LOCUS       NM_004917               1416 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens kallikrein related peptidase 4 (KLK4), transcript
            variant 1, mRNA.
ACCESSION   NM_004917 XM_001134318
VERSION     NM_004917.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1416)
  AUTHORS   Shi,J., Qi,Y., Sun,Y. and Huang,Y.
  TITLE     Kallikrein-Related Peptidase 4 Promotes Proliferation, Migration,
            Invasion, and Pro-Angiogenesis of Endometrial Stromal Cells via
            Regulation of Brain-Derived Neurotrophic Factor Production in
            Endometriosis
  JOURNAL   Am J Pathol 194 (1), 121-134 (2024)
   PUBMED   37918799
  REMARK    GeneRIF: Kallikrein-Related Peptidase 4 Promotes Proliferation,
            Migration, Invasion, and Pro-Angiogenesis of Endometrial Stromal
            Cells via Regulation of Brain-Derived Neurotrophic Factor
            Production in Endometriosis.
REFERENCE   2  (bases 1 to 1416)
  AUTHORS   Bakker,A., Slack,J.C., Palanisamy,N., Carskadon,S., Ghosh,S.,
            Khalifeh,I. and Bismar,T.A.
  TITLE     Loss of KLK4::KLKP1 pseudogene expression by RNA chromogenic
            in-situ hybridization is associated with PTEN loss and increased
            risk of biochemical recurrence in a cohort of middle eastern men
            with prostate cancer
  JOURNAL   J Cancer Res Clin Oncol 149 (7), 3721-3728 (2023)
   PUBMED   35982181
  REMARK    GeneRIF: Loss of KLK4::KLKP1 pseudogene expression by RNA
            chromogenic in-situ hybridization is associated with PTEN loss and
            increased risk of biochemical recurrence in a cohort of middle
            eastern men with prostate cancer.
REFERENCE   3  (bases 1 to 1416)
  AUTHORS   Fan,B., Niu,Y., Zhang,A., Wei,S., Ma,Y., Su,J. and Ren,Z.
  TITLE     KLK4 Silencing Inhibits the Growth of Chromophobe Renal Cell
            Carcinoma through ERK/AKT Signaling Pathway
  JOURNAL   Kidney Blood Press Res 47 (12), 702-710 (2022)
   PUBMED   36260980
  REMARK    GeneRIF: KLK4 Silencing Inhibits the Growth of Chromophobe Renal
            Cell Carcinoma through ERK/AKT Signaling Pathway.
REFERENCE   4  (bases 1 to 1416)
  AUTHORS   Tang,J.Z., Zhao,G.Y., Zhao,J.Z., Di,D.H. and Wang,B.
  TITLE     lncRNA IGF2-AS promotes the osteogenic differentiation of bone
            marrow mesenchymal stem cells by sponging miR-3,126-5p to
            upregulate KLK4
  JOURNAL   J Gene Med 23 (10), e3372 (2021)
   PUBMED   34101307
  REMARK    GeneRIF: lncRNA IGF2-AS promotes the osteogenic differentiation of
            bone marrow mesenchymal stem cells by sponging miR-3,126-5p to
            upregulate KLK4.
REFERENCE   5  (bases 1 to 1416)
  AUTHORS   Cui,Z., Bao,X., Liu,Q., Li,Q., Huang,L., Wang,H. and Jiao,K.
  TITLE     MicroRNA-378-3p/5p represses proliferation and induces apoptosis of
            oral squamous carcinoma cells via targeting KLK4
  JOURNAL   Clin Exp Pharmacol Physiol 47 (4), 713-724 (2020)
   PUBMED   31868942
  REMARK    GeneRIF: MicroRNA-378-3p/5p represses proliferation and induces
            apoptosis of oral squamous carcinoma cells via targeting KLK4.
REFERENCE   6  (bases 1 to 1416)
  AUTHORS   Yousef,G.M., Obiezu,C.V., Luo,L.Y., Black,M.H. and Diamandis,E.P.
  TITLE     Prostase/KLK-L1 is a new member of the human kallikrein gene
            family, is expressed in prostate and breast tissues, and is
            hormonally regulated
  JOURNAL   Cancer Res 59 (17), 4252-4256 (1999)
   PUBMED   10485467
REFERENCE   7  (bases 1 to 1416)
  AUTHORS   Stephenson,S.A., Verity,K., Ashworth,L.K. and Clements,J.A.
