LOCUS       NM_015990               7718 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens kelch like family member 5 (KLHL5), transcript variant
            1, mRNA.
ACCESSION   NM_015990
VERSION     NM_015990.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7718)
  AUTHORS   Swaney,D.L., Ramms,D.J., Wang,Z., Park,J., Goto,Y., Soucheray,M.,
            Bhola,N., Kim,K., Zheng,F., Zeng,Y., McGregor,M., Herrington,K.A.,
            O'Keefe,R., Jin,N., VanLandingham,N.K., Foussard,H., Von Dollen,J.,
            Bouhaddou,M., Jimenez-Morales,D., Obernier,K., Kreisberg,J.F.,
            Kim,M., Johnson,D.E., Jura,N., Grandis,J.R., Gutkind,J.S.,
            Ideker,T. and Krogan,N.J.
  TITLE     A protein network map of head and neck cancer reveals PIK3CA mutant
            drug sensitivity
  JOURNAL   Science 374 (6563), eabf2911 (2021)
   PUBMED   34591642
REFERENCE   2  (bases 1 to 7718)
  AUTHORS   Powell,J.A., Pitman,M.R., Zebol,J.R., Moretti,P.A.B.,
            Neubauer,H.A., Davies,L.T., Lewis,A.C., Dagley,L.F., Webb,A.I.,
            Costabile,M. and Pitson,S.M.
  TITLE     Kelch-like protein 5-mediated ubiquitination of lysine 183 promotes
            proteasomal degradation of sphingosine kinase 1
  JOURNAL   Biochem J 476 (21), 3211-3226 (2019)
   PUBMED   31652307
  REMARK    GeneRIF: KLHL5/Cul3-based E3 ubiquitin ligase complex is important
            for regulation of SK1 protein stability via Lys183 ubiquitination.
REFERENCE   3  (bases 1 to 7718)
  AUTHORS   Mena,E.L., Kjolby,R.A.S., Saxton,R.A., Werner,A., Lew,B.G.,
            Boyle,J.M., Harland,R. and Rape,M.
  TITLE     Dimerization quality control ensures neuronal development and
            survival
  JOURNAL   Science 362 (6411) (2018)
   PUBMED   30190310
REFERENCE   4  (bases 1 to 7718)
  AUTHORS   Ding,L., Abebe,T., Beyene,J., Wilke,R.A., Goldberg,A., Woo,J.G.,
            Martin,L.J., Rothenberg,M.E., Rao,M., Hershey,G.K., Chakraborty,R.
            and Mersha,T.B.
  TITLE     Rank-based genome-wide analysis reveals the association of
            ryanodine receptor-2 gene variants with childhood asthma among
            human populations
  JOURNAL   Hum Genomics 7 (1), 16 (2013)
   PUBMED   23829686
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7718)
  AUTHORS   Dhanoa,B.S., Cogliati,T., Satish,A.G., Bruford,E.A. and
            Friedman,J.S.
  TITLE     Update on the Kelch-like (KLHL) gene family
  JOURNAL   Hum Genomics 7 (1), 13 (2013)
   PUBMED   23676014
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7718)
  AUTHORS   Wang,J., Huo,K., Ma,L., Tang,L., Li,D., Huang,X., Yuan,Y., Li,C.,
            Wang,W., Guan,W., Chen,H., Jin,C., Wei,J., Zhang,W., Yang,Y.,
            Liu,Q., Zhou,Y., Zhang,C., Wu,Z., Xu,W., Zhang,Y., Liu,T., Yu,D.,
            Zhang,Y., Chen,L., Zhu,D., Zhong,X., Kang,L., Gan,X., Yu,X., Ma,Q.,
            Yan,J., Zhou,L., Liu,Z., Zhu,Y., Zhou,T., He,F. and Yang,X.
  TITLE     Toward an understanding of the protein interaction network of the
            human liver
  JOURNAL   Mol Syst Biol 7, 536 (2011)
   PUBMED   21988832
  REMARK    Erratum:[Mol Syst Biol. 2017 Dec 18;13(12):965. doi:
            10.15252/msb.20178107.. PMID: 29254952]
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 7718)
  AUTHORS   Charles,B.A., Shriner,D., Doumatey,A., Chen,G., Zhou,J., Huang,H.,
            Herbert,A., Gerry,N.P., Christman,M.F., Adeyemo,A. and Rotimi,C.N.
