LOCUS       NM_001369775            1054 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens kallikrein related peptidase 14 (KLK14), transcript
            variant 3, mRNA.
ACCESSION   NM_001369775
VERSION     NM_001369775.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1054)
  AUTHORS   Falkowski,K., Bielecka,E., Thogersen,I.B., Bochenska,O., Plaza,K.,
            Kalinska,M., Sasiadek,L., Magoch,M., Pecak,A., Wisniewska,M.,
            Gruba,N., Wysocka,M., Wojtysiak,A., Brzezinska-Bodal,M.,
            Sychowska,K., Pejkovska,A., Rehders,M., Butler,G., Overall,C.M.,
            Brix,K., Dubin,G., Lesner,A., Kozik,A., Enghild,J.J., Potempa,J.
            and Kantyka,T.
  TITLE     Kallikrein-Related Peptidase 14 Activates Zymogens of Membrane Type
            Matrix Metalloproteinases (MT-MMPs)-A CleavEx Based Analysis
  JOURNAL   Int J Mol Sci 21 (12), 4383 (2020)
   PUBMED   32575583
  REMARK    GeneRIF: Kallikrein-Related Peptidase 14 Activates Zymogens of
            Membrane Type Matrix Metalloproteinases (MT-MMPs)-A CleavEx Based
            Analysis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1054)
  AUTHORS   Gouin,O., Barbieux,C., Leturcq,F., Bonnet des Claustres,M.,
            Petrova,E. and Hovnanian,A.
  TITLE     Transgenic Kallikrein 14 Mice Display Major Hair Shaft Defects
            Associated with Desmoglein 3 and 4 Degradation, Abnormal Epidermal
            Differentiation, and IL-36 Signature
  JOURNAL   J Invest Dermatol 140 (6), 1184-1194 (2020)
   PUBMED   32169475
  REMARK    GeneRIF: Transgenic Kallikrein 14 Mice Display Major Hair Shaft
            Defects Associated with Desmoglein 3 and 4 Degradation, Abnormal
            Epidermal Differentiation, and IL-36 Signature.
REFERENCE   3  (bases 1 to 1054)
  AUTHORS   Kryza,T., Bock,N., Lovell,S., Rockstroh,A., Lehman,M.L., Lesner,A.,
            Panchadsaram,J., Silva,L.M., Srinivasan,S., Snell,C.E.,
            Williams,E.D., Fazli,L., Gleave,M., Batra,J., Nelson,C., Tate,E.W.,
            Harris,J., Hooper,J.D. and Clements,J.A.
  TITLE     The molecular function of kallikrein-related peptidase 14
            demonstrates a key modulatory role in advanced prostate cancer
  JOURNAL   Mol Oncol 14 (1), 105-128 (2020)
   PUBMED   31630475
  REMARK    GeneRIF: The molecular function of kallikrein-related peptidase 14
            demonstrates a key modulatory role in advanced prostate cancer.
REFERENCE   4  (bases 1 to 1054)
  AUTHORS   Dettmar,L., Ahmed,N., Kotzsch,M., Diersch,S., Napieralski,R.,
            Darmoul,D., Schmitt,M., Weichert,W., Kiechle,M., Dorn,J. and
            Magdolen,V.
  TITLE     Advanced high-grade serous ovarian cancer: inverse association of
            KLK13 and KLK14 mRNA levels in tumor tissue and patients' prognosis
  JOURNAL   J Cancer Res Clin Oncol 144 (6), 1109-1118 (2018)
   PUBMED   29546479
  REMARK    GeneRIF: There was no significant association of KLK13 and KLK14
            mRNA expression with the clinical factors ascitic fluid volume or
            residual tumor mass. High KLK14 mRNA levels were significantly
            associated with prolonged PFS (HR = 0.44, P = 0.017) and showed a
            trend towards significance for OS (HR = 0.55, P = 0.070).
REFERENCE   5  (bases 1 to 1054)
  AUTHORS   Stefansson,K., Brattsand,M., Ny,A., Glas,B. and Egelrud,T.
