LOCUS       NM_001031710            5619 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens kelch like family member 7 (KLHL7), transcript variant
            1, mRNA.
ACCESSION   NM_001031710
VERSION     NM_001031710.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5619)
  AUTHORS   Yilmaz Gulec,E., Turgut,G.T., Gezdirici,A., Karaman,V.,
            Ozturk,F.N., Avci,S., Kalayci,T., Senturk,L., Ayaz,A.,
            Kayserili,H., Uyguner,Z.O. and Altunoglu,U.
  TITLE     Clinical and molecular genetic findings of Crisponi/cold-induced
            sweating syndrome (CS/CISS) spectrum in patients from Turkey
  JOURNAL   Clin Genet 102 (3), 201-217 (2022)
   PUBMED   35699517
  REMARK    GeneRIF: Clinical and molecular genetic findings of
            Crisponi/cold-induced sweating syndrome (CS/CISS) spectrum in
            patients from Turkey.
REFERENCE   2  (bases 1 to 5619)
  AUTHORS   Swaney,D.L., Ramms,D.J., Wang,Z., Park,J., Goto,Y., Soucheray,M.,
            Bhola,N., Kim,K., Zheng,F., Zeng,Y., McGregor,M., Herrington,K.A.,
            O'Keefe,R., Jin,N., VanLandingham,N.K., Foussard,H., Von Dollen,J.,
            Bouhaddou,M., Jimenez-Morales,D., Obernier,K., Kreisberg,J.F.,
            Kim,M., Johnson,D.E., Jura,N., Grandis,J.R., Gutkind,J.S.,
            Ideker,T. and Krogan,N.J.
  TITLE     A protein network map of head and neck cancer reveals PIK3CA mutant
            drug sensitivity
  JOURNAL   Science 374 (6563), eabf2911 (2021)
   PUBMED   34591642
REFERENCE   3  (bases 1 to 5619)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 5619)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 5619)
  AUTHORS   Kigoshi,Y., Tsuruta,F. and Chiba,T.
  TITLE     Ubiquitin ligase activity of Cul3-KLHL7 protein is attenuated by
            autosomal dominant retinitis pigmentosa causative mutation
  JOURNAL   J Biol Chem 286 (38), 33613-33621 (2011)
   PUBMED   21828050
  REMARK    GeneRIF: KLHL7 forms a dimer, assembles with Cul3 through its BTB
            and BACK domains, and exerts E3 activity.
REFERENCE   6  (bases 1 to 5619)
  AUTHORS   Bennett,E.J., Rush,J., Gygi,S.P. and Harper,J.W.
  TITLE     Dynamics of cullin-RING ubiquitin ligase network revealed by
            systematic quantitative proteomics
  JOURNAL   Cell 143 (6), 951-965 (2010)
   PUBMED   21145461
REFERENCE   7  (bases 1 to 5619)
  AUTHORS   Hugosson,T., Friedman,J.S., Ponjavic,V., Abrahamson,M., Swaroop,A.
            and Andreasson,S.
  TITLE     Phenotype associated with mutation in the recently identified
            autosomal dominant retinitis pigmentosa KLHL7 gene
  JOURNAL   Arch Ophthalmol 128 (6), 772-778 (2010)
   PUBMED   20547956
  REMARK    GeneRIF: Observed in 2 Scandinavian families to date, KLHL7
            mutation has recently been associated with autosomal dominant
            retinitis pigmentosa.
REFERENCE   8  (bases 1 to 5619)
  AUTHORS   Friedman,J.S., Ray,J.W., Waseem,N., Johnson,K., Brooks,M.J.,
            Hugosson,T., Breuer,D., Branham,K.E., Krauth,D.S., Bowne,S.J.,
            Sullivan,L.S., Ponjavic,V., Granse,L., Khanna,R., Trager,E.H.,
            Gieser,L.M., Hughbanks-Wheaton,D., Cojocaru,R.I., Ghiasvand,N.M.,
            Chakarova,C.F., Abrahamson,M., Goring,H.H., Webster,A.R.,
            Birch,D.G., Abecasis,G.R., Fann,Y., Bhattacharya,S.S., Daiger,S.P.,
            Heckenlively,J.R., Andreasson,S. and Swaroop,A.
