LOCUS       NM_002258               1478 bp    mRNA    linear   PRI 15-JUL-2024
DEFINITION  Homo sapiens killer cell lectin like receptor B1 (KLRB1), mRNA.
ACCESSION   NM_002258
VERSION     NM_002258.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1478)
  AUTHORS   Fang,S. and Zhou,Y.
  TITLE     Deciphering the role of KLRB1: a novel prognostic indicator in
            hepatocellular carcinoma
  JOURNAL   BMC Gastroenterol 24 (1), 210 (2024)
   PUBMED   38914941
  REMARK    GeneRIF: Deciphering the role of KLRB1: a novel prognostic
            indicator in hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1478)
  AUTHORS   Zhang,Z., Bahabayi,A., Liu,D., Hasimu,A., Zhang,Y., Guo,S., Liu,R.,
            Zhang,K., Li,Q., Xiong,Z., Wang,P. and Liu,C.
  TITLE     KLRB1 defines an activated phenotype of CD4+ T cells and shows
            significant upregulation in patients with primary Sjogren's
            syndrome
  JOURNAL   Int Immunopharmacol 133, 112072 (2024)
   PUBMED   38636371
  REMARK    GeneRIF: KLRB1 defines an activated phenotype of CD4+ T cells and
            shows significant upregulation in patients with primary Sjogren's
            syndrome.
REFERENCE   3  (bases 1 to 1478)
  AUTHORS   Chen,J.L., Wu,C.Y., Luo,X.Y., Wang,X.Y., Wang,F.M., Huang,X.,
            Yuan,W. and Guo,Q.
  TITLE     Down-regulation of KLRB1 is associated with increased cell growth,
            metastasis, poor prognosis, as well as a dysfunctional immune
            microenvironment in LUAD
  JOURNAL   Sci Rep 14 (1), 11782 (2024)
   PUBMED   38782996
  REMARK    GeneRIF: Down-regulation of KLRB1 is associated with increased cell
            growth, metastasis, poor prognosis, as well as a dysfunctional
            immune microenvironment in LUAD.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1478)
  AUTHORS   Li,L., Hu,Y., Li,X. and Ju,B.
  TITLE     A comprehensive analysis of the KLRB1 expression and its clinical
            implication in testicular germ cell tumors: A review
  JOURNAL   Medicine (Baltimore) 103 (15), e37688 (2024)
   PUBMED   38608099
  REMARK    GeneRIF: A comprehensive analysis of the KLRB1 expression and its
            clinical implication in testicular germ cell tumors: A review.
            Review article
REFERENCE   5  (bases 1 to 1478)
  AUTHORS   Hu,X., Dong,Y., Xie,S., Song,Y., Yu,C., He,Y., Wang,Z., Hu,Q.,
            Ni,Y. and Ding,L.
  TITLE     Immune checkpoint CD161/LLT1-associated immunological landscape and
            diagnostic value in oral squamous cell carcinoma
  JOURNAL   J Pathol Clin Res 10 (2), e353 (2024)
   PUBMED   38502058
  REMARK    GeneRIF: Immune checkpoint CD161/LLT1-associated immunological
            landscape and diagnostic value in oral squamous cell carcinoma.
REFERENCE   6  (bases 1 to 1478)
  AUTHORS   Poggi,A., Rubartelli,A., Moretta,L. and Zocchi,M.R.
  TITLE     Expression and function of NKRP1A molecule on human monocytes and
            dendritic cells
  JOURNAL   Eur J Immunol 27 (11), 2965-2970 (1997)
   PUBMED   9394825
REFERENCE   7  (bases 1 to 1478)
  AUTHORS   Poggi,A., Costa,P., Zocchi,M.R. and Moretta,L.
  TITLE     Phenotypic and functional analysis of CD4+ NKRP1A+ human T
            lymphocytes. Direct evidence that the NKRP1A molecule is involved
            in transendothelial migration
  JOURNAL   Eur J Immunol 27 (9), 2345-2350 (1997)
   PUBMED   9341779
REFERENCE   8  (bases 1 to 1478)
  AUTHORS   Renedo,M., Arce,I., Rodriguez,A., Carretero,M., Lanier,L.L.,
            Lopez-Botet,M. and Fernandez-Ruiz,E.
