LOCUS       NM_145888               2984 bp    mRNA    linear   PRI 01-JUL-2024
DEFINITION  Homo sapiens kallikrein related peptidase 10 (KLK10), transcript
            variant 2, mRNA.
ACCESSION   NM_145888
VERSION     NM_145888.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2984)
  AUTHORS   Awad,A.M., Dabous,E., Alalem,M., Alalem,N., Nasr,M.E.,
            Elawdan,K.A., Nasr,G.M., Said,W., El Khashab,K., Basiouny,M.S.,
            Guirgis,A.A. and Khalil,H.
  TITLE     MicroRNA-141-regulated KLK10 and TNFSF-15 gene expression in
            hepatoblastoma cells as a novel mechanism in liver carcinogenesis
  JOURNAL   Sci Rep 14 (1), 13492 (2024)
   PUBMED   38866875
  REMARK    GeneRIF: MicroRNA-141-regulated KLK10 and TNFSF-15 gene expression
            in hepatoblastoma cells as a novel mechanism in liver
            carcinogenesis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2984)
  AUTHORS   Kato,K., Noda,T., Kobayashi,S., Sasaki,K., Iwagami,Y., Yamada,D.,
            Tomimaru,Y., Takahashi,H., Uemura,M., Asaoka,T., Shimizu,J.,
            Doki,Y. and Eguchi,H.
  TITLE     KLK10 derived from tumor endothelial cells accelerates colon cancer
            cell proliferation and hematogenous liver metastasis formation
  JOURNAL   Cancer Sci 115 (5), 1520-1535 (2024)
   PUBMED   38475666
  REMARK    GeneRIF: KLK10 derived from tumor endothelial cells accelerates
            colon cancer cell proliferation and hematogenous liver metastasis
            formation.
REFERENCE   3  (bases 1 to 2984)
  AUTHORS   Wu,K., Wu,B., Yan,K., Ding,Q. and Miao,Z.
  TITLE     KLK10 promotes the progression of KRAS mutant colorectal cancer via
            PAR1-PDK1-AKT signaling pathway
  JOURNAL   Cell Biol Int 48 (4), 440-449 (2024)
   PUBMED   38115179
  REMARK    GeneRIF: KLK10 promotes the progression of KRAS mutant colorectal
            cancer via PAR1-PDK1-AKT signaling pathway.
REFERENCE   4  (bases 1 to 2984)
  AUTHORS   Luo,Y.C., Lv,Y.L., He,R.X., Shi,X.X. and Jiang,T.
  TITLE     Kallikrein-related peptidase 10 predicts prognosis and mediates
            tumor immunomodulation in colorectal cancer
  JOURNAL   Biochem Biophys Res Commun 689, 149217 (2023)
   PUBMED   37972446
  REMARK    GeneRIF: Kallikrein-related peptidase 10 predicts prognosis and
            mediates tumor immunomodulation in colorectal cancer.
REFERENCE   5  (bases 1 to 2984)
  AUTHORS   Zhao,J., Wang,Y., Wang,Y., Gao,J., Wu,X. and Li,H.
  TITLE     miR-194-3p represses the docetaxel resistance in colon cancer by
            targeting KLK10
  JOURNAL   Pathol Res Pract 236, 153962 (2022)
   PUBMED   35691099
  REMARK    GeneRIF: miR-194-3p represses the docetaxel resistance in colon
            cancer by targeting KLK10.
REFERENCE   6  (bases 1 to 2984)
  AUTHORS   Diamandis,E.P., Yousef,G.M., Luo,L.Y., Magklara,A. and Obiezu,C.V.
  TITLE     The new human kallikrein gene family: implications in
            carcinogenesis
  JOURNAL   Trends Endocrinol Metab 11 (2), 54-60 (2000)
   PUBMED   10675891
  REMARK    Review article
REFERENCE   7  (bases 1 to 2984)
  AUTHORS   Goyal,J., Smith,K.M., Cowan,J.M., Wazer,D.E., Lee,S.W. and Band,V.