  TITLE     Mutations in a BTB-Kelch protein, KLHL7, cause autosomal-dominant
            retinitis pigmentosa
  JOURNAL   Am J Hum Genet 84 (6), 792-800 (2009)
   PUBMED   19520207
  REMARK    GeneRIF: Mutations in a BTB-Kelch protein, KLHL7, cause
            autosomal-dominant retinitis pigmentosa.
REFERENCE   9  (bases 1 to 5619)
  AUTHORS   Bredholt,G., Storstein,A., Haugen,M., Krossnes,B.K., Husebye,E.,
            Knappskog,P. and Vedeler,C.A.
  TITLE     Detection of autoantibodies to the BTB-kelch protein KLHL7 in
            cancer sera
  JOURNAL   Scand J Immunol 64 (3), 325-335 (2006)
   PUBMED   16918702
  REMARK    GeneRIF: The present results indicate that KLHL7 antibodies are
            associated with various cancers, and in some patients also with
            neurological disease. Whether KLHL7 antibodies can be used as
            paraneoplastic markers for PNS remains to be determined.
REFERENCE   10 (bases 1 to 5619)
  AUTHORS   Fahim,A.T., Daiger,S.P. and Weleber,R.G.
  TITLE     Nonsyndromic Retinitis Pigmentosa Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301590
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC370850.1, AK290479.1,
            AK056390.1, BC039585.1 and AC005082.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001031710.2.
            
            Summary: This gene encodes a BTB-Kelch-related protein. The encoded
            protein may be involved in protein degradation. Mutations in this
            gene have been associated with retinitis pigmentosa 42. [provided
            by RefSeq, Feb 2010].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.48226.1,
                                           SRR1660807.189431.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000339077.10/ ENSP00000343273.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-155               DC370850.1         52-206
            156-786             AK290479.1         1-631
            787-3007            AK056390.1         920-3140
            3008-3126           BC039585.1         3001-3119
            3127-5619           AC005082.3         11949-14441
FEATURES             Location/Qualifiers
     source          1..5619
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p15.3"
     gene            1..5619
                     /gene="KLHL7"
                     /gene_synonym="CISS3; KLHL6; PERCHING; SBBI26"
                     /note="kelch like family member 7"
                     /db_xref="GeneID:55975"
                     /db_xref="HGNC:HGNC:15646"
                     /db_xref="MIM:611119"
     exon            1..362
                     /gene="KLHL7"
                     /gene_synonym="CISS3; KLHL6; PERCHING; SBBI26"
                     /inference="alignment:Splign:2.1.0"
     CDS             243..2003
                     /gene="KLHL7"
                     /gene_synonym="CISS3; KLHL6; PERCHING; SBBI26"
                     /note="isoform 1 is encoded by transcript variant 1;
                     kelch-like 6; kelch-like protein 7; kelch/BTB; kelch-like
                     7"
                     /codon_start=1
                     /product="kelch-like protein 7 isoform 1"
                     /protein_id="NP_001026880.2"
                     /db_xref="CCDS:CCDS34609.1"
                     /db_xref="GeneID:55975"
                     /db_xref="HGNC:HGNC:15646"
                     /db_xref="MIM:611119"
                     /translation="MAASGVEKSSKKKTEKKLAAREEAKLLAGFMGVMNNMRKQKTLC
                     DVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFA
