LOCUS       NP_057074                709 aa            linear   PRI 10-FEB-2025
DEFINITION  kelch-like protein 5 isoform 1 [Homo sapiens].
ACCESSION   NP_057074
VERSION     NP_057074.4
DBSOURCE    REFSEQ: accession NM_015990.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 709)
  AUTHORS   Swaney,D.L., Ramms,D.J., Wang,Z., Park,J., Goto,Y., Soucheray,M.,
            Bhola,N., Kim,K., Zheng,F., Zeng,Y., McGregor,M., Herrington,K.A.,
            O'Keefe,R., Jin,N., VanLandingham,N.K., Foussard,H., Von Dollen,J.,
            Bouhaddou,M., Jimenez-Morales,D., Obernier,K., Kreisberg,J.F.,
            Kim,M., Johnson,D.E., Jura,N., Grandis,J.R., Gutkind,J.S.,
            Ideker,T. and Krogan,N.J.
  TITLE     A protein network map of head and neck cancer reveals PIK3CA mutant
            drug sensitivity
  JOURNAL   Science 374 (6563), eabf2911 (2021)
   PUBMED   34591642
REFERENCE   2  (residues 1 to 709)
  AUTHORS   Powell,J.A., Pitman,M.R., Zebol,J.R., Moretti,P.A.B.,
            Neubauer,H.A., Davies,L.T., Lewis,A.C., Dagley,L.F., Webb,A.I.,
            Costabile,M. and Pitson,S.M.
  TITLE     Kelch-like protein 5-mediated ubiquitination of lysine 183 promotes
            proteasomal degradation of sphingosine kinase 1
  JOURNAL   Biochem J 476 (21), 3211-3226 (2019)
   PUBMED   31652307
  REMARK    GeneRIF: KLHL5/Cul3-based E3 ubiquitin ligase complex is important
            for regulation of SK1 protein stability via Lys183 ubiquitination.
REFERENCE   3  (residues 1 to 709)
  AUTHORS   Mena,E.L., Kjolby,R.A.S., Saxton,R.A., Werner,A., Lew,B.G.,
            Boyle,J.M., Harland,R. and Rape,M.
  TITLE     Dimerization quality control ensures neuronal development and
            survival
  JOURNAL   Science 362 (6411) (2018)
   PUBMED   30190310
REFERENCE   4  (residues 1 to 709)
  AUTHORS   Ding,L., Abebe,T., Beyene,J., Wilke,R.A., Goldberg,A., Woo,J.G.,
            Martin,L.J., Rothenberg,M.E., Rao,M., Hershey,G.K., Chakraborty,R.
            and Mersha,T.B.
  TITLE     Rank-based genome-wide analysis reveals the association of
            ryanodine receptor-2 gene variants with childhood asthma among
            human populations
  JOURNAL   Hum Genomics 7 (1), 16 (2013)
   PUBMED   23829686
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 709)
  AUTHORS   Dhanoa,B.S., Cogliati,T., Satish,A.G., Bruford,E.A. and
            Friedman,J.S.
  TITLE     Update on the Kelch-like (KLHL) gene family
  JOURNAL   Hum Genomics 7 (1), 13 (2013)
   PUBMED   23676014
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 709)
  AUTHORS   Wang,J., Huo,K., Ma,L., Tang,L., Li,D., Huang,X., Yuan,Y., Li,C.,
            Wang,W., Guan,W., Chen,H., Jin,C., Wei,J., Zhang,W., Yang,Y.,
            Liu,Q., Zhou,Y., Zhang,C., Wu,Z., Xu,W., Zhang,Y., Liu,T., Yu,D.,
            Zhang,Y., Chen,L., Zhu,D., Zhong,X., Kang,L., Gan,X., Yu,X., Ma,Q.,
            Yan,J., Zhou,L., Liu,Z., Zhu,Y., Zhou,T., He,F. and Yang,X.
  TITLE     Toward an understanding of the protein interaction network of the
            human liver
  JOURNAL   Mol Syst Biol 7, 536 (2011)
   PUBMED   21988832
  REMARK    Erratum:[Mol Syst Biol. 2017 Dec 18;13(12):965. doi:
            10.15252/msb.20178107.. PMID: 29254952]
            Publication Status: Online-Only
REFERENCE   7  (residues 1 to 709)
  AUTHORS   Charles,B.A., Shriner,D., Doumatey,A., Chen,G., Zhou,J., Huang,H.,
            Herbert,A., Gerry,N.P., Christman,M.F., Adeyemo,A. and Rotimi,C.N.
