LOCUS       NM_001207053            1824 bp    mRNA    linear   PRI 10-JUN-2024
DEFINITION  Homo sapiens kallikrein related peptidase 7 (KLK7), transcript
            variant 3, mRNA.
ACCESSION   NM_001207053
VERSION     NM_001207053.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1824)
  AUTHORS   Shanmugam,A., Rudasill,J. and Criswell,S.
  TITLE     Increase of KLK7, cytokeratin 5/6, and elafin expression in head
            and neck squamous cell carcinoma compared with lung squamous cell
            carcinoma
  JOURNAL   J Histotechnol 47 (2), 80-86 (2024)
   PUBMED   38189409
  REMARK    GeneRIF: Increase of KLK7, cytokeratin 5/6, and elafin expression
            in head and neck squamous cell carcinoma compared with lung
            squamous cell carcinoma.
REFERENCE   2  (bases 1 to 1824)
  AUTHORS   Xiang,F., Wang,Y., Cao,C., Li,Q., Deng,H., Zheng,J., Liu,X. and
            Tan,X.
  TITLE     The Role of Kallikrein 7 in Tumorigenesis
  JOURNAL   Curr Med Chem 29 (15), 2617-2631 (2022)
   PUBMED   34525904
  REMARK    GeneRIF: The Role of Kallikrein 7 in Tumorigenesis.
            Review article
REFERENCE   3  (bases 1 to 1824)
  AUTHORS   Tian,J., Wang,V., Wang,N., Khadang,B., Boudreault,J., Bakdounes,K.,
            Ali,S. and Lebrun,J.J.
  TITLE     Identification of MFGE8 and KLK5/7 as mediators of breast
            tumorigenesis and resistance to COX-2 inhibition
  JOURNAL   Breast Cancer Res 23 (1), 23 (2021)
   PUBMED   33588911
  REMARK    GeneRIF: Identification of MFGE8 and KLK5/7 as mediators of breast
            tumorigenesis and resistance to COX-2 inhibition.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1824)
  AUTHORS   Vasilopoulos,Y., Cork,M.J., Murphy,R., Williams,H.C.,
            Robinson,D.A., Duff,G.W., Ward,S.J. and Tazi-Ahnini,R.
  TITLE     Genetic association between an AACC insertion in the 3'UTR of the
            stratum corneum chymotryptic enzyme gene and atopic dermatitis
  JOURNAL   J Invest Dermatol 123 (1), 62-66 (2004)
   PUBMED   15191543
  REMARK    GeneRIF: The AACC insertion in the SCCE gene may result in a change
            to SCCE activity within the skin barrier so SCCE could have an
            important role in the development of atopic dermatitis.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 1824)
  AUTHORS   Dong,Y., Kaushal,A., Brattsand,M., Nicklin,J. and Clements,J.A.
  TITLE     Differential splicing of KLK5 and KLK7 in epithelial ovarian cancer
            produces novel variants with potential as cancer biomarkers
  JOURNAL   Clin Cancer Res 9 (5), 1710-1720 (2003)
   PUBMED   12738725
  REMARK    GeneRIF: High expression of KLK7 transcript with a long
            3'-untranslated region is associated with ovarian cancer
REFERENCE   6  (bases 1 to 1824)
  AUTHORS   Gan,L., Lee,I., Smith,R., Argonza-Barrett,R., Lei,H., McCuaig,J.,
            Moss,P., Paeper,B. and Wang,K.
  TITLE     Sequencing and expression analysis of the serine protease gene
            cluster located in chromosome 19q13 region
  JOURNAL   Gene 257 (1), 119-130 (2000)
   PUBMED   11054574
REFERENCE   7  (bases 1 to 1824)
  AUTHORS   Yousef,G.M., Scorilas,A., Magklara,A., Soosaipillai,A. and
            Diamandis,E.P.
  TITLE     The KLK7 (PRSS6) gene, encoding for the stratum corneum
            chymotryptic enzyme is a new member of the human kallikrein gene
            family - genomic characterization, mapping, tissue expression and
            hormonal regulation
  JOURNAL   Gene 254 (1-2), 119-128 (2000)
   PUBMED   10974542
REFERENCE   8  (bases 1 to 1824)
  AUTHORS   Skytt,A., Stromqvist,M. and Egelrud,T.
