LOCUS       NM_002774               1429 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens kallikrein related peptidase 6 (KLK6), transcript
            variant A, mRNA.
ACCESSION   NM_002774
VERSION     NM_002774.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1429)
  AUTHORS   Zhang,L., Lovell,S., De Vita,E., Jagtap,P.K.A., Lucy,D., Goya
            Grocin,A., Kjaer,S., Borg,A., Hennig,J., Miller,A.K. and Tate,E.W.
  TITLE     A KLK6 Activity-Based Probe Reveals a Role for KLK6 Activity in
            Pancreatic Cancer Cell Invasion
  JOURNAL   J Am Chem Soc 144 (49), 22493-22504 (2022)
   PUBMED   36413626
  REMARK    GeneRIF: A KLK6 Activity-Based Probe Reveals a Role for KLK6
            Activity in Pancreatic Cancer Cell Invasion.
REFERENCE   2  (bases 1 to 1429)
  AUTHORS   Zhao,K., Gao,M. and Lin,M.
  TITLE     KLK6 Functions as an Oncogene and Unfavorable Prognostic Factor in
            Bladder Urothelial Carcinoma
  JOURNAL   Dis Markers 2022, 3373851 (2022)
   PUBMED   36193495
  REMARK    GeneRIF: KLK6 Functions as an Oncogene and Unfavorable Prognostic
            Factor in Bladder Urothelial Carcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1429)
  AUTHORS   Bouzid,H., Soualmia,F., Oikonomopoulou,K., Soosaipillai,A.,
            Walker,F., Louati,K., Lo Dico,R., Pocard,M., El Amri,C.,
            Ignatenko,N.A. and Darmoul,D.
  TITLE     Kallikrein-Related Peptidase 6 (KLK6) as a Contributor toward an
            Aggressive Cancer Cell Phenotype: A Potential Role in Colon Cancer
            Peritoneal Metastasis
  JOURNAL   Biomolecules 12 (7), 1003 (2022)
   PUBMED   35883559
  REMARK    GeneRIF: Kallikrein-Related Peptidase 6 (KLK6) as a Contributor
            toward an Aggressive Cancer Cell Phenotype: A Potential Role in
            Colon Cancer Peritoneal Metastasis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1429)
  AUTHORS   Pandey,R., Zhou,M., Chen,Y., Darmoul,D., Kisiel,C.C., Nfonsam,V.N.
            and Ignatenko,N.A.
  TITLE     Molecular Pathways Associated with Kallikrein 6 Overexpression in
            Colorectal Cancer
  JOURNAL   Genes (Basel) 12 (5), 749 (2021)
   PUBMED   34065672
  REMARK    GeneRIF: Molecular Pathways Associated with Kallikrein 6
            Overexpression in Colorectal Cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1429)
  AUTHORS   Bayani,J. and Diamandis,E.P.
  TITLE     The physiology and pathobiology of human kallikrein-related
            peptidase 6 (KLK6)
  JOURNAL   Clin Chem Lab Med 50 (2), 211-233 (2011)
   PUBMED   22047144
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1429)
  AUTHORS   Gan,L., Lee,I., Smith,R., Argonza-Barrett,R., Lei,H., McCuaig,J.,
            Moss,P., Paeper,B. and Wang,K.
  TITLE     Sequencing and expression analysis of the serine protease gene
            cluster located in chromosome 19q13 region
  JOURNAL   Gene 257 (1), 119-130 (2000)
   PUBMED   11054574
REFERENCE   7  (bases 1 to 1429)
  AUTHORS   Yousef,G.M., Luo,L.Y., Scherer,S.W., Sotiropoulou,G. and
            Diamandis,E.P.
  TITLE     Molecular characterization of zyme/protease M/neurosin (PRSS9), a
            hormonally regulated kallikrein-like serine protease
  JOURNAL   Genomics 62 (2), 251-259 (1999)
   PUBMED   10610719
REFERENCE   8  (bases 1 to 1429)
  AUTHORS   Little,S.P., Dixon,E.P., Norris,F., Buckley,W., Becker,G.W.,
            Johnson,M., Dobbins,J.R., Wyrick,T., Miller,J.R., MacKellar,W.,
            Hepburn,D., Corvalan,J., McClure,D., Liu,X., Stephenson,D.,
            Clemens,J. and Johnstone,E.M.