  TITLE     A genome-wide association study of serum uric acid in African
            Americans
  JOURNAL   BMC Med Genomics 4, 17 (2011)
   PUBMED   21294900
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 7718)
  AUTHORS   Bennett,E.J., Rush,J., Gygi,S.P. and Harper,J.W.
  TITLE     Dynamics of cullin-RING ubiquitin ligase network revealed by
            systematic quantitative proteomics
  JOURNAL   Cell 143 (6), 951-965 (2010)
   PUBMED   21145461
REFERENCE   9  (bases 1 to 7718)
  AUTHORS   Xu,J., Gu,S., Wang,S., Dai,J., Ji,C., Jin,Y., Qian,J., Wang,L.,
            Ye,X., Xie,Y. and Mao,Y.
  TITLE     Characterization of a novel splicing variant of KLHL5, a member of
            the kelch protein family
  JOURNAL   Mol Biol Rep 30 (4), 239-242 (2003)
   PUBMED   14672410
  REMARK    GeneRIF: Data report a novel splicing variant of KLHL5, named
            KLHL5b, and describe its expression pattern in many tissues.
REFERENCE   10 (bases 1 to 7718)
  AUTHORS   Wang,S., Zhou,Z., Ying,K., Tang,R., Huang,Y., Wu,C., Xie,Y. and
            Mao,Y.
  TITLE     Cloning and characterization of KLHL5, a novel human gene encoding
            a kelch-related protein with a BTB domain
  JOURNAL   Biochem Genet 39 (7-8), 227-238 (2001)
   PUBMED   11590829
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC079921.5.
            
            On Jul 10, 2020 this sequence version replaced NM_015990.4.
            
            Transcript Variant: This variant (1), also known as KLHL5a,
            represents the longest transcript and encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK289785.1, SRR1660807.193738.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000504108.7/
                                                ENSP00000423897.2
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-804               AC079921.5         109147-109950
            805-987             AC079921.5         122880-123062
            988-1124            AC079921.5         128018-128154
            1125-1321           AC079921.5         128878-129074
            1322-1534           AC079921.5         133430-133642
            1535-1721           AC079921.5         143607-143793
            1722-1946           AC079921.5         150202-150426
            1947-2109           AC079921.5         154484-154646
            2110-2322           AC079921.5         159935-160147
            2323-2494           AC079921.5         162074-162245
            2495-7718           AC079921.5         167925-173148
FEATURES             Location/Qualifiers
     source          1..7718
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p14"
     gene            1..7718
                     /gene="KLHL5"
                     /note="kelch like family member 5"
                     /db_xref="GeneID:51088"
                     /db_xref="HGNC:HGNC:6356"
                     /db_xref="MIM:608064"
     exon            1..804
                     /gene="KLHL5"
                     /inference="alignment:Splign:2.1.0"
     CDS             422..2551
                     /gene="KLHL5"
                     /note="isoform 1 is encoded by transcript variant 1;
                     lymphocyte activation-associated protein; kelch-like