                     YTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLAECLDCPE
                     LKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYD
                     EPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLLSPED
                     REELVDGTRPRRKKHDYRIALFGGSQPQSCRYFNPKDYSWTDIRCPFEKRRDAACVFW
                     DNVVYILGGSQLFPIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEV
                     GNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNS
                     CEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLGGLDNVEYYDIKLNEW
                     KMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKWVANSKVRAFPV
                     TSCLICVVDTCGANEETLET"
     exon            363..465
                     /gene="KLHL7"
                     /gene_synonym="CISS3; KLHL6; PERCHING; SBBI26"
                     /inference="alignment:Splign:2.1.0"
     exon            466..559
                     /gene="KLHL7"
                     /gene_synonym="CISS3; KLHL6; PERCHING; SBBI26"
                     /inference="alignment:Splign:2.1.0"
     exon            560..684
                     /gene="KLHL7"
                     /gene_synonym="CISS3; KLHL6; PERCHING; SBBI26"
                     /inference="alignment:Splign:2.1.0"
     exon            685..860
                     /gene="KLHL7"
                     /gene_synonym="CISS3; KLHL6; PERCHING; SBBI26"
                     /inference="alignment:Splign:2.1.0"
     exon            861..1035
                     /gene="KLHL7"
                     /gene_synonym="CISS3; KLHL6; PERCHING; SBBI26"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1178
                     /gene="KLHL7"
                     /gene_synonym="CISS3; KLHL6; PERCHING; SBBI26"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1419
                     /gene="KLHL7"
                     /gene_synonym="CISS3; KLHL6; PERCHING; SBBI26"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..1621
                     /gene="KLHL7"
                     /gene_synonym="CISS3; KLHL6; PERCHING; SBBI26"
                     /inference="alignment:Splign:2.1.0"
     exon            1622..1719
                     /gene="KLHL7"
                     /gene_synonym="CISS3; KLHL6; PERCHING; SBBI26"
                     /inference="alignment:Splign:2.1.0"
     exon            1720..5619
                     /gene="KLHL7"
                     /gene_synonym="CISS3; KLHL6; PERCHING; SBBI26"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2988..2993
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLHL7"
                     /gene_synonym="CISS3; KLHL6; PERCHING; SBBI26"
                     /note="hexamer: AATAAA"
     polyA_site      3009
                     /gene="KLHL7"
                     /gene_synonym="CISS3; KLHL6; PERCHING; SBBI26"
                     /note="major polyA site"
     regulatory      3104..3109
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLHL7"
                     /gene_synonym="CISS3; KLHL6; PERCHING; SBBI26"
                     /note="hexamer: ATTAAA"
     polyA_site      3126
                     /gene="KLHL7"
                     /gene_synonym="CISS3; KLHL6; PERCHING; SBBI26"
                     /note="major polyA site"
     regulatory      5599..5604
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLHL7"
                     /gene_synonym="CISS3; KLHL6; PERCHING; SBBI26"
                     /note="hexamer: AATAAA"
     polyA_site      5619
                     /gene="KLHL7"
                     /gene_synonym="CISS3; KLHL6; PERCHING; SBBI26"
