   Immunogenetics 44 (4), 286-291 (1996)
   PUBMED   8753859
REFERENCE   9  (bases 1 to 1436)
  AUTHORS   Yabe,T., McSherry,C., Bach,F.H., Fisch,P., Schall,R.P., Sondel,P.M.
            and Houchins,J.P.
  TITLE     A multigene family on human chromosome 12 encodes natural
            killer-cell lectins
  JOURNAL   Immunogenetics 37 (6), 455-460 (1993)
   PUBMED   8436421
REFERENCE   10 (bases 1 to 1436)
  AUTHORS   Houchins,J.P., Yabe,T., McSherry,C. and Bach,F.H.
  TITLE     DNA sequence analysis of NKG2, a family of related cDNA clones
            encoding type II integral membrane proteins on human natural killer
            cells
  JOURNAL   J Exp Med 173 (4), 1017-1020 (1991)
   PUBMED   2007850
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC068775.52.
            
            On Jun 2, 2019 this sequence version replaced NM_002259.4.
            
            Summary: Natural killer (NK) cells are lymphocytes that can mediate
            lysis of certain tumor cells and virus-infected cells without
            previous activation. They can also regulate specific humoral and
            cell-mediated immunity. The protein encoded by this gene belongs to
            the killer cell lectin-like receptor family, also called NKG2
            family, which is a group of transmembrane proteins preferentially
            expressed in NK cells. This family of proteins is characterized by
            the type II membrane orientation and the presence of a C-type
            lectin domain. This protein forms a complex with another family
            member, KLRD1/CD94, and has been implicated in the recognition of
            the MHC class I HLA-E molecules in NK cells. The genes of NKG2
            family members form a killer cell lectin-like receptor gene cluster
            on chromosome 12. Multiple alternatively spliced transcript
            variants encoding distinct isoforms have been observed. [provided
            by RefSeq, Jan 2015].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (NKG2-A). Variants 1 and 3 encode the same isoform (NKG2-A).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF461812.1, X54867.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000359151.8/ ENSP00000352064.3
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-180               AC068775.52        37383-37562         c
            181-398             AC068775.52        35155-35372         c
            399-494             AC068775.52        34669-34764         c
            495-548             AC068775.52        34099-34152         c
            549-700             AC068775.52        33422-33573         c
            701-801             AC068775.52        31717-31817         c
            802-1436            AC068775.52        30213-30847         c
FEATURES             Location/Qualifiers
     source          1..1436
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.2"
     gene            1..1436
                     /gene="KLRC1"
                     /gene_synonym="CD159A; NKG2; NKG2A"
                     /note="killer cell lectin like receptor C1"
                     /db_xref="GeneID:3821"
                     /db_xref="HGNC:HGNC:6374"
                     /db_xref="MIM:161555"
     exon            1..180
                     /gene="KLRC1"
                     /gene_synonym="CD159A; NKG2; NKG2A"
                     /inference="alignment:Splign:2.1.0"
     exon            181..398
                     /gene="KLRC1"
                     /gene_synonym="CD159A; NKG2; NKG2A"
                     /inference="alignment:Splign:2.1.0"
     CDS             212..913
                     /gene="KLRC1"
                     /gene_synonym="CD159A; NKG2; NKG2A"
                     /note="isoform NKG2-A is encoded by transcript variant 1;
                     natural killer cell lectin; NKG2-1/B activating NK