  TITLE     Zyme, a novel and potentially amyloidogenic enzyme cDNA isolated
            from Alzheimer's disease brain
  JOURNAL   J Biol Chem 272 (40), 25135-25142 (1997)
   PUBMED   9312124
REFERENCE   9  (bases 1 to 1429)
  AUTHORS   Yamashiro,K., Tsuruoka,N., Kodama,S., Tsujimoto,M., Yamamura,Y.,
            Tanaka,T., Nakazato,H. and Yamaguchi,N.
  TITLE     Molecular cloning of a novel trypsin-like serine protease
            (neurosin) preferentially expressed in brain
  JOURNAL   Biochim Biophys Acta 1350 (1), 11-14 (1997)
   PUBMED   9003450
REFERENCE   10 (bases 1 to 1429)
  AUTHORS   Anisowicz,A., Sotiropoulou,G., Stenman,G., Mok,S.C. and Sager,R.
  TITLE     A novel protease homolog differentially expressed in breast and
            ovarian cancer
  JOURNAL   Mol Med 2 (5), 624-636 (1996)
   PUBMED   8898378
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC011483.7.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_002774.3.
            
            Summary: This gene encodes a member of the kallikrein subfamily of
            the peptidase S1 family of serine proteases. Growing evidence
            suggests that many kallikreins are implicated in carcinogenesis and
            some have potential as novel cancer and other disease biomarkers.
            The encoded preproprotein is proteolytically processed to generate
            the mature protease. Expression of this protease is regulated by
            steroid hormones and may be elevated in multiple human cancers and
            in serum from psoriasis patients. The encoded protease may
            participate in the cleavage of amyloid precursor protein and
            alpha-synuclein, thus implicating this protease in Alzheimer's and
            Parkinson's disease, respectively. This gene is located in a gene
            cluster on chromosome 19. Alternative splicing results in multiple
            transcript variants, at least one of which encodes an isoform that
            is proteolytically processed. [provided by RefSeq, Feb 2016].
            
            Transcript Variant: This variant (A), also called the classical
            form, is the most frequently occurring transcript. Variants A and B
            encode the same isoform (A).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.128515.1,
                                           SRR3476690.390092.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2147975 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000310157.7/ ENSP00000309148.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-102               AC011483.7         74832-74933         c
            103-153             AC011483.7         73883-73933         c
            154-201             AC011483.7         73407-73454         c
            202-358             AC011483.7         72511-72667         c
            359-606             AC011483.7         68644-68891         c
            607-743             AC011483.7         67086-67222         c
            744-1429            AC011483.7         63973-64658         c
FEATURES             Location/Qualifiers
     source          1..1429
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.41"
     gene            1..1429
                     /gene="KLK6"
                     /gene_synonym="Bssp; hK6; Klk7; PRSS18; PRSS9; SP59"
                     /note="kallikrein related peptidase 6"
                     /db_xref="GeneID:5653"
                     /db_xref="HGNC:HGNC:6367"
                     /db_xref="MIM:602652"
     exon            1..102
                     /gene="KLK6"
                     /gene_synonym="Bssp; hK6; Klk7; PRSS18; PRSS9; SP59"
                     /inference="alignment:Splign:2.1.0"
     exon            103..153
                     /gene="KLK6"
                     /gene_synonym="Bssp; hK6; Klk7; PRSS18; PRSS9; SP59"
                     /inference="alignment:Splign:2.1.0"
     exon            154..201
                     /gene="KLK6"
                     /gene_synonym="Bssp; hK6; Klk7; PRSS18; PRSS9; SP59"
