LOCUS       NM_130446               6295 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens kelch like family member 6 (KLHL6), mRNA.
ACCESSION   NM_130446
VERSION     NM_130446.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6295)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 6295)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 6295)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 6295)
  AUTHORS   Choi,J., Lee,K., Ingvarsdottir,K., Bonasio,R., Saraf,A.,
            Florens,L., Washburn,M.P., Tadros,S., Green,M.R. and Busino,L.
  TITLE     Loss of KLHL6 promotes diffuse large B-cell lymphoma growth and
            survival by stabilizing the mRNA decay factor roquin2
  JOURNAL   Nat Cell Biol 20 (5), 586-596 (2018)
   PUBMED   29695787
  REMARK    GeneRIF: Loss of KLHL6 promotes diffuse large B-cell lymphoma
            growth and survival by stabilizing the mRNA decay factor roquin2.
REFERENCE   5  (bases 1 to 6295)
  AUTHORS   Kunder,C.A., Roncador,G., Advani,R.H., Gualco,G., Bacchi,C.E.,
            Sabile,J.M., Lossos,I.S., Nie,K., Tibshirani,R.J., Green,M.R.,
            Alizadeh,A.A. and Natkunam,Y.
  TITLE     KLHL6 Is Preferentially Expressed in Germinal Center-Derived B-Cell
            Lymphomas
  JOURNAL   Am J Clin Pathol 148 (6), 465-476 (2017)
   PUBMED   29140403
  REMARK    GeneRIF: KLHL6 was positive mainly in B-cell neoplasms of germinal
            center derivation, including 95% of follicular lymphomas (106/112)
REFERENCE   6  (bases 1 to 6295)
  AUTHORS   Dhanoa,B.S., Cogliati,T., Satish,A.G., Bruford,E.A. and
            Friedman,J.S.
  TITLE     Update on the Kelch-like (KLHL) gene family
  JOURNAL   Hum Genomics 7 (1), 13 (2013)
   PUBMED   23676014
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 6295)
  AUTHORS   Kroll,J., Shi,X., Caprioli,A., Liu,H.H., Waskow,C., Lin,K.M.,
            Miyazaki,T., Rodewald,H.R. and Sato,T.N.
  TITLE     The BTB-kelch protein KLHL6 is involved in B-lymphocyte antigen
            receptor signaling and germinal center formation
  JOURNAL   Mol Cell Biol 25 (19), 8531-8540 (2005)
   PUBMED   16166635
REFERENCE   8  (bases 1 to 6295)
  AUTHORS   Stogios,P.J. and Prive,G.G.
  TITLE     The BACK domain in BTB-kelch proteins
  JOURNAL   Trends Biochem Sci 29 (12), 634-637 (2004)
   PUBMED   15544948
  REMARK    Review article
REFERENCE   9  (bases 1 to 6295)
  AUTHORS   Gupta-Rossi,N., Storck,S., Griebel,P.J., Reynaud,C.A., Weill,J.C.
            and Dahan,A.
  TITLE     Specific over-expression of deltex and a new Kelch-like protein in
            human germinal center B cells
  JOURNAL   Mol Immunol 39 (13), 791-799 (2003)
   PUBMED   12617994
  REMARK    GeneRIF: characterization of two genes expressed in centroblasts of
            human tonsils: deltex (Drosophila) homolog 1 (DTX1), which is
            related to the Notch pathway and a new Kelch-like protein, KLHL6
REFERENCE   10 (bases 1 to 6295)
  AUTHORS   Adams,J., Kelso,R. and Cooley,L.
  TITLE     The kelch repeat superfamily of proteins: propellers of cell
            function
  JOURNAL   Trends Cell Biol 10 (1), 17-24 (2000)
   PUBMED   10603472
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP284594.1, BC032348.1,
            AK097125.1 and AC092960.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_130446.3.
