LOCUS       NM_020782               6490 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens kelch like family member 42 (KLHL42), mRNA.
ACCESSION   NM_020782 XM_044836
VERSION     NM_020782.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6490)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 6490)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 6490)
  AUTHORS   Lear,T.B., Lockwood,K.C., Larsen,M., Tuncer,F., Kennerdell,J.R.,
            Morse,C., Valenzi,E., Tabib,T., Jurczak,M.J., Kass,D.J.,
            Evankovich,J.W., Finkel,T., Lafyatis,R., Liu,Y. and Chen,B.B.
  TITLE     Kelch-like protein 42 is a profibrotic ubiquitin E3 ligase involved
            in systemic sclerosis
  JOURNAL   J Biol Chem 295 (13), 4171-4180 (2020)
   PUBMED   32071084
  REMARK    GeneRIF: Kelch-like protein 42 is a profibrotic ubiquitin E3 ligase
            involved in systemic sclerosis.
REFERENCE   4  (bases 1 to 6490)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 6490)
  AUTHORS   Dhanoa,B.S., Cogliati,T., Satish,A.G., Bruford,E.A. and
            Friedman,J.S.
  TITLE     Update on the Kelch-like (KLHL) gene family
  JOURNAL   Hum Genomics 7 (1), 13 (2013)
   PUBMED   23676014
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6490)
  AUTHORS   Cummings,C.M., Bentley,C.A., Perdue,S.A., Baas,P.W. and Singer,J.D.
  TITLE     The Cul3/Klhdc5 E3 ligase regulates p60/katanin and is required for
            normal mitosis in mammalian cells
  JOURNAL   J Biol Chem 284 (17), 11663-11675 (2009)
   PUBMED   19261606
  REMARK    GeneRIF: Cul3-deficient cells or Ctb9/KLHDC5-deficient cells show
            an increase in p60/katanin levels, indicating that Cul3/Ctb9/KLHDC5
            is required for efficient p60/katanin removal
REFERENCE   7  (bases 1 to 6490)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
REFERENCE   8  (bases 1 to 6490)
  AUTHORS   Scherer,S.E., Muzny,D.M., Buhay,C.J., Chen,R., Cree,A., Ding,Y.,
            Dugan-Rocha,S., Gill,R., Gunaratne,P., Harris,R.A., Hawes,A.C.,
            Hernandez,J., Hodgson,A.V., Hume,J., Jackson,A., Khan,Z.M.,
            Kovar-Smith,C., Lewis,L.R., Lozado,R.J., Metzker,M.L.,
            Milosavljevic,A., Miner,G.R., Montgomery,K.T., Morgan,M.B.,
            Nazareth,L.V., Scott,G., Sodergren,E., Song,X.Z., Steffen,D.,
            Lovering,R.C., Wheeler,D.A., Worley,K.C., Yuan,Y., Zhang,Z.,
            Adams,C.Q., Ansari-Lari,M.A., Ayele,M., Brown,M.J., Chen,G.,
            Chen,Z., Clerc-Blankenburg,K.P., Davis,C., Delgado,O., Dinh,H.H.,
            Draper,H., Gonzalez-Garay,M.L., Havlak,P., Jackson,L.R.,
            Jacob,L.S., Kelly,S.H., Li,L., Li,Z., Liu,J., Liu,W., Lu,J.,
            Maheshwari,M., Nguyen,B.V., Okwuonu,G.O., Pasternak,S., Perez,L.M.,
            Plopper,F.J., Santibanez,J., Shen,H., Tabor,P.E., Verduzco,D.,
            Waldron,L., Wang,Q., Williams,G.A., Zhang,J., Zhou,J., Allen,C.C.,
            Amin,A.G., Anyalebechi,V., Bailey,M., Barbaria,J.A., Bimage,K.E.,
            Bryant,N.P., Burch,P.E., Burkett,C.E., Burrell,K.L., Calderon,E.,
            Cardenas,V., Carter,K., Casias,K., Cavazos,I., Cavazos,S.R.,
            Ceasar,H., Chacko,J., Chan,S.N., Chavez,D., Christopoulos,C.,
            Chu,J., Cockrell,R., Cox,C.D., Dang,M., Dathorne,S.R., David,R.,
            Davis,C.M., Davy-Carroll,L., Deshazo,D.R., Donlin,J.E., D'Souza,L.,