  TITLE     The human natural killer gene complex is located on chromosome
            12p12-p13
  JOURNAL   Immunogenetics 46 (4), 307-311 (1997)
   PUBMED   9218532
REFERENCE   9  (bases 1 to 1478)
  AUTHORS   Poggi,A., Costa,P., Morelli,L., Cantoni,C., Pella,N., Spada,F.,
            Biassoni,R., Nanni,L., Revello,V., Tomasello,E., Mingari,M.C.,
            Moretta,A. and Moretta,L.
  TITLE     Expression of human NKRP1A by CD34+ immature thymocytes:
            NKRP1A-mediated regulation of proliferation and cytolytic activity
  JOURNAL   Eur J Immunol 26 (6), 1266-1272 (1996)
   PUBMED   8647203
REFERENCE   10 (bases 1 to 1478)
  AUTHORS   Lanier,L.L., Chang,C. and Phillips,J.H.
  TITLE     Human NKR-P1A. A disulfide-linked homodimer of the C-type lectin
            superfamily expressed by a subset of NK and T lymphocytes
  JOURNAL   J Immunol 153 (6), 2417-2428 (1994)
   PUBMED   8077657
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC006432.15, BF432813.1 and
            U11276.1.
            
            On May 17, 2019 this sequence version replaced NM_002258.2.
            
            Summary: Natural killer (NK) cells are lymphocytes that mediate
            cytotoxicity and secrete cytokines after immune stimulation.
            Several genes of the C-type lectin superfamily, including the
            rodent NKRP1 family of glycoproteins, are expressed by NK cells and
            may be involved in the regulation of NK cell function. The KLRB1
            protein contains an extracellular domain with several motifs
            characteristic of C-type lectins, a transmembrane domain, and a
            cytoplasmic domain. The KLRB1 protein is classified as a type II
            membrane protein because it has an external C terminus. [provided
            by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC027885.1, AK292022.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000229402.4/ ENSP00000229402.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AC006432.15        2626-2640
            16-21               BF432813.1         2-7
            22-755              U11276.1           5-738
            756-1478            AC006432.15        15269-15991
FEATURES             Location/Qualifiers
     source          1..1478
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.31"
     gene            1..1478
                     /gene="KLRB1"
                     /gene_synonym="CD161; CLEC5B; hNKR-P1A; NKR; NKR-P1;
                     NKR-P1A; NKRP1A"
                     /note="killer cell lectin like receptor B1"
                     /db_xref="GeneID:3820"
                     /db_xref="HGNC:HGNC:6373"
                     /db_xref="MIM:602890"
     exon            1..162
                     /gene="KLRB1"
                     /gene_synonym="CD161; CLEC5B; hNKR-P1A; NKR; NKR-P1;
                     NKR-P1A; NKRP1A"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..755
                     /gene="KLRB1"
                     /gene_synonym="CD161; CLEC5B; hNKR-P1A; NKR; NKR-P1;
                     NKR-P1A; NKRP1A"
                     /note="C-type lectin domain family 5 member B; natural
                     killer cell surface protein P1A; killer cell lectin-like
                     receptor subfamily B, member 1"
                     /codon_start=1
                     /product="killer cell lectin-like receptor subfamily B
                     member 1"
                     /protein_id="NP_002249.1"
                     /db_xref="CCDS:CCDS8601.1"
                     /db_xref="GeneID:3820"
                     /db_xref="HGNC:HGNC:6373"
                     /db_xref="MIM:602890"
                     /translation="MDQQAIYAELNLPTDSGPESSSPSSLPRDVCQGSPWHQFALKLS
                     CAGIILLVLVVTGLSVSVTSLIQKSSIEKCSVDIQQSRNKTTERPGLLNCPIYWQQLR
                     EKCLLFSHTVNPWNNSLADCSTKESSLLLIRDKDELIHTQNLIRDKAILFWIGLNFSL
                     SEKNWKWINGSFLNSNDLEIRGDAKENSCISISQTSVYSEYCSTEIRWICQKELTPVR