  TITLE     Primary substrate specificity of recombinant human stratum corneum
            chymotryptic enzyme
  JOURNAL   Biochem Biophys Res Commun 211 (2), 586-589 (1995)
   PUBMED   7794273
REFERENCE   9  (bases 1 to 1824)
  AUTHORS   Hansson,L., Stromqvist,M., Backman,A., Wallbrandt,P., Carlstein,A.
            and Egelrud,T.
  TITLE     Cloning, expression, and characterization of stratum corneum
            chymotryptic enzyme. A skin-specific human serine proteinase
  JOURNAL   J Biol Chem 269 (30), 19420-19426 (1994)
   PUBMED   8034709
REFERENCE   10 (bases 1 to 1824)
  AUTHORS   Egelrud,T.
  TITLE     Purification and preliminary characterization of stratum corneum
            chymotryptic enzyme: a proteinase that may be involved in
            desquamation
  JOURNAL   J Invest Dermatol 101 (2), 200-204 (1993)
   PUBMED   8393902
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF411215.1, AF411214.1,
            AI049783.1 and AC011483.7.
            
            On May 31, 2019 this sequence version replaced NM_001207053.1.
            
            Summary: This gene encodes a member of the kallikrein subfamily of
            serine proteases. These enzymes have diverse physiological
            functions and many kallikrein genes are biomarkers for cancer. The
            encoded protein has chymotrypsin-like activity and plays a role in
            the proteolysis of intercellular cohesive structures that precedes
            desquamation, the shedding of the outermost layer of the epidermis.
            The encoded protein may play a role in cancer invasion and
            metastasis, and increased expression of this gene is associated
            with unfavorable prognosis and progression of several types of
            cancer. Polymorphisms in this gene may play a role in the
            development of atopic dermatitis. Alternatively spliced transcript
            variants encoding multiple isoforms have been observed for this
            gene, which is one of fifteen kallikrein subfamily members located
            in a gene cluster on chromosome 19. [provided by RefSeq, May 2011].
            
            Transcript Variant: This variant (3) differs in the 5' UTR, lacks a
            portion of the 5' coding region and initiates translation at a
            downstream, in-frame start site, compared to variant 1. The encoded
            isoform (2) has a shorter N-terminus compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript
            sequence data to make the sequence consistent with the reference
            genome assembly, which represents the 'AACCAACC' allele with
            regards to the 3' UTR polymorphism described in PMID 15191543.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF411215.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2147596 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-933               AF411215.1         122-1054
            934-1504            AF411214.1         1186-1756
            1505-1813           AI049783.1         14-322              c
            1814-1824           AC011483.7         81810-81820         c
FEATURES             Location/Qualifiers
     source          1..1824
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.41"
     gene            1..1824
                     /gene="KLK7"
                     /gene_synonym="hK7; PRSS6; SCCE"
                     /note="kallikrein related peptidase 7"
                     /db_xref="GeneID:5650"
                     /db_xref="HGNC:HGNC:6368"
                     /db_xref="MIM:604438"
     exon            1..67
                     /gene="KLK7"
                     /gene_synonym="hK7; PRSS6; SCCE"
                     /inference="alignment:Splign:2.1.0"
     exon            68..215
                     /gene="KLK7"
                     /gene_synonym="hK7; PRSS6; SCCE"
                     /inference="alignment:Splign:2.1.0"
     CDS             211..756
                     /gene="KLK7"
                     /gene_synonym="hK7; PRSS6; SCCE"
                     /EC_number="3.4.21.117"
                     /note="isoform 2 is encoded by transcript variant 3;
                     kallikrein 7 (chymotryptic, stratum corneum);