                     protein 5"
                     /codon_start=1
                     /product="kelch-like protein 5 isoform 1"
                     /protein_id="NP_057074.4"
                     /db_xref="CCDS:CCDS33975.1"
                     /db_xref="GeneID:51088"
                     /db_xref="HGNC:HGNC:6356"
                     /db_xref="MIM:608064"
                     /translation="MSGSRKEFDVKQILKIRWRWFGHQASSPNSTVDSQQGEFWNRGQ
                     TGANGGRKFLDPCSLQLPLASIGYRRSSQLDFQNSPSWPMASTSEVPAFEFTAEDCGG
                     AHWLDRPEVDDGTSEEENESDSSSCRTSNSSQTLSSCHTMEPCTSDEFFQALNHAEQT
                     FKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKME
                     GVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNC
                     LGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNE
                     ETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFLADMENNVLFRDDIECQKLI
                     MEAMKYHLLPERRPMLQSPRTKPRKSTVGTLFAVGGMDSTKGATSIEKYDLRTNMWTP
                     VANMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGL
                     GVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYA
                     VGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNL
                     TSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAY
                     DPQTNEWTQVAPLCLGRAGACVVTVKL"
     exon            805..987
                     /gene="KLHL5"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1124
                     /gene="KLHL5"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..1321
                     /gene="KLHL5"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1534
                     /gene="KLHL5"
                     /inference="alignment:Splign:2.1.0"
     exon            1535..1721
                     /gene="KLHL5"
                     /inference="alignment:Splign:2.1.0"
     exon            1722..1946
                     /gene="KLHL5"
                     /inference="alignment:Splign:2.1.0"
     exon            1947..2109
                     /gene="KLHL5"
                     /inference="alignment:Splign:2.1.0"
     exon            2110..2322
                     /gene="KLHL5"
                     /inference="alignment:Splign:2.1.0"
     exon            2323..2494
                     /gene="KLHL5"
                     /inference="alignment:Splign:2.1.0"
     exon            2495..7718
                     /gene="KLHL5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3670..3675
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLHL5"
                     /note="hexamer: GATAAA"
     polyA_site      3694
                     /gene="KLHL5"
                     /note="major polyA site"
     regulatory      7463..7468
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLHL5"
                     /note="hexamer: AATGAA"
     polyA_site      7483
                     /gene="KLHL5"
                     /note="major polyA site"
     regulatory      7691..7696
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLHL5"
                     /note="hexamer: AATAAA"
     polyA_site      7718
                     /gene="KLHL5"
ORIGIN      
        1 actgcaacgg ggatagtgtt ttctgtctct gtcatttgtg gtttaagaaa aagggggtgg