                     /inference="alignment:Splign:2.1.0"
     CDS             162..896
                     /gene="KLK6"
                     /gene_synonym="Bssp; hK6; Klk7; PRSS18; PRSS9; SP59"
                     /note="isoform A preproprotein is encoded by transcript
                     variant A; zyme; neurosin; protease M; serine protease 9;
                     serine protease 18"
                     /codon_start=1
                     /product="kallikrein-6 isoform A preproprotein"
                     /protein_id="NP_002765.1"
                     /db_xref="CCDS:CCDS12811.1"
                     /db_xref="GeneID:5653"
                     /db_xref="HGNC:HGNC:6367"
                     /db_xref="MIM:602652"
                     /translation="MKKLMVVLSLIAAAWAEEQNKLVHGGPCDKTSHPYQAALYTSGH
                     LLCGGVLIHPLWVLTAAHCKKPNLQVFLGKHNLRQRESSQEQSSVVRAVIHPDYDAAS
                     HDQDIMLLRLARPAKLSELIQPLPLERDCSANTTSCHILGWGKTADGDFPDTIQCAYI
                     HLVSREECEHAYPGQITQNMLCAGDEKYGKDSCQGDSGGPLVCGDHLRGLVSWGNIPC
                     GSKEKPGVYTNVCRYTNWIQKTIQAK"
     exon            202..358
                     /gene="KLK6"
                     /gene_synonym="Bssp; hK6; Klk7; PRSS18; PRSS9; SP59"
                     /inference="alignment:Splign:2.1.0"
     exon            359..606
                     /gene="KLK6"
                     /gene_synonym="Bssp; hK6; Klk7; PRSS18; PRSS9; SP59"
                     /inference="alignment:Splign:2.1.0"
     exon            607..743
                     /gene="KLK6"
                     /gene_synonym="Bssp; hK6; Klk7; PRSS18; PRSS9; SP59"
                     /inference="alignment:Splign:2.1.0"
     exon            744..1429
                     /gene="KLK6"
                     /gene_synonym="Bssp; hK6; Klk7; PRSS18; PRSS9; SP59"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1406..1411
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLK6"
                     /gene_synonym="Bssp; hK6; Klk7; PRSS18; PRSS9; SP59"
                     /note="hexamer: AATAAA"
     polyA_site      1429
                     /gene="KLK6"
                     /gene_synonym="Bssp; hK6; Klk7; PRSS18; PRSS9; SP59"
                     /note="major polyA site"
ORIGIN      
        1 agtgtggtga cacacgctgt agctgtctcc ccggctggct ggctcgctct ctcctgggga
       61 cacagaggtc ggcaggcagc acacagaggg acctacgggc agctgttcct tcccccgact
      121 caagaatccc cggagcccgg aggcctgcag caggagcggc catgaagaag ctgatggtgg
      181 tgctgagtct gattgctgca gcctgggcag aggagcagaa taagttggtg catggcggac
      241 cctgcgacaa gacatctcac ccctaccaag ctgccctcta cacctcgggc cacttgctct
      301 gtggtggggt ccttatccat ccactgtggg tcctcacagc tgcccactgc aaaaaaccga
      361 atcttcaggt cttcctgggg aagcataacc ttcggcaaag ggagagttcc caggagcaga
      421 gttctgttgt ccgggctgtg atccaccctg actatgatgc cgccagccat gaccaggaca
      481 tcatgctgtt gcgcctggca cgcccagcca aactctctga actcatccag ccccttcccc
      541 tggagaggga ctgctcagcc aacaccacca gctgccacat cctgggctgg ggcaagacag
      601 cagatggtga tttccctgac accatccagt gtgcatacat ccacctggtg tcccgtgagg
      661 agtgtgagca tgcctaccct ggccagatca cccagaacat gttgtgtgct ggggatgaga
      721 agtacgggaa ggattcctgc cagggtgatt ctgggggtcc gctggtatgt ggagaccacc
      781 tccgaggcct tgtgtcatgg ggtaacatcc cctgtggatc aaaggagaag ccaggagtct
      841 acaccaacgt ctgcagatac acgaactgga tccaaaaaac cattcaggcc aagtgaccct
      901 gacatgtgac atctacctcc cgacctacca ccccactggc tggttccaga acgtctctca
      961 cctagacctt gcctcccctc ctctcctgcc cagctctgac cctgatgctt aataaacgca
     1021 gcgacgtgag ggtcctgatt ctccctggtt ttaccccagc tccatccttg catcactggg
     1081 gaggacgtga tgagtgagga cttgggtcct cggtcttacc cccaccacta agagaataca
     1141 ggaaaatccc ttctaggcat ctcctctccc caacccttcc acacgtttga tttcttcctg
     1201 cagaggccca gccacgtgtc tggaatccca gctccgctgc ttactgtcgg tgtccccttg
     1261 ggatgtacct ttcttcactg cagatttctc acctgtaaga tgaagataag gatgatacag
     1321 tctccataag gcagtggctg ttggaaagat ttaaggtttc acacctatga catacatgga
     1381 atagcacctg ggccaccatg cactcaataa agaatgaatt ttattatga
//