                     receptor; NK cell receptor A; NKG2-A/B type II integral
                     membrane protein; natural killer group protein 2; C-lectin
                     type II protein; NKG2-A/NKG2-B type II integral membrane
                     protein; NKG2-A/B-activating NK receptor; CD159
                     antigen-like family member A; killer cell lectin-like
                     receptor subfamily C, member 1"
                     /codon_start=1
                     /product="NKG2-A/NKG2-B type II integral membrane protein
                     isoform NKG2-A"
                     /protein_id="NP_002250.2"
                     /db_xref="CCDS:CCDS8625.1"
                     /db_xref="GeneID:3821"
                     /db_xref="HGNC:HGNC:6374"
                     /db_xref="MIM:161555"
                     /translation="MDNQGVIYSDLNLPPNPKRQQRKPKGNKNSILATEQEITYAELN
                     LQKASQDFQGNDKTYHCKDLPSAPEKLIVGILGIICLILMASVVTIVVIPSTLIQRHN
                     NSSLNTRTQKARHCGHCPEEWITYSNSCYYIGKERRTWEESLLACTSKNSSLLSIDNE
                     EEMKFLSIISPSSWIGVFRNSSHHPWVTMNGLAFKHEIKDSDNAELNCAVLQVNRLKS
                     AQCGSSIIYHCKHKL"
     exon            399..494
                     /gene="KLRC1"
                     /gene_synonym="CD159A; NKG2; NKG2A"
                     /inference="alignment:Splign:2.1.0"
     exon            495..548
                     /gene="KLRC1"
                     /gene_synonym="CD159A; NKG2; NKG2A"
                     /inference="alignment:Splign:2.1.0"
     exon            549..700
                     /gene="KLRC1"
                     /gene_synonym="CD159A; NKG2; NKG2A"
                     /inference="alignment:Splign:2.1.0"
     exon            701..801
                     /gene="KLRC1"
                     /gene_synonym="CD159A; NKG2; NKG2A"
                     /inference="alignment:Splign:2.1.0"
     exon            802..1436
                     /gene="KLRC1"
                     /gene_synonym="CD159A; NKG2; NKG2A"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccactcttga ctcactctga gccttcacag ggcagtctgc gaagattgca ggcattgttt
       61 gttcttgtct tggatttatg cctttaaatt tcacctttta ttacacagct atagcaggcc
      121 tttttatgag actaacctgg cctctccact aaaggatgtg tgactttctg gggacagaag
      181 agtacagtcc ctgacatcac acactgcaga gatggataac caaggagtaa tctactcaga
      241 cctgaatctg cccccaaacc caaagaggca gcaacgaaaa cctaaaggca ataaaaactc
      301 cattttagca actgaacagg aaataaccta tgcggaatta aaccttcaaa aagcttctca
      361 ggattttcaa gggaatgaca aaacctatca ctgcaaagat ttaccatcag ctccagagaa
      421 gctcattgtt gggatcctgg gaattatctg tcttatctta atggcctctg tggtaacgat
      481 agttgttatt ccctctacat taatacagag gcacaacaat tcttccctga atacaagaac
      541 tcagaaagca cgtcattgtg gccattgtcc tgaggagtgg attacatatt ccaacagttg
      601 ttactacatt ggtaaggaaa gaagaacttg ggaagagagt ttgctggcct gtacttcgaa
      661 gaactccagt ctgctttcta tagataatga agaagaaatg aaatttctgt ccatcatttc
      721 accatcctca tggattggtg tgtttcgtaa cagcagtcat catccatggg tgacaatgaa
      781 tggtttggct ttcaaacatg agataaaaga ctcagataat gctgaactta actgtgcagt
      841 gctacaagta aatcgactta aatcagccca gtgtggatct tcaataatat atcattgtaa
      901 gcataagctt tagaggtaaa gcgtttgcat ttgcagtgca tcagataaat tgtatatttc
      961 ttaaaataga aatatattat gattgcataa atcttaaaat gaattatgtt atttgctcta
     1021 ataagaaaat tctaaatcaa ttattgaaac aggatacaca caattactaa agtacagaca
     1081 tcctagcatt tgtgtcgggc tcattttgct caacatggta tttgtggttt tcagcctttc
     1141 taaaagttgc atgttatgtg agtcagctta taggaagtac caagaacagt caaacccatg
     1201 gagacagaaa gtagaatagt ggttgccaat gtctgaggga ggttgaaata ggagatgacc
     1261 tctaactgat agaacgttac tttgtgtcgt gatgaaaact ttctaaattt cagtagtggt
     1321 gatggttgta actctgcgaa tatactaaac atcattgatt tttaatcatt ttaagtgcat
     1381 gaaatgtatg ctttgtacac gacacttcaa taaagctatc cagaaaaaaa aaaaaa
//