  TITLE     The role for NES1 serine protease as a novel tumor suppressor
  JOURNAL   Cancer Res 58 (21), 4782-4786 (1998)
   PUBMED   9809976
REFERENCE   8  (bases 1 to 2984)
  AUTHORS   Luo,L., Herbrick,J.A., Scherer,S.W., Beatty,B., Squire,J. and
            Diamandis,E.P.
  TITLE     Structural characterization and mapping of the normal epithelial
            cell-specific 1 gene
  JOURNAL   Biochem Biophys Res Commun 247 (3), 580-586 (1998)
   PUBMED   9647736
REFERENCE   9  (bases 1 to 2984)
  AUTHORS   Polikoff,D., Kuo,W.L., Cochran,J.F., Wernick,M., Kowbel,D.,
            Myambo,K. and Collins,C.C.
  TITLE     Assignment of protease, serine-like 1 (PRSSL1) to human chromosome
            19q13 by in situ hybridization and radiation hybrid mapping
  JOURNAL   Cytogenet Cell Genet 79 (1-2), 147-148 (1997)
   PUBMED   9533035
REFERENCE   10 (bases 1 to 2984)
  AUTHORS   Liu,X.L., Wazer,D.E., Watanabe,K. and Band,V.
  TITLE     Identification of a novel serine protease-like gene, the expression
            of which is down-regulated during breast cancer progression
  JOURNAL   Cancer Res 56 (14), 3371-3379 (1996)
   PUBMED   8764136
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC011473.4, AF024605.1,
            AY561635.1 and BU685208.1.
            
            On Nov 22, 2018 this sequence version replaced NM_145888.2.
            
            Summary: Kallikreins are a subgroup of serine proteases having
            diverse physiological functions. Growing evidence suggests that
            many kallikreins are implicated in carcinogenesis and some have
            potential as novel cancer and other disease biomarkers. This gene
            is one of the fifteen kallikrein subfamily members located in a
            cluster on chromosome 19. Its encoded protein is secreted and may
            play a role in suppression of tumorigenesis in breast and prostate
            cancers. Alternate splicing of this gene results in multiple
            transcript variants encoding the same protein. [provided by RefSeq,
            Jul 2008].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. All transcript variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853566.14519.1,
                                           SRR11853562.18346.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000358789.8/ ENSP00000351640.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                AC011473.4         19780-19790         c
            12-84               AF024605.1         1-73
            85-1453             AY561635.1         141-1509
            1454-2954           AC011473.4         12850-14350         c
            2955-2979           BU685208.1         18-42               c
            2980-2984           AC011473.4         12820-12824         c
FEATURES             Location/Qualifiers
     source          1..2984
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.41"
     gene            1..2984
                     /gene="KLK10"
                     /gene_synonym="NES1; PRSSL1"
                     /note="kallikrein related peptidase 10"
                     /db_xref="GeneID:5655"
                     /db_xref="HGNC:HGNC:6358"
                     /db_xref="MIM:602673"
     exon            1..83
                     /gene="KLK10"
                     /gene_synonym="NES1; PRSSL1"
                     /inference="alignment:Splign:2.1.0"
     exon            84..180
                     /gene="KLK10"
                     /gene_synonym="NES1; PRSSL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..923
