LOCUS       NP_569713                621 aa            linear   PRI 20-SEP-2024
DEFINITION  kelch-like protein 6 [Homo sapiens].
ACCESSION   NP_569713
VERSION     NP_569713.2
DBSOURCE    REFSEQ: accession NM_130446.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 621)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (residues 1 to 621)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (residues 1 to 621)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (residues 1 to 621)
  AUTHORS   Choi,J., Lee,K., Ingvarsdottir,K., Bonasio,R., Saraf,A.,
            Florens,L., Washburn,M.P., Tadros,S., Green,M.R. and Busino,L.
  TITLE     Loss of KLHL6 promotes diffuse large B-cell lymphoma growth and
            survival by stabilizing the mRNA decay factor roquin2
  JOURNAL   Nat Cell Biol 20 (5), 586-596 (2018)
   PUBMED   29695787
  REMARK    GeneRIF: Loss of KLHL6 promotes diffuse large B-cell lymphoma
            growth and survival by stabilizing the mRNA decay factor roquin2.
REFERENCE   5  (residues 1 to 621)
  AUTHORS   Kunder,C.A., Roncador,G., Advani,R.H., Gualco,G., Bacchi,C.E.,
            Sabile,J.M., Lossos,I.S., Nie,K., Tibshirani,R.J., Green,M.R.,
            Alizadeh,A.A. and Natkunam,Y.
  TITLE     KLHL6 Is Preferentially Expressed in Germinal Center-Derived B-Cell
            Lymphomas
  JOURNAL   Am J Clin Pathol 148 (6), 465-476 (2017)
   PUBMED   29140403
  REMARK    GeneRIF: KLHL6 was positive mainly in B-cell neoplasms of germinal
            center derivation, including 95% of follicular lymphomas (106/112)
REFERENCE   6  (residues 1 to 621)
  AUTHORS   Dhanoa,B.S., Cogliati,T., Satish,A.G., Bruford,E.A. and
            Friedman,J.S.
  TITLE     Update on the Kelch-like (KLHL) gene family
  JOURNAL   Hum Genomics 7 (1), 13 (2013)
   PUBMED   23676014
  REMARK    Publication Status: Online-Only
REFERENCE   7  (residues 1 to 621)
  AUTHORS   Kroll,J., Shi,X., Caprioli,A., Liu,H.H., Waskow,C., Lin,K.M.,
            Miyazaki,T., Rodewald,H.R. and Sato,T.N.
  TITLE     The BTB-kelch protein KLHL6 is involved in B-lymphocyte antigen
            receptor signaling and germinal center formation
  JOURNAL   Mol Cell Biol 25 (19), 8531-8540 (2005)
   PUBMED   16166635
REFERENCE   8  (residues 1 to 621)
  AUTHORS   Stogios,P.J. and Prive,G.G.
  TITLE     The BACK domain in BTB-kelch proteins
  JOURNAL   Trends Biochem Sci 29 (12), 634-637 (2004)
   PUBMED   15544948
  REMARK    Review article
REFERENCE   9  (residues 1 to 621)
  AUTHORS   Gupta-Rossi,N., Storck,S., Griebel,P.J., Reynaud,C.A., Weill,J.C.
            and Dahan,A.
  TITLE     Specific over-expression of deltex and a new Kelch-like protein in
            human germinal center B cells
  JOURNAL   Mol Immunol 39 (13), 791-799 (2003)
   PUBMED   12617994
  REMARK    GeneRIF: characterization of two genes expressed in centroblasts of
            human tonsils: deltex (Drosophila) homolog 1 (DTX1), which is
            related to the Notch pathway and a new Kelch-like protein, KLHL6
REFERENCE   10 (residues 1 to 621)
  AUTHORS   Adams,J., Kelso,R. and Cooley,L.
  TITLE     The kelch repeat superfamily of proteins: propellers of cell
            function
  JOURNAL   Trends Cell Biol 10 (1), 17-24 (2000)
   PUBMED   10603472
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP284594.1, BC032348.1,
            AK097125.1 and AC092960.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 16, 2006 this sequence version replaced NP_569713.1.
            
            Summary: This gene encodes a member of the kelch-like (KLHL) family
            of proteins, which is involved in B-lymphocyte antigen receptor
            signaling and germinal-center B-cell maturation. The encoded
            protein contains an N-terminal broad-complex, tramtrack and bric a
            brac (BTB) domain that facilitates protein binding and
            dimerization, a BTB and C-terminal kelch (BACK) domain, and six
            C-terminal kelch repeat domains. Naturally occurring mutations in
            this gene are associated with chronic lymphocytic leukemia.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Feb 2017].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.155198.1, BC032348.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000341319.8/ ENSP00000341342.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..621
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q27.1"
     Protein         1..621
                     /product="kelch-like protein 6"
                     /calculated_mol_wt=70228
     Region          48..176
                     /region_name="BTB_POZ_KLHL6"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in Kelch-like
                     protein 6 (KLHL6); cd18236"
                     /db_xref="CDD:349545"
     Region          86..565
                     /region_name="PHA03098"
                     /note="kelch-like protein; Provisional"
                     /db_xref="CDD:222983"
     Region          169..276
                     /region_name="BACK_KLHL6"
                     /note="BACK (BTB and C-terminal Kelch) domain found in
                     Kelch-like protein 6 (KLHL6); cd18446"
                     /db_xref="CDD:350521"
     Region          320..367
                     /region_name="Kelch 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8WZ60.3)"
     Region          370..407
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          378..421
                     /region_name="Kelch 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8WZ60.3)"
     Region          411..455
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          422..468
                     /region_name="Kelch 3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8WZ60.3)"
     Region          458..504
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          470..516
                     /region_name="Kelch 4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8WZ60.3)"
     Region          506..546
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          517..558
                     /region_name="Kelch 5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8WZ60.3)"
     Region          548..593
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          548..585
                     /region_name="Kelch_1"
                     /note="Kelch motif; pfam01344"
                     /db_xref="CDD:396078"
     Region          560..606
                     /region_name="Kelch 6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8WZ60.3)"
     CDS             1..621
                     /gene="KLHL6"
                     /coded_by="NM_130446.4:54..1919"
                     /db_xref="CCDS:CCDS3245.2"
                     /db_xref="GeneID:89857"
                     /db_xref="HGNC:HGNC:18653"
                     /db_xref="MIM:614214"
ORIGIN      
        1 mlmagqrgaw tmgdvveksl egplapstde psqktgdlve ilngekvkfd daglslilqn
       61 gletlrmena ltdvilcvdi qefschrvvl aaasnyfram fcndlkekye kriiikgvda
      121 etmhtlldyt ytskalitkq nvqrvleaan lfqflrmvda casfltealn pencvgilrl
      181 adthsldslk kqvqsyiiqn fvqilnseef ldlpvdtlhh ilksddlyvt eeaqvfetvm
      241 swvrhkpser lcllpyvlen vrlplldpwy fvetveadpl irqcpevfpl lqearmyhls
      301 gneiisertk prmhefqsev fmiiggctkd erfvaevtcl dplrrsrlev aklpltehel
      361 esenkkwvef acvtlknevy isggketqhd vwkynssink wiqieylnig rwrhkmvvlg
      421 gkvyviggfd glqrinnvet ydpfhncwse aapllvhvss faatshkkkl yvigggpngk
      481 latdktqcyd pstnkwslka ampveakcin avsfrdriyv vggamralya yspledswcl
      541 vtqlsheras cgiapcnnrl yitggrdekn eviatvlcwd peaqklteec vlprgvshhg
      601 svtirksyth irrivpgavs v
//