            
            Summary: This gene encodes a member of the kelch-like (KLHL) family
            of proteins, which is involved in B-lymphocyte antigen receptor
            signaling and germinal-center B-cell maturation. The encoded
            protein contains an N-terminal broad-complex, tramtrack and bric a
            brac (BTB) domain that facilitates protein binding and
            dimerization, a BTB and C-terminal kelch (BACK) domain, and six
            C-terminal kelch repeat domains. Naturally occurring mutations in
            this gene are associated with chronic lymphocytic leukemia.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Feb 2017].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.155198.1, BC032348.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000341319.8/ ENSP00000341342.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                BP284594.1         6-22
            18-1363             BC032348.1         1-1346
            1364-2327           AK097125.1         1323-2286
            2328-6295           AC092960.3         7404-11371
FEATURES             Location/Qualifiers
     source          1..6295
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q27.1"
     gene            1..6295
                     /gene="KLHL6"
                     /note="kelch like family member 6"
                     /db_xref="GeneID:89857"
                     /db_xref="HGNC:HGNC:18653"
                     /db_xref="MIM:614214"
     exon            1..346
                     /gene="KLHL6"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..1919
                     /gene="KLHL6"
                     /codon_start=1
                     /product="kelch-like protein 6"
                     /protein_id="NP_569713.2"
                     /db_xref="CCDS:CCDS3245.2"
                     /db_xref="GeneID:89857"
                     /db_xref="HGNC:HGNC:18653"
                     /db_xref="MIM:614214"
                     /translation="MLMAGQRGAWTMGDVVEKSLEGPLAPSTDEPSQKTGDLVEILNG
                     EKVKFDDAGLSLILQNGLETLRMENALTDVILCVDIQEFSCHRVVLAAASNYFRAMFC
                     NDLKEKYEKRIIIKGVDAETMHTLLDYTYTSKALITKQNVQRVLEAANLFQFLRMVDA
                     CASFLTEALNPENCVGILRLADTHSLDSLKKQVQSYIIQNFVQILNSEEFLDLPVDTL
                     HHILKSDDLYVTEEAQVFETVMSWVRHKPSERLCLLPYVLENVRLPLLDPWYFVETVE
                     ADPLIRQCPEVFPLLQEARMYHLSGNEIISERTKPRMHEFQSEVFMIIGGCTKDERFV
                     AEVTCLDPLRRSRLEVAKLPLTEHELESENKKWVEFACVTLKNEVYISGGKETQHDVW
                     KYNSSINKWIQIEYLNIGRWRHKMVVLGGKVYVIGGFDGLQRINNVETYDPFHNCWSE
                     AAPLLVHVSSFAATSHKKKLYVIGGGPNGKLATDKTQCYDPSTNKWSLKAAMPVEAKC
                     INAVSFRDRIYVVGGAMRALYAYSPLEDSWCLVTQLSHERASCGIAPCNNRLYITGGR
                     DEKNEVIATVLCWDPEAQKLTEECVLPRGVSHHGSVTIRKSYTHIRRIVPGAVSV"
     exon            347..512
                     /gene="KLHL6"
