LOCUS       NM_002257                876 bp    mRNA    linear   PRI 17-APR-2022
DEFINITION  Homo sapiens kallikrein 1 (KLK1), mRNA.
ACCESSION   NM_002257
VERSION     NM_002257.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 876)
  AUTHORS   Huang S, Chen M, Yu H, Lin K, Guo Y and Zhu P.
  TITLE     Coexpression of tissue kallikrein 1 and tissue inhibitor of matrix
            metalloproteinase 1 improves myocardial ischemiareperfusion injury
            by promoting angiogenesis and inhibiting oxidative stress
  JOURNAL   Mol Med Rep 23 (2) (2021)
   PUBMED   33355364
  REMARK    GeneRIF: Coexpression of tissue kallikrein 1 and tissue inhibitor
            of matrix metalloproteinase 1 improves myocardial
            ischemiareperfusion injury by promoting angiogenesis and inhibiting
            oxidative stress.
REFERENCE   2  (bases 1 to 876)
  AUTHORS   Kearney KJ, Butler J, Posada OM, Wilson C, Heal S, Ali M, Hardy L,
            Ahnstrom J, Gailani D, Foster R, Hethershaw E, Longstaff C and
            Philippou H.
  TITLE     Kallikrein directly interacts with and activates Factor IX,
            resulting in thrombin generation and fibrin formation independent
            of Factor XI
  JOURNAL   Proc Natl Acad Sci U S A 118 (3) (2021)
   PUBMED   33397811
  REMARK    GeneRIF: Kallikrein directly interacts with and activates Factor
            IX, resulting in thrombin generation and fibrin formation
            independent of Factor XI.
REFERENCE   3  (bases 1 to 876)
  AUTHORS   Dai S, Ding M, Liang N, Li Z, Li D, Guan L and Liu H.
  TITLE     Associations of ACE I/D polymorphism with the levels of ACE,
            kallikrein, angiotensin II and interleukin-6 in STEMI patients
  JOURNAL   Sci Rep 9 (1), 19719 (2019)
   PUBMED   31873176
  REMARK    GeneRIF: Associations of ACE I/D polymorphism with the levels of
            ACE, kallikrein, angiotensin II and interleukin-6 in STEMI
            patients.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 876)
  AUTHORS   Magnen M, Gueugnon F, Petit-Courty A, Baranek T, Sizaret D, Brewah
            YA, Humbles AA, Si-Tahar M and Courty Y.
  TITLE     Tissue kallikrein regulates alveolar macrophage apoptosis early in
            influenza virus infection
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 316 (6), L1127-L1140 (2019)
   PUBMED   30908937
  REMARK    GeneRIF: The findings indicate that KLK1 intervenes early in the
            antiviral defense modulating the severity of influenza infection.
            Decreased KLK1 expression in Chronic obstructive pulmonary disease
            patients could contribute to the worsening of influenza.
REFERENCE   5  (bases 1 to 876)
  AUTHORS   Li C, Voos KM, Pathak M, Hall G, McCrae KR, Dreveny I, Li R and
            Emsley J.
  TITLE     Plasma kallikrein structure reveals apple domain disc rotated
            conformation compared to factor XI
  JOURNAL   J Thromb Haemost 17 (5), 759-770 (2019)
   PUBMED   30801944
  REMARK    GeneRIF: kallikrein has an apple domain disc with a rotated
            conformation compared to factor XI
REFERENCE   6  (bases 1 to 876)
  AUTHORS   Riegman PH, Vlietstra RJ, Suurmeijer L, Cleutjens CB and Trapman J.
  TITLE     Characterization of the human kallikrein locus
  JOURNAL   Genomics 14 (1), 6-11 (1992)
   PUBMED   1385301
REFERENCE   7  (bases 1 to 876)
  AUTHORS   Richards RI, Holman K, Shen Y, Kozman H, Harley H, Brook D and Shaw
            D.
  TITLE     Human glandular Kallikrein genes: genetic and physical mapping of
            the KLK1 locus using a highly polymorphic microsatellite PCR marker
  JOURNAL   Genomics 11 (1), 77-82 (1991)
   PUBMED   1684954
REFERENCE   8  (bases 1 to 876)
  AUTHORS   Qin H, Kemp J, Yip MY, Lam-Po-Tang PR and Morris BJ.
  TITLE     Localization of human glandular kallikrein-1 gene to chromosome
            19q13.3-13.4 by in situ hybridization
  JOURNAL   Hum Hered 41 (4), 222-226 (1991)
   PUBMED   1783409
REFERENCE   9  (bases 1 to 876)
  AUTHORS   Henttu P, Lukkarinen O and Vihko P.
  TITLE     Expression of the gene coding for human prostate-specific antigen
            and related hGK-1 in benign and malignant tumors of the human
            prostate
  JOURNAL   Int J Cancer 45 (4), 654-660 (1990)
   PUBMED   1691151
REFERENCE   10 (bases 1 to 876)
  AUTHORS   Lottspeich,F., Geiger,R., Henschen,A. and Kutzbach,C.
  TITLE     N-Terminal amino acid sequence of human urinary kallikrein homology
            with other serine proteases
  JOURNAL   Hoppe Seylers Z Physiol Chem 360 (12), 1947-1950 (1979)
   PUBMED   393608
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP323011.1, X13561.1 and
            CA772631.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_002257.3.