            Eaves,K.A., Simons,R., Emery-Cohen,A.J., Escotto,M., Flagg,N.,
            Forbes,L.D., Gabisi,A.M., Garza,M., Hamilton,C., Henderson,N.,
            Hernandez,O., Hines,S., Hogues,M.E., Huang,M., Idlebird,D.G.,
            Johnson,R., Jolivet,A., Jones,S., Kagan,R., King,L.M., Leal,B.,
            Lebow,H., Lee,S., LeVan,J.M., Lewis,L.C., London,P.,
            Lorensuhewa,L.M., Loulseged,H., Lovett,D.A., Lucier,A.,
            Lucier,R.L., Ma,J., Madu,R.C., Mapua,P., Martindale,A.D.,
            Martinez,E., Massey,E., Mawhiney,S., Meador,M.G., Mendez,S.,
            Mercado,C., Mercado,I.C., Merritt,C.E., Miner,Z.L., Minja,E.,
            Mitchell,T., Mohabbat,F., Mohabbat,K., Montgomery,B., Moore,N.,
            Morris,S., Munidasa,M., Ngo,R.N., Nguyen,N.B., Nickerson,E.,
            Nwaokelemeh,O.O., Nwokenkwo,S., Obregon,M., Oguh,M., Oragunye,N.,
            Oviedo,R.J., Parish,B.J., Parker,D.N., Parrish,J., Parks,K.L.,
            Paul,H.A., Payton,B.A., Perez,A., Perrin,W., Pickens,A.,
            Primus,E.L., Pu,L.L., Puazo,M., Quiles,M.M., Quiroz,J.B.,
            Rabata,D., Reeves,K., Ruiz,S.J., Shao,H., Sisson,I., Sonaike,T.,
            Sorelle,R.P., Sutton,A.E., Svatek,A.F., Svetz,L.A., Tamerisa,K.S.,
            Taylor,T.R., Teague,B., Thomas,N., Thorn,R.D., Trejos,Z.Y.,
            Trevino,B.K., Ukegbu,O.N., Urban,J.B., Vasquez,L.I., Vera,V.A.,
            Villasana,D.M., Wang,L., Ward-Moore,S., Warren,J.T., Wei,X.,
            White,F., Williamson,A.L., Wleczyk,R., Wooden,H.S., Wooden,S.H.,
            Yen,J., Yoon,L., Yoon,V., Zorrilla,S.E., Nelson,D.,
            Kucherlapati,R., Weinstock,G. and Gibbs,R.A.
  CONSRTM   Baylor College of Medicine Human Genome Sequencing Center Sequence
            Production Team
  TITLE     The finished DNA sequence of human chromosome 12
  JOURNAL   Nature 440 (7082), 346-351 (2006)
   PUBMED   16541075
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC009511.16.
            
            On Nov 23, 2018 this sequence version replaced NM_020782.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.19655.1,
                                           SRR1803615.245818.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000381271.7/ ENSP00000370671.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-970               AC009511.16        57764-58733         c
            971-1164            AC009511.16        47065-47258         c
            1165-6490           AC009511.16        35926-41251         c
FEATURES             Location/Qualifiers
     source          1..6490
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p11.22"
     gene            1..6490
                     /gene="KLHL42"
                     /gene_synonym="Ctb9; KLHDC5"
                     /note="kelch like family member 42"
                     /db_xref="GeneID:57542"
                     /db_xref="HGNC:HGNC:29252"
                     /db_xref="MIM:618919"
     exon            1..970
                     /gene="KLHL42"
                     /gene_synonym="Ctb9; KLHDC5"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..1616
                     /gene="KLHL42"
                     /gene_synonym="Ctb9; KLHDC5"
                     /note="kelch domain-containing protein 5; kelch domain
                     containing 5; cullin-3-binding protein 9"
                     /codon_start=1
                     /product="kelch-like protein 42"