                     /gene="KLK10"
                     /gene_synonym="NES1; PRSSL1"
                     /EC_number="3.4.21.35"
                     /note="normal epithelial cell-specific 1; breast normal
                     epithelial cell associated serine protease; kallikrein-10;
                     protease serine-like 1; kallikrein 10 protein 8;
                     kallikrein 10 protein 9; kallikrein 10 protein 12;
                     kallikrein 10 protein 2; kallikrein 10 protein 3;
                     kallikrein 10 protein 4; kallikrein 10 protein 7;
                     kallikrein 10 protein 13; kallikrein 10 protein 5"
                     /codon_start=1
                     /product="kallikrein-10 preproprotein"
                     /protein_id="NP_665895.1"
                     /db_xref="CCDS:CCDS12817.1"
                     /db_xref="GeneID:5655"
                     /db_xref="HGNC:HGNC:6358"
                     /db_xref="MIM:602673"
                     /translation="MRAPHLHLSAASGARALAKLLPLLMAQLWAAEAALLPQNDTRLD
                     PEAYGSPCARGSQPWQVSLFNGLSFHCAGVLVDQSWVLTAAHCGNKPLWARVGDDHLL
                     LLQGEQLRRTTRSVVHPKYHQGSGPILPRRTDEHDLMLLKLARPVVLGPRVRALQLPY
                     RCAQPGDQCQVAGWGTTAARRVKYNKGLTCSSITILSPKECEVFYPGVVTNNMICAGL
                     DRGQDPCQSDSGGPLVCDETLQGILSWGVYPCGSAQHPAVYTQICKYMSWINKVIRSN
                     "
     exon            181..361
                     /gene="KLK10"
                     /gene_synonym="NES1; PRSSL1"
                     /inference="alignment:Splign:2.1.0"
     exon            362..636
                     /gene="KLK10"
                     /gene_synonym="NES1; PRSSL1"
                     /inference="alignment:Splign:2.1.0"
     exon            637..770
                     /gene="KLK10"
                     /gene_synonym="NES1; PRSSL1"
                     /inference="alignment:Splign:2.1.0"
     exon            771..2984
                     /gene="KLK10"
                     /gene_synonym="NES1; PRSSL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1430..1435
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLK10"
                     /gene_synonym="NES1; PRSSL1"
                     /note="hexamer: ACTAAA"
     polyA_site      1435
                     /gene="KLK10"
                     /gene_synonym="NES1; PRSSL1"
     polyA_site      1458
                     /gene="KLK10"
                     /gene_synonym="NES1; PRSSL1"
                     /note="major polyA site"
     regulatory      1822..1827
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLK10"
                     /gene_synonym="NES1; PRSSL1"
                     /note="hexamer: AAGAAA"
     polyA_site      1852
                     /gene="KLK10"
                     /gene_synonym="NES1; PRSSL1"
     regulatory      2680..2685
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLK10"
                     /gene_synonym="NES1; PRSSL1"
                     /note="hexamer: ATTAAA"
     polyA_site      2706
                     /gene="KLK10"
                     /gene_synonym="NES1; PRSSL1"
     regulatory      2964..2969
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLK10"
                     /gene_synonym="NES1; PRSSL1"
                     /note="hexamer: ATTATA"
     polyA_site      2984
                     /gene="KLK10"
                     /gene_synonym="NES1; PRSSL1"
ORIGIN      
        1 gggcagagga taccagcggc agaccacagg cagggcagag gcacgtctgg gtcccctccc
       61 tccttcctat cggcgactcc cagatcctgg ccatgagagc tccgcacctc cacctctccg
      121 ccgcctctgg cgcccgggct ctggcgaagc tgctgccgct gctgatggcg caactctggg
