LOCUS       NM_005551               2829 bp    mRNA    linear   PRI 17-MAR-2024
DEFINITION  Homo sapiens kallikrein related peptidase 2 (KLK2), transcript
            variant 1, mRNA.
ACCESSION   NM_005551
VERSION     NM_005551.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2829)
  AUTHORS   Paniagua-Herranz,L., Moreno,I., Nieto-Jimenez,C.,
            Garcia-Lorenzo,E., Diaz-Tejeiro,C., Sanvicente,A., Doger,B.,
            Pedregal,M., Ramon,J., Bartolome,J., Manzano,A., Gyorffy,B.,
            Gutierrez-Uzquiza,A., Perez Segura,P., Calvo,E., Moreno,V. and
            Ocana,A.
  TITLE     Genomic and Immunologic Correlates in Prostate Cancer with High
            Expression of KLK2
  JOURNAL   Int J Mol Sci 25 (4), 2222 (2024)
   PUBMED   38396898
  REMARK    GeneRIF: Genomic and Immunologic Correlates in Prostate Cancer with
            High Expression of KLK2.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2829)
  AUTHORS   Do Carmo Silva,J., Vesely,S., Luksanova,H., Prusa,R. and Babjuk,M.
  TITLE     Early prediction of prostate cancer biochemical recurrence and
            identification of disease persistence using PSA isoforms and human
            kallikrein-2
  JOURNAL   Tumour Biol 43 (1), 197-207 (2021)
   PUBMED   34486998
  REMARK    GeneRIF: Early prediction of prostate cancer biochemical recurrence
            and identification of disease persistence using PSA isoforms and
            human kallikrein-2.
REFERENCE   3  (bases 1 to 2829)
  AUTHORS   Bonk,S., Kluth,M., Jansen,K., Hube-Magg,C., Makrypidi-Fraune,G.,
            Hoflmayer,D., Weidemann,S., Moller,K., Uhlig,R., Buscheck,F.,
            Luebke,A.M., Burandt,E., Clauditz,T.S., Steurer,S., Schlomm,T.,
            Huland,H., Heinzer,H., Sauter,G., Simon,R. and Dum,D.
  TITLE     Reduced KLK2 expression is a strong and independent predictor of
            poor prognosis in ERG-negative prostate cancer
  JOURNAL   Prostate 80 (13), 1097-1107 (2020)
   PUBMED   32628300
  REMARK    GeneRIF: Reduced KLK2 expression is a strong and independent
            predictor of poor prognosis in ERG-negative prostate cancer.
REFERENCE   4  (bases 1 to 2829)
  AUTHORS   Liu,X.F., Essand,M., Vasmatzis,G., Lee,B. and Pastan,I.
  TITLE     Identification of three new alternate human kallikrein 2
            transcripts: evidence of long transcript and alternative splicing
  JOURNAL   Biochem Biophys Res Commun 264 (3), 833-839 (1999)
   PUBMED   10544017
REFERENCE   5  (bases 1 to 2829)
  AUTHORS   Bourgeois,L., Brillard-Bourdet,M., Deperthes,D., Juliano,M.A.,
            Juliano,L., Tremblay,R.R., Dube,J.Y. and Gauthier,F.
  TITLE     Serpin-derived peptide substrates for investigating the substrate
            specificity of human tissue kallikreins hK1 and hK2
  JOURNAL   J Biol Chem 272 (47), 29590-29595 (1997)
   PUBMED   9368023
REFERENCE   6  (bases 1 to 2829)
  AUTHORS   Frenette,G., Deperthes,D., Tremblay,R.R., Lazure,C. and Dube,J.Y.
  TITLE     Purification of enzymatically active kallikrein hK2 from human
            seminal plasma
  JOURNAL   Biochim Biophys Acta 1334 (1), 109-115 (1997)
   PUBMED   9042371
REFERENCE   7  (bases 1 to 2829)
  AUTHORS   Riegman,P.H., Vlietstra,R.J., van der Korput,H.A., Romijn,J.C. and
            Trapman,J.
  TITLE     Identification and androgen-regulated expression of two major human
            glandular kallikrein-1 (hGK-1) mRNA species
  JOURNAL   Mol Cell Endocrinol 76 (1-3), 181-190 (1991)
   PUBMED   1726490
REFERENCE   8  (bases 1 to 2829)
  AUTHORS   Qin,H., Kemp,J., Yip,M.Y., Lam-Po-Tang,P.R. and Morris,B.J.
  TITLE     Localization of human glandular kallikrein-1 gene to chromosome
            19q13.3-13.4 by in situ hybridization
  JOURNAL   Hum Hered 41 (4), 222-226 (1991)
   PUBMED   1783409
REFERENCE   9  (bases 1 to 2829)
  AUTHORS   Riegman,P.H., Vlietstra,R.J., Klaassen,P., van der Korput,J.A.,
            Geurts van Kessel,A., Romijn,J.C. and Trapman,J.