                     /protein_id="NP_065833.1"
                     /db_xref="CCDS:CCDS31763.1"
                     /db_xref="GeneID:57542"
                     /db_xref="HGNC:HGNC:29252"
                     /db_xref="MIM:618919"
                     /translation="MSAEEMVQIRLEDRCYPVSKRKLIEQSDYFRALYRSGMREALSQ
                     EAGGPEVQQLRGLSAPGLRLVLDFINAGGAREGWLLGPRGEKGGGVDEDEEMDEVSLL
                     SELVEAASFLQVTSLLQLLLSQVRLNNCLEMYRLAQVYGLPDLQEACLRFMVVHFHEV
                     LCKPQFHLLGSPPQAPGDVSLKQRLREARMTGTPVLVALGDFLGGPLAPHPYQGEPPS
                     MLRYEEMTERWFPLANNLPPDLVNVRGYGSAILDNYLFIVGGYRITSQEISAAHSYNP
                     STNEWLQVASMNQKRSNFKLVAVNSKLYAIGGQAVSNVECYNPEQDAWNFVAPLPNPL
                     AEFSACECKGKIYVIGGYTTRDRNMNILQYCPSSDMWTLFETCDVHIRKQQMVSVEET
                     IYIVGGCLHELGPNRRSSQSEDMLTVQSYNTVTRQWLYLKENTSKSGLNLTCALHNDG
                     IYIMSRDVTLSTSLEHRVFLKYNIFSDSWEAFRRFPAFGHNLLVSSLYLPNKAET"
     exon            971..1164
                     /gene="KLHL42"
                     /gene_synonym="Ctb9; KLHDC5"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..6490
                     /gene="KLHL42"
                     /gene_synonym="Ctb9; KLHDC5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1599..1604
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLHL42"
                     /gene_synonym="Ctb9; KLHDC5"
                     /note="hexamer: AATAAA"
     polyA_site      1643
                     /gene="KLHL42"
                     /gene_synonym="Ctb9; KLHDC5"
                     /note="major polyA site"
     regulatory      6471..6476
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLHL42"
                     /gene_synonym="Ctb9; KLHDC5"
                     /note="hexamer: AATAAA"
     polyA_site      6490
                     /gene="KLHL42"
                     /gene_synonym="Ctb9; KLHDC5"
                     /note="major polyA site"
ORIGIN      
        1 atccctcggc gccccgcccg gaaccggcgc gcgcgtaggg gctgggaggc cggcgcgcag
       61 atctggcggt gagcgctgcc gccccggggc ccccagccat gtcggccgag gagatggtgc
      121 agatccgcct ggaggaccgc tgctacccgg tgagcaagag gaagctcatc gagcagagcg
      181 actacttccg cgccctctac cgctccggca tgcgcgaggc cctgagccag gaggccggcg
      241 gcccggaggt gcagcagctg cgcggcctca gcgcgccggg cctgcggctg gtgctggact
      301 tcatcaacgc cggcggggcc cgcgaaggct ggctcctggg cccgcgcggg gaaaagggcg
      361 gcggggtgga cgaggacgag gagatggatg aggtgagcct gctgtccgag ctggtggagg
      421 cggcctcctt cctgcaggtc acgtccctgc tgcagctgct gctgtcccag gtgcggctca
      481 ataactgcct ggagatgtac cgcctggcgc aggtgtacgg gctgcccgac ctgcaggagg
      541 cctgcctgcg cttcatggtc gtccacttcc acgaggtgct gtgcaagccc cagttccacc
      601 tcctggggtc tcctccccaa gctccagggg atgtcagcct gaagcagagg ctgagggagg
      661 cccggatgac tgggactcct gtcctcgtgg ccctcgggga cttcctgggg ggacccctgg
      721 cccctcaccc ctaccagggg gagcccccgt ccatgctcag gtacgaggag atgactgagc
      781 gttggttccc gctggccaac aaccttcctc ccgacctggt caatgtcagg ggctatgggt
      841 ctgccatcct ggacaactac ctcttcatag tgggcgggta caggatcact agccaggaga
      901 tctccgctgc gcattcctac aaccccagca ccaacgagtg gctccaggtg gcctccatga
      961 accagaagag gtctaacttc aaacttgtgg ctgttaattc aaaactctat gccatcggag
     1021 ggcaggccgt ttctaacgtt gagtgttaca accccgagca ggatgcgtgg aattttgtgg
     1081 cgcccttacc caatcctctg gctgagttct ctgcctgtga gtgtaaggga aaaatttatg
