LOCUS       NM_001370125            1171 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens kallikrein related peptidase 12 (KLK12), transcript
            variant 4, mRNA.
ACCESSION   NM_001370125
VERSION     NM_001370125.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1171)
  AUTHORS   Gong,W., Liu,Y., Preis,S., Geng,X., Petit-Courty,A., Kiechle,M.,
            Muckenhuber,A., Dreyer,T., Dorn,J., Courty,Y. and Magdolen,V.
  TITLE     Prognostic value of kallikrein-related peptidase 12 (KLK12) mRNA
            expression in triple-negative breast cancer patients
  JOURNAL   Mol Med 26 (1), 19 (2020)
   PUBMED   32028882
  REMARK    GeneRIF: Prognostic value of kallikrein-related peptidase 12
            (KLK12) mRNA expression in triple-negative breast cancer patients.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1171)
  AUTHORS   Li,Q., Zhou,X., Fang,Z. and Zhou,H.
  TITLE     Knockdown of KLK12 inhibits viability and induces apoptosis in
            human colorectal cancer HT-29 cell line
  JOURNAL   Int J Mol Med 44 (5), 1667-1676 (2019)
   PUBMED   31485623
  REMARK    GeneRIF: KLK12 was overexpressed in colorectal cancer.
REFERENCE   3  (bases 1 to 1171)
  AUTHORS   Adamopoulos,P.G., Kontos,C.K. and Scorilas,A.
  TITLE     Novel splice variants of the human kallikrein-related peptidases 11
            (KLK11) and 12 (KLK12), unraveled by next-generation sequencing
            technology
  JOURNAL   Biol Chem 399 (9), 1065-1071 (2018)
   PUBMED   29874189
  REMARK    GeneRIF: novel KLK11 and KLK12 splice variants represent new
            potential cancer biomarkers
REFERENCE   4  (bases 1 to 1171)
  AUTHORS   Papachristopoulou,G., Tsapralis,N., Michaelidou,K.,
            Ardavanis-Loukeris,G., Griniatsos,I., Scorilas,A. and Talieri,M.
  TITLE     Human kallikrein-related peptidase 12 (KLK12) splice variants
            discriminate benign from cancerous breast tumors
  JOURNAL   Clin Biochem 58, 78-85 (2018)
   PUBMED   29807016
  REMARK    GeneRIF: results demonstrate the discriminative value of KLK12sv1/2
            and KLK12sv3 between benign and malignant breast tumors as well as
            their potential favorable prognostic significance in breast
            adenocarcinoma.
REFERENCE   5  (bases 1 to 1171)
  AUTHORS   Li,X.S. and He,X.L.
  TITLE     Kallikrein 12 downregulation reduces AGS gastric cancer cell
            proliferation and migration
  JOURNAL   Genet Mol Res 15 (3) (2016)
   PUBMED   27706634
  REMARK    GeneRIF: KLK12 gene silencing reduces gastric cancer cell
            proliferation and migration.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1171)
  AUTHORS   Harvey,T.J., Hooper,J.D., Myers,S.A., Stephenson,S.A.,
            Ashworth,L.K. and Clements,J.A.
  TITLE     Tissue-specific expression patterns and fine mapping of the human
            kallikrein (KLK) locus on proximal 19q13.4
  JOURNAL   J Biol Chem 275 (48), 37397-37406 (2000)
   PUBMED   10969073
REFERENCE   7  (bases 1 to 1171)
  AUTHORS   Gan,L., Lee,I., Smith,R., Argonza-Barrett,R., Lei,H., McCuaig,J.,
            Moss,P., Paeper,B. and Wang,K.
  TITLE     Sequencing and expression analysis of the serine protease gene
            cluster located in chromosome 19q13 region
  JOURNAL   Gene 257 (1), 119-130 (2000)
   PUBMED   11054574
REFERENCE   8  (bases 1 to 1171)
  AUTHORS   Yousef,G.M., Chang,A., Scorilas,A. and Diamandis,E.P.
  TITLE     Genomic organization of the human kallikrein gene family on
            chromosome 19q13.3-q13.4
  JOURNAL   Biochem Biophys Res Commun 276 (1), 125-133 (2000)
   PUBMED   11006094
REFERENCE   9  (bases 1 to 1171)
  AUTHORS   Diamandis,E.P., Yousef,G.M., Luo,L.Y., Magklara,A. and Obiezu,C.V.
  TITLE     The new human kallikrein gene family: implications in
            carcinogenesis
  JOURNAL   Trends Endocrinol Metab 11 (2), 54-60 (2000)
   PUBMED   10675891
  REMARK    Review article
REFERENCE   10 (bases 1 to 1171)
  AUTHORS   Yousef,G.M., Luo,L.Y. and Diamandis,E.P.
  TITLE     Identification of novel human kallikrein-like genes on chromosome
            19q13.3-q13.4
  JOURNAL   Anticancer Res 19 (4B), 2843-2852 (1999)
   PUBMED   10652563
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC011473.4.