       61 tgttctgcat ttgaaaggac tttaatgaat gctgtcagtg tttgtgagac ctaatggtca
      121 gtatgggaaa ggagagccgg gaaagtggtc tagctgcttc aggataggtg gatgagagtt
      181 tgctctgatt gaacggaatg ttccaccgtg tttcatcttt attcattatc ctttgttctt
      241 taaaatctga tatattggca taaaagtaat tgtagatata tatatgaatg tgatttattt
      301 tcctttacat atttttgttg tgtacagcag ggcatatact tctcttgtct tggttggatg
      361 cacaaatctg tgtgcagtgc tttttgcccg ttgcctagac gatcacttgg tttctctgag
      421 gatgtctggt tctcgtaaag agtttgatgt gaaacagatt ttgaaaatca gatggaggtg
      481 gtttggtcat caagcatcat ctcctaattc tacagttgac agccagcagg gagaattttg
      541 gaaccgagga cagactggag caaacggtgg gagaaagttt ttagatccat gtagcctaca
      601 attgcctttg gcttcaattg gttaccgaag gtccagccaa ctggattttc agaattcacc
      661 ttcttggcca atggcatcca cctctgaagt ccctgcattt gagtttacag cagaagattg
      721 tggcggtgca cattggctgg atagaccaga agtggatgat ggcactagtg aagaagaaaa
      781 tgaatctgat tccagttcat gcaggacttc caatagtagt cagacattat catcctgtca
      841 tactatggag ccatgtacat cagatgaatt tttccaagcc cttaatcatg ccgagcaaac
      901 atttaaaaaa atggaaaact atttgagaca taaacagttg tgtgatgtaa ttttagtcgc
      961 tggtgatcgc agaattccag ctcacagatt ggtgctctcc tctgtctcag actattttgc
     1021 tgccatgttt actaatgatg tcagagaggc aagacaagaa gaaataaaaa tggaaggtgt
     1081 agaaccaaat tcgttgtggt ccttgatcca gtatgcttat acaggccgcc ttgaattaaa
     1141 agaagataat attgagtgcc tgttatctac agcttgcctt cttcagcttt cacaggttgt
     1201 agaagcatgc tgtaagtttt taatgaaaca gcttcatcca tccaactgtc ttggaattcg
     1261 ttcttttgct gatgcccaag gttgtacaga tttgcataaa gtggctcaca attatactat
     1321 ggagcatttc atggaagtaa tcagaaacca ggaatttgta ttattaccag ccagcgaaat
     1381 tgcaaagctc ttggctagtg atgacatgaa cattcctaat gaggagacaa tattgaatgc
     1441 acttcttact tgggtccgtc atgatttgga acagagacgg aaagatctaa gtaaactttt
     1501 ggcttatatt aggctacctc ttcttgcacc acagttcctg gcagacatgg aaaataatgt
     1561 actttttcgg gatgatatag aatgtcagaa actcattatg gaagcaatga agtaccattt
     1621 attaccagag agacgaccca tgttacaaag tcctcggaca aaacctagga agtcaactgt
     1681 tggtacatta tttgcagttg ggggaatgga ttcaacaaaa ggagcaacaa gcattgaaaa
     1741 gtatgatctc cgtacaaata tgtggactcc agtagcaaat atgaatggga ggaggctaca
     1801 gttcggtgtt gcagtgctag atgacaaact gtatgtggtt ggaggaagag atggactgaa
     1861 gactttgaat actgtagagt gctacaaccc caaaacaaaa acttggagtg tgatgccacc
     1921 tatgtccaca catagacatg gccttggtgt ggctgtactg gaaggtccca tgtatgccgt
     1981 aggaggacat gatggctgga gctatctgaa cacagtggaa agatgggacc ctcaggctcg
     2041 ccagtggaat tttgttgcca ctatgtctac ccctaggagt acagtaggtg tggcagtact
     2101 aagtggaaaa ctttatgcag ttggtggtcg tgatggaagt tcttgtctca aatcagtaga
     2161 atgttttgat cctcatacta ataagtggac actgtgtgca cagatgtcaa aaaggagagg
     2221 tggcgtagga gtgacgacct ggaatggact gctgtatgct ataggggggc acgatgctcc
     2281 cgcatccaac ttgacttcca gactctcaga ctgtgtggaa agatatgatc ccaaaacaga
     2341 catgtggact gcagtagcat ccatgagcat cagcagagat gcagtggggg tctgtttact
     2401 tggtgataag ttatatgctg ttggggggta tgatggacag gcatacctta atactgtgga
     2461 ggcttatgat ccccagacaa atgagtggac ccaggttgct ccactgtgcc taggaagagc
     2521 tggagcttgt gttgtgactg taaaattata atttagtgcc ccgttttcta catgaagaca
