LOCUS       NM_015596               1820 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens kallikrein related peptidase 13 (KLK13), transcript
            variant 1, mRNA.
ACCESSION   NM_015596
VERSION     NM_015596.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1820)
  AUTHORS   Gruba,N., Rachubik,P., Piwkowska,A. and Lesner,A.
  TITLE     Analysis of urinary kallikrein-related peptidase 13 for monitoring
            bladder cancer
  JOURNAL   Biomarkers 26 (8), 770-779 (2021)
   PUBMED   34704886
  REMARK    GeneRIF: Analysis of urinary kallikrein-related peptidase 13 for
            monitoring bladder cancer.
REFERENCE   2  (bases 1 to 1820)
  AUTHORS   Milewska,A., Falkowski,K., Kulczycka,M., Bielecka,E., Naskalska,A.,
            Mak,P., Lesner,A., Ochman,M., Urlik,M., Diamandis,E., Prassas,I.,
            Potempa,J., Kantyka,T. and Pyrc,K.
  TITLE     Kallikrein 13 serves as a priming protease during infection by the
            human coronavirus HKU1
  JOURNAL   Sci Signal 13 (659) (2020)
   PUBMED   33234691
  REMARK    GeneRIF: Kallikrein 13 serves as a priming protease during
            infection by the human coronavirus HKU1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1820)
  AUTHORS   Wang,Y., Tan,T.Z., Wang,L.Q. and Zhang,K.
  TITLE     LncRNA WT-AS inhibits metastatic ability of non-small cell lung
            cancer by regulating KLK13
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (18), 9429-9437 (2020)
   PUBMED   33015785
  REMARK    GeneRIF: LncRNA WT-AS inhibits metastatic ability of non-small cell
            lung cancer by regulating KLK13.
REFERENCE   4  (bases 1 to 1820)
  AUTHORS   Muytjens,C.M.J., Yu,Y. and Diamandis,E.P.
  TITLE     Functional proteomic profiling reveals KLK13 and TMPRSS11D as
            active proteases in the lower female reproductive tract
  JOURNAL   F1000Res 7, 1666 (2018)
   PUBMED   30647911
  REMARK    GeneRIF: serine proteases transmembrane protein serine 11D and
            kallikrein-related peptidase 13 were shown as active proteases in
            Cervical-vaginal fluid.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1820)
  AUTHORS   Nohara,K., Yamada,K., Yamada,L., Hagiwara,T., Igari,T., Yokoi,C.,
            Soma,D., Yamashita,S., Dohi,T. and Kawamura,Y.I.
  TITLE     Expression of kallikrein-related peptidase 13 is associated with
            poor prognosis in esophageal squamous cell carcinoma
  JOURNAL   Gen Thorac Cardiovasc Surg 66 (6), 351-357 (2018)
   PUBMED   29582368
  REMARK    GeneRIF: Relatively high levels of KLK13 expression in ESCC were
            associated with cell proliferation and correlated with tumor
            progression, advanced cancer stage, and poor prognosis
            Erratum:[Gen Thorac Cardiovasc Surg. 2018 Jun;66(6):376-377. doi:
            10.1007/s11748-018-0923-0.. PMID: 29693222]
REFERENCE   6  (bases 1 to 1820)
  AUTHORS   Chang,A., Yousef,G.M., Jung,K., Rajpert-De Meyts,E. and
            Diamandis,E.P.
  TITLE     Identification and molecular characterization of five novel
            kallikrein gene 13 (KLK13; KLK-L4) splice variants: differential
            expression in the human testis and testicular cancer
  JOURNAL   Anticancer Res 21 (5), 3147-3152 (2001)
   PUBMED   11848466
REFERENCE   7  (bases 1 to 1820)
  AUTHORS   Gan,L., Lee,I., Smith,R., Argonza-Barrett,R., Lei,H., McCuaig,J.,
            Moss,P., Paeper,B. and Wang,K.
  TITLE     Sequencing and expression analysis of the serine protease gene
            cluster located in chromosome 19q13 region
  JOURNAL   Gene 257 (1), 119-130 (2000)
   PUBMED   11054574
REFERENCE   8  (bases 1 to 1820)
  AUTHORS   Yousef,G.M., Chang,A., Scorilas,A. and Diamandis,E.P.