      181 ccgcagaggc ggcgctgctc ccccaaaacg acacgcgctt ggaccccgaa gcctatggct
      241 ccccgtgcgc gcgcggctcg cagccctggc aggtctcgct cttcaacggc ctctcgttcc
      301 actgcgcggg tgtcctggtg gaccagagtt gggtgctgac ggccgcgcac tgcggaaaca
      361 agccactgtg ggctcgagta ggggatgacc acctgctgct tcttcaggga gagcagctcc
      421 gccggaccac tcgctctgtt gtccatccca agtaccacca gggctcaggc cccatcctgc
      481 caaggcgaac ggatgagcac gatctcatgt tgctgaagct ggccaggccc gtagtgctgg
      541 ggccccgcgt ccgggccctg cagcttccct accgctgtgc tcagcccgga gaccagtgcc
      601 aggttgctgg ctggggcacc acggccgccc ggagagtgaa gtacaacaag ggcctgacct
      661 gctccagcat cactatcctg agccctaaag agtgtgaggt cttctaccct ggcgtggtca
      721 ccaacaacat gatatgtgct ggactggacc ggggccagga cccttgccag agtgactctg
      781 gaggccccct ggtctgtgac gagaccctcc aaggcatcct ctcgtggggt gtttacccct
      841 gtggctctgc ccagcatcca gctgtctaca cccagatctg caaatacatg tcctggatca
      901 ataaagtcat acgctccaac tgatccagat gctacgctcc agctgatcca gatgttatgc
      961 tcctgctgat ccagatgccc agaggctcca tcgtccatcc tcttcctccc cagtcggctg
     1021 aactctcccc ttgtctgcac tgttcaaacc tctgccgccc tccacacctc taaacatctc
     1081 ccctctcacc tcattccccc acctatcccc attctctgcc tgtactgaag ctgaaatgca
     1141 ggaagtggtg gcaaaggttt attccagaga agccaggaag ccggtcatca cccagcctct
     1201 gagagcagtt actggggtca cccaacctga cttcctctgc cactccctgc tgtgtgactt
     1261 tgggcaagcc aagtgccctc tctgaacctc agtttcctca tctgcaaaat gggaacaatg
     1321 acgtgcctac ctcttagaca tgttgtgagg agactatgat ataacatgtg tatgtaaatc
     1381 ttcatggtga ttgtcatgta aggcttaaca cagtgggtgg tgagttctga ctaaaggtta
     1441 cctgttgtcg tgatctgacc acgtcccggt gaaagcgtgt gtccagggaa gaagtgcaca
     1501 gggtagcccc cagtcccaac cttccatccc caacccttag ggatgatgga agaatcattt
     1561 tcctcaccct agttccaagt cccaggaaac accttttaac cacttccttc tcatctccca
     1621 ctgtttccca cttctggttc cacccaacac cagttcctcc gagctaggct ggccctgagt
     1681 cattagcacc ttctctgcct tcatgaggcc actgaactca agggacctca ccttgcttct
     1741 atcccagcct ctaagaccag agggccgagg gggtagtgaa gattgggaaa cccttgccac
     1801 ctcaactgcc cagcttgtgc caagaaacct ccctctgaca tttaggggaa aatctttggt
     1861 ttgtctgtta ttaattggct gtgagatttt cgtcctgaaa acttgggagg aggaattgtt
     1921 tgattctccc tgaaattggg ggagggaagg ggagttaata cacagaatcc aggtaaggct
     1981 aatagaagct tcagtgtccg ctgggtgtgg tggctcacgc ctgtaatcct agcactttgg
     2041 gaggccgagg aaagcagatc atctgaggtc aggtgttcga gaccagtctg gccaaaatgg
     2101 tgaaatccca tctctactga aaatacaaaa actagccagg catggtggca ggcacctata
     2161 atcccatcta cttgggaggc tgaggcagaa gaatcacttg aacccggggg gcagaggttg
     2221 cagtgagcca agattgcacc attgcactcc atccagcctg gacaaaagag caaaactcca
     2281 tctcaaaaaa agaagaagtt tgagtgtctc agcttatcct gaactttgaa gcagtaacat
     2341 aagctagctg aatataggca caacagaaat ttcccattaa gcacggggtt tttgtttgtt
     2401 tgtttgtcct ttcagttacc aatttatgga gcatctatta tgtgccaggc ccagtgctgg
     2461 gtgctgggga catacgtagg ggtgatcaca aggtccccca ccctgcagag cccacaggag
     2521 gttgatgtac aaggtctgag cacacagctc ccttccgtgg cctctttccc attctgcccc
     2581 cattagcaca cgcaggaaat gtcagacagg cgtatcagct gggtttgtca tccaaagacc
     2641 agaagcgagg tcggtggaaa cttgaaaact cgattcatta ttaaaggcaa ctcacccgtc
     2701 cctttagtca ctccacaatg tttatcgagc cacgtcttat gccaggcctc aaagatgaat
     2761 cagaccaggc actaccctca aggagctgct agttaggtca gggagacagg ccagtcttac
     2821 attcctgtca ttcaggtctc cactcaaaag tcacctcctc cgggaggcct tcctgaattg
     2881 cccaggctat aggagtccac ttttggtcat ccagtcccga tgctctgttt tttgtttgtt
     2941 tgtttttttt tttaatagca cctattatac ctgaaattat ctca
//
