LOCUS       NM_001081675            3260 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens kelch like family member 38 (KLHL38), mRNA.
ACCESSION   NM_001081675 XM_005250901 XR_015432 XR_017775
VERSION     NM_001081675.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3260)
  AUTHORS   Xu,Y., Wang,C., Jiang,X., Zhang,Y., Su,H., Jiang,J., Ren,H. and
            Qiu,X.
  TITLE     KLHL38 involvement in non-small cell lung cancer progression via
            activation of the Akt signaling pathway
  JOURNAL   Cell Death Dis 12 (6), 556 (2021)
   PUBMED   34050138
  REMARK    GeneRIF: KLHL38 involvement in non-small cell lung cancer
            progression via activation of the Akt signaling pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3260)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3260)
  AUTHORS   Sano,M., Kamitsuji,S., Kamatani,N., Hong,K.W., Han,B.G., Kim,Y.,
            Kim,J.W., Aizawa,Y. and Fukuda,K.
  CONSRTM   Japan Pharmacogenomics Data Science Consortium (JPDSC)
  TITLE     Genome-wide association study of electrocardiographic parameters
            identifies a new association for PR interval and confirms
            previously reported associations
  JOURNAL   Hum Mol Genet 23 (24), 6668-6676 (2014)
   PUBMED   25055868
REFERENCE   4  (bases 1 to 3260)
  AUTHORS   Taipale,M., Tucker,G., Peng,J., Krykbaeva,I., Lin,Z.Y., Larsen,B.,
            Choi,H., Berger,B., Gingras,A.C. and Lindquist,S.
  TITLE     A quantitative chaperone interaction network reveals the
            architecture of cellular protein homeostasis pathways
  JOURNAL   Cell 158 (2), 434-448 (2014)
   PUBMED   25036637
REFERENCE   5  (bases 1 to 3260)
  AUTHORS   Dhanoa,B.S., Cogliati,T., Satish,A.G., Bruford,E.A. and
            Friedman,J.S.
  TITLE     Update on the Kelch-like (KLHL) gene family
  JOURNAL   Hum Genomics 7 (1), 13 (2013)
   PUBMED   23676014
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3260)
  AUTHORS   Taipale,M., Krykbaeva,I., Koeva,M., Kayatekin,C., Westover,K.D.,
            Karras,G.I. and Lindquist,S.
  TITLE     Quantitative analysis of HSP90-client interactions reveals
            principles of substrate recognition
  JOURNAL   Cell 150 (5), 987-1001 (2012)
   PUBMED   22939624
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC135166.8.
            
            On or before Sep 20, 2018 this sequence version replaced
            XM_005250901.5, NM_001081675.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.57505.1,
                                           SRR1803614.257648.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142853, SAMEA2144335
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000684634.1/ ENSP00000508228.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-216               AC135166.8         41307-41522         c
            217-1567            AC135166.8         39298-40648         c
            1568-1673           AC135166.8         34630-34735         c
            1674-3260           AC135166.8         32163-33749         c
FEATURES             Location/Qualifiers
     source          1..3260
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.13"
     gene            1..3260
                     /gene="KLHL38"
                     /gene_synonym="C8ORFK36"