     1141 tcattggagg atacactacc agagaccgga acatgaacat tttgcagtac tgcccctctt
     1201 ccgacatgtg gacgctcttt gaaacatgtg acgtccacat tcgcaagcag cagatggtgt
     1261 ctgtggaaga gaccatctac atcgtggggg ggtgtctcca cgagctgggg cccaaccgca
     1321 ggagcagcca gagcgaggac atgctcaccg tgcagtccta caacaccgtc acccgccagt
     1381 ggctctacct caaggagaac acgtccaaat cgggtcttaa cttgacttgt gcgctccata
     1441 acgacggcat ctacatcatg agcagagacg tcaccctgtc gaccagcttg gaacaccgag
     1501 tgttcctcaa gtacaacatc ttttcagata gttgggaagc atttcggcgt tttccagctt
     1561 ttggacataa cttgctggtt tcttctcttt atctgcccaa taaagcagaa acatgactga
     1621 attgaattgg tagatgaaaa aaacctggtt caagtttttt ttaaaatgtg gtgtcccatt
     1681 ccaagggaga ccaattccta aagggtaaag aagggttaaa gtaggtcaca tatatacagt
     1741 agcagctgta aataagctta cttgaactaa ttacttgaaa actggtggaa aaaagagacc
     1801 aactttgtta ttttttaaat tattgatttt taaattatgg gagcaaatcc atctccaaac
     1861 atgatactct tgggccaatg acggatcatc aaaatgtaga ttcattgtgt ctgtgtggta
     1921 aagggccaaa gtcaataatt gggacaaatg gtaaagatga ttttaaaatc tgttgtattt
     1981 aggtcccttg acatatcatt agcaccttaa gtgagaggtt ttctttttct tatcagtgtc
     2041 cttgacaagc attcatatta acatattcat tctctcttct ccatcaccca tacccacaca
     2101 tacatctagt atgtttaggg ttctgtgttc agatattttg tttgcacact actttttagg
     2161 aaacttataa tgatggagcc ctacagtgaa tccttaccag tgttcagtcc tccccaaaac
     2221 ttgcataaaa atattcttag ctatttttcc agcctttttt gcagttacaa atgctggata
     2281 aatagactga taaaacctct tattttattt atgtggcagg ttgcatattt atgtggacac
     2341 ataggttgca ctgctaggca ttctgtattg ttttaaagag gatatattat ttagaaaaat
     2401 ggacatatga atattattaa aaattgagtc ttaaatttaa atgggaaggg aagaaaacac
     2461 caaataagaa aaaaatttgc ctttaagagt tacttttgtt gaatgtattt gacttagttc
     2521 ttattttaag gctaaaaaaa ctttgtcata tttaagtcgg cagctttcta atttaatctt
     2581 agctttgtaa ttcatgtttt gcttttgtgg actaaggtaa ggacagcatt taaatatttg
     2641 tgctggagtg aggggaagaa gctgttacag aagtggaatg gtttctggtg gtatttctga
     2701 agttaggtaa agtgctttac ttgccttggt tgttaattga aatagaattc agctcaagca
     2761 gttgttttca gtgagtgagt taacaataaa agcttctgcc aatcatagat caacattcct
     2821 caaaaataca tacactcata cttatggaaa ttttattttg attgaaaaca ctctgaaatt
     2881 atctgatatt ttgtaatggc atcagttaaa ctgtgagctg gattccatct ttctgcagta
     2941 acagcgggca gaaccatttc agttagcatg tgcctcactt taagaaagtc ctgtagggga
     3001 aaaaaaaaac tgtcagagcg aattcatgca ttcaacaaac acttatgagt gcctggagta
     3061 tgccgtccac tgtgcagatg taggacaggg gctaatcact tagagttctt cagtttatta
     3121 gaggagtgac tacaggtttt ctttacaacc atggcctcta gtatacttaa aataagcgtc
     3181 cagttataaa aagcctattt gcacaacttt ttgggaatac ttctattaac taaaatgagg
     3241 taagccatta ttttggacat agaaacagat ctttgtatct tgtcaccaaa taatcttacc
     3301 tctagtctac ttacaacttt gtaagggttt ctaagctatg cccatttatt cccaaatatt
     3361 aagcccttaa aaaaataaaa cctctgaacc aaaatcttcc caggaatagt acttaataga
     3421 ttttaatgtt aatttatatt cattgtagaa ttgaatttcc agtgacctgt aatttcatta
     3481 catatatttt aaaatctatt tattttagat ggtgttaact tttcgttgct gaagagctta
     3541 actttttaaa ggctttgtcc tatacattta gaagatgagt cagttgaatt agtactggac
     3601 aaacagttgg agattagttt gcaaataagc atatcatatc aaatacaata ttccagccaa
     3661 ccagttaatt ctcttcctgg ttacattcat tgggtctatt tgcctaatgt tgacaattag
     3721 attcttggac caagtgaggg tgtactctga tccacaaagc tcttttataa accaggtttg
     3781 aggttgtgtg tgtgtgtggg ggtgtgtgtg tgtgtgtgtg tgtatgtttg catattatag