  TITLE     Genomic organization of the human kallikrein gene family on
            chromosome 19q13.3-q13.4
  JOURNAL   Biochem Biophys Res Commun 276 (1), 125-133 (2000)
   PUBMED   11006094
REFERENCE   9  (bases 1 to 1820)
  AUTHORS   Yousef,G.M., Chang,A. and Diamandis,E.P.
  TITLE     Identification and characterization of KLK-L4, a new
            kallikrein-like gene that appears to be down-regulated in breast
            cancer tissues
  JOURNAL   J Biol Chem 275 (16), 11891-11898 (2000)
   PUBMED   10766816
REFERENCE   10 (bases 1 to 1820)
  AUTHORS   Diamandis,E.P., Yousef,G.M., Luo,L.Y., Magklara,A. and Obiezu,C.V.
  TITLE     The new human kallikrein gene family: implications in
            carcinogenesis
  JOURNAL   Trends Endocrinol Metab 11 (2), 54-60 (2000)
   PUBMED   10675891
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC069334.1 and AC011473.4.
            
            On Nov 22, 2018 this sequence version replaced NM_015596.2.
            
            Summary: Kallikreins are a subgroup of serine proteases having
            diverse physiological functions. Growing evidence suggests that
            many kallikreins are implicated in carcinogenesis and some have
            potential as novel cancer and other disease biomarkers. This gene
            is one of the fifteen kallikrein subfamily members located in a
            cluster on chromosome 19. Expression of this gene is regulated by
            steroid hormones and may be useful as a marker for breast cancer.
            [provided by RefSeq, Jan 2017].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC069543.1, ERR279836.10445.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2147975 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000595793.6/ ENSP00000470555.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-906               BC069334.1         20-925
            907-1820            AC011473.4         55708-56621         c
FEATURES             Location/Qualifiers
     source          1..1820
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.41"
     gene            1..1820
                     /gene="KLK13"
                     /gene_synonym="KLK-L4; KLKL4"
                     /note="kallikrein related peptidase 13"
                     /db_xref="GeneID:26085"
                     /db_xref="HGNC:HGNC:6361"
                     /db_xref="MIM:605505"
     exon            1..77
                     /gene="KLK13"
                     /gene_synonym="KLK-L4; KLKL4"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..859
                     /gene="KLK13"
                     /gene_synonym="KLK-L4; KLKL4"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; kallikrein-like gene 4; kallikrein-13;
                     kallikrein-like protein 4"
                     /codon_start=1
                     /product="kallikrein-13 isoform 1 precursor"
                     /protein_id="NP_056411.1"
                     /db_xref="CCDS:CCDS12822.1"
                     /db_xref="GeneID:26085"
                     /db_xref="HGNC:HGNC:6361"
                     /db_xref="MIM:605505"
                     /translation="MWPLALVIASLTLALSGGVSQESSKVLNTNGTSGFLPGGYTCFP
                     HSQPWQAALLVQGRLLCGGVLVHPKWVLTAAHCLKEGLKVYLGKHALGRVEAGEQVRE
                     VVHSIPHPEYRRSPTHLNHDHDIMLLELQSPVQLTGYIQTLPLSHNNRLTPGTTCRVS
                     GWGTTTSPQVNYPKTLQCANIQLRSDEECRQVYPGKITDNMLCAGTKEGGKDSCEGDS
                     GGPLVCNRTLYGIVSWGDFPCGQPDRPGVYTRVSRYVLWIRETIRKYETQQQKWLKGP
                     Q"
     exon            78..264
                     /gene="KLK13"