     2581 ccgtcttcct ttattaattt agtataatta ttctatcaat ggatacattt ttagtaaatg
     2641 tgcattgtca caatcctggg cacaaagtgc ctgatgtcaa aatgaagata gtaaaacaag
     2701 ggaggaagca gtggatggac caggattaat tcctttcatt tcttagtaaa ttaaaacctg
     2761 cagctggtgg attgtgatca cacattcccg aagtaataag tgaggacgaa tgcactgctc
     2821 tggaacataa cccagtgcta actgggggtt tcatttattc agtcaagcac atcttactca
     2881 catccagatt tattttccta cagtgcaaac acaccagatg aaactttaaa atgttacttt
     2941 ttgtaagctt atcataaatg agttgcagta atttgtttgc ttgtttgttt aaccacaacc
     3001 actattttaa tgatatacta aagataacac tatttagttt tttcagaaac atctgcatta
     3061 tatgtgtgtt ggttgtggat tttgtttcta aaattggctt agtccaataa ataaagaaaa
     3121 gcattaagga cttaaagcaa caataaccaa ataaaaactt gataggatct ttgaagtcta
     3181 tttaaatatt cattccatta catctagact caccaagaac tacatgttat gatgttaagt
     3241 tgaagttgaa acatgatgtt ttgcattaaa tttaagatat gcaaatttat gtagagaaaa
     3301 taaatgttat ataccctata atctttcacc taattagtat ttaattatat ggatttgttt
     3361 tatattataa aagatgtttt gattttgtct tttgatattg acaaaattgt ttggatatcc
     3421 ttatgttctc aagtctgtat ctgcctcccc tgccttattt cttatgtttt gccacagtta
     3481 acccattgtg cttctttgta atcaaacagt ttgtgggaga atgggcttat tgaatgtcta
     3541 aaaaataagt ttaaagtgtt tgttacccta agttttttac atttttaaac tctaattaca
     3601 tatgtgaatg ttattactct cagtgaattg ttattgtttg caaaaatgca ctgggcagta
     3661 acattttgtg ataaatccta taagatataa gtcattgaga tgtctaagat gctttttatt
     3721 ttaaccccag ttaataacca ccttacggaa aataatattt gctaatattg tttattgtga
     3781 actaggaatc aaagtttttg tatgcatcaa tgcacttaat ccttataaca accttatgag
     3841 gtagttctat tcccttttta tagctaagga aattggggta cagagaagtt agccccaagg
     3901 ttatatattg caagtaagtg gcagagcagg gattcataca aagaccttct cactcagcag
     3961 tcttcactct tactattcct gccactaggt agaaaaagaa agatttcggc cgggcacagt
     4021 ggctcacgcc tataattccc agcactttgg gaggctgagg tgggcggatc acgaggtcag
     4081 gagatggaga ccatcctggc taacacagtg aaaccccgtc tctactaaaa ataaaaaata
     4141 aaaaaaaatt agccaggcgt ggtggcgggt gcctgtacgc ccagctactc gggaggctga
     4201 ggcgggagaa tggcgtgaac ccaggaggag gagcttgcag tgtgccaaga tcgcaccact
     4261 gcactccagc ctgggtgaca gagcgagact ccatcaaaaa aaaataaata aaaaaaaaat
     4321 aaaagatttc attttatgtg aggaattatt ttaataaaaa aaagagggtt tatgctctat
     4381 agtaataaaa tttaccagta acacccaatc agaaaatttt ggttccttag tatttaggga
     4441 agacttttgt ttaaatctct tatggaattt tacatgtttt gatttagaaa agtagatgca
     4501 atataatata tttcaagttt tatacatatt agatgaattg catggtattt taggcaactt
     4561 aactataaac aaatttattc atagaagcat tgttgccaac aatttagatg acctcgatga
     4621 aaaaacacac caattgacaa aactggctca aaaggaaata aaaaatccaa acagacctgt
     4681 aacaagtaaa gagattgaac cagtaatcaa aaatctccca acaaagaaag tccaggacta
     4741 aatgagttta ctggcaaact atgccaaaca tataaagaag aattaacact aatccttctc
     4801 gaactctccc aaaaaatgga agagaaagga gcaccctgtg acattctata aggcggacat
     4861 taccttaaca ccaaagccag acaaagacct cacagggaag ctacagacca atatccctta
     4921 tgaatataga tgcaaaaaaa cttcaaaata ctagcaggcc aaatccagca gcttattaaa
     4981 atgatcacac agcatgacca agtgagattt atcaaagaaa tgcagggatg gttctacata
     5041 caaatgtcaa tcgatgtaat aatataccat attaatagaa tgaaggggaa aaaacagcat
     5101 gatcacctca attgataaga aaaagcattt gacaaaaatc caacaccctt tcatggtaaa