            
            Summary: Kallikreins are a subgroup of serine proteases having
            diverse physiological functions. Growing evidence suggests that
            many kallikreins are implicated in carcinogenesis and some have
            potential as novel cancer and other disease biomarkers. This gene
            is one of the fifteen kallikrein subfamily members located in a
            cluster on chromosome 19. This protein is functionally conserved in
            its capacity to release the vasoactive peptide, Lys-bradykinin,
            from low molecular weight kininogen. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BI759204.1, M25629.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA2150585
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000301420.3/ ENSP00000301420.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 BP323011.1         1-3
            4-874               X13561.1           1-871
            875-876             CA772631.1         202-203
FEATURES             Location/Qualifiers
     source          1..876
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     gene            1..876
                     /gene="KLK1"
                     /gene_synonym="hK1; Klk6; KLKR"
                     /note="kallikrein 1"
                     /db_xref="GeneID:3816"
                     /db_xref="HGNC:HGNC:6357"
                     /db_xref="MIM:147910"
     exon            1..85
                     /gene="KLK1"
                     /gene_synonym="hK1; Klk6; KLKR"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..828
                     /gene="KLK1"
                     /gene_synonym="hK1; Klk6; KLKR"
                     /EC_number="3.4.21.35"
                     /note="kallikrein 1, renal/pancreas/salivary; tissue
                     kallikrein; kallikrein serine protease 1; glandular
                     kallikrein 1; kidney/pancreas/salivary gland kallikrein"
                     /codon_start=1
                     /product="kallikrein-1 preproprotein"
                     /protein_id="NP_002248.1"
                     /db_xref="CCDS:CCDS12804.1"
                     /db_xref="GeneID:3816"
                     /db_xref="HGNC:HGNC:6357"
                     /db_xref="MIM:147910"
                     /translation="MWFLVLCLALSLGGTGAAPPIQSRIVGGWECEQHSQPWQAALYH
                     FSTFQCGGILVHRQWVLTAAHCISDNYQLWLGRHNLFDDENTAQFVHVSESFPHPGFN
                     MSLLENHTRQADEDYSHDLMLLRLTEPADTITDAVKVVELPTEEPEVGSTCLASGWGS
                     IEPENFSFPDDLQCVDLKILPNDECKKAHVQKVTDFMLCVGHLEGGKDTCVGDSGGPL
                     MCDGVLQGVTSWGYVPCGTPNKPSVAVRVLSYVKWIEDTIAENS"
     exon            86..245
                     /gene="KLK1"
                     /gene_synonym="hK1; Klk6; KLKR"
                     /inference="alignment:Splign:2.1.0"
     exon            246..535
                     /gene="KLK1"
                     /gene_synonym="hK1; Klk6; KLKR"
                     /inference="alignment:Splign:2.1.0"
     exon            536..672
                     /gene="KLK1"
                     /gene_synonym="hK1; Klk6; KLKR"
                     /inference="alignment:Splign:2.1.0"
     exon            673..876
                     /gene="KLK1"
                     /gene_synonym="hK1; Klk6; KLKR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      854..859
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLK1"
                     /gene_synonym="hK1; Klk6; KLKR"
                     /note="hexamer: AGTAAA"
     polyA_site      876
                     /gene="KLK1"
                     /gene_synonym="hK1; Klk6; KLKR"
                     /note="major polyA site"
ORIGIN      
        1 agttcctcca cctgctggcc cctggacacc tctgtcacca tgtggttcct ggttctgtgc
       61 ctcgccctgt ccctgggggg gactggtgct gcgcccccga ttcagtcccg gattgtggga
      121 ggctgggagt gtgagcagca ttcccagccc tggcaggcgg ctctgtacca tttcagcact
      181 ttccagtgtg ggggcatcct ggtgcaccgc cagtgggtgc tcacagctgc tcattgcatc
      241 agcgacaatt accagctctg gctgggtcgc cacaacttgt ttgacgacga aaacacagcc
      301 cagtttgttc atgtcagtga gagcttccca caccctggct tcaacatgag cctcctggag
      361 aaccacaccc gccaagcaga cgaggactac agccacgacc tcatgctgct ccgcctgaca
      421 gagcctgctg ataccatcac agatgctgtg aaggtcgtgg agttgcccac cgaggaaccc
      481 gaagtgggga gcacctgttt ggcttccggc tggggcagca tcgaaccaga gaatttctca
      541 tttccagatg atctccagtg tgtggacctc aaaatcctgc ctaatgatga gtgcaaaaaa
      601 gcccacgtcc agaaggtgac agacttcatg ctgtgtgtcg gacacctgga aggtggcaaa
      661 gacacctgtg tgggtgattc agggggcccg ctgatgtgtg atggtgtgct ccaaggtgtc
      721 acatcatggg gctacgtccc ttgtggcacc cccaataagc cttctgtcgc cgtcagagtg
      781 ctgtcttatg tgaagtggat cgaggacacc atagcggaga actcctgaac gcccagccct
      841 gtcccctacc cccagtaaaa tcaaatgtgc atccaa
//
