LOCUS       NM_012427               1513 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens kallikrein related peptidase 5 (KLK5), transcript
            variant 1, mRNA.
ACCESSION   NM_012427
VERSION     NM_012427.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1513)
  AUTHORS   Kim,H., Kang,Y., Kim,S., Park,D., Heo,S.Y., Yoo,J.S., Choi,I.,
            N,M.P.A., Ahn,J.W., Yang,J.S., Bak,N., Kim,K.K., Lee,J.Y. and
            Choi,Y.K.
  TITLE     The host protease KLK5 primes and activates spike proteins to
            promote human betacoronavirus replication and lung inflammation
  JOURNAL   Sci Signal 17 (850), eadn3785 (2024)
   PUBMED   39163389
  REMARK    GeneRIF: The host protease KLK5 primes and activates spike proteins
            to promote human betacoronavirus replication and lung inflammation.
REFERENCE   2  (bases 1 to 1513)
  AUTHORS   Lin,Y., Ma,L., Dan,H., Chen,G., Dai,J., Xu,L. and Liu,Y.
  TITLE     MiR-107-3p Knockdown Alleviates Endothelial Injury in Sepsis via
            Kallikrein-Related Peptidase 5
  JOURNAL   J Surg Res 292, 264-274 (2023)
   PUBMED   37666089
  REMARK    GeneRIF: MiR-107-3p Knockdown Alleviates Endothelial Injury in
            Sepsis via Kallikrein-Related Peptidase 5.
REFERENCE   3  (bases 1 to 1513)
  AUTHORS   Jackman,J.K., Stockwell,A., Choy,D.F., Xie,M.M., Lu,P., Jia,G.,
            Li,H., Abbas,A.R., Bronson,P.G., Lin,W.Y., Chiu,C.P.C., Maun,H.R.,
            Roose-Girma,M., Tam,L., Zhang,J., Modrusan,Z., Graham,R.R.,
            Behrens,T.W., White,S.R., Naureckas,T., Ober,C., Ferreira,M.,
            Sedlacek,R., Wu,J., Lee,W.P., Lazarus,R.A., Koerber,J.T.,
            Arron,J.R., Yaspan,B.L. and Yi,T.
  TITLE     Genome-wide association study identifies kallikrein 5 in type 2
            inflammation-low asthma
  JOURNAL   J Allergy Clin Immunol 150 (4), 972-978 (2022)
   PUBMED   35487308
  REMARK    GeneRIF: Genome-wide association study identifies kallikrein 5 in
            type 2 inflammation-low asthma.
REFERENCE   4  (bases 1 to 1513)
  AUTHORS   Zhou,S., Liu,S., Tian,G., Zhao,L., Wang,H., Li,Y., Shen,Y. and
            Han,L.
  TITLE     KLK5 is associated with the radioresistance, aggression, and
            progression of cervical cancer
  JOURNAL   Gynecol Oncol 166 (1), 138-147 (2022)
   PUBMED   35595569
  REMARK    GeneRIF: KLK5 is associated with the radioresistance, aggression,
            and progression of cervical cancer.
REFERENCE   5  (bases 1 to 1513)
  AUTHORS   Lenga Ma Bonda,W., Lavergne,M., Vasseur,V., Brisson,L., Roger,S.,
            Legras,A., Guillon,A., Guyetant,S., Hiemstra,P.S., Si-Tahar,M.,
            Iochmann,S. and Reverdiau,P.
  TITLE     Kallikrein-related peptidase 5 contributes to the remodeling and
            repair of bronchial epithelium
  JOURNAL   FASEB J 35 (10), e21838 (2021)
   PUBMED   34582061
  REMARK    GeneRIF: Kallikrein-related peptidase 5 contributes to the
            remodeling and repair of bronchial epithelium.
REFERENCE   6  (bases 1 to 1513)
  AUTHORS   Harvey,T.J., Hooper,J.D., Myers,S.A., Stephenson,S.A.,
            Ashworth,L.K. and Clements,J.A.