  TITLE     Kallikrein-related peptidase 14 may be a major contributor to
            trypsin-like proteolytic activity in human stratum corneum
  JOURNAL   Biol Chem 387 (6), 761-768 (2006)
   PUBMED   16800737
  REMARK    GeneRIF: The majority of KLK14 in the plantar stratum corneum is
            present in its catalytically active form. KLK14 could be
            immunohistochemically detected in sweat ducts, preferentially in
            the intraepidermal parts (the acrosyringium), and in sweat glands.
REFERENCE   6  (bases 1 to 1054)
  AUTHORS   Yousef,G.M., Stephan,C., Scorilas,A., Ellatif,M.A., Jung,K.,
            Kristiansen,G., Jung,M., Polymeris,M.E. and Diamandis,E.P.
  TITLE     Differential expression of the human kallikrein gene 14 (KLK14) in
            normal and cancerous prostatic tissues
  JOURNAL   Prostate 56 (4), 287-292 (2003)
   PUBMED   12858357
  REMARK    GeneRIF: KLK14 expression upregulated in advanced and more
            aggressive prostate tumors; may play role in tumor spread and may
            be new marker for prostate cancer diagnosis and prognosis
REFERENCE   7  (bases 1 to 1054)
  AUTHORS   Yousef,G.M., Borgono,C.A., Scorilas,A., Ponzone,R., Biglia,N.,
            Iskander,L., Polymeris,M.E., Roagna,R., Sismondi,P. and
            Diamandis,E.P.
  TITLE     Quantitative analysis of human kallikrein gene 14 expression in
            breast tumours indicates association with poor prognosis
  JOURNAL   Br J Cancer 87 (11), 1287-1293 (2002)
   PUBMED   12439719
  REMARK    GeneRIF: KLK14 overexpression was found to be a significant
            predictor of decreased disease-free survival and overall survival
            in breast cancer patients
REFERENCE   8  (bases 1 to 1054)
  AUTHORS   Yousef,G.M., Magklara,A., Chang,A., Jung,K., Katsaros,D. and
            Diamandis,E.P.
  TITLE     Cloning of a new member of the human kallikrein gene family, KLK14,
            which is down-regulated in different malignancies
  JOURNAL   Cancer Res 61 (8), 3425-3431 (2001)
   PUBMED   11309303
REFERENCE   9  (bases 1 to 1054)
  AUTHORS   Hooper,J.D., Bui,L.T., Rae,F.K., Harvey,T.J., Myers,S.A.,
            Ashworth,L.K. and Clements,J.A.
  TITLE     Identification and characterization of KLK14, a novel kallikrein
            serine protease gene located on human chromosome 19q13.4 and
            expressed in prostate and skeletal muscle
  JOURNAL   Genomics 73 (1), 117-122 (2001)
   PUBMED   11352573
REFERENCE   10 (bases 1 to 1054)
  AUTHORS   Harvey,T.J., Hooper,J.D., Myers,S.A., Stephenson,S.A.,
            Ashworth,L.K. and Clements,J.A.
  TITLE     Tissue-specific expression patterns and fine mapping of the human
            kallikrein (KLK) locus on proximal 19q13.4
  JOURNAL   J Biol Chem 275 (48), 37397-37406 (2000)
   PUBMED   10969073
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC011473.4.
            
            On Jun 2, 2019 this sequence version replaced NM_001369775.1.
            
            Summary: This gene encodes a member of the kallikrein subfamily of
            serine proteases that have diverse physiological functions such as
            regulation of blood pressure and desquamation. The altered
            expression of this gene is implicated in the progression of
            different cancers including breast and prostate tumors. The encoded
            protein is a precursor that is proteolytically processed to
            generate the functional enzyme. This gene is one of the fifteen
            kallikrein subfamily members located in a cluster on chromosome 19.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Jul 2015].