  TITLE     The prostate-specific antigen gene and the human glandular
            kallikrein-1 gene are tandemly located on chromosome 19
  JOURNAL   FEBS Lett 247 (1), 123-126 (1989)
   PUBMED   2468530
REFERENCE   10 (bases 1 to 2829)
  AUTHORS   Schedlich,L.J., Bennetts,B.H. and Morris,B.J.
  TITLE     Primary structure of a human glandular kallikrein gene
  JOURNAL   DNA 6 (5), 429-437 (1987)
   PUBMED   2824146
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK300527.1, AF188746.1 and
            AC037199.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 24, 2018 this sequence version replaced NM_005551.4.
            
            Summary: This gene encodes a member of the grandular kallikrein
            protein family. Kallikreins are a subgroup of serine proteases that
            are clustered on chromosome 19. Members of this family are involved
            in a diverse array of biological functions. The protein encoded by
            this gene is a highly active trypsin-like serine protease that
            selectively cleaves at arginine residues. This protein is primarily
            expressed in prostatic tissue and is responsible for cleaving
            pro-prostate-specific antigen into its enzymatically active form.
            This gene is highly expressed in prostate tumor cells and may be a
            prognostic maker for prostate cancer risk. Alternate splicing
            results in both coding and non-coding transcript variants.
            [provided by RefSeq, Jan 2012].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF188746.1, ERR279876.4503.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145240, SAMEA2145544
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000325321.8/ ENSP00000313581.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                AK300527.1         7-25
            20-991              AF188746.1         1-972
            992-1863            AC037199.2         10001-10872
            1864-2829           AF188746.1         1845-2810
FEATURES             Location/Qualifiers
     source          1..2829
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     gene            1..2829
                     /gene="KLK2"
                     /gene_synonym="hGK-1; hK2; KLK2A2"
                     /note="kallikrein related peptidase 2"
                     /db_xref="GeneID:3817"
                     /db_xref="HGNC:HGNC:6363"
                     /db_xref="MIM:147960"
     exon            1..81
                     /gene="KLK2"
                     /gene_synonym="hGK-1; hK2; KLK2A2"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..821
                     /gene="KLK2"
                     /gene_synonym="hGK-1; hK2; KLK2A2"
                     /EC_number="3.4.21.35"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; kallikrein 2, prostatic; glandular kallikrein
                     2; tissue kallikrein-2; glandular kallikrein-1"
                     /codon_start=1
                     /product="kallikrein-2 isoform 1 preproprotein"
                     /protein_id="NP_005542.1"
                     /db_xref="CCDS:CCDS12808.1"
                     /db_xref="GeneID:3817"
                     /db_xref="HGNC:HGNC:6363"
                     /db_xref="MIM:147960"
                     /translation="MWDLVLSIALSVGCTGAVPLIQSRIVGGWECEKHSQPWQVAVYS
                     HGWAHCGGVLVHPQWVLTAAHCLKKNSQVWLGRHNLFEPEDTGQRVPVSHSFPHPLYN
                     MSLLKHQSLRPDEDSSHDLMLLRLSEPAKITDVVKVLGLPTQEPALGTTCYASGWGSI
                     EPEEFLRPRSLQCVSLHLLSNDMCARAYSEKVTEFMLCAGLWTGGKDTCGGDSGGPLV
                     CNGVLQGITSWGPEPCALPEKPAVYTKVVHYRKWIKDTIAANP"
     exon            82..241
                     /gene="KLK2"
                     /gene_synonym="hGK-1; hK2; KLK2A2"
                     /inference="alignment:Splign:2.1.0"
     exon            242..528
                     /gene="KLK2"
                     /gene_synonym="hGK-1; hK2; KLK2A2"
                     /inference="alignment:Splign:2.1.0"
     exon            529..665
                     /gene="KLK2"
                     /gene_synonym="hGK-1; hK2; KLK2A2"
                     /inference="alignment:Splign:2.1.0"
     exon            666..2829
                     /gene="KLK2"