                     kallikrein-7; signal protein; serine protease 6; stratum
                     corneum chymotryptic enzyme"
                     /codon_start=1
                     /product="kallikrein-7 isoform 2"
                     /protein_id="NP_001193982.1"
                     /db_xref="CCDS:CCDS59414.1"
                     /db_xref="GeneID:5650"
                     /db_xref="HGNC:HGNC:6368"
                     /db_xref="MIM:604438"
                     /translation="MNEYTVHLGSDTLGDRRAQRIKASKSFRHPGYSTQTHVNDLMLV
                     KLNSQARLSSMVKKVRLPSRCEPPGTTCTVSGWGTTTSPDVTFPSDLMCVDVKLISPQ
                     DCTKVYKDLLENSMLCAGIPDSKKNACNGDSGGPLVCRGTLQGLVSWGTFPCGQPNDP
                     GVYTQVCKFTKWINDTMKKHR"
     exon            216..463
                     /gene="KLK7"
                     /gene_synonym="hK7; PRSS6; SCCE"
                     /inference="alignment:Splign:2.1.0"
     exon            464..600
                     /gene="KLK7"
                     /gene_synonym="hK7; PRSS6; SCCE"
                     /inference="alignment:Splign:2.1.0"
     exon            601..1824
                     /gene="KLK7"
                     /gene_synonym="hK7; PRSS6; SCCE"
                     /inference="alignment:Splign:2.1.0"
     regulatory      929..934
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLK7"
                     /gene_synonym="hK7; PRSS6; SCCE"
                     /note="hexamer: AATAAA"
     polyA_site      951
                     /gene="KLK7"
                     /gene_synonym="hK7; PRSS6; SCCE"
                     /note="major polyA site"
     regulatory      1792..1797
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLK7"
                     /gene_synonym="hK7; PRSS6; SCCE"
                     /note="hexamer: AATAAA"
     polyA_site      1824
                     /gene="KLK7"
                     /gene_synonym="hK7; PRSS6; SCCE"
                     /note="major polyA site"
ORIGIN      
        1 gaagattttg gagcccagct gtgtgccagc ccaagtcgga acttggatca catcagatcc
       61 tctcgagccc agggtgacaa gattattgat ggcgccccat gtgcaagagg ctcccaccca
      121 tggcaggtgg ccctgctcag tggcaatcag ctccactgcg gaggcgtcct ggtcaatgag
      181 cgctgggtgc tcactgccgc ccactgcaag atgaatgagt acaccgtgca cctgggcagt
      241 gatacgctgg gcgacaggag agctcagagg atcaaggcct cgaagtcatt ccgccacccc
      301 ggctactcca cacagaccca tgttaatgac ctcatgctcg tgaagctcaa tagccaggcc
      361 aggctgtcat ccatggtgaa gaaagtcagg ctgccctccc gctgcgaacc ccctggaacc
      421 acctgtactg tctccggctg gggcactacc acgagcccag atgtgacctt tccctctgac
      481 ctcatgtgcg tggatgtcaa gctcatctcc ccccaggact gcacgaaggt ttacaaggac
      541 ttactggaaa attccatgct gtgcgctggc atccccgact ccaagaaaaa cgcctgcaat
      601 ggtgactcag ggggaccgtt ggtgtgcaga ggtaccctgc aaggtctggt gtcctgggga
      661 actttccctt gcggccaacc caatgaccca ggagtctaca ctcaagtgtg caagttcacc
      721 aagtggataa atgacaccat gaaaaagcat cgctaacgcc acactgagtt aattaactgt
      781 gtgcttccaa cagaaaatgc acaggagtga ggacgccgat gacctatgaa gtcaaatttg
      841 actttacctt tcctcaaaga tatatttaaa ccaacctcat gccctgttga taaaccaatc
      901 aaattggtaa agacctaaaa ccaaaacaaa taaagaaaca caaaaccctc agtgctggag
      961 aagagtcagt gagaccagca ctctcaaaca ctggaactgg acgttcgtac agtctttacg
     1021 gaagacactt ggtcaacgta caccgagacc cttattcacc acctttgacc cagtaactct
     1081 aatcttagga agaacctact gaaacaaaaa aaatccaaaa tgtagaacaa gacttgaatt
     1141 taccatgata ttatttatca cagaaatgaa gtgaaaccat caaacatgtt ccaaaagtac
     1201 cagatggctt aaataatagt ctggcttggc acaacgatgt tttttttctt tgagacagag
     1261 tctctgttgc ttgggctgca atgcagtgat gcaatcttgg ctcactgcaa cctccgcctc
     1321 ctgggttcaa gtgattctcg tgcttcagcc tcccaagtac ctgggactac aggtgtgcac
     1381 caccacacca ggctaatttt ttgtgtattt ttactagaga cagggtttca ccatgttggc
     1441 cagcatggtc ttgaacgcct gacctcagat gatccaccca ccttggcctc ccaaagtgct
     1501 gggattacag gcatgagcca ccacggccag cccacaatga tattacaaac ctattaaaaa
     1561 tgatacttag acagaattgt cagtattatt caagaacatt taggctatag gatgttaaat
     1621 gacaaaagga aggacaaaaa tatatatgta tgtgacccta cccataaaaa atgaaatatt
     1681 cacagaatca gatctgaaaa cacatgtccc agactgcata ctggggtcgt catgaggtgt
     1741 ctccttcctt ctgtgtactt ttccttgaat gtgcactttt ataacatgaa aaataaaggt
     1801 ggggaaaaaa gtctgaagat ctaa
//
