LOCUS       NM_017509               1357 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens kallikrein related peptidase 15 (KLK15), transcript
            variant 4, mRNA.
ACCESSION   NM_017509 XM_006723265
VERSION     NM_017509.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1357)
  AUTHORS   Adamopoulos,P.G., Koukouzeli,F.Epsilon., Kontos,C.K. and
            Scorilas,A.
  TITLE     Identification of six novel alternative transcripts of the human
            kallikrein-related peptidase 15 (KLK15), using 3'RACE and
            high-throughput sequencing
  JOURNAL   Gene 749, 144708 (2020)
   PUBMED   32334022
  REMARK    GeneRIF: Identification and characterization of novel KLK15
            alternative splice variants and their expression patterns in a wide
            panel of human cancer and normal cell lines
REFERENCE   2  (bases 1 to 1357)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1357)
  AUTHORS   Filippou,P.S., Ren,A.H., Soosaipillai,A., Papaioannou,M.D.,
            Korbakis,D., Safar,R., Diamandis,E.P. and Conner,J.R.
  TITLE     Expression profile of human tissue kallikrein 15 provides
            preliminary insights into its roles in the prostate and testis
  JOURNAL   Clin Biochem 59, 78-85 (2018)
   PUBMED   29958881
  REMARK    GeneRIF: Data provide insights into the localization and possible
            role of KLK15 in human physiology.
REFERENCE   4  (bases 1 to 1357)
  AUTHORS   Filippou,P.S., Ren,A.H., Bala,S., Papaioannou,M.D., Brinc,D.,
            Prassas,I., Karakosta,T. and Diamandis,E.P.
  TITLE     Biochemical characterization of human tissue kallikrein 15 and
            examination of its potential role in cancer
  JOURNAL   Clin Biochem 58, 108-115 (2018)
   PUBMED   29928903
  REMARK    GeneRIF: KLK15 may be able to cleave many ECM components, similar
            to several members of the KLK family. Thus the protease could
            potentially be linked to tumorigenesis by promoting metastasis via
            this mechanism.
REFERENCE   5  (bases 1 to 1357)
  AUTHORS   Takayama,T.K., Carter,C.A. and Deng,T.
  TITLE     Activation of prostate-specific antigen precursor (pro-PSA) by
            prostin, a novel human prostatic serine protease identified by
            degenerate PCR
  JOURNAL   Biochemistry 40 (6), 1679-1687 (2001)
   PUBMED   11327827
REFERENCE   6  (bases 1 to 1357)
  AUTHORS   Yousef,G.M., Scorilas,A., Jung,K., Ashworth,L.K. and Diamandis,E.P.
  TITLE     Molecular cloning of the human kallikrein 15 gene (KLK15).
            Up-regulation in prostate cancer
  JOURNAL   J Biol Chem 276 (1), 53-61 (2001)
   PUBMED   11010966
REFERENCE   7  (bases 1 to 1357)
  AUTHORS   Gan,L., Lee,I., Smith,R., Argonza-Barrett,R., Lei,H., McCuaig,J.,
            Moss,P., Paeper,B. and Wang,K.
  TITLE     Sequencing and expression analysis of the serine protease gene
            cluster located in chromosome 19q13 region
  JOURNAL   Gene 257 (1), 119-130 (2000)
   PUBMED   11054574
REFERENCE   8  (bases 1 to 1357)
  AUTHORS   Yousef,G.M., Chang,A., Scorilas,A. and Diamandis,E.P.
  TITLE     Genomic organization of the human kallikrein gene family on
            chromosome 19q13.3-q13.4
  JOURNAL   Biochem Biophys Res Commun 276 (1), 125-133 (2000)
   PUBMED   11006094
REFERENCE   9  (bases 1 to 1357)
  AUTHORS   Diamandis,E.P., Yousef,G.M., Luo,L.Y., Magklara,A. and Obiezu,C.V.
  TITLE     The new human kallikrein gene family: implications in
            carcinogenesis
  JOURNAL   Trends Endocrinol Metab 11 (2), 54-60 (2000)
   PUBMED   10675891
  REMARK    Review article
REFERENCE   10 (bases 1 to 1357)
  AUTHORS   Dihanich,M. and Spiess,M.
  TITLE     A novel serine proteinase-like sequence from human brain
  JOURNAL   Biochim Biophys Acta 1218 (2), 225-228 (1994)
   PUBMED   8018728
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC010325.7.
            This sequence is a reference standard in the RefSeqGene project.
            
            On or before Jul 7, 2021 this sequence version replaced
            XM_006723265.3, NM_017509.3.