  TITLE     Tissue-specific expression patterns and fine mapping of the human
            kallikrein (KLK) locus on proximal 19q13.4
  JOURNAL   J Biol Chem 275 (48), 37397-37406 (2000)
   PUBMED   10969073
REFERENCE   7  (bases 1 to 1513)
  AUTHORS   Diamandis,E.P., Yousef,G.M., Luo,L.Y., Magklara,A. and Obiezu,C.V.
  TITLE     The new human kallikrein gene family: implications in
            carcinogenesis
  JOURNAL   Trends Endocrinol Metab 11 (2), 54-60 (2000)
   PUBMED   10675891
  REMARK    Review article
REFERENCE   8  (bases 1 to 1513)
  AUTHORS   Yousef,G.M. and Diamandis,E.P.
  TITLE     The new kallikrein-like gene, KLK-L2. Molecular characterization,
            mapping, tissue expression, and hormonal regulation
  JOURNAL   J Biol Chem 274 (53), 37511-37516 (1999)
   PUBMED   10608802
REFERENCE   9  (bases 1 to 1513)
  AUTHORS   Brattsand,M. and Egelrud,T.
  TITLE     Purification, molecular cloning, and expression of a human stratum
            corneum trypsin-like serine protease with possible function in
            desquamation
  JOURNAL   J Biol Chem 274 (42), 30033-30040 (1999)
   PUBMED   10514489
REFERENCE   10 (bases 1 to 1513)
  AUTHORS   Yousef,G.M., Luo,L.Y. and Diamandis,E.P.
  TITLE     Identification of novel human kallikrein-like genes on chromosome
            19q13.3-q13.4
  JOURNAL   Anticancer Res 19 (4B), 2843-2852 (1999)
   PUBMED   10652563
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY359010.1.
            
            On Nov 22, 2018 this sequence version replaced NM_012427.4.
            
            Summary: Kallikreins are a subgroup of serine proteases having
            diverse physiological functions. Growing evidence suggests that
            many kallikreins are implicated in carcinogenesis and some have
            potential as novel cancer and other disease biomarkers. This gene
            is one of the fifteen kallikrein subfamily members located in a
            cluster on chromosome 19. Its expression is up-regulated by
            estrogens and progestins. The encoded protein is secreted and may
            be involved in desquamation in the epidermis. Alternative splicing
            results in multiple transcript variants encoding the same protein.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript. All variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY359010.1, AF435980.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968832,
                                           SAMEA1968968 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000336334.8/ ENSP00000337733.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1513              AY359010.1         51-1563
FEATURES             Location/Qualifiers
     source          1..1513
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.41"
     gene            1..1513
                     /gene="KLK5"
                     /gene_synonym="KLK-L2; KLKL2; SCTE"
                     /note="kallikrein related peptidase 5"
                     /db_xref="GeneID:25818"
                     /db_xref="HGNC:HGNC:6366"
                     /db_xref="MIM:605643"
     exon            1..292
                     /gene="KLK5"
                     /gene_synonym="KLK-L2; KLKL2; SCTE"
                     /inference="alignment:Splign:2.1.0"
     exon            293..376
                     /gene="KLK5"
                     /gene_synonym="KLK-L2; KLKL2; SCTE"
                     /inference="alignment:Splign:2.1.0"
     CDS             304..1185
                     /gene="KLK5"
                     /gene_synonym="KLK-L2; KLKL2; SCTE"
                     /note="stratum corneum tryptic enzyme; kallikrein-like
                     protein 2; kallikrein-5"