                     /gene_synonym="hGK-1; hK2; KLK2A2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1472..1477
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLK2"
                     /gene_synonym="hGK-1; hK2; KLK2A2"
                     /note="hexamer: AATAAA"
     polyA_site      1498
                     /gene="KLK2"
                     /gene_synonym="hGK-1; hK2; KLK2A2"
                     /note="major polyA site"
     regulatory      2800..2805
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLK2"
                     /gene_synonym="hGK-1; hK2; KLK2A2"
                     /note="hexamer: AATAAA"
     polyA_site      2829
                     /gene="KLK2"
                     /gene_synonym="hGK-1; hK2; KLK2A2"
ORIGIN      
        1 aaactcacca cctggccgtg gacacctgtg tcagcatgtg ggacctggtt ctctccatcg
       61 ccttgtctgt ggggtgcact ggtgccgtgc ccctcatcca gtctcggatt gtgggaggct
      121 gggagtgtga gaagcattcc caaccctggc aggtggctgt gtacagtcat ggatgggcac
      181 actgtggggg tgtcctggtg cacccccagt gggtgctcac agctgcccat tgcctaaaga
      241 agaatagcca ggtctggctg ggtcggcaca acctgtttga gcctgaagac acaggccaga
      301 gggtccctgt cagccacagc ttcccacacc cgctctacaa tatgagcctt ctgaagcatc
      361 aaagccttag accagatgaa gactccagcc atgacctcat gctgctccgc ctgtcagagc
      421 ctgccaagat cacagatgtt gtgaaggtcc tgggcctgcc cacccaggag ccagcactgg
      481 ggaccacctg ctacgcctca ggctggggca gcatcgaacc agaggagttc ttgcgcccca
      541 ggagtcttca gtgtgtgagc ctccatctcc tgtccaatga catgtgtgct agagcttact
      601 ctgagaaggt gacagagttc atgttgtgtg ctgggctctg gacaggtggt aaagacactt
      661 gtgggggtga ttctgggggt ccacttgtct gtaatggtgt gcttcaaggt atcacatcat
      721 ggggccctga gccatgtgcc ctgcctgaaa agcctgctgt gtacaccaag gtggtgcatt
      781 accggaagtg gatcaaggac accatcgcag ccaacccctg agtgcccctg tcccacccct
      841 acctctagta aatttaagtc cacctcacgt tctggcatca cttggccttt ctggatgctg
      901 gacacctgaa gcttggaact cacctggccg aagctcgagc ctcctgagtc ctactgacct
      961 gtgctttctg gtgtggagtc cagggctgct aggaaaagga atgggcagac acaggtgtat
     1021 gccaatgttt ctgaaatggg tataatttcg tcctctcctt cggaacactg gctgtctctg
     1081 aagacttctc gctcagtttc agtgaggaca cacacaaaga cgtgggtgac catgttgttt
     1141 gtggggtgca gagatgggag gggtggggcc caccctggaa gagtggacag tgacacaagg
     1201 tggacactct ctacagatca ctgaggataa gctggagcca caatgcatga ggcacacaca
     1261 cagcaaggat gacgctgtaa acatagccca cgctgtcctg ggggcactgg gaagcctaga
     1321 taaggccgtg agcagaaaga aggggaggat cctcctatgt tgttgaagga gggactaggg
     1381 ggagaaactg aaagctgatt aattacagga ggtttgttca ggtcccccaa accaccgtca
     1441 gatttgatga tttcctagca ggacttacag aaataaagag ctatcatgct gtggtttatt
     1501 atggtttgtt acattgatag gatacatact gaaatcagca aacaaaacag atgtatagat
     1561 tagagtgtgg agaaaacaga ggaaaacttg cagttacgaa gactggcaac ttggctttac
     1621 taagttttca gactggcagg aagtcaaacc tattaggctg aggaccttgt ggagtgtagc
     1681 tgatccagct gatagaggaa ctagccaggt gggggccttt ccctttggat ggggggcata
     1741 tctgacagtt attctctcca agtggagact tacggacagc atataattct ccctgcaagg
     1801 atgtatgata atatgtacaa agtaattcca actgaggaag ctcacctgat ccttagtgtc
     1861 cagggttttt actgggggtc tgtaggacga gtatggagta cttgaataat tgacctgaag
     1921 tcctcagacc tgaggttccc tagagttcaa acagatacag catggtccag agtcccagat
     1981 gtacaaaaac agggattcat cacaaatccc atctttagca tgaagggtct ggcatggccc
     2041 aaggccccaa gtatatcaag gcacttgggc agaacatgcc aaggaatcaa atgtcatctc
     2101 ccaggagtta ttcaagggtg agccctttac ttgggatgta caggctttga gcagtgcagg
     2161 gctgctgagt caacctttta ttgtacaggg gatgagggaa agggagagga tgaggaagcc
     2221 cccctgggga tttggtttgg tcttgtgatc aggtggtcta tggggctatc cctacaaaga
     2281 agaatccaga aataggggca cattgaggaa tgatactgag cccaaagagc attcaatcat
     2341 tgttttattt gccttctttt cacaccattg gtgagggagg gattaccacc ctggggttat
     2401 gaagatggtt gaacacccca cacatagcac cggagatatg agatcaacag tttcttagcc
     2461 atagagattc acagcccaga gcaggaggac gctgcacacc atgcaggatg acatggggga
     2521 tgcgctcggg attggtgtga agaagcaagg actgttagag gcaggcttta tagtaacaag
     2581 acggtggggc aaactctgat ttccgtgggg gaatgtcatg gtcttgcttt actaagtttt
     2641 gagactggca ggtagtgaaa ctcattaggc tgagaacctt gtggaatgca gctgacccag
     2701 ctgatagagg aagtagccag gtgggagcct ttcccagtgg gtgtgggaca tatctggcaa
     2761 gattttgtgg cactcctggt tacagatact ggggcagcaa ataaaactga atcttgtttt
     2821 cagacctta
//