            
            Summary: Kallikreins are a subgroup of serine proteases having
            diverse physiological functions. Growing evidence suggests that
            many kallikreins are implicated in carcinogenesis and some have
            potential as novel cancer and other disease biomarkers. This gene
            is one of the fifteen kallikrein subfamily members located in a
            cluster on chromosome 19. Alternate splicing of this gene results
            in three transcript variants encoding different isoforms. [provided
            by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR279842.822.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968540,
                                           SAMEA1968832 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000684732.1/ ENSP00000508282.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-197               AC011473.4         34887-35083         c
            198-253             AC011473.4         34666-34721         c
            254-413             AC011473.4         34061-34220         c
            414-673             AC011473.4         31957-32216         c
            674-807             AC011473.4         30869-31002         c
            808-1171            AC011473.4         29175-29538         c
FEATURES             Location/Qualifiers
     source          1..1171
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.41"
     gene            1..1171
                     /gene="KLK12"
                     /gene_synonym="KLK-L5; KLKL5"
                     /note="kallikrein related peptidase 12"
                     /db_xref="GeneID:43849"
                     /db_xref="HGNC:HGNC:6360"
                     /db_xref="MIM:605539"
     exon            1..197
                     /gene="KLK12"
                     /gene_synonym="KLK-L5; KLKL5"
                     /inference="alignment:Splign:2.1.0"
     exon            198..253
                     /gene="KLK12"
                     /gene_synonym="KLK-L5; KLKL5"
                     /inference="alignment:Splign:2.1.0"
     CDS             217..963
                     /gene="KLK12"
                     /gene_synonym="KLK-L5; KLKL5"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 4; kallikrein-like protein 5; kallikrein-12"
                     /codon_start=1
                     /product="kallikrein-12 isoform 2 precursor"
                     /protein_id="NP_001357054.1"
                     /db_xref="CCDS:CCDS12821.1"
                     /db_xref="GeneID:43849"
                     /db_xref="HGNC:HGNC:6360"
                     /db_xref="MIM:605539"
                     /translation="MGLSIFLLLCVLGLSQAATPKIFNGTECGRNSQPWQVGLFEGTS
                     LRCGGVLIDHRWVLTAAHCSGSRYWVRLGEHSLSQLDWTEQIRHSGFSVTHPGYLGAS
                     TSHEHDLRLLRLRLPVRVTSSVQPLPLPNDCATAGTECHVSGWGITNHPRNPFPDLLQ
                     CLNLSIVSHATCHGVYPGRITSNMVCAGGVPGQDACQGDSGGPLVCGGVLQGLVSWGS
                     VGPCGQDGIPGVYTYICKYVDWIRMIMRNN"
     exon            254..413
                     /gene="KLK12"
                     /gene_synonym="KLK-L5; KLKL5"
                     /inference="alignment:Splign:2.1.0"
     exon            414..673
                     /gene="KLK12"
                     /gene_synonym="KLK-L5; KLKL5"
                     /inference="alignment:Splign:2.1.0"
     exon            674..807
                     /gene="KLK12"
                     /gene_synonym="KLK-L5; KLKL5"
                     /inference="alignment:Splign:2.1.0"
     exon            808..1171
                     /gene="KLK12"
                     /gene_synonym="KLK-L5; KLKL5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1150..1155
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLK12"
                     /gene_synonym="KLK-L5; KLKL5"
                     /note="hexamer: AATAAA"
     polyA_site      1171
                     /gene="KLK12"
                     /gene_synonym="KLK-L5; KLKL5"
                     /note="major polyA site"
ORIGIN      
        1 agcgacagat ggaaggaaag ggaccggttg agcaacatga caggtggctg aggagccagg
       61 tgcagagtgg tagagttggc tggcggagtg gccagcacat gagaagacag gcaggtaggt
      121 ggacggagag atagcagcga cgaggacagg ccaaacagtg acagccacgt agaggatctg
      181 gcagacaaag agacaagact ttggaagtga cccaccatgg ggctcagcat ctttttgctc
      241 ctgtgtgttc ttgggctcag ccaggcagcc acaccgaaga ttttcaatgg cactgagtgt
      301 gggcgtaact cacagccgtg gcaggtgggg ctgtttgagg gcaccagcct gcgctgcggg
      361 ggtgtcctta ttgaccacag gtgggtcctc acagcggctc actgcagcgg cagcaggtac
      421 tgggtgcgcc tgggggaaca cagcctcagc cagctcgact ggaccgagca gatccggcac
      481 agcggcttct ctgtgaccca tcccggctac ctgggagcct cgacgagcca cgagcacgac
      541 ctccggctgc tgcggctgcg cctgcccgtc cgcgtaacca gcagcgttca acccctgccc
      601 ctgcccaatg actgtgcaac cgctggcacc gagtgccacg tctcaggctg gggcatcacc
      661 aaccacccac ggaacccatt cccggatctg ctccagtgcc tcaacctctc catcgtctcc
      721 catgccacct gccatggtgt gtatcccggg agaatcacga gcaacatggt gtgtgcaggc
      781 ggcgtcccgg ggcaggatgc ctgccagggt gattctgggg gccccctggt gtgtggggga
      841 gtccttcaag gtctggtgtc ctgggggtct gtggggccct gtggacaaga tggcatccct
      901 ggagtctaca cctatatttg caagtatgtg gactggatcc ggatgatcat gaggaacaac
      961 tgacctgttt cctccacctc cacccccacc ccttaacttg ggtacccctc tggccctcag
     1021 agcaccaata tctcctccat cacttcccct agctccactc ttgttggcct gggaacttct
     1081 tggaacttta actcctgcca gcccttctaa gacccacgag cggggtgaga gaagtgtgca
     1141 atagtctgga ataaatataa atgaaggagg g
//