ORIGIN      
        1 gggttctgcc cggggacgca gcccagttgg tagcgtcgct ccctgagcgt ttctaagggg
       61 gccgcccggc cttgtctttc ggcagtggcc gagccaccgc cgcctgccgc gcgttccaga
      121 gctgggcgct gcagctgcac tgccgatcgc cgtgtttggt cgatagaatc cccagtgtgc
      181 ccagagagtg cgacccctcg cccggcccgg cgagccccgg gcgtgaaccg agctgaggga
      241 ggatggcagc ctctggggtg gagaagagca gcaagaagaa gaccgagaag aaacttgctg
      301 ctcgggaaga agctaaattg ttggcgggtt tcatgggcgt catgaataac atgcggaaac
      361 agaaaacgtt gtgtgacgtg atcctcatgg tccaggaaag aaagatacct gctcatcgtg
      421 ttgttcttgc tgcagccagt cattttttta acttaatgtt cacaactaac atgcttgaat
      481 caaagtcctt tgaagtagaa ctcaaagatg ctgaacctga tattattgaa caactggtgg
      541 aatttgctta tactgctaga atttccgtga atagcaacaa tgttcagtct ttgctggatg
      601 cagcaaacca atatcagatt gaacctgtga agaaaatgtg tgttgatttt ttgaaagaac
      661 aagttgatgc ttcaaattgt cttggtataa gtgtgctagc ggagtgtcta gattgtcctg
      721 aattgaaagc aactgcagat gactttattc atcagcactt tactgaagtt tacaaaactg
      781 atgaatttct tcaacttgat gtcaagcgag taacacatct tctcaaccag gacactctga
      841 ctgtgagagc agaggatcag gtttatgatg ctgcagtcag gtggttgaaa tacgatgaac
      901 ctaatcgcca gccatttatg gttgatatcc ttgctaaagt caggtttcct cttatatcaa
      961 agaatttctt aagtaaaacg gtacaagctg aaccacttat tcaagacaat cctgaatgcc
     1021 ttaagatggt gataagtgga atgaggtacc atctactgtc tccagaggac cgagaagaac
     1081 ttgtagatgg cacaagacct agaagaaaga aacatgacta ccgcatagcc ctatttggag
     1141 gctctcaacc acagtcttgt agatatttta acccaaagga ttatagctgg acagacatcc
     1201 gctgcccctt tgaaaaacga agagatgcag catgcgtgtt ttgggacaat gtagtataca
     1261 ttttgggagg ctctcagctt ttcccaataa agcgaatgga ctgctataat gtagtgaagg
     1321 atagctggta ttcgaaactg ggtcctccga cacctcgaga cagccttgct gcatgtgctg
     1381 cagaaggcaa aatttataca tctggaggtt cagaagtagg aaactcagct ctgtatttat
     1441 ttgagtgcta tgatacgaga actgaaagct ggcacacaaa gcccagcatg ctgacccagc
     1501 gctgcagcca tgggatggtg gaagccaatg gcctaatcta tgtttgtggt ggaagtttag
     1561 gaaacaatgt ttctgggaga gtgcttaatt cctgtgaagt ttatgatcct gccacagaaa
     1621 catggactga gctgtgtcca atgattgaag ccaggaagaa tcatgggctg gtatttgtaa
     1681 aagacaagat atttgctgtg ggtggtcaga atggtttagg tggtctggac aatgtggaat
     1741 attacgatat taagttgaac gaatggaaga tggtctcacc aatgccatgg aagggtgtaa
     1801 cagtgaaatg tgcagcagtt ggctctatag tttatgtctt ggctggtttt cagggtgttg
     1861 gtcgattagg acacattctc gaatataata ccgaaacaga caaatgggtt gccaactcca
     1921 aagttcgtgc ttttccagtc acaagttgtt taatttgtgt tgtcgatact tgtggagcaa
     1981 atgaagagac ccttgaaaca tgaaaaatga gtggacttca gactcatcag agactctaaa
     2041 atatagccac cagtgctttg ttccaggagt ttggtgacaa agttttggtt tggtgttttg
     2101 gtaaagaaag tttcaagtga aatgaggttc ctataaaata gatgtttctt ttatatggat
     2161 ttccttaatt caaagatcat attttagctg gccacaaaac caagaacata tctagcaaga
     2221 aaacttgaaa aagtataagc atttgttaaa aatgtgaatt tcttgaatga atttcacatt
     2281 tgtaactatg attttggcag aatagaagat tggctcatca gtgaagcgca gtatcttagc
     2341 tctagattct attttcatgc atcacagaag tgctatacgg ttaggtctgt ttgtgctcag
     2401 tcaagaacta agaaatagta tgaattgtaa gtcaagatgg gcaactcaga tggagcagct
     2461 tagtctcaca gtttgcttgt ctatttattt tatttagtgc caaatgtatt ccattttaaa
     2521 agtaagccag agtgagtcaa ggcatataca cactttctca caaaacttcc taaacagatt
     2581 tgggggttta atatgtccaa ctcctcatga aatatattca atccacttaa atatattcca
     2641 tctttttaac ataaaatgta aagcttagca cccatcatta atttatgtct ctgttttatc
     2701 cagtggttaa aaaaggattc tgcctcttta gtcctcactg ttaaataaaa cccaatcata
     2761 gtaagtgatt aactagcaaa aagtaaagct atttatagca aatttctaga tcattagaaa