                     /inference="alignment:Splign:2.1.0"
     exon            513..962
                     /gene="KLHL6"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1200
                     /gene="KLHL6"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1403
                     /gene="KLHL6"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..1617
                     /gene="KLHL6"
                     /inference="alignment:Splign:2.1.0"
     exon            1618..6295
                     /gene="KLHL6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6274..6279
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLHL6"
                     /note="hexamer: AATAAA"
     polyA_site      6295
                     /gene="KLHL6"
                     /note="major polyA site"
ORIGIN      
        1 gctcagctcc tgcaatgggg cctgcctgac acttgggcgc tccttcagtc tcgatgttga
       61 tggcaggaca aaggggcgcc tggaccatgg gtgatgtggt cgagaagagt ttggaagggc
      121 ccctggcacc ttctacagat gagccctccc agaaaacagg agacttggtc gagatcttaa
      181 atggggaaaa ggtcaaattt gacgacgcgg gactctcctt aattcttcag aatggcctgg
      241 aaaccctgcg aatggaaaac gctctgacag atgtcatctt gtgtgtggac attcaggaat
      301 tctcctgcca ccgcgtggtg cttgccgcag ccagcaacta tttcagggcc atgttctgca
      361 acgatttaaa ggaaaagtat gagaaaagga tcattattaa aggggttgat gctgagacca
      421 tgcacactct gttggactac acgtacacca gcaaggcgct gatcaccaag cagaatgtcc
      481 agcgggtcct ggaggctgct aacctcttcc agttcctgcg gatggtggat gcctgtgcca
      541 gcttcctcac tgaagccttg aacccagaaa actgcgttgg aatactgagg ctggctgaca
      601 cacactcgct ggacagtcta aagaagcagg ttcagagtta catcattcaa aactttgtgc
      661 agattctgaa ctctgaggag tttcttgacc tgcccgtgga cactctgcac cacatcttga
      721 agagtgatga cctttacgtg accgaggagg ctcaggtgtt tgagaccgtg atgagctggg
      781 tccggcacaa gccatcagaa cgactctgct tactccccta tgtcctcgag aacgtgcgct
      841 taccgcttct ggacccgtgg tactttgtgg agacggtgga agcagatcct ctcatcaggc
      901 agtgcccaga ggtcttcccg ctgctccagg aagccaggat gtaccacctt tctggcaatg
      961 agatcatttc ggaacgcacc aagcccagga tgcatgagtt ccagtctgag gtgttcatga
     1021 tcattggcgg ctgcacgaag gatgaacggt ttgtggcaga ggtgacctgc ctggaccccc
     1081 tgaggcgcag ccgcctggag gtggccaagc tcccgctaac agagcatgag ctggagagtg
     1141 agaataagaa gtgggtggag tttgcatgcg tgacattgaa aaatgaggtc tacatctcag
     1201 gtggcaaaga aacacagcat gatgtttgga aatataattc ttcgatcaac aagtggattc
     1261 agattgagta tttaaacata ggccgctgga ggcataagat ggtggtgttg ggtggcaagg
     1321 tctatgtgat cggaggcttt gacggcttac agagaatcaa caatgtggag acctacgacc
     1381 cctttcacaa ctgctggtca gaggccgcac ccctccttgt ccatgtcagt tcctttgcag
     1441 ccaccagcca taagaagaag ctgtatgtga tcgggggagg gcccaatggg aaactggcca
     1501 cagacaagac tcagtgttat gacccttcca ccaacaagtg gagtttgaag gcggccatgc
     1561 ccgtggaggc taaatgcatc aatgcagtga gtttccggga ccgcatctat gtcgttggtg
     1621 gggccatgag agcgctgtac gcctacagcc cgctggaaga cagctggtgc ctggtgaccc