                     /note="kelch like family member 38"
                     /db_xref="GeneID:340359"
                     /db_xref="HGNC:HGNC:34435"
     exon            1..216
                     /gene="KLHL38"
                     /gene_synonym="C8ORFK36"
                     /inference="alignment:Splign:2.1.0"
     exon            217..1567
                     /gene="KLHL38"
                     /gene_synonym="C8ORFK36"
                     /inference="alignment:Splign:2.1.0"
     CDS             218..1963
                     /gene="KLHL38"
                     /gene_synonym="C8ORFK36"
                     /note="kelch-like 38"
                     /codon_start=1
                     /product="kelch-like protein 38"
                     /protein_id="NP_001075144.2"
                     /db_xref="CCDS:CCDS43766.1"
                     /db_xref="GeneID:340359"
                     /db_xref="HGNC:HGNC:34435"
                     /translation="MDEESLDGLLFKDHDFSSDLLRQLNSLRQSRILTDVSICAGARE
                     IPCHRNVLASSSPYFRAMFCSSFREKSEAKVQLKGIDPPTLDQIVSYVYTGEAHIATD
                     NVLPVMEAASMLQFPKLFEACSSYLQSQLAPSNCLGMIRLSEILSCETLKKKAREVAL
                     TSFPEVAASADLKELCALELRDYLGDDGLCGEEEKVFEALMVWIKHDLQARKRYMQEL
                     FKQVRLQYIHPAFFHHFIANDALLQSSPACQIILETAKRQMFSLCGTTVPDCKLLLHV
                     PPRNSYQDFLILLGGRKDSQQTTRDVLLYSKQTGQWQSLAKLPTRLYKASAITLHRSI
                     YVLGGMAVSSGRSLVSHNVYIFSLKLNQWRLGEPMLVARYSHRSTAHKNFIFSIGGIG
                     EGQELMGSMERYDSICNVWESMASMPVGVLHPAVAVKDQRLYLFGGEDIMQNPVRLIQ
                     VYHISRNSWFKMETRMIKNVCAPAVVLGERIVIVGGYTRRILAYDPQSNKFVKCADMK
                     DRRMHHGATVMGNKLYVTGGRRLTTDCNIEDSASFDCYDPETDTWTSQGQLPHKLFDH
                     ACLTLQCIPRTSGLP"
     exon            1568..1673
                     /gene="KLHL38"
                     /gene_synonym="C8ORFK36"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..3260
                     /gene="KLHL38"
                     /gene_synonym="C8ORFK36"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3236..3241
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLHL38"
                     /gene_synonym="C8ORFK36"
                     /note="hexamer: AATAAA"
     polyA_site      3260
                     /gene="KLHL38"
                     /gene_synonym="C8ORFK36"
                     /note="major polyA site"
ORIGIN      
        1 atacactgtc tccctgccca gcagtccttg cacaaagctc tagaaaacta tgaaagtgcc
       61 ttcagcataa acaaatccag aaatctccca ggacaaatca tttgccaact gaaagaaagg
      121 cctggggttt atggtttccc ttggagctag aggtagaaac tctccggggg gataagtcag
      181 accaggcacc agtggatgtc accgcagcaa aacaaggatg gacgaggagt cactagatgg
      241 gctgctcttc aaagaccacg acttctcttc tgacttgttg aggcagctca acagcttaag
      301 gcaaagcagg atcctgactg atgtgagcat ctgtgccggt gcccgggaga tcccctgcca
      361 ccgcaacgtg ctggcctcca gcagccccta cttcagggct atgttctgca gcagcttccg
      421 ggagaagagt gaagccaaag tgcagctgaa aggcattgac cccccaaccc tggaccagat
      481 cgtctcctac gtgtatacgg gggaggcaca tattgccact gacaatgtcc tccccgtgat
      541 ggaggccgcc tccatgctac agttccccaa gctgtttgag gcctgctcct cgtacttgca
      601 gagccagttg gcccccagca actgcctggg tatgatcaga ctctcagaaa tcttaagctg