            
            Summary: Kallikreins are a subgroup of serine proteases having
            diverse physiological functions. Growing evidence suggests that
            many kallikreins are implicated in carcinogenesis and some have
            potential as novel cancer and other disease biomarkers. This gene
            is one of the fifteen kallikrein subfamily members located in a
            cluster on chromosome 19. In prostate cancer, this gene has
            increased expression, which indicates its possible use as a
            diagnostic or prognostic marker for prostate cancer. The gene
            contains multiple polyadenylation sites and alternative splicing
            results in multiple transcript variants encoding distinct isoforms.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: BC069507.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA2156266 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000598239.6/ ENSP00000469315.1
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                AC010325.7         166191-166238       c
            49-122              AC010325.7         164114-164187       c
            123-276             AC010325.7         160326-160479       c
            277-560             AC010325.7         159542-159825       c
            561-697             AC010325.7         159285-159421       c
            698-1357            AC010325.7         157953-158612       c
FEATURES             Location/Qualifiers
     source          1..1357
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     gene            1..1357
                     /gene="KLK15"
                     /gene_synonym="ACO; HSRNASPH"
                     /note="kallikrein related peptidase 15"
                     /db_xref="GeneID:55554"
                     /db_xref="HGNC:HGNC:20453"
                     /db_xref="MIM:610601"
     exon            1..48
                     /gene="KLK15"
                     /gene_synonym="ACO; HSRNASPH"
                     /inference="alignment:Splign:2.1.0"
     exon            49..122
                     /gene="KLK15"
                     /gene_synonym="ACO; HSRNASPH"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..850
                     /gene="KLK15"
                     /gene_synonym="ACO; HSRNASPH"
                     /note="isoform 4 preproprotein is encoded by transcript
                     variant 4; prostinogen; ACO protease; kallikrein-like
                     serine protease"
                     /codon_start=1
                     /product="kallikrein-15 isoform 4 preproprotein"
                     /protein_id="NP_059979.2"
                     /db_xref="CCDS:CCDS12805.1"
                     /db_xref="GeneID:55554"
                     /db_xref="HGNC:HGNC:20453"
                     /db_xref="MIM:610601"
                     /translation="MWLLLTLSFLLASTAAQDGDKLLEGDECAPHSQPWQVALYERGR
                     FNCGASLISPHWVLSAAHCQSRFMRVRLGEHNLRKRDGPEQLRTTSRVIPHPRYEARS
                     HRNDIMLLRLVQPARLNPQVRPAVLPTRCPHPGEACVVSGWGLVSHNEPGTAGSPRSQ
                     VSLPDTLHCANISIISDTSCDKSYPGRLTNTMVCAGAEGRGAESCEGDSGGPLVCGGI
                     LQGIVSWGDVPCDNTTKPGVYTKVCHYLEWIRETMKRN"
     exon            123..276
                     /gene="KLK15"
                     /gene_synonym="ACO; HSRNASPH"
                     /inference="alignment:Splign:2.1.0"
     exon            277..560
                     /gene="KLK15"
                     /gene_synonym="ACO; HSRNASPH"
                     /inference="alignment:Splign:2.1.0"
     exon            561..697
                     /gene="KLK15"
                     /gene_synonym="ACO; HSRNASPH"
                     /inference="alignment:Splign:2.1.0"
     exon            698..1357
                     /gene="KLK15"
                     /gene_synonym="ACO; HSRNASPH"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1308..1313
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLK15"
                     /gene_synonym="ACO; HSRNASPH"
                     /note="hexamer: ATTAAA"
     regulatory      1335..1340
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLK15"
                     /gene_synonym="ACO; HSRNASPH"
                     /note="hexamer: ATTAAA"
     polyA_site      1341
                     /gene="KLK15"
                     /gene_synonym="ACO; HSRNASPH"
                     /note="major polyA site"
     polyA_site      1357
                     /gene="KLK15"
                     /gene_synonym="ACO; HSRNASPH"
ORIGIN      
        1 cttctggcac ccaagctgcc ctagatgctg ctggaggatc tggaggagac tgcagccgaa
       61 ccctggtccc tcctccacaa tgtggcttct cctcactctc tccttcctgc tggcatccac
      121 agcagcccag gatggtgaca agttgctgga aggtgacgag tgtgcacccc actcccagcc
      181 atggcaagtg gctctctacg agcgtggacg ctttaactgt ggcgcttccc tcatctcccc
      241 acactgggtg ctgtctgcgg cccactgcca aagccgcttc atgagagtgc gcctgggaga
      301 gcacaacctg cgcaagcgcg atggcccaga gcaactacgg accacgtctc gggtcattcc
      361 acacccgcgc tacgaagcgc gcagccaccg caacgacatc atgttgctgc gcctagtcca
      421 gcccgcacgc ctgaaccccc aggtgcgccc cgcggtgcta cccacgcgtt gcccccaccc
      481 gggggaggcc tgtgtggtgt ctggctgggg cctggtgtcc cacaacgagc ctgggaccgc
      541 tgggagcccc cggtcacaag tgagtctccc agatacgttg cattgtgcca acatcagcat
      601 tatctcggac acatcttgtg acaagagcta cccagggcgc ctgacaaaca ccatggtgtg
      661 tgcaggcgcg gagggcagag gcgcagaatc ctgtgagggt gactctgggg gacccctggt
      721 ctgtgggggc atcctgcagg gcattgtgtc ctggggtgac gtcccttgtg acaacaccac
      781 caagcctggt gtctatacca aagtctgcca ctacttggag tggatcaggg aaaccatgaa
      841 gaggaactga ctattctagc ctatctcctg tgcccctgac tgagcagaag cccccacagc
      901 tggccagcag ccccgcctga catggaacag aacggagcca tcccccaaga ccctgtccaa
      961 ggcccagatg ttagccaagg acttgtccca cctgaggaca aagctggcgc tcaaggtcac
     1021 ctgtttaatg ccaagataac aaagcgctga tccaagttgc tctgtaggaa tttctgtgac
     1081 ttttttctgg ggtcaaagag aaaccccgag acactgtaca ctgttccttt tcacccacca
     1141 ccccgatccc taggtgagga gaagcggctt gaagcagggc tccattcatt caacacacat
     1201 gaccacccgt gtgatcttga acaagaggcc caatctcact tcgccttggt ttccttatct
     1261 gtaaaatgag accatcttat tgctgacttc aaagggctgt tgtgaggatt aaatgagatg
     1321 attcgtctga actgattaaa atcgtgtctg gcactga
//