                     /codon_start=1
                     /product="kallikrein-5 preproprotein"
                     /protein_id="NP_036559.1"
                     /db_xref="CCDS:CCDS12810.1"
                     /db_xref="GeneID:25818"
                     /db_xref="HGNC:HGNC:6366"
                     /db_xref="MIM:605643"
                     /translation="MATARPPWMWVLCALITALLLGVTEHVLANNDVSCDHPSNTVPS
                     GSNQDLGAGAGEDARSDDSSSRIINGSDCDMHTQPWQAALLLRPNQLYCGAVLVHPQW
                     LLTAAHCRKKVFRVRLGHYSLSPVYESGQQMFQGVKSIPHPGYSHPGHSNDLMLIKLN
                     RRIRPTKDVRPINVSSHCPSAGTKCLVSGWGTTKSPQVHFPKVLQCLNISVLSQKRCE
                     DAYPRQIDDTMFCAGDKAGRDSCQGDSGGPVVCNGSLQGLVSWGDYPCARPNRPGVYT
                     NLCKFTKWIQETIQANS"
     exon            377..638
                     /gene="KLK5"
                     /gene_synonym="KLK-L2; KLKL2; SCTE"
                     /inference="alignment:Splign:2.1.0"
     exon            639..895
                     /gene="KLK5"
                     /gene_synonym="KLK-L2; KLKL2; SCTE"
                     /inference="alignment:Splign:2.1.0"
     exon            896..1029
                     /gene="KLK5"
                     /gene_synonym="KLK-L2; KLKL2; SCTE"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1513
                     /gene="KLK5"
                     /gene_synonym="KLK-L2; KLKL2; SCTE"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1495..1500
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLK5"
                     /gene_synonym="KLK-L2; KLKL2; SCTE"
                     /note="hexamer: AATAAA"
     polyA_site      1513
                     /gene="KLK5"
                     /gene_synonym="KLK-L2; KLKL2; SCTE"
                     /note="major polyA site"
ORIGIN      
        1 aggaggaggc agtggccagg aaggcacagg cctgagaagt ctgcggctga gctgggagca
       61 aatcccccac cccctacctg ggggacaggg caagtgagac ctggtgaggg tggctcagca
      121 ggcagggaag gagaggtgtc tgtgcgtcct gcacccacat ctttctctgt cccctccttg
      181 ccctgtctgg aggctgctag actcctatct tctgaattct atagtgcctg ggtctcagcg
      241 cagtgccgat ggtggcccgt ccttgtggtt cctctctacc tggggaaata aggtgcagcg
      301 gccatggcta cagcaagacc cccctggatg tgggtgctct gtgctctgat cacagccttg
      361 cttctggggg tcacagagca tgttctcgcc aacaatgatg tttcctgtga ccacccctct
      421 aacaccgtgc cctctgggag caaccaggac ctgggagctg gggccgggga agacgcccgg
      481 tcggatgaca gcagcagccg catcatcaat ggatccgact gcgatatgca cacccagccg
      541 tggcaggccg cgctgttgct aaggcccaac cagctctact gcggggcggt gttggtgcat
      601 ccacagtggc tgctcacggc cgcccactgc aggaagaaag ttttcagagt ccgtctcggc
      661 cactactccc tgtcaccagt ttatgaatct gggcagcaga tgttccaggg ggtcaaatcc
      721 atcccccacc ctggctactc ccaccctggc cactctaacg acctcatgct catcaaactg
      781 aacagaagaa ttcgtcccac taaagatgtc agacccatca acgtctcctc tcattgtccc
      841 tctgctggga caaagtgctt ggtgtctggc tgggggacaa ccaagagccc ccaagtgcac
      901 ttccctaagg tcctccagtg cttgaatatc agcgtgctaa gtcagaaaag gtgcgaggat
      961 gcttacccga gacagataga tgacaccatg ttctgcgccg gtgacaaagc aggtagagac
     1021 tcctgccagg gtgattctgg ggggcctgtg gtctgcaatg gctccctgca gggactcgtg
     1081 tcctggggag attacccttg tgcccggccc aacagaccgg gtgtctacac gaacctctgc
     1141 aagttcacca agtggatcca ggaaaccatc caggccaact cctgagtcat cccaggactc
     1201 agcacaccgg catccccacc tgctgcaggg acagccctga cactcctttc agaccctcat
     1261 tccttcccag agatgttgag aatgttcatc tctccagccc ctgaccccat gtctcctgga
     1321 ctcagggtct gcttccccca cattgggctg accgtgtctc tctagttgaa ccctgggaac
     1381 aatttccaaa actgtccagg gcgggggttg cgtctcaatc tccctggggc actttcatcc
     1441 tcaagctcag ggcccatccc ttctctgcag ctctgaccca aatttagtcc cagaaataaa
     1501 ctgagaagtg gaa
//
