LOCUS       XM_047415755            8354 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens kelch like family member 5 (KLHL5),
            transcript variant X12, mRNA.
ACCESSION   XM_047415755
VERSION     XM_047415755.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000004.12) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..8354
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
     gene            1..8354
                     /gene="KLHL5"
                     /note="kelch like family member 5; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 8
                     mRNAs, 36 ESTs, 1095 long SRA reads, 20 Proteins, and 95%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 15 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:51088"
                     /db_xref="HGNC:HGNC:6356"
                     /db_xref="MIM:608064"
     CDS             872..3187
                     /gene="KLHL5"
                     /codon_start=1
                     /product="kelch-like protein 5 isoform X7"
                     /protein_id="XP_047271711.1"
                     /db_xref="GeneID:51088"
                     /db_xref="HGNC:HGNC:6356"
                     /db_xref="MIM:608064"
                     /translation="MSESKALLSFFIASFHFQKYSSVVDKFTEFKRAYTSLVLVGCTN
                     LCAVLFARCLDDHLVSLRMSGSRKEFDVKQILKIRWRWFGHQASSPNSTVDSQQGEFW
                     NRGQTGANGGRKFLDPCSLQLPLASIGYRRSSQLDFQNSPSWPMASTSEVPAFEFTAE
                     DCGGAHWLDRPEVDDGTSEEENESDSSSCRTSNSSQTLSSCHTMEPCTSDEFFQALNH
                     AEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEE
                     IKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLH
                     PSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMN
                     IPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFLADMENNVLFRDDIEC
                     QKLIMEAMKYHLLPERRPMLQSPRTKPRKSTVGTLFAVGGMDSTKGATSIEKYDLRTN
                     MWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMSTH
                     RHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSG
                     KLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAP
                     ASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNT
                     VEAYDPQTNEWTQVAPLCLGRAGACVVTVKL"
ORIGIN      
        1 aaccggtccc ctacccccac ctactcgccc gccccctccg gggccacccg gggactctga
       61 ccccccggcc tggcgccgcc tgacggagcg ggagtggctc gctccgggcc ggccggcgcc
      121 ggggatgagg ctgcccggac agggtctagg ggcgcgcgag gggccgagca tcccactcag
      181 ctcgccggcc ccggcccccg cctcccccgc tcctcccgcc tggccgcccc ggcccgccgt
      241 gacccacggc cgcctccgga gcccgacgcg gtaagtgcga cttccttctc ggcatcgggg
      301 agggggccgc ctcgggcagg gcccgcttcc cgcccccacg cgactctcac gccccgctgc
      361 ggcctcccgg agcgcgcggg gcgcgaagac gctgcccctc ccggaggcgg ctgcgaggcc
      421 ctcgggtccg gaggggctgg gccgggcggg ggcctccgca caccgcgccc ggggctcgaa
      481 ccccggcccg gcctccccgc tgcgcacccc cgagcgccgg agccggcgcc cgggccgccc
      541 tggagttgtg gaaagttgtg gacgcggtgc tggtggccgg cagtgaggag cggactgcgg
      601 tgcacccgtt gctgctttcc cggactgtcc ctgccaataa aacaaactgg aaaccatttc
      661 ggattttttt tttcctctcc ttattacttg caggcaattt tgacctaagt ttttaagctt