  TITLE     Localization of a new prostate-specific antigen-related serine
            protease gene, KLK4, is evidence for an expanded human kallikrein
            gene family cluster on chromosome 19q13.3-13.4
  JOURNAL   J Biol Chem 274 (33), 23210-23214 (1999)
   PUBMED   10438493
REFERENCE   8  (bases 1 to 1416)
  AUTHORS   Nelson,P.S., Gan,L., Ferguson,C., Moss,P., Gelinas,R., Hood,L. and
            Wang,K.
  TITLE     Molecular cloning and characterization of prostase, an
            androgen-regulated serine protease with prostate-restricted
            expression
  JOURNAL   Proc Natl Acad Sci U S A 96 (6), 3114-3119 (1999)
   PUBMED   10077646
REFERENCE   9  (bases 1 to 1416)
  AUTHORS   DuPont,B.R., Hu,C.C., Reveles,X. and Simmer,J.P.
  TITLE     Assignment of serine protease 17 (PRSS17) to human chromosome bands
            19q13.3-->q13.4 by in situ hybridization
  JOURNAL   Cytogenet Cell Genet 86 (3-4), 212-213 (1999)
   PUBMED   10575207
REFERENCE   10 (bases 1 to 1416)
  AUTHORS   Simmer,J.P., Fukae,M., Tanabe,T., Yamakoshi,Y., Uchida,T., Xue,J.,
            Margolis,H.C., Shimizu,M., DeHart,B.C., Hu,C.C. and Bartlett,J.D.
  TITLE     Purification, characterization, and cloning of enamel matrix serine
            proteinase 1
  JOURNAL   J Dent Res 77 (2), 377-386 (1998)
   PUBMED   9465170
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC011483.7, BC069403.1,
            AF113140.1 and CA425532.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 21, 2021 this sequence version replaced NM_004917.4.
            
            Summary: Kallikreins are a subgroup of serine proteases having
            diverse physiological functions. Growing evidence suggests that
            many kallikreins are implicated in carcinogenesis and some have
            potential as novel cancer and other disease biomarkers. This gene
            is one of the fifteen kallikrein subfamily members located in a
            cluster on chromosome 19. In some tissues its expression is
            hormonally regulated. The expression pattern of a similar mouse
            protein in murine developing teeth supports a role for the protein
            in the degradation of enamel proteins. Several transcript variants
            encoding different proteins have been found for this gene.
            [provided by RefSeq, Dec 2014].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AF113140.1, BC096178.3 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMEA1966682,
                                    SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000324041.6/ ENSP00000326159.1
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, expression, longest
                                         protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                AC011483.7         16681-16737         c
            58-68               AC011483.7         16081-16091         c
            69-883              BC069403.1         1-815
            884-1260            AF113140.1         816-1192
            1261-1416           CA425532.1         18-173              c
FEATURES             Location/Qualifiers
     source          1..1416
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.41"
     gene            1..1416
                     /gene="KLK4"
                     /gene_synonym="AI2A1; ARM1; EMSP; EMSP1; kallikrein;
                     KLK-L1; PRSS17; PSTS"
                     /note="kallikrein related peptidase 4"
                     /db_xref="GeneID:9622"
                     /db_xref="HGNC:HGNC:6365"
                     /db_xref="MIM:603767"
     exon            1..57
                     /gene="KLK4"
                     /gene_synonym="AI2A1; ARM1; EMSP; EMSP1; kallikrein;
                     KLK-L1; PRSS17; PSTS"
                     /inference="alignment:Splign:2.1.0"
     exon            58..129
                     /gene="KLK4"
                     /gene_synonym="AI2A1; ARM1; EMSP; EMSP1; kallikrein;
                     KLK-L1; PRSS17; PSTS"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..833
                     /gene="KLK4"
                     /gene_synonym="AI2A1; ARM1; EMSP; EMSP1; kallikrein;