     3841 ctctctttaa gacagacatc taaaaagatt ttggttattc tgggctgcca gcagtacgtg
     3901 ggaaaggtgg aatgtgcaat aggaacagat ctgtgcattt tgtgacatcg tccttcctgc
     3961 tgtgcacatc agctgtgatg acattttgag ggtagtttta atttagctcg gttctcttgt
     4021 tggtgccagt attacattga agactaccta tgatagaggc aatgttgctt tgaaaatctc
     4081 ccttcaggcg gaggttgcag tgagccgaga ttgtgccatt gcactccagc ctgggcgaca
     4141 gtgcaagact ctgtctccaa aaaaaaaaaa agaaaaaaga aaatccccct tcatccccca
     4201 ggactgtcct ttactctttg atagtatccc tctattttct tcccaattct ctaaatgctt
     4261 tatcattttt tcctgagatg cttctgaggg atgctgacct cccactatgg ggaaaagggt
     4321 tgcttggagg acctggggtg gcagcccccc gaccagaagc accctatttt atagatagca
     4381 gtctgaatgg tagagagtcc tgtgtgtggg ttgttagaag gttggttctt cctgttattc
     4441 tctctggctt tcctttcaac ccacttattt tcagaggcct ctccccttag catcctttaa
     4501 aaggttttct gatgaatgtg tgaaagagtt gattatttca acagtattgg ttaagtcaca
     4561 acgacgaagt gctgagaagg ttatgggtac caggaagaaa caaacagaag tcttaagatt
     4621 agaatgagaa ccaaagagaa tttaaccctg ccattttttt ttttttaaca ccaagatcct
     4681 aagtaattcc aaatgcctta gatatcaatg aaagctacac accattgaga tgggcaaaat
     4741 tctttctcta caaagggagt aatcaagtaa atacctgttc tctttcaatg gactgttgcc
     4801 tattgagcat tgtggatgat gtgttttcag atttccaggt gaagttctga ccctacctgt
     4861 ttggccaaag acgtaaattg agaggaaagg ccttggtctt cctgatcaac cagcatttaa
     4921 cgaacagtgg cttaatgcag atcactcaag aggcagcata gcaatgtaaa aggaatataa
     4981 gtaggtgttg gatgcctttt tcctagacca ggaatgggga atatataaca cctgtgccac
     5041 cgctctttta aggaggcatt atgaatgagt gcagcattcc tgtcctctgt gccaggattt
     5101 ggtcttagaa tccatgtcag attggtgctt ccagacatct attcccagtc catcagagtg
     5161 aaatgaaggc tatttgccat ccctgcctta gacagaggag tgaaagaatt aagtgggtag
     5221 acaccaacca aaatgacttt gaaagcagtg agctgattga gctccagttc tgtggttacc
     5281 agaaatactg agtgtctgtc atgtgcaaga caatgctaag aacagaatac agacataaat
     5341 aagtcacggc ccatgacctt gaagagctta cggccttata aagaggttca ctgtaattgt
     5401 cttcaccagg gcgtccttct caaagatgcc cacttttgtc tggcacattg gggctcggtg
     5461 gtctggtggt cccttcggtc ttggccctgt ccgtcctttg tttttgtgat ttactaacaa
     5521 tcatcacgaa ccagttttgt ttttctttta aatttgaaca tcacatcttg tgttttagtt
     5581 ttttgctcta tgattttttt ctcactgctt ttcagtcttc tctgtacttc atttttgtga
     5641 aaaagtgaaa atcacatata atctttattt aaaaatgctc accaagcact gcagactttg
     5701 gagttaggga ttcagcagct tgttccagtg aaaaggagga gtgaagctgg ggaagttagt
     5761 atctaagagg ggcaagctga ttgcatgtgc atttatacct atgcctttaa aacattccca
     5821 taaaaagtat taataaagaa atttccattc cacactagta ctgatgaaaa ggtggttgat
     5881 tttgccttgt gataattatc aaaggatagt ttttcatcct tagattttat tcacatgaga
     5941 gatttttttt attttctctg ttgacttagg aacacatcat aaattcacac caactgacac
     6001 gttgctgacg tctgtacttg acataaccat ttttattcat acaggaagca ttaaatataa
     6061 aagatggtca gttttgaaga gcaaagggtg ctgaaatgac ttgtacggtt ggctggtgct
     6121 ttctcaaatg gattgccata gttcattact agtaaagaaa aggaaaatgt gatttacgtt
     6181 gtcatttttc ctattaaaaa aaacccttaa gaatggggca cttgagctgt ccctgcaatg
     6241 ttttcatatc tagtagtcat tttagggaaa gtgataatct gtagaatgaa tagttatgtt
     6301 ttgatatgac tgatactttc tttgttaaaa ggttgtatta agtcttcaat ttcaagtcta
     6361 gcttaaaagt gtaaacatta tgtgattcat ttgaatacaa gaatgcctat gaaataccca
     6421 ctataacagc attccttttg tgtttagaac tatagaagaa aatgtcttca aataaagtag
     6481 ttttcagtca
//