                     /gene_synonym="KLK-L4; KLKL4"
                     /inference="alignment:Splign:2.1.0"
     exon            265..533
                     /gene="KLK13"
                     /gene_synonym="KLK-L4; KLKL4"
                     /inference="alignment:Splign:2.1.0"
     exon            534..670
                     /gene="KLK13"
                     /gene_synonym="KLK-L4; KLKL4"
                     /inference="alignment:Splign:2.1.0"
     exon            671..1820
                     /gene="KLK13"
                     /gene_synonym="KLK-L4; KLKL4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      855..860
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLK13"
                     /gene_synonym="KLK-L4; KLKL4"
                     /note="hexamer: AATAAA"
     polyA_site      874
                     /gene="KLK13"
                     /gene_synonym="KLK-L4; KLKL4"
                     /note="major polyA site"
     regulatory      1796..1801
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLK13"
                     /gene_synonym="KLK-L4; KLKL4"
                     /note="hexamer: AATAAA"
     polyA_site      1820
                     /gene="KLK13"
                     /gene_synonym="KLK-L4; KLKL4"
                     /note="major polyA site"
ORIGIN      
        1 gccctcccct cccgatcccg gagccatgtg gcccctggcc ctagtgatcg cctccctgac
       61 cttggccttg tcaggaggtg tctcccagga gtcttccaag gttctcaaca ccaatgggac
      121 cagtgggttt ctcccaggtg gctacacctg cttcccccac tctcagccct ggcaggctgc
      181 cctactagtg caagggcggc tactctgtgg gggagtcctg gtccacccca aatgggtcct
      241 cactgccgca cactgtctaa aggaggggct caaagtttac ctaggcaagc acgccctagg
      301 gcgtgtggaa gctggtgagc aggtgaggga agttgtccac tctatccccc accctgaata
      361 ccggagaagc cccacccacc tgaaccacga ccatgacatc atgcttctgg agctgcagtc
      421 cccggtccag ctcacaggct acatccaaac cctgcccctt tcccacaaca accgcctaac
      481 ccctggcacc acctgtcggg tgtctggctg gggcaccacc accagccccc aggtgaatta
      541 ccccaaaact ctacaatgtg ccaacatcca acttcgctca gatgaggagt gtcgtcaagt
      601 ctacccagga aagatcactg acaacatgtt gtgtgccggc acaaaagagg gtggcaaaga
      661 ctcctgtgag ggtgactctg ggggccccct ggtctgtaac agaacactgt atggcatcgt
      721 ctcctgggga gacttcccat gtgggcaacc tgaccggcct ggtgtctaca cccgtgtctc
      781 aagatacgtc ctgtggatcc gtgaaacaat ccgaaaatat gaaacccagc agcaaaaatg
      841 gttgaagggc ccacaataaa agttgagaaa tgtaccggct tccatcctgt caccatgact
      901 tcctcacatg gtctgcttag cccttctctg ctccttattc ccagtgttcc atttgaacca
      961 gtgatccatg tcctgaaaaa tgctcaatct cagctaacat tccatgtttc agaagcattc
     1021 aggcactgcc aggcttgcag tctcccagat gttgcatccc tgaaacatct caacaacctg
     1081 aatgtcccaa cccagacaat ggcccaggtc tctcaacttc atcagtgtgg cttctatgag
     1141 cccagatcac cacctgaacg ttctgtctgt ggcacattct taaatatttc catcagccca
     1201 tctcaacaat atatgtccta taaatggacc atccttgaca acatcctcta actcttcaag
     1261 tatttattca atgccagtat cctagacctt ctattttttg cactcaagaa ggctctagac
     1321 tcccatgata gttcatcctg aaaatattct cttatgccca caatcttctg ccctgacaac
     1381 attctgtgta cctctgtgac tcaccacagc taacattgga tcctcagaat atttcattct
     1441 cacactgtta tgggtgtctc agaagtccca acccaaccta catcccacat tcttccaata
     1501 ccccacctct gccaacattc cctctctgaa tcaatggcac cctagtctct agagttatag
     1561 ggttcagtat accaaagggt cttcttgcct gaactttatt gtctaccaaa tattccgtct
     1621 tgtatcccct ccatgaacat ccttggtcag tgtcccttgc tgttacatct ttgtgcatga
     1681 ccctaaaatg tagtgcaaat ccttgctttg gacaagttat aaaactcaca gtctctgtgc
     1741 tttctcatct gtaaaatggg ttcataattt tttttaattg taacattatt acaagaataa
     1801 atgtcaagca tttatcacta
//