     1681 agctcagcca cgagcgggcc agctgcggta tcgcgccctg caacaaccgg ctctacatca
     1741 ccggcgggcg ggacgagaag aacgaggtta tcgccacggt gctgtgctgg gaccccgagg
     1801 cccagaaact gacagaggag tgcgtcctgc cccggggcgt gtcgcaccac ggcagcgtca
     1861 ccatcaggaa gtcgtacacc cacatccgca ggatcgtgcc cggagcagtg tctgtctgac
     1921 ggcaggatgg ggagctggag agcccccccg accctcagcg tacccgcctc acctctcacc
     1981 ctcctccagt cccacttcag gcagcaggct cgagtttgag gccatacatc aggggatccc
     2041 cttgactcac tttgggggaa ccttggaagt cacagtttgg ggtcacttga gaccggccag
     2101 gaatgtttgc atgacctacc tcaggagggg aggcgaggaa gagtaatatt tagcattcag
     2161 gacccaccca ccctatgccg gcttctgtgc caggcacttc cttttatcgg ttcatttaac
     2221 ctggtgactg gctcttatca cttctagttt acaggtgagg gaaccaagtt tcacagaggc
     2281 taagtggcgt gcccctgatc actcagatag caagtagcta ccccaggagt ctaaaatcca
     2341 ggtctttcat ctccgaagtc aatgctcttt ccaccatgct gcctatctca gagcaggaaa
     2401 aacaaacaaa aaacaacaac aaaacctggc tcttgctggg cgtggcggct cacgcctgta
     2461 atcccagccc tatgggaggc tgaggcgggc ggatgacctg aggtcaggag ttcaagacca
     2521 gcctggccaa catggtgaga ccgccccgtc tctactaaaa atacaaaaat tagccgcgtg
     2581 cagtggcagg cgcctgtaat tccagctact caggaggctg aggcaggagg atcacttgaa
     2641 cttgggaggt ggaggttgca gtgagccgag atcgccacac tgcactgcag cccgggaaac
     2701 aaaagtgaag ctctgtcttc aaaacaaaaa caaaaacaaa aacaaaaaca aagaaacctg
     2761 gctcatttct tgtttcggca agtctgctaa aagattcact cagcacagca gggaaataaa
     2821 ggtgtttcct gctttctttc cttttctttc ttattctgca tcctccctcg tccccgccct
     2881 ttaccaatat ttaaaccaag gagtcatttg ggctccttgc caagaacatc tcataggttc
     2941 ttccacttga aaggtctggg ggatgggctt gggaaggcct gtttgctttg aaagagatga
     3001 aatacttgtg ttctgtcctc ctcccattga aaccctcttt tttttttttt tgagatgaag
     3061 tcgcccaggc tggagtgcag tggcatgatc tcggctcact gcaacctctg tcaccctggt
     3121 tcaagtgatt ttcctgcctc agcctcctga gtagctggga ttacaggcac ctgccaccgc
     3181 gcctggctaa tttttgtagt tttagtagag acggggtttc accatcttgg ccaggctggt
     3241 cttgaacgcc tgaccttgtg atctgcccgc ctcggcctcc cgaagtgctg ggattacagg
     3301 tgtgagccac tgggcccggt cttttttttt ttaaatgatc ataagatggc ccattttgga
     3361 ccggaactgt cattgccaga cagaattgta cctttagcac attctggtgc cctggcctct
     3421 tagtgttcac cagttgtact gcaatataga caagatgtct ctagagactc aaactactgt
     3481 tttattaaaa aagtaaacac ctgagcacag ctggcctaca caggagcgac agattctcct
     3541 tgatggtaca ctttctagtt tttacacagt gatttaggtc cacgttcctg ataccccatc
     3601 ctcctgaagc cttcgttttc aagactttta aaaagcactt ctacttggtt ttttgatcag
     3661 tgtagctcaa ttgtgactta aagaacagaa tctgtccttc actgtaagag ctacagcttt
     3721 caaatgagct cactggaaat tcattctaat ccccaagctg gagaaacagg ttaagagatc
     3781 ctgtttcata tgctgtattt aaaaagcaac aatgataaca acatagtaac tgcgttaccc
     3841 aatggacttt attttcatca tatgatttca attctcttta tagagtttta tttcatatcc
     3901 ggtgtggctt gttcttttca gcagtttggg aagttagtta ttagagttga tagtgaattg