      721 ttcttttaaa taataccctc gcccccggag tgtggagaat aagacgggga cttcattttc
      781 ccgagacccg gcgtgcctgg tgaaactttt gcatttaggc atttatttca gtgcatgctc
      841 tgggatcaga agctggcggt aaaagtttgc tatgtcagag agtaaagcgt tactgtcgtt
      901 ttttatcgct tcatttcatt ttcaaaaata ttcttcagta gtcgacaagt tcacagaatt
      961 caaaagggca tatacttctc ttgtcttggt tggatgcaca aatctgtgtg cagtgctttt
     1021 tgcccgttgc ctagacgatc acttggtttc tctgaggatg tctggttctc gtaaagagtt
     1081 tgatgtgaaa cagattttga aaatcagatg gaggtggttt ggtcatcaag catcatctcc
     1141 taattctaca gttgacagcc agcagggaga attttggaac cgaggacaga ctggagcaaa
     1201 cggtgggaga aagtttttag atccatgtag cctacaattg cctttggctt caattggtta
     1261 ccgaaggtcc agccaactgg attttcagaa ttcaccttct tggccaatgg catccacctc
     1321 tgaagtccct gcatttgagt ttacagcaga agattgtggc ggtgcacatt ggctggatag
     1381 accagaagtg gatgatggca ctagtgaaga agaaaatgaa tctgattcca gttcatgcag
     1441 gacttccaat agtagtcaga cattatcatc ctgtcatact atggagccat gtacatcaga
     1501 tgaatttttc caagccctta atcatgccga gcaaacattt aaaaaaatgg aaaactattt
     1561 gagacataaa cagttgtgtg atgtaatttt agtcgctggt gatcgcagaa ttccagctca
     1621 cagattggtg ctctcctctg tctcagacta ttttgctgcc atgtttacta atgatgtcag
     1681 agaggcaaga caagaagaaa taaaaatgga aggtgtagaa ccaaattcgt tgtggtcctt
     1741 gatccagtat gcttatacag gccgccttga attaaaagaa gataatattg agtgcctgtt
     1801 atctacagct tgccttcttc agctttcaca ggttgtagaa gcatgctgta agtttttaat
     1861 gaaacagctt catccatcca actgtcttgg aattcgttct tttgctgatg cccaaggttg
     1921 tacagatttg cataaagtgg ctcacaatta tactatggag catttcatgg aagtaatcag
     1981 aaaccaggaa tttgtattat taccagccag cgaaattgca aagctcttgg ctagtgatga
     2041 catgaacatt cctaatgagg agacaatatt gaatgcactt cttacttggg tccgtcatga
     2101 tttggaacag agacggaaag atctaagtaa acttttggct tatattaggc tacctcttct
     2161 tgcaccacag ttcctggcag acatggaaaa taatgtactt tttcgggatg atatagaatg
     2221 tcagaaactc attatggaag caatgaagta ccatttatta ccagagagac gacccatgtt
     2281 acaaagtcct cggacaaaac ctaggaagtc aactgttggt acattatttg cagttggggg
     2341 aatggattca acaaaaggag caacaagcat tgaaaagtat gatctccgta caaatatgtg
     2401 gactccagta gcaaatatga atgggaggag gctacagttc ggtgttgcag tgctagatga
     2461 caaactgtat gtggttggag gaagagatgg actgaagact ttgaatactg tagagtgcta
     2521 caaccccaaa acaaaaactt ggagtgtgat gccacctatg tccacacata gacatggcct
     2581 tggtgtggct gtactggaag gtcccatgta tgccgtagga ggacatgatg gctggagcta
     2641 tctgaacaca gtggaaagat gggaccctca ggctcgccag tggaattttg ttgccactat
     2701 gtctacccct aggagtacag taggtgtggc agtactaagt ggaaaacttt atgcagttgg
     2761 tggtcgtgat ggaagttctt gtctcaaatc agtagaatgt tttgatcctc atactaataa
     2821 gtggacactg tgtgcacaga tgtcaaaaag gagaggtggc gtaggagtga cgacctggaa
     2881 tggactgctg tatgctatag gggggcacga tgctcccgca tccaacttga cttccagact
     2941 ctcagactgt gtggaaagat atgatcccaa aacagacatg tggactgcag tagcatccat
     3001 gagcatcagc agagatgcag tgggggtctg tttacttggt gataagttat atgctgttgg
     3061 ggggtatgat ggacaggcat accttaatac tgtggaggct tatgatcccc agacaaatga
     3121 gtggacccag gttgctccac tgtgcctagg aagagctgga gcttgtgttg tgactgtaaa
     3181 attataattt agtgccccgt tttctacatg aagacaccgt cttcctttat taatttagta