     5161 aacactctgc aaactaggaa gaaaagggaa ctttcttaac ctgataaaga catccataaa
     5221 aacccacagc taacaacata atagcaaaac attgaaaatt tttcccctaa tatcatgaaa
     5281 attcctgatt tccccactgc tattcaacat tatactagaa ggtctagcca gagcaattag
     5341 gcaagaaaaa gaaataaaat gaatcccaaa taggaagaag taaaactaca tttgcagaaa
     5401 acatggtcct atatattaaa aatcctaaag aatccacaaa atgattccgg ctgattttaa
     5461 aaattcagca atgttgcagg ttgcaagatc aacacacaaa agtctaagaa aaacctgagg
     5521 ggaaattaaa acaatttcat ttacaataac atgaaaaaga ataaaatact tagaaataaa
     5581 tttgaccaag aaagtgcaag acttggacac tgaaaagtac aaaacgttgc tgaaagaaat
     5641 taaagaagac ctaaataaat ggaagacatc ctgtgctggc aggttggaag acttaacatt
     5701 gttaagatgg cattactccc aaaattagtc tatagattta atacaatccc cattaaaatt
     5761 ccagtgaccc ttttacagaa actgaaaagc tgaccctaga atttatatgg gattgcaagt
     5821 tactgaaggt actcaagtct gttcaaaaca atcttgaaca agaataaagt tgaaggactc
     5881 acattttcca atttcaaaat ttactgcaaa gctacttcaa tcaaaacagt gttgtgctgg
     5941 tataaaaata tataaagcaa tagagtagaa tggaaagtcc agaaacaaat tacgccaata
     6001 cactatggtc aattgatttt tgacaagggt tccaggacca ttcaatgaag aaagaacagt
     6061 gtcttcaact aatagtgcta agacaagtga atattcacat gcaaaagaat gaatttgtac
     6121 ctgtacttca taccatatat aaaaattaat tcaaaataga tcaaagacct aaatgtaaga
     6181 gctaaaacca taaaactttg agaagaaaat acaggaataa atcttcatga ccttggattt
     6241 ggcaatggtt tcttagatat ggcaccaaaa gcacaagcaa caacagcaaa aaaaaaaaaa
     6301 aaaaaaaaaa atcaaaatta aaagcttcta catatcaagg gacactatga agaaagtgaa
     6361 aagacaaccc acagaatggg agaaaatatt tgtaaatctt acatatctgg taaggaacta
     6421 atacctagaa tatataagga actccgatgc tcgacaacaa aaagacaaac caattttaaa
     6481 atgggcaaag gacttaaata gacatttctc taatgaagat atacaaatgg ccgacaagca
     6541 catggaaagc actcaacctc atcagtcatt atgcaaatca gcgccacaag aagataccac
     6601 ttcacaccta ttagaatgac gaaatagacc taggatctaa acctacagga aaaaaaatga
     6661 ataatagaga aaataaatgt tagagaggat gtggagaaat tgaaaacctt cattcgttgt
     6721 tggtgggaat gttaaatggt gtagccactg tggaaaacag tttggcagtt cctcaataag
     6781 ttaaaaaaaa gaattaccat atgacccagc aagtccactc ctgggcatat actgaaaaga
     6841 actgaaaaca ggtgttcaag caaaaacttt cacgcaaata ttcattgcag cactagtcac
     6901 agtagccaaa aaagaggaaa caacccaaat ggccatcagc tgatgaatga ataaacaaat
     6961 tgtggtatct ccacacggca caatagaata ttcagccata aagagaaatg agggactgat
     7021 acatgctaaa gcatggatga gccttgagcg catttttgcc aagtgaaaga aggcagacac
     7081 aaaaggcaac gtattgcatg agtgcattta tatgaaatat ccaaaatagg caaatccatg
     7141 gagacagaaa gcagataaat ggttgtaaga agctgagaga aaggagtggg gagagattgc
     7201 taaaaaggag tttccttcta gggtgatgaa aatgttctgg aactacttat tggggatgat
     7261 tgcacaacat ggtgaaggta ctcaatgtca ctaatggtaa atttcacata cactttacca
     7321 taatttttaa aaagctttat tagctacatt atgttatgat acttaaatgt cataacaata
     7381 gcattctgta cgcttcacta ggataaaaac ttcggattta tatgcatctg gaagagaaat
     7441 ttttcactgt aatttgcaaa taaatgaatt tctaaaaatc taacagaaag gctcttaaat
     7501 cttaatttca acctaagaag ggagtgagaa acaacgagaa ccatgagggg agagttaacg
     7561 gggaacttcc ccaccgtccg gtacatggca ggcattccac aaatgttttc tgaaagttga
     7621 aatagacatc ttttcatgaa ctctgtaata tttgaaatta ttgataactc ttacacaaaa
     7681 acaaatattc aataaaatga tatttaattt cactgtga
//