            
            Transcript Variant: This variant (3) differs in the 5' and 3' UTRs
            compared to variant 1. Variants 1-3 all encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC074905.2, AF283670.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2145893
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000650543.2/
                                                ENSP00000497141.1
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation, expression,
                                                longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 5' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-166               AC011473.4         82804-82969         c
            167-228             AC011473.4         82657-82718         c
            229-400             AC011473.4         81614-81785         c
            401-654             AC011473.4         79531-79784         c
            655-791             AC011473.4         78897-79033         c
            792-1054            AC011473.4         77979-78241         c
FEATURES             Location/Qualifiers
     source          1..1054
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.41"
     gene            1..1054
                     /gene="KLK14"
                     /gene_synonym="KLK-L6"
                     /note="kallikrein related peptidase 14"
                     /db_xref="GeneID:43847"
                     /db_xref="HGNC:HGNC:6362"
                     /db_xref="MIM:606135"
     exon            1..166
                     /gene="KLK14"
                     /gene_synonym="KLK-L6"
                     /inference="alignment:Splign:2.1.0"
     exon            167..228
                     /gene="KLK14"
                     /gene_synonym="KLK-L6"
                     /inference="alignment:Splign:2.1.0"
     CDS             189..944
                     /gene="KLK14"
                     /gene_synonym="KLK-L6"
                     /note="kallikrein-like protein 6; kallikrein-14"
                     /codon_start=1
                     /product="kallikrein-14 preproprotein"
                     /protein_id="NP_001356704.1"
                     /db_xref="CCDS:CCDS12823.3"
                     /db_xref="GeneID:43847"
                     /db_xref="HGNC:HGNC:6362"
                     /db_xref="MIM:606135"
                     /translation="MFLLLTALQVLAIAMTQSQEDENKIIGGHTCTRSSQPWQAALLA
                     GPRRRFLCGGALLSGQWVITAAHCGRPILQVALGKHNLRRWEATQQVLRVVRQVTHPN
                     YNSRTHDNDLMLLQLQQPARIGRAVRPIEVTQACASPGTSCRVSGWGTISSPIARYPA
                     SLQCVNINISPDEVCQKAYPRTITPGMVCAGVPQGGKDSCQGDSGGPLVCRGQLQGLV
                     SWGMERCALPGYPGVYTNLCKYRSWIEETMRDK"
     exon            229..400
                     /gene="KLK14"
                     /gene_synonym="KLK-L6"
                     /inference="alignment:Splign:2.1.0"
     exon            401..654
                     /gene="KLK14"
                     /gene_synonym="KLK-L6"
                     /inference="alignment:Splign:2.1.0"
     exon            655..791
                     /gene="KLK14"
                     /gene_synonym="KLK-L6"
                     /inference="alignment:Splign:2.1.0"
     exon            792..1054
                     /gene="KLK14"
                     /gene_synonym="KLK-L6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagagacacc tcccctcctt ccttcatcaa gacatcaagg agggacctgt gccctgctcc
       61 acatcctccc acctgccgcc cgcagagcct gcaggccccg cccccctcgt ctctggtccc
      121 tacctctctg ctgtgtcttc atgtccctga gggtcttggg ctctgggacc tggccctcag
      181 cccctaaaat gttcctcctg ctgacagcac ttcaagtcct ggctatagcc atgacacaga
      241 gccaagagga tgagaacaag ataattggtg gccatacgtg cacccggagc tcccagccgt
      301 ggcaggcggc cctgctggcg ggtcccaggc gccgcttcct ctgcggaggc gccctgcttt
      361 caggccagtg ggtcatcact gctgctcact gcggccgccc gatccttcag gttgccctgg
      421 gcaagcacaa cctgaggagg tgggaggcca cccagcaggt gctgcgcgtg gttcgtcagg
      481 tgacgcaccc caactacaac tcccggaccc acgacaacga cctcatgctg ctgcagctac
      541 agcagcccgc acggatcggg agggcagtca ggcccattga ggtcacccag gcctgtgcca
      601 gccccgggac ctcctgccga gtgtcaggct ggggaactat atccagcccc atcgccaggt
      661 accccgcctc tctgcaatgc gtgaacatca acatctcccc ggatgaggtg tgccagaagg
      721 cctatcctag aaccatcacg cctggcatgg tctgtgcagg agttccccag ggcgggaagg
      781 actcttgtca gggtgactct gggggacccc tggtgtgcag aggacagctc cagggcctcg
      841 tgtcttgggg aatggagcgc tgcgccctgc ctggctaccc cggtgtctac accaacctgt
      901 gcaagtacag aagctggatt gaggaaacga tgcgggacaa atgatggtct tcacggtggg
      961 atggacctcg tcagctgccc aggccctcct ctctctactc aggacccagg agtccaggcc
     1021 ccagcccctc ctccctcaga cccaggagtc cagg
//