     3241 taattattct atcaatggat acatttttag taaatgtgca ttgtcacaat cctgggcaca
     3301 aagtgcctga tgtcaaaatg aagatagtaa aacaagggag gaagcagtgg atggaccagg
     3361 attaattcct ttcatttctt agtaaattaa aacctgcagc tggtggattg tgatcacaca
     3421 ttcccgaagt aataagtgag gacgaatgca ctgctctgga acataaccca gtgctaactg
     3481 ggggtttcat ttattcagtc aagcacatct tactcacatc cagatttatt ttcctacagt
     3541 gcaaacacac cagatgaaac tttaaaatgt tactttttgt aagcttatca taaatgagtt
     3601 gcagtaattt gtttgcttgt ttgtttaacc acaaccacta ttttaatgat atactaaaga
     3661 taacactatt tagttttttc agaaacatct gcattatatg tgtgttggtt gtggattttg
     3721 tttctaaaat tggcttagtc caataaataa agaaaagcat taaggactta aagcaacaat
     3781 aaccaaataa aaacttgata ggatctttga agtctattta aatattcatt ccattacatc
     3841 tagactcacc aagaactaca tgttatgatg ttaagttgaa gttgaaacat gatgttttgc
     3901 attaaattta agatatgcaa atttatgtag agaaaataaa tgttatatac cctataatct
     3961 ttcacctaat tagtatttaa ttatatggat ttgttttata ttataaaaga tgttttgatt
     4021 ttgtcttttg atattgacaa aattgtttgg atatccttat gttctcaagt ctgtatctgc
     4081 ctcccctgcc ttatttctta tgttttgcca cagttaaccc attgtgcttc tttgtaatca
     4141 aacagtttgt gggagaatgg gcttattgaa tgtctaaaaa ataagtttaa agtgtttgtt
     4201 accctaagtt ttttacattt ttaaactcta attacatatg tgaatgttat tactctcagt
     4261 gaattgttat tgtttgcaaa aatgcactgg gcagtaacat tttgtgataa atcctataag
     4321 atataagtca ttgagatgtc taagatgctt tttattttaa ccccagttaa taaccacctt
     4381 acggaaaata atatttgcta atattgttta ttgtgaacta ggaatcaaag tttttgtatg
     4441 catcaatgca cttaatcctt ataacaacct tatgaggtag ttctattccc tttttatagc
     4501 taaggaaatt ggggtacaga gaagttagcc ccaaggttat atattgcaag taagtggcag
     4561 agcagggatt catacaaaga ccttctcact cagcagtctt cactcttact attcctgcca
     4621 ctaggtagaa aaagaaagat ttcggccggg cacagtggct cacgcctata attcccagca
     4681 ctttgggagg ctgaggtggg cggatcacga ggtcaggaga tggagaccat cctggctaac
     4741 acagtgaaac cccgtctcta ctaaaaataa aaaataaaaa aaaattagcc aggcgtggtg
     4801 gcgggtgcct gtacgcccag ctactcggga ggctgaggcg ggagaatggc gtgaacccag
     4861 gaggaggagc ttgcagtgtg ccaagatcgc accactgcac tccagcctgg gtgacagagc
     4921 gagactccat caaaaaaaaa taaataaaaa aaaaataaaa gatttcattt tatgtgagga
     4981 attattttaa taaaaaaaag agggtttatg ctctatagta ataaaattta ccagtaacac
     5041 ccaatcagaa aattttggtt ccttagtatt tagggaagac ttttgtttaa atctcttatg
     5101 gaattttaca tgttttgatt tagaaaagta gatgcaatat aatatatttc aagttttata
     5161 catattagat gaattgcatg gtattttagg caacttaact ataaacaaat ttattcatag
     5221 aagcattgtt gccaacaatt tagatgacct cgatgaaaaa acacaccaat tgacaaaact
     5281 ggctcaaaag gaaataaaaa atccaaacag acctgtaaca agtaaagaga ttgaaccagt
     5341 aatcaaaaat ctcccaacaa agaaagtcca ggactaaatg agtttactgg caaactatgc
     5401 caaacatata aagaagaatt aacactaatc cttctcgaac tctcccaaaa aatggaagag
     5461 aaaggagcac cctgtgacat tctataaggc ggacattacc ttaacaccaa agccagacaa
     5521 agacctcaca gggaagctac agaccaatat cccttatgaa tatagatgca aaaaaacttc
     5581 aaaatactag caggccaaat ccagcagctt attaaaatga tcacacagca tgaccaagtg
     5641 agatttatca aagaaatgca gggatggttc tacatacaaa tgtcaatcga tgtaataata
     5701 taccatatta atagaatgaa ggggaaaaaa cagcatgatc acctcaattg ataagaaaaa
     5761 gcatttgaca aaaatccaac accctttcat ggtaaaaaca ctctgcaaac taggaagaaa