                     KLK-L1; PRSS17; PSTS"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; enamel matrix serine protease 1;
                     kallikrein-like protein 1; androgen-regulated message 1;
                     prostase; serine protease 17; enamel matrix serine
                     proteinase 1"
                     /codon_start=1
                     /product="kallikrein-4 isoform 1 preproprotein"
                     /protein_id="NP_004908.4"
                     /db_xref="CCDS:CCDS12809.1"
                     /db_xref="GeneID:9622"
                     /db_xref="HGNC:HGNC:6365"
                     /db_xref="MIM:603767"
                     /translation="MATAGNPWGWFLGYLILGVAGSLVSGSCSQIINGEDCSPHSQPW
                     QAALVMENELFCSGVLVHPQWVLSAAHCFQNSYTIGLGLHSLEADQEPGSQMVEASLS
                     VRHPEYNRPLLANDLMLIKLDESVSESDTIRSISIASQCPTAGNSCLVSGWGLLANGR
                     MPTVLQCVNVSVVSEEVCSKLYDPLYHPSMFCAGGGQDQKDSCNGDSGGPLICNGYLQ
                     GLVSFGKAPCGQVGVPGVYTNLCKFTEWIEKTVQAS"
     exon            130..292
                     /gene="KLK4"
                     /gene_synonym="AI2A1; ARM1; EMSP; EMSP1; kallikrein;
                     KLK-L1; PRSS17; PSTS"
                     /inference="alignment:Splign:2.1.0"
     exon            293..543
                     /gene="KLK4"
                     /gene_synonym="AI2A1; ARM1; EMSP; EMSP1; kallikrein;
                     KLK-L1; PRSS17; PSTS"
                     /inference="alignment:Splign:2.1.0"
     exon            544..680
                     /gene="KLK4"
                     /gene_synonym="AI2A1; ARM1; EMSP; EMSP1; kallikrein;
                     KLK-L1; PRSS17; PSTS"
                     /inference="alignment:Splign:2.1.0"
     exon            681..1416
                     /gene="KLK4"
                     /gene_synonym="AI2A1; ARM1; EMSP; EMSP1; kallikrein;
                     KLK-L1; PRSS17; PSTS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1395..1400
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLK4"
                     /gene_synonym="AI2A1; ARM1; EMSP; EMSP1; kallikrein;
                     KLK-L1; PRSS17; PSTS"
                     /note="hexamer: AATAAA"
     polyA_site      1416
                     /gene="KLK4"
                     /gene_synonym="AI2A1; ARM1; EMSP; EMSP1; kallikrein;
                     KLK-L1; PRSS17; PSTS"
                     /note="major polyA site"
ORIGIN      
        1 aggcagcagg ctggagctca gcccagcagt ggaatccagg agcccagagg tggccgggtg
       61 ctgacgtgat ggccacagca ggaaatccct ggggctggtt cctggggtac ctcatccttg
      121 gtgtcgcagg atcgctcgtc tctggtagct gcagccaaat cataaacggc gaggactgca
      181 gcccgcactc gcagccctgg caggcggcac tggtcatgga aaacgaattg ttctgctcgg
      241 gcgtcctggt gcatccgcag tgggtgctgt cagccgcaca ctgtttccag aactcctaca
      301 ccatcgggct gggcctgcac agtcttgagg ccgaccaaga gccagggagc cagatggtgg
      361 aggccagcct ctccgtacgg cacccagagt acaacagacc cttgctcgct aacgacctca
      421 tgctcatcaa gttggacgaa tccgtgtccg agtctgacac catccggagc atcagcattg
      481 cttcgcagtg ccctaccgcg gggaactctt gcctcgtttc tggctggggt ctgctggcga
      541 acggcagaat gcctaccgtg ctgcagtgcg tgaacgtgtc ggtggtgtct gaggaggtct
      601 gcagtaagct ctatgacccg ctgtaccacc ccagcatgtt ctgcgccggc ggagggcaag
      661 accagaagga ctcctgcaac ggtgactctg gggggcccct gatctgcaac gggtacttgc
      721 agggccttgt gtctttcgga aaagccccgt gtggccaagt tggcgtgcca ggtgtctaca
      781 ccaacctctg caaattcact gagtggatag agaaaaccgt ccaggccagt taactctggg
      841 gactgggaac ccatgaaatt gacccccaaa tacatcctgc ggaaggaatt caggaatatc
      901 tgttcccagc ccctcctccc tcaggcccag gagtccaggc ccccagcccc tcctccctca
      961 aaccaagggt acagatcccc agcccctcct ccctcagacc caggagtcca gaccccccag
     1021 cccctcctcc ctcagaccca ggagtccagc ccctcctccc tcagacccag gagtccagac
     1081 cccccagccc ctcctccctc agacccagga gtccagcccc tcctccctca gacccaggag
     1141 tccagacccc ccagcccctc ctccctcaga cccaggggtc caggccccca acccctcctc
     1201 cctcagactc agaggtccag gcccccaacc cctccttccc cagacccaga ggtccaggtc
     1261 ccagcccctc ctccctcaga cccagcggtc caatgccacc tagactctcc ctgtacacag
     1321 tgcccccttg tggcacgttg acccaacctt accagttggt ttttcatttt ttgtcccttt
     1381 cccctagatc cagaaataaa gtctaagaga agcgca
//