     2821 agcactggta gttgtacaat atcagtgttg actttgaact tctttaacga gatcatgaat
     2881 tcttttccct tagccaaaac atgaaatatt taacctagtt gtctctaaaa gttttgtaat
     2941 catgagttag atatatgtca tctcctattc attgctttta tgtgatcaat aaatctttta
     3001 caaacccaac tactcatttc cttcctagta atactttgcc tttttcactg tgtatggaat
     3061 gaaacatgta aagctgtcac aatcaatgtt tttatctgat aatattaaat attttttaac
     3121 ttaaaatagg ccactcagtt tgttcttcaa gtattttagg taatggttgt ttttagaatt
     3181 tgtgaaccag tgtctcttaa ttttcagttt tctttatata gaggttataa tagtcttaaa
     3241 ccctaaaaat gtttaaatca aaaaggaatt aggaaaaaca taatgatagg tatatttcta
     3301 tttgtgtagg gttttttaat gtacagcttt attgagatat aattcacata ccatacaatt
     3361 caccatttaa agtatactat tcaggccagg cacagtggct cacgcctgta atcccagcac
     3421 tttgggaggc caaggtgggt agatcatttg aggtcagcag ttcaagacca ccctggccaa
     3481 catgatgaga ccccgtctct actaaaaata caaaaattag ccaggcctgg tggtgtgcac
     3541 ttgtaatccc agctattcag gagactgagg caggaggatt gcttgaacct gacaggcaga
     3601 ggttgcagtg agctgagatc aagccactgc accccagcct gggcaacaga gcaagactaa
     3661 aaaaaaaaaa aaaaaaaaaa aaatgtatta ttcagtggtt tttaatatat ccacagagtt
     3721 acgcaaccat caccacaatt ttagaacatt ttcatcaccc caaaaagaaa ccttgtactg
     3781 attagcaatg gttccctatt tcccccaacg cccctgtatt tcctagggct accataacaa
     3841 actactgcaa acttggtggc tttaaagaac agaaatttat tctctcacaa ttcaggaagc
     3901 cagcactcct aaatcaagtt gtcagcaggg ttagttcctt ctggagggtc tgcagcagaa
     3961 accacacatg cctctcccct agcttctggt ggttgccagc aatcctcagc attctttggc
     4021 ttgtagctgc agcacttcag tctctgtctc tgtcttcgca tgggcttttt ccctgtgtgt
     4081 ctctgtatct tcacatggtg ttcttataag gacaacatag gagccagaca cagtggctca
     4141 ggccggtaat ttcaacactt tgggaggtgg aggcagtagg atcacttgag gctaggagtt
     4201 caagaccctg tctctacaaa aaaataaaaa gttagcaggt gtggtatata cctgcagttc
     4261 tagctactca gaaggctgag gtgggaggat cacttgagcc caggagttca aggatgtagt
     4321 gagctatgat tgtgccactg cactccagcc tgggtgacag actgagaccc tgtctcatta
     4381 aaaaaaaaaa aaaaaaagct gggcgctgtg tctcacgccc ttaatcccag cactttggga
     4441 ggccgaggcg ggtggattac ctgaggtcag gagtttgaga ccagcctgga caacatgcca
     4501 aaaccccgtc tctactaaaa atacaaaaat tagccaggta tggtggtgtg cacctgtagt
     4561 cccagctact caggaggctg aggtaggaga attgcttgaa cctgggaggc agaggttgca
     4621 gtgagctgag attgcgccac ttcattccag cctgggtgac agagcaagac accttctcaa
     4681 agcaaaatac aaacaaaaaa aggacaacat agggcccgca atccagtatg accttatttt
     4741 aattacacct gtaaagaccc catttccaaa cgaggacaca ttctgagctt ctggatagac
     4801 atgaatttgg ggagatgctg ttcaacacag aaaacctccc aaacaccata gccctaggca
     4861 accactaatc tactttctgt ctctagattt gattattctg aacattttta gtagggtttt
     4921 caattttgca ctctattgaa aaatgtggct agtttaattt tttgagagtg aaatatccat
     4981 ttattatatt acaatatagc tatataattt gacaatctcc tatgtagaat atacagtacc
     5041 tgtctaagat attttaagta caccagcatt tccttttagg ctatgtcaat tgactagaac
     5101 acactatagt aaatacatac acaggtttga tgtggattat aatgaagtgg tttttttcct
     5161 tagtaatctg tatcataatt cccaattagt gtctttttct gccttggaaa tttctacaga
     5221 attgtcaata tcaggatagt gcgtaaaagt acactcacca tactgacaag cacattttct
     5281 attttgttgc ccaaaactcc ctgtcctgta aagtgctctg cttgcttttt agtagacatt
     5341 tgataagtta atgttatatc ctttgcaatg atattatttt gatgacaaag taagtttatg
     5401 ctttcaaaaa tcacaattcg gtcagaaaag tttagcatct taaaaaaatt gttgctattt
     5461 gaaaaaaaca aaacaaaaca tatacttgtg actttgtggt ccagctggca aaaacttgac
     5521 atatcatccc atgaaaattt taagtcatga attattttga catgacaata ttgctaacaa
     5581 aatcaaaatc agccgtttaa taaacaatta ttccaccaa
//