     5821 agggaacttt cttaacctga taaagacatc cataaaaacc cacagctaac aacataatag
     5881 caaaacattg aaaatttttc ccctaatatc atgaaaattc ctgatttccc cactgctatt
     5941 caacattata ctagaaggtc tagccagagc aattaggcaa gaaaaagaaa taaaatgaat
     6001 cccaaatagg aagaagtaaa actacatttg cagaaaacat ggtcctatat attaaaaatc
     6061 ctaaagaatc cacaaaatga ttccggctga ttttaaaaat tcagcaatgt tgcaggttgc
     6121 aagatcaaca cacaaaagtc taagaaaaac ctgaggggaa attaaaacaa tttcatttac
     6181 aataacatga aaaagaataa aatacttaga aataaatttg accaagaaag tgcaagactt
     6241 ggacactgaa aagtacaaaa cgttgctgaa agaaattaaa gaagacctaa ataaatggaa
     6301 gacatcctgt gctggcaggt tggaagactt aacattgtta agatggcatt actcccaaaa
     6361 ttagtctata gatttaatac aatccccatt aaaattccag tgaccctttt acagaaactg
     6421 aaaagctgac cctagaattt atatgggatt gcaagttact gaaggtactc aagtctgttc
     6481 aaaacaatct tgaacaagaa taaagttgaa ggactcacat tttccaattt caaaatttac
     6541 tgcaaagcta cttcaatcaa aacagtgttg tgctggtata aaaatatata aagcaataga
     6601 gtagaatgga aagtccagaa acaaattacg ccaatacact atggtcaatt gatttttgac
     6661 aagggttcca ggaccattca atgaagaaag aacagtgtct tcaactaata gtgctaagac
     6721 aagtgaatat tcacatgcaa aagaatgaat ttgtacctgt acttcatacc atatataaaa
     6781 attaattcaa aatagatcaa agacctaaat gtaagagcta aaaccataaa actttgagaa
     6841 gaaaatacag gaataaatct tcatgacctt ggatttggca atggtttctt agatatggca
     6901 ccaaaagcac aagcaacaac agcaaaaaaa aaaaaaaaaa aaaaaaatca aaattaaaag
     6961 cttctacata tcaagggaca ctatgaagaa agtgaaaaga caacccacag aatgggagaa
     7021 aatatttgta aatcttacat atctggtaag gaactaatac ctagaatata taaggaactc
     7081 cgatgctcga caacaaaaag acaaaccaat tttaaaatgg gcaaaggact taaatagaca
     7141 tttctctaat gaagatatac aaatggccga caagcacatg gaaagcactc aacctcatca
     7201 gtcattatgc aaatcagcgc cacaagaaga taccacttca cacctattag aatgacgaaa
     7261 tagacctagg atctaaacct acaggaaaaa aaatgaataa tagagaaaat aaatgttaga
     7321 gaggatgtgg agaaattgaa aaccttcatt cgttgttggt gggaatgtta aatggtgtag
     7381 ccactgtgga aaacagtttg gcagttcctc aataagttaa aaaaaagaat taccatatga
     7441 cccagcaagt ccactcctgg gcatatactg aaaagaactg aaaacaggtg ttcaagcaaa
     7501 aactttcacg caaatattca ttgcagcact agtcacagta gccaaaaaag aggaaacaac
     7561 ccaaatggcc atcagctgat gaatgaataa acaaattgtg gtatctccac acggcacaat
     7621 agaatattca gccataaaga gaaatgaggg actgatacat gctaaagcat ggatgagcct
     7681 tgagcgcatt tttgccaagt gaaagaaggc agacacaaaa ggcaacgtat tgcatgagtg
     7741 catttatatg aaatatccaa aataggcaaa tccatggaga cagaaagcag ataaatggtt
     7801 gtaagaagct gagagaaagg agtggggaga gattgctaaa aaggagtttc cttctagggt
     7861 gatgaaaatg ttctggaact acttattggg gatgattgca caacatggtg aaggtactca
     7921 atgtcactaa tggtaaattt cacatacact ttaccataat ttttaaaaag ctttattagc
     7981 tacattatgt tatgatactt aaatgtcata acaatagcat tctgtacgct tcactaggat
     8041 aaaaacttcg gatttatatg catctggaag agaaattttt cactgtaatt tgcaaataaa
     8101 tgaatttcta aaaatctaac agaaaggctc ttaaatctta atttcaacct aagaagggag
     8161 tgagaaacaa cgagaaccat gaggggagag ttaacgggga acttccccac cgtccggtac
     8221 atggcaggca ttccacaaat gttttctgaa agttgaaata gacatctttt catgaactct
     8281 gtaatatttg aaattattga taactcttac acaaaaacaa atattcaata aaatgatatt
     8341 taatttcact gtga
//
