LOCUS       NM_024731               7559 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens kelch like family member 36 (KLHL36), transcript
            variant 1, mRNA.
ACCESSION   NM_024731
VERSION     NM_024731.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7559)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 7559)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 7559)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 7559)
  AUTHORS   Dhanoa,B.S., Cogliati,T., Satish,A.G., Bruford,E.A. and
            Friedman,J.S.
  TITLE     Update on the Kelch-like (KLHL) gene family
  JOURNAL   Hum Genomics 7 (1), 13 (2013)
   PUBMED   23676014
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7559)
  AUTHORS   Croteau-Chonka,D.C., Marvelle,A.F., Lange,E.M., Lee,N.R.,
            Adair,L.S., Lange,L.A. and Mohlke,K.L.
  TITLE     Genome-wide association study of anthropometric traits and evidence
            of interactions with age and study year in Filipino women
  JOURNAL   Obesity (Silver Spring) 19 (5), 1019-1027 (2011)
   PUBMED   20966902
REFERENCE   6  (bases 1 to 7559)
  AUTHORS   Furukawa,M., He,Y.J., Borchers,C. and Xiong,Y.
  TITLE     Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin
            ligases
  JOURNAL   Nat Cell Biol 5 (11), 1001-1007 (2003)
   PUBMED   14528312
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA049618.1, AK022605.1, BC033821.1, AC009116.8 and AW337439.1.
            
            On Nov 22, 2018 this sequence version replaced NM_024731.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.150660.1, BC033821.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000564996.6/ ENSP00000456743.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-147               DA049618.1         3-149
            148-1634            AK022605.1         1-1487
            1635-2183           BC033821.1         1621-2169
            2184-7500           AC009116.8         34304-39620
            7501-7559           AW337439.1         13-71               c
FEATURES             Location/Qualifiers
     source          1..7559
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q24.1"
     gene            1..7559
                     /gene="KLHL36"
                     /gene_synonym="C16orf44"
                     /note="kelch like family member 36"
                     /db_xref="GeneID:79786"
                     /db_xref="HGNC:HGNC:17844"
     exon            1..139
                     /gene="KLHL36"
                     /gene_synonym="C16orf44"
                     /inference="alignment:Splign:2.1.0"
     exon            140..218
                     /gene="KLHL36"
                     /gene_synonym="C16orf44"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..2006
                     /gene="KLHL36"
                     /gene_synonym="C16orf44"
                     /note="isoform 1 is encoded by transcript variant 1;
                     kelch-like protein 36; kelch-like 36"
                     /codon_start=1
                     /product="kelch-like protein 36 isoform 1"
                     /protein_id="NP_079007.2"
                     /db_xref="CCDS:CCDS10948.1"
                     /db_xref="GeneID:79786"
                     /db_xref="HGNC:HGNC:17844"
                     /translation="MMEGSRQTRVSRPYKISESSKVYRWADHSSTVLQRLNEQRLRGL
                     FCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYIGLKAVVD
                     FLYGGELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQEVSEDNYLYLQELASIYSL
                     KRLDAFIDGFILNHFGTLSFTPDFLQNVSMQKLCVYLSSSEVQRECEHDLLQAALQWL
                     TQQPEREAHARQVLENIHFPLIPKNDLLHRVKPAVCSLLPKEANCEGFIEEAVRYHNN
                     LAAQPVMQTKRTALRTNQERLLFVGGEVSERCLELSDDTCYLDAKSEQWVKETPLPAR
                     RSHHCVAVLGGFIFIAGGSFSRDNGGDAASNLLYRYDPRCKQWIKVASMNQRRVDFYL
                     ASIEDMLVAIGGRNENGALSSVETYSPKTDSWSYVAGLPRFTYGHAGTIYKDFVYISG
                     GHDYQIGPYRKNLLCYDHRTDVWEERRPMTTARGWHSMCSLGDSIYSIGGSDDNIESM
                     ERFDVLGVEAYSPQCNQWTRVAPLLHANSESGVAVWEGRIYILGGYSWENTAFSKTVQ
