LOCUS       NM_007196                915 bp    mRNA    linear   PRI 15-FEB-2024
DEFINITION  Homo sapiens kallikrein related peptidase 8 (KLK8), transcript
            variant 1, mRNA.
ACCESSION   NM_007196
VERSION     NM_007196.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 915)
  AUTHORS   Tian,H., Wei,R., Xiao,C., Fan,T., Che,Y., Liu,T., Zheng,B., Li,C.
            and He,J.
  TITLE     Tumor-derived KLK8 predicts inferior survival and promotes an
            immune-suppressive tumor microenvironment in lung squamous cell
            carcinoma
  JOURNAL   BMC Pulm Med 24 (1), 53 (2024)
   PUBMED   38273291
  REMARK    GeneRIF: Tumor-derived KLK8 predicts inferior survival and promotes
            an immune-suppressive tumor microenvironment in lung squamous cell
            carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 915)
  AUTHORS   Luo,Q., Li,J., Miao,H., Su,S., Chen,Y., Xu,C., Zhao,C., Huang,J.,
            Ling,K., Lin,C., Yan,H. and Zhang,S.
  TITLE     circSSPO boosts growth of esophageal squamous cell carcinoma
            through upregulation of micrRNA-6820-5p-mediated KLK8 and PKD1
            expression
  JOURNAL   Cell Biol Toxicol 39 (6), 3219-3234 (2023)
   PUBMED   37812360
  REMARK    GeneRIF: circSSPO boosts growth of esophageal squamous cell
            carcinoma through upregulation of micrRNA-6820-5p-mediated KLK8 and
            PKD1 expression.
REFERENCE   3  (bases 1 to 915)
  AUTHORS   Shiosaka,S.
  TITLE     Kallikrein 8: A key sheddase to strengthen and stabilize neural
            plasticity
  JOURNAL   Neurosci Biobehav Rev 140, 104774 (2022)
   PUBMED   35820483
  REMARK    GeneRIF: Kallikrein 8: A key sheddase to strengthen and stabilize
            neural plasticity.
            Review article
REFERENCE   4  (bases 1 to 915)
  AUTHORS   Starnawska,A., Bukowski,L., Chernomorchenko,A., Elfving,B.,
            Muller,H.K., van den Oord,E., Aberg,K., Guintivano,J., Grove,J.,
            Mors,O., Borglum,A.D., Nielsen,A.L., Qvist,P. and Staunstrup,N.H.
  TITLE     DNA methylation of the KLK8 gene in depression symptomatology
  JOURNAL   Clin Epigenetics 13 (1), 200 (2021)
   PUBMED   34715912
  REMARK    GeneRIF: DNA methylation of the KLK8 gene in depression
            symptomatology.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 915)
  AUTHORS   Hua,Q., Sun,Z., Liu,Y., Shen,X., Zhao,W., Zhu,X. and Xu,P.
  TITLE     KLK8 promotes the proliferation and metastasis of colorectal cancer
            via the activation of EMT associated with PAR1
  JOURNAL   Cell Death Dis 12 (10), 860 (2021)
   PUBMED   34552064
  REMARK    GeneRIF: KLK8 promotes the proliferation and metastasis of
            colorectal cancer via the activation of EMT associated with PAR1.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 915)
  AUTHORS   Planque,C., Choi,Y.H., Guyetant,S., Heuze-Vourc'h,N., Briollais,L.
            and Courty,Y.
  TITLE     Alternative splicing variant of kallikrein-related peptidase 8 as
            an independent predictor of unfavorable prognosis in lung cancer
  JOURNAL   Clin Chem 56 (6), 987-997 (2010)
   PUBMED   20360129
  REMARK    GeneRIF: The KLK8-T4 alternative splice variant, alone or in
            combination, may be a new independent marker of unfavorable
            prognosis in lung cancer.
REFERENCE   7  (bases 1 to 915)
  AUTHORS   Underwood,L.J., Tanimoto,H., Wang,Y., Shigemasa,K., Parmley,T.H.
            and O'Brien,T.J.
  TITLE     Cloning of tumor-associated differentially expressed gene-14, a
            novel serine protease overexpressed by ovarian carcinoma
  JOURNAL   Cancer Res 59 (17), 4435-4439 (1999)
   PUBMED   10485494
REFERENCE   8  (bases 1 to 915)
  AUTHORS   Mitsui,S., Tsuruoka,N., Yamashiro,K., Nakazato,H. and Yamaguchi,N.
  TITLE     A novel form of human neuropsin, a brain-related serine protease,
            is generated by alternative splicing and is expressed
            preferentially in human adult brain
  JOURNAL   Eur J Biochem 260 (3), 627-634 (1999)
   PUBMED   10102990
REFERENCE   9  (bases 1 to 915)
  AUTHORS   Yoshida,S., Taniguchi,M., Hirata,A. and Shiosaka,S.
  TITLE     Sequence analysis and expression of human neuropsin cDNA and gene
  JOURNAL   Gene 213 (1-2), 9-16 (1998)
   PUBMED   9714609
REFERENCE   10 (bases 1 to 915)
  AUTHORS   Adams,M.D., Kerlavage,A.R., Fleischmann,R.D., Fuldner,R.A.,
            Bult,C.J., Lee,N.H., Kirkness,E.F., Weinstock,K.G., Gocayne,J.D.,
            White,O. et al.
  TITLE     Initial assessment of human gene diversity and expression patterns
            based upon 83 million nucleotides of cDNA sequence
  JOURNAL   Nature 377 (6547 Suppl), 3-174 (1995)
   PUBMED   7566098
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY359036.1 and AA587273.1.
            
            On Jun 2, 2019 this sequence version replaced NM_007196.3.
            