     3961 aattttcatt aaacagtcac ggttagaaga agctaatatt tgaaacagat tttaaaaact
     4021 tgaaaaatta caggtgagat ttctgtttat gccagattat tgaagataaa tataaatgta
     4081 tgttggtgtg tgaaatgctc tgtgccttag aagcgtgaca gttcagctct ctgctgtgga
     4141 aagtaacaca gggcaataga aacatatttg tggaatttta gaacaaacta ttgctgactc
     4201 atgagcacta taataaccat caggaagctc ccaactgaag caatgtaaca gtgtaatcta
     4261 gttcaattca gcaaacattc atggagttct tcatgtctgt caagccttga ggacacccac
     4321 gaatggcaaa tctccacgct agacactcaa tacaggtaaa taggccacca gttaatattc
     4381 ttgtttttat tttcttcaag ttagctaaaa atgagatgcg tatgaagtga ggaggctgga
     4441 tccaagtctt gattgccttt cagggggtca aggtggtaag ctgtgcagtg aagtcaacca
     4501 gtggccatgg cttacatgtt tgtctctttg agatcgccac cagaaccatt tgtgaactga
     4561 tttgtgaagg aaaagtcagt cttactccaa agactattgc agggaggaac ttccagagag
     4621 gaaatccaat gacaatggta ctggcataca cagggagcct cccttcaaaa agacagcgcc
     4681 cctagtcagg gaggggatgg cggtcctttg ataagaccca taggcaaact tcgagcccat
     4741 cagcaggtca accctatgct gggaaagtga ggatttggga tttctgtgct ataaacctga
     4801 ttctaaatgt aggacccaag tttctggact acttcagaat acctaaatga atcatggaaa
     4861 cactctttat gattttttac aacaccagat atgcaggtga attgtggaaa atgtcatgta
     4921 gctgacactc aagaaatagg gattcctaat aatggcatgg gtagggaaca gatacacctg
     4981 gttagaaggt ctagggttct gtatatgaag ctgccagtct gtagctcttc gagaaagaaa
     5041 gttcaagtca tttgggggaa acttaagaat agtcatcagg gttttagctt ctaggcacca
     5101 gccaaggatg agaacttcta aaatctaaaa tccatttcaa gaaataaaga cgaacacatt
     5161 tgcaggaagg taactgttat aacccacacc atcagcaggg ggaaagccaa gctgagaata
     5221 aacccagaga caaagaaccc tcggactcag gcaggacatg gcaggatgtt ctggcacagc
     5281 agactggaga ctgaggcagg gcctgtgagt ggacagagca cccctggctg ggaagaagaa
     5341 gatggggtag gaggaggtca ggttccaagg atgcaggtct ggaaaatgat atcggaggcc
     5401 ctggagtttg tgagcttggc tctagtccca agaagggtga gggagaataa gggtaaggga
     5461 gtattctagg caaggaacta aggaaggaat ccccttctta gagcagaggc acaagttaga
     5521 gcaggcccag catttgggcc aacttactgt ggggcctctg agctgctcag ctgggtctcc
     5581 tgtcctagag ggaaggtggc ccagagtctt tggtggagcg gaatctgtag atgaggttaa
     5641 gggactccag ttgccaaggt tgatctgaaa caggcaggga gctaagctca tcagaacacc
     5701 aacagattca tgttctcgtc ttagctttca tctattctgg tctcaatggc ttcgggaaac
     5761 acacatatac acatacacca tgcccttgaa ctcaaagcaa actacgctct cagggaaata
     5821 caaatatcac gttcttatag ctgtaaagta tagcttagct atttatagaa gactatgagg
     5881 tactgttgtg agttatttgc ttatcctgtt ttattctgaa aaatgaaagt gctcaataga
     5941 atttttaacg ttggcaacac cataaggatt tcttatgtta agtcccaact tggggttgca
     6001 aaatcatttt ttcccttaat acctgggtgt tgtattagat ctcataattt gacaagttaa
     6061 ccttttagaa atccacatat atctcaaatc tggctactgc aaaaccagtt ttgacaggtc
     6121 agattttcat atgtataggt ataaatagcc aacactcagt gaacaaaatc ctttaagcat
     6181 tttggttaca taaagttgta tgttttaagt gatcaaacta agaatattgt ttataggttt
     6241 taaaaaccaa accaataaaa tttttattta ttcaataaaa tatgcacaga acaga
//
