LOCUS       NM_001136032            1176 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens kallikrein related peptidase 11 (KLK11), transcript
            variant 4, mRNA.
ACCESSION   NM_001136032
VERSION     NM_001136032.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1176)
  AUTHORS   Ding,Y., Wang,Z., Chen,C., Li,D., Wang,W., Jia,Y. and Qin,Y.
  TITLE     miR-1304 targets KLK11 to regulate gastric cancer cell
            proliferation through the mTOR signaling pathway
  JOURNAL   Carcinogenesis 45 (1-2), 45-56 (2024)
   PUBMED   37971062
  REMARK    GeneRIF: miR-1304 targets KLK11 to regulate gastric cancer cell
            proliferation through the mTOR signaling pathway.
REFERENCE   2  (bases 1 to 1176)
  AUTHORS   Ozturk,T., Kain,E.Z., Tuzuner,M.B., Diren,A., Batur,S.,
            Yilmaz-Aydogan,H., Ozturk,O. and Isbir,T.
  TITLE     Kallikrein 11 Down-regulation in Breast Carcinoma: Correlation With
            Prognostic Parameters
  JOURNAL   In Vivo 35 (6), 3233-3243 (2021)
   PUBMED   34697154
  REMARK    GeneRIF: Kallikrein 11 Down-regulation in Breast Carcinoma:
            Correlation With Prognostic Parameters.
REFERENCE   3  (bases 1 to 1176)
  AUTHORS   Wang,Y., Liao,H., Wang,Y., Zhou,J., Wang,F., Xie,Y., Zhao,K. and
            Gao,W.
  TITLE     KLK11 promotes the activation of mTOR and protein synthesis to
            facilitate cardiac hypertrophy
  JOURNAL   BMC Cardiovasc Disord 21 (1), 266 (2021)
   PUBMED   34059001
  REMARK    GeneRIF: KLK11 promotes the activation of mTOR and protein
            synthesis to facilitate cardiac hypertrophy.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1176)
  AUTHORS   Siriphak,S., Chanakankun,R., Proungvitaya,T., Roytrakul,S.,
            Tummanatsakun,D., Seubwai,W., Wongwattanakul,M. and Proungvitaya,S.
  TITLE     Kallikrein-11, in Association with Coiled-Coil Domain Containing
            25, as a Potential Prognostic Marker for Cholangiocarcinoma with
            Lymph Node Metastasis
  JOURNAL   Molecules 26 (11), 3105 (2021)
   PUBMED   34067437
  REMARK    GeneRIF: Kallikrein-11, in Association with Coiled-Coil Domain
            Containing 25, as a Potential Prognostic Marker for
            Cholangiocarcinoma with Lymph Node Metastasis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1176)
  AUTHORS   Mitsui,S., Nakamura,T., Okui,A., Kominami,K., Uemura,H. and
            Yamaguchi,N.
  TITLE     Multiple promoters regulate tissue-specific alternative splicing of
            the human kallikrein gene, KLK11/hippostasin
  JOURNAL   FEBS J 273 (16), 3678-3686 (2006)
   PUBMED   16911518
  REMARK    GeneRIF: The gene promoter regions of kallikrein and the
            corresponding transcriptional initiation sites were studied.
REFERENCE   6  (bases 1 to 1176)
  AUTHORS   Nakamura,T., Mitsui,S., Okui,A., Kominami,K., Nomoto,T.,
            Ukimura,O., Kawauchi,A., Miki,T. and Yamaguchi,N.
  TITLE     Alternative splicing isoforms of hippostasin (PRSS20/KLK11) in
            prostate cancer cell lines
  JOURNAL   Prostate 49 (1), 72-78 (2001)
   PUBMED   11550212
  REMARK    GeneRIF: may be useful marker for distinguishing prostate cancer
            and benign prostatic hypertrophy
REFERENCE   7  (bases 1 to 1176)
  AUTHORS   Gan,L., Lee,I., Smith,R., Argonza-Barrett,R., Lei,H., McCuaig,J.,
            Moss,P., Paeper,B. and Wang,K.
  TITLE     Sequencing and expression analysis of the serine protease gene
            cluster located in chromosome 19q13 region
  JOURNAL   Gene 257 (1), 119-130 (2000)
   PUBMED   11054574
REFERENCE   8  (bases 1 to 1176)
  AUTHORS   Mitsui,S., Yamada,T., Okui,A., Kominami,K., Uemura,H. and
            Yamaguchi,N.
  TITLE     A novel isoform of a kallikrein-like protease, TLSP/hippostasin,
            (PRSS20), is expressed in the human brain and prostate
  JOURNAL   Biochem Biophys Res Commun 272 (1), 205-211 (2000)
   PUBMED   10872828
REFERENCE   9  (bases 1 to 1176)
  AUTHORS   Yousef,G.M., Scorilas,A. and Diamandis,E.P.
  TITLE     Genomic organization, mapping, tissue expression, and hormonal
            regulation of trypsin-like serine protease (TLSP PRSS20), a new
            member of the human kallikrein gene family
  JOURNAL   Genomics 63 (1), 88-96 (2000)
   PUBMED   10662548
REFERENCE   10 (bases 1 to 1176)
  AUTHORS   Yoshida,S., Taniguchi,M., Suemoto,T., Oka,T., He,X. and Shiosaka,S.
  TITLE     cDNA cloning and expression of a novel serine protease, TLSP
  JOURNAL   Biochim Biophys Acta 1399 (2-3), 225-228 (1998)
   PUBMED   9765601
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG697071.1 and AB259014.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001136032.2.