                     NKVYPDS"
     exon            163..261
                     /gene="KLRB1"
                     /gene_synonym="CD161; CLEC5B; hNKR-P1A; NKR; NKR-P1;
                     NKR-P1A; NKRP1A"
                     /inference="alignment:Splign:2.1.0"
     exon            262..336
                     /gene="KLRB1"
                     /gene_synonym="CD161; CLEC5B; hNKR-P1A; NKR; NKR-P1;
                     NKR-P1A; NKRP1A"
                     /inference="alignment:Splign:2.1.0"
     exon            337..491
                     /gene="KLRB1"
                     /gene_synonym="CD161; CLEC5B; hNKR-P1A; NKR; NKR-P1;
                     NKR-P1A; NKRP1A"
                     /inference="alignment:Splign:2.1.0"
     exon            492..607
                     /gene="KLRB1"
                     /gene_synonym="CD161; CLEC5B; hNKR-P1A; NKR; NKR-P1;
                     NKR-P1A; NKRP1A"
                     /inference="alignment:Splign:2.1.0"
     exon            608..1478
                     /gene="KLRB1"
                     /gene_synonym="CD161; CLEC5B; hNKR-P1A; NKR; NKR-P1;
                     NKR-P1A; NKRP1A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      732..737
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLRB1"
                     /gene_synonym="CD161; CLEC5B; hNKR-P1A; NKR; NKR-P1;
                     NKR-P1A; NKRP1A"
                     /note="hexamer: AATAAA"
     polyA_site      755
                     /gene="KLRB1"
                     /gene_synonym="CD161; CLEC5B; hNKR-P1A; NKR; NKR-P1;
                     NKR-P1A; NKRP1A"
                     /note="major polyA site"
     regulatory      1219..1224
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLRB1"
                     /gene_synonym="CD161; CLEC5B; hNKR-P1A; NKR; NKR-P1;
                     NKR-P1A; NKRP1A"
                     /note="hexamer: AATAAA"
     polyA_site      1239
                     /gene="KLRB1"
                     /gene_synonym="CD161; CLEC5B; hNKR-P1A; NKR; NKR-P1;
                     NKR-P1A; NKRP1A"
ORIGIN      
        1 ccttttgctg attttgcctc acagaattga gagtttgttc ttacacacaa gtttaatgcc
       61 accttcctct gtctgccatg gaccaacaag caatatatgc tgagttaaac ttacccacag
      121 actcaggccc agaaagttct tcaccttcat ctcttcctcg ggatgtctgt cagggttcac
      181 cttggcatca atttgccctg aaacttagct gtgctgggat tattctcctt gtcttggttg
      241 ttactgggtt gagtgtttca gtgacatcct taatacagaa atcatcaata gaaaaatgca
      301 gtgtggacat tcaacagagc aggaataaaa caacagagag accgggtctc ttaaactgcc
      361 caatatattg gcagcaactc cgagagaaat gcttgttatt ttctcacact gtcaaccctt
      421 ggaataacag tctagctgat tgttccacca aagaatccag cctgctgctt attcgagata
      481 aggatgaatt gatacacaca cagaacctga tacgtgacaa agcaattctg ttttggattg
      541 gattaaattt ttcattatca gaaaagaact ggaagtggat aaacggctct tttttaaatt
      601 ctaatgactt agaaattaga ggtgatgcta aagaaaacag ctgtatttcc atctcacaga
      661 catctgtgta ttctgagtac tgtagtacag aaatcagatg gatctgccaa aaagaactaa
      721 cacctgtgag aaataaagtg tatcctgact cttgactatg aatcccatct caatttattt
      781 gcttcccatt actgatctct gtacttgtag ctgcacatac tattggtact acctaatagt
      841 gccacattta gtggcacaaa gtgaacaatt ctgagaattg acaactgtta tgaatcttac
      901 agaagttcat gtttatcata ttcattctat taaatgagga aacagagaca tagagaaaaa
      961 cgtgcatcgt tttaaagaaa cagtgatatt ctatggtgaa ggagtgaagg atgtccccga
     1021 atatgccaga ttggtatatg attgttttgt gtttaaaaca gtggagaaat tgtagattca
     1081 gaaagggaga gctgacctgt ctcttcccgc acgcggcaag ccgtgaagat tcctctggga
     1141 gggctatccg agtcatacaa gggcaagaaa atagctctta tcgccagaga cctggaattg
     1201 gatgctgcaa tgaacctgaa taaagatact taataaacac ctatctttca cctattttac
     1261 agccccccgc aaccaatata tctcctagtg actcctctag aaaatttatt gcccctagcc
     1321 agcttttctt catcctgtca tttcttttca aatttatcat tcttggtcta aaaagcataa
     1381 aagcatcttg cttaggccac ttctatggat ttcactctct tgcgagttcc tcatgtacat
     1441 gcaaaacgaa taaaatgtgt atacttttat tttgttca
//