            Summary: Kallikreins are a subgroup of serine proteases having
            diverse physiological functions. Growing evidence suggests that
            many kallikreins are implicated in carcinogenesis and some have
            potential as novel cancer and other disease biomarkers. This gene
            is one of the fifteen kallikrein subfamily members located in
            tandem in a gene cluster on chromosome 19. The encoded protein may
            be involved in proteolytic cascade in the skin and may serve as a
            biomarker for ovarian cancer. Alternate splicing of this gene
            results in multiple transcript variants encoding different
            isoforms. [provided by RefSeq, Jul 2013].
            
            Transcript Variant: This variant (1, also known as T1) uses an
            alternate splice site in the 5' coding region, compared to variant
            2. It encodes isoform 1, which is shorter than isoform 2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY359036.1, AB009849.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2156670 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000695909.1/ ENSP00000512260.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-911               AY359036.1         85-995
            912-915             AA587273.1         11-14               c
FEATURES             Location/Qualifiers
     source          1..915
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.41"
     gene            1..915
                     /gene="KLK8"
                     /gene_synonym="HNP; NP; NRPN; PRSS19; TADG14"
                     /note="kallikrein related peptidase 8"
                     /db_xref="GeneID:11202"
                     /db_xref="HGNC:HGNC:6369"
                     /db_xref="MIM:605644"
     exon            1..73
                     /gene="KLK8"
                     /gene_synonym="HNP; NP; NRPN; PRSS19; TADG14"
                     /inference="alignment:Splign:2.1.0"
     exon            74..151
                     /gene="KLK8"
                     /gene_synonym="HNP; NP; NRPN; PRSS19; TADG14"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..864
                     /gene="KLK8"
                     /gene_synonym="HNP; NP; NRPN; PRSS19; TADG14"
                     /EC_number="3.4.21.118"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; serine protease 19; ovasin; kallikrein-8;
                     serine protease TADG-14; tumor-associated differentially
                     expressed gene 14 protein"
                     /codon_start=1
                     /product="kallikrein-8 isoform 1 preproprotein"
                     /protein_id="NP_009127.1"
                     /db_xref="CCDS:CCDS12813.1"
                     /db_xref="GeneID:11202"
                     /db_xref="HGNC:HGNC:6369"
                     /db_xref="MIM:605644"
                     /translation="MGRPRPRAAKTWMFLLLLGGAWAGHSRAQEDKVLGGHECQPHSQ
                     PWQAALFQGQQLLCGGVLVGGNWVLTAAHCKKPKYTVRLGDHSLQNKDGPEQEIPVVQ
                     SIPHPCYNSSDVEDHNHDLMLLQLRDQASLGSKVKPISLADHCTQPGQKCTVSGWGTV
                     TSPRENFPDTLNCAEVKIFPQKKCEDAYPGQITDGMVCAGSSKGADTCQGDSGGPLVC
                     DGALQGITSWGSDPCGRSDKPGVYTNICRYLDWIKKIIGSKG"
     exon            152..311
                     /gene="KLK8"
                     /gene_synonym="HNP; NP; NRPN; PRSS19; TADG14"
                     /inference="alignment:Splign:2.1.0"
     exon            312..574
                     /gene="KLK8"
                     /gene_synonym="HNP; NP; NRPN; PRSS19; TADG14"
                     /inference="alignment:Splign:2.1.0"
     exon            575..708
                     /gene="KLK8"
                     /gene_synonym="HNP; NP; NRPN; PRSS19; TADG14"
                     /inference="alignment:Splign:2.1.0"
     exon            709..915
                     /gene="KLK8"
                     /gene_synonym="HNP; NP; NRPN; PRSS19; TADG14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      892..897
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLK8"
                     /gene_synonym="HNP; NP; NRPN; PRSS19; TADG14"
                     /note="hexamer: AATAAA"
     polyA_site      915
                     /gene="KLK8"
                     /gene_synonym="HNP; NP; NRPN; PRSS19; TADG14"
                     /note="major polyA site"
ORIGIN      
        1 agagaactga agtactgggg cctcctccac tgggtccgaa tcagtaggtg accccgcccc
       61 tggattctgg aagacctcac catgggacgc ccccgacctc gtgcggccaa gacgtggatg
      121 ttcctgctct tgctgggggg agcctgggca ggacactcca gggcacagga ggacaaggtg
      181 ctggggggtc atgagtgcca accccattcg cagccttggc aggcggcctt gttccagggc
      241 cagcaactac tctgtggcgg tgtccttgta ggtggcaact gggtccttac agctgcccac
      301 tgtaaaaaac cgaaatacac agtacgcctg ggagaccaca gcctacagaa taaagatggc
      361 ccagagcaag aaatacctgt ggttcagtcc atcccacacc cctgctacaa cagcagcgat
      421 gtggaggacc acaaccatga tctgatgctt cttcaactgc gtgaccaggc atccctgggg
      481 tccaaagtga agcccatcag cctggcagat cattgcaccc agcctggcca gaagtgcacc
      541 gtctcaggct ggggcactgt caccagtccc cgagagaatt ttcctgacac tctcaactgt
      601 gcagaagtaa aaatctttcc ccagaagaag tgtgaggatg cttacccggg gcagatcaca
      661 gatggcatgg tctgtgcagg cagcagcaaa ggggctgaca cgtgccaggg cgattctgga
      721 ggccccctgg tgtgtgatgg tgcactccag ggcatcacat cctggggctc agacccctgt
      781 gggaggtccg acaaacctgg cgtctatacc aacatctgcc gctacctgga ctggatcaag
      841 aagatcatag gcagcaaggg ctgattctag gataagcact agatctccct taataaactc
      901 acaactctct ggttc
//