            
            Summary: Kallikreins are a subgroup of serine proteases having
            diverse physiological functions. Growing evidence suggests that
            many kallikreins are implicated in carcinogenesis and some have
            potential as novel cancer and other disease biomarkers. This gene
            is one of the fifteen kallikrein subfamily members located in a
            cluster on chromosome 19. Alternate splicing and the use of
            alternate promoters results in multiple transcript variants
            encoding distinct isoforms which are differentially expressed.
            [provided by RefSeq, Dec 2016].
            
            Transcript Variant: This variant (4) has an alternate 5' terminal
            exon, which results in a downstream translation start codon,
            compared to variant 2. The encoded isoform (1) has a shorter
            N-terminus than isoform 2, and is preferentially expressed in
            brain. Variants 1 and 4 encode the same isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB259014.1, DRR138512.258031.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968189,
                                           SAMEA1968540 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000453757.8/ ENSP00000413958.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 BG697071.1         1-2
            3-1176              AB259014.1         1-1174
FEATURES             Location/Qualifiers
     source          1..1176
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.41"
     gene            1..1176
                     /gene="KLK11"
                     /gene_synonym="IEKD; PRSS20; TLSP"
                     /note="kallikrein related peptidase 11"
                     /db_xref="GeneID:11012"
                     /db_xref="HGNC:HGNC:6359"
                     /db_xref="MIM:604434"
     exon            1..79
                     /gene="KLK11"
                     /gene_synonym="IEKD; PRSS20; TLSP"
                     /inference="alignment:Splign:2.1.0"
     exon            80..154
                     /gene="KLK11"
                     /gene_synonym="IEKD; PRSS20; TLSP"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..867
                     /gene="KLK11"
                     /gene_synonym="IEKD; PRSS20; TLSP"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 4; hippostasin; kallikrein-11; hK11; serine
                     protease 20; trypsin-like protease"
                     /codon_start=1
                     /product="kallikrein-11 isoform 1 precursor"
                     /protein_id="NP_001129504.1"
                     /db_xref="CCDS:CCDS12819.1"
                     /db_xref="GeneID:11012"
                     /db_xref="HGNC:HGNC:6359"
                     /db_xref="MIM:604434"
                     /translation="MRILQLILLALATGLVGGETRIIKGFECKPHSQPWQAALFEKTR
                     LLCGATLIAPRWLLTAAHCLKPRYIVHLGQHNLQKEEGCEQTRTATESFPHPGFNNSL
                     PNKDHRNDIMLVKMASPVSITWAVRPLTLSSRCVTAGTSCLISGWGSTSSPQLRLPHT
                     LRCANITIIEHQKCENAYPGNITDTMVCASVQEGGKDSCQGDSGGPLVCNQSLQGIIS
                     WGQDPCAITRKPGVYTKVCKYVDWIQETMKNN"
     exon            155..311
                     /gene="KLK11"
                     /gene_synonym="IEKD; PRSS20; TLSP"
                     /inference="alignment:Splign:2.1.0"
     exon            312..577
                     /gene="KLK11"
                     /gene_synonym="IEKD; PRSS20; TLSP"
                     /inference="alignment:Splign:2.1.0"
     exon            578..714
                     /gene="KLK11"
                     /gene_synonym="IEKD; PRSS20; TLSP"
                     /inference="alignment:Splign:2.1.0"
     exon            715..1176
                     /gene="KLK11"
                     /gene_synonym="IEKD; PRSS20; TLSP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1157..1162
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLK11"
                     /gene_synonym="IEKD; PRSS20; TLSP"
                     /note="hexamer: AATAAA"
     polyA_site      1176
                     /gene="KLK11"
                     /gene_synonym="IEKD; PRSS20; TLSP"
                     /note="major polyA site"
ORIGIN      
        1 aacccagcct acctgctgta gctgccgcca ctgccgtctc cgccgccact gggcccccag
       61 agccccagcc ccagagccta ggaacctggg gcccgctcct cccccctcca ggccatgagg
      121 attctgcagt taatcctgct tgctctggca acagggcttg tagggggaga gaccaggatc
      181 atcaaggggt tcgagtgcaa gcctcactcc cagccctggc aggcagccct gttcgagaag
      241 acgcggctac tctgtggggc gacgctcatc gcccccagat ggctcctgac agcagcccac
      301 tgcctcaagc cccgctacat agttcacctg gggcagcaca acctccagaa ggaggagggc
      361 tgtgagcaga cccggacagc cactgagtcc ttcccccacc ccggcttcaa caacagcctc
      421 cccaacaaag accaccgcaa tgacatcatg ctggtgaaga tggcatcgcc agtctccatc
      481 acctgggctg tgcgacccct caccctctcc tcacgctgtg tcactgctgg caccagctgc
      541 ctcatttccg gctggggcag cacgtccagc ccccagttac gcctgcctca caccttgcga
      601 tgcgccaaca tcaccatcat tgagcaccag aagtgtgaga acgcctaccc cggcaacatc
      661 acagacacca tggtgtgtgc cagcgtgcag gaagggggca aggactcctg ccagggtgac
      721 tccgggggcc ctctggtctg taaccagtct cttcaaggca ttatctcctg gggccaggat
      781 ccgtgtgcga tcacccgaaa gcctggtgtc tacacgaaag tctgcaaata tgtggactgg
      841 atccaggaga cgatgaagaa caattagact ggacccaccc accacagccc atcaccctcc
      901 atttccactt ggtgtttggt tcctgttcac tctgttaata agaaacccta agccaagacc
      961 ctctacgaac attctttggg cctcctggac tacaggagat gctgtcactt aataatcaac
     1021 ctggggttcg aaatcagtga gacctggatt caaattctgc cttgaaatat tgtgactctg
     1081 ggaatgacaa cacctggttt gttctctgtt gtatccccag ccccaaagac agctcctggc
     1141 catatatcaa ggtttcaata aatatttgct aaatga
//