      661 cgagaccctc aagaagaaag ccagggaggt ggcactgacg tccttcccag aggtggccgc
      721 atcggccgac ctgaaggagc tctgtgcctt ggagttgagg gactatctcg gagatgatgg
      781 gctctgtggg gaggaggaaa aggtgtttga ggccctcatg gtttggatca agcatgacct
      841 ccaggcccgg aagcgataca tgcaggaact gttcaagcag gtcaggctgc agtacatcca
      901 cccagccttc tttcaccact tcatcgccaa cgatgccctc ctgcagtcct cgcctgcatg
      961 ccagatcatc ttggagaccg ccaagagaca gatgttctct ttgtgtggca ccaccgtccc
     1021 agactgcaaa ctcctgttgc atgtccctcc aagaaactct taccaagatt tcctcatcct
     1081 cttgggcgga aggaaggaca gccagcagac caccagggac gtcctactgt acagcaaaca
     1141 gaccggccaa tggcagagcc ttgccaaact cccgacacgg ctgtacaagg cctctgccat
     1201 caccttgcac cgcagcatct atgtgctggg gggcatggct gtcagctcag ggaggagtct
     1261 ggtcagtcac aatgtctaca tcttctccct gaaactcaat cagtggaggc tgggggagcc
     1321 catgctggtg gcccgctact cccacagaag cactgcccat aagaacttca tcttctccat
     1381 cggggggatt ggagaagggc aggagctcat gggctccatg gaaaggtatg acagcatctg
     1441 caatgtctgg gagagtatgg ccagcatgcc cgtgggggtg ctccaccccg cagtcgctgt
     1501 gaaagaccaa agactctatc tctttggagg agaggacatc atgcagaacc ctgtgcgcct
     1561 tatccaggtt tatcacattt ccagaaactc gtggttcaaa atggagacaa gaatgatcaa
     1621 gaacgtgtgt gcccctgcag tggtgcttgg ggagcggatt gtcattgtgg gaggttacac
     1681 aaggaggatt cttgcttatg accctcaatc caacaaattt gtcaaatgtg cggacatgaa
     1741 agaccggagg atgcaccatg gggccacagt gatgggaaac aaactctacg tgacgggcgg
     1801 gcggcggctg accacggact gcaacattga ggactccgcc tccttcgatt gctacgaccc
     1861 cgagacggac acctggacat cccagggaca gctgccgcac aagctctttg accatgcctg
     1921 cctcactctc cagtgcatac cccgcacgtc tggcctccca tgaggtcgac aagaaacctt
     1981 ctgccctagt caaaatgcct tctgtcgcca gggacacaaa cccagctcca aagggcttaa
     2041 cccttaaagg ctgcagggag agctcacaag actgaggtac cagagtcggg aggcctggaa
     2101 ctaggcattg cattgccaga actctctctc tccttctctg cctctctcct tatctctctc
     2161 ccccacctcc atctgtctct gtctttcccc cttctttctt tctctcccct atctctgtct
     2221 gtctctctct ctctctctct ctctctctct ctttttcttt tttttgagat ggagtttcac
     2281 tctgtagccc aggctggagt gcagtggtgc tatctcagct cactgaaacc cccacctccc
     2341 aggttcaagc gattctcacg cctcagcctc ctgagtagct gggattatag gcatgtgcca
     2401 ccaagtccag ctaatttttg cgttttagta aagacagggt ttcactatgt tggccaggct
     2461 ggtcacgaac tcctggtctc aagtgatcca ccggcctcag cctcccaaat gctgagatta
     2521 caggcgtgag ccaccacgcc tggcctgtct cctttctgtc tcagtttctg tctctcttct
     2581 ctctctctgt ctgtctcccc ctctctgctt ctctctcttc tctgtctctc tgcctctctc
     2641 tgcccctctc tctctctctc tctctcagtc tcccctctgt cttcctctct ctcatcccta
     2701 ggttttcctc tctctctagc aatcttcttc atttacccac acagtgtgtg gacaatgaca
     2761 aatgataaac ccagactcat tttccagctt tatatcttca ggagagaact ttgccattat
     2821 ccatatatta aacctaaaaa acaatgctta tgggcctctt ttgaattcca tgtctacctc
     2881 ttgagccaat cactgttgcc aggactggct agtcctggac cacatcccca cagacagagg
     2941 tggggttacc tgttgtcact gacagcccat ccaaactgca tataatgggt tagaagcatt
     3001 tccccaaaga gagaaatcca gacaaaaacc acatctgccc aggacaccac tgaaatctgg
     3061 aacaagaggg ctgagagaac ccagaggatt cctggaactg cttggtccag gtggcagcgt
     3121 gagaaattgg ccctgacctt gtttttctgc attctatgga tgtagtacat tgaaattcca
     3181 gagatatatg cacaattcag tatctaatgt ttgtaaaatt atcctgcatt gccagaataa
     3241 agtttgtttc tggtgccaaa
//