  TITLE     A genome-wide association study of serum uric acid in African
            Americans
  JOURNAL   BMC Med Genomics 4, 17 (2011)
   PUBMED   21294900
  REMARK    Publication Status: Online-Only
REFERENCE   8  (residues 1 to 709)
  AUTHORS   Bennett,E.J., Rush,J., Gygi,S.P. and Harper,J.W.
  TITLE     Dynamics of cullin-RING ubiquitin ligase network revealed by
            systematic quantitative proteomics
  JOURNAL   Cell 143 (6), 951-965 (2010)
   PUBMED   21145461
REFERENCE   9  (residues 1 to 709)
  AUTHORS   Xu,J., Gu,S., Wang,S., Dai,J., Ji,C., Jin,Y., Qian,J., Wang,L.,
            Ye,X., Xie,Y. and Mao,Y.
  TITLE     Characterization of a novel splicing variant of KLHL5, a member of
            the kelch protein family
  JOURNAL   Mol Biol Rep 30 (4), 239-242 (2003)
   PUBMED   14672410
  REMARK    GeneRIF: Data report a novel splicing variant of KLHL5, named
            KLHL5b, and describe its expression pattern in many tissues.
REFERENCE   10 (residues 1 to 709)
  AUTHORS   Wang,S., Zhou,Z., Ying,K., Tang,R., Huang,Y., Wu,C., Xie,Y. and
            Mao,Y.
  TITLE     Cloning and characterization of KLHL5, a novel human gene encoding
            a kelch-related protein with a BTB domain
  JOURNAL   Biochem Genet 39 (7-8), 227-238 (2001)
   PUBMED   11590829
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC079921.5.
            
            On Jul 10, 2020 this sequence version replaced NP_057074.3.
            
            Transcript Variant: This variant (1), also known as KLHL5a,
            represents the longest transcript and encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK289785.1, SRR1660807.193738.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000504108.7/
                                                ENSP00000423897.2
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..709
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p14"
     Protein         1..709
                     /product="kelch-like protein 5 isoform 1"
                     /note="lymphocyte activation-associated protein;
                     kelch-like protein 5"
                     /calculated_mol_wt=79097
     Region          174..696
                     /region_name="PHA03098"
                     /note="kelch-like protein; Provisional"
                     /db_xref="CDD:222983"
     Region          458..501
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          505..549
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          552..595
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          599..649
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          652..695
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     CDS             1..709
                     /gene="KLHL5"
                     /coded_by="NM_015990.5:422..2551"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS33975.1"
                     /db_xref="GeneID:51088"
                     /db_xref="HGNC:HGNC:6356"
                     /db_xref="MIM:608064"
ORIGIN      
        1 msgsrkefdv kqilkirwrw fghqasspns tvdsqqgefw nrgqtgangg rkfldpcslq
       61 lplasigyrr ssqldfqnsp swpmastsev pafeftaedc ggahwldrpe vddgtseeen
      121 esdssscrts nssqtlssch tmepctsdef fqalnhaeqt fkkmenylrh kqlcdvilva
      181 gdrripahrl vlssvsdyfa amftndvrea rqeeikmegv epnslwsliq yaytgrlelk
      241 edniecllst acllqlsqvv eacckflmkq lhpsnclgir sfadaqgctd lhkvahnytm
      301 ehfmevirnq efvllpasei akllasddmn ipneetilna lltwvrhdle qrrkdlskll
      361 ayirlpllap qfladmennv lfrddiecqk limeamkyhl lperrpmlqs prtkprkstv
      421 gtlfavggmd stkgatsiek ydlrtnmwtp vanmngrrlq fgvavlddkl yvvggrdglk
      481 tlntvecynp ktktwsvmpp msthrhglgv avlegpmyav gghdgwsyln tverwdpqar
      541 qwnfvatmst prstvgvavl sgklyavggr dgssclksve cfdphtnkwt lcaqmskrrg
      601 gvgvttwngl lyaigghdap asnltsrlsd cverydpktd mwtavasmsi srdavgvcll
      661 gdklyavggy dgqaylntve aydpqtnewt qvaplclgra gacvvtvkl
//