                     VYDREADKWSRGVDLPKAIAGGSACVCALEPRPEDKKKKGKGKRHQDRGQ"
     exon            219..1292
                     /gene="KLHL36"
                     /gene_synonym="C16orf44"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1450
                     /gene="KLHL36"
                     /gene_synonym="C16orf44"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..7559
                     /gene="KLHL36"
                     /gene_synonym="C16orf44"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2161..2166
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLHL36"
                     /gene_synonym="C16orf44"
                     /note="hexamer: ATTAAA"
     polyA_site      2183
                     /gene="KLHL36"
                     /gene_synonym="C16orf44"
                     /note="major polyA site"
     regulatory      7541..7546
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLHL36"
                     /gene_synonym="C16orf44"
                     /note="hexamer: AATATA"
     polyA_site      7559
                     /gene="KLHL36"
                     /gene_synonym="C16orf44"
                     /note="major polyA site"
ORIGIN      
        1 ctcggcctcg cacttcctgg cggagccatg gctgcgcagc gggctggccg ggggtctcct
       61 gaacccgggc cccgccgccc cgaccgcccg gccccgccgc cggggctgtc cccgccgcgt
      121 ccgtagcgcg tcctgccagg gctgaaatct ctttaatgat ggagggaagc aggcagacgc
      181 gagtgtctcg gccatacaag atcagcgaat catcaaaggt ataccgctgg gccgaccact
      241 caagcacggt gctgcagcgg ctgaacgagc agcgtctccg cgggctcttc tgcgacgtcg
      301 tcctggtggc cgatgagcag cgtgtgccag cccatcgcaa cctgctggcc gtgtgcagcg
      361 actacttcaa ctccatgttc accatcggca tgcgggaagc tttccagaag gaggtggagc
      421 tgatcggcgc ctcctacatt gggctcaagg ccgtggtgga cttcctgtac ggcggggagc
      481 tggtgctgga tggcggcaac attgactacg tcctggagac ggctcacctg ctgcagatct
      541 ggacggtggt agacttctgc tgtgagtacc tggagcagga ggtgagcgag gacaactacc
      601 tgtacctgca ggagctggcc tccatctaca gcctcaagcg gcttgatgcc ttcatcgatg
      661 gcttcatcct gaaccacttc ggcacgctgt cctttacgcc cgacttcctg cagaacgtct
      721 ccatgcagaa gctgtgtgtc tacctgagca gcagcgaggt gcagcgggag tgtgagcacg
      781 acctcctgca ggccgccctg cagtggctga cgcagcagcc cgagcgcgag gcccacgccc
      841 gccaggtgct ggagaacatc cacttcccgc tcatccccaa gaacgacctg ctgcaccgcg
      901 tcaagccggc cgtgtgctcg ctgctgccca aggaggccaa ctgcgagggc ttcatcgagg
      961 aggccgtgcg ctaccacaac aacctggcgg cccagcccgt catgcagacc aagcgcacgg
     1021 cgctgcgcac caaccaggag cgcctgctgt ttgtgggcgg cgaggtctcc gagcggtgtc
     1081 tggagctcag tgacgacacc tgctacctgg acgccaagag cgagcagtgg gtcaaagaga
     1141 cgccgctgcc cgcccggcgg agccaccact gtgtcgcggt gctggggggc ttcatcttca
     1201 tcgccggcgg cagcttctca cgggacaacg gaggggatgc ggcctccaat cttctttata
     1261 ggtatgaccc ccgctgtaaa cagtggatca aggtggcctc catgaaccag cgccgtgtgg
     1321 atttctacct tgcctccatc gaagacatgc tggtggccat cggcggccgg aatgagaacg
     1381 gagcgctctc ttcagtagag acgtacagtc ccaagactga ctcctggtcc tatgtggccg
     1441 gcttgccaag gttcacgtac ggccacgcgg gcaccatcta caaagacttc gtgtacatct
     1501 cggggggcca cgactaccaa attggcccct accgcaagaa cctgctatgc tacgaccacc
     1561 ggacagacgt gtgggaggag cggcggccca tgaccacggc gcgcggctgg cacagcatgt
     1621 gcagcctggg tgacagcatc tactccatcg ggggcagcga tgacaacatc gagtccatgg
     1681 agcgcttcga cgtgctgggc gtggaggcct acagcccgca gtgcaaccag tggacccgcg
     1741 tggcgccgct gctgcacgcc aacagcgagt cgggcgtggc agtgtgggag ggccgcatct
     1801 acatcctggg cggctacagc tgggagaaca ctgccttctc caagaccgtg caggtgtacg
     1861 accgcgaggc cgacaagtgg agcaggggcg tcgacctgcc caaggccatc gctggcgggt
     1921 ccgcctgtgt ctgcgccctg gagccacggc cagaggacaa gaagaagaaa ggcaaaggca
     1981 agaggcacca ggaccggggc cagtgaccct agctgcgcct cttgggacca tcctcaccgt
     2041 cacctcccag ggctctgtag accagcagca acttcttagt attccggaaa cattatgtac
     2101 aacttagcag ctttttttac ttttatgatt cttggtattt ctatgatatc acagtaacca
     2161 attaaatact atctgtaact ttacatatct tgcttgaata actaaccctg ggcccaggca
     2221 gtgagcaacc ccttgtatct tcacaggtct ttgccccgtg ttatgattcc tcatgggtcc
     2281 ttgctgactg tccccctgag agtagctggc acgtgggtaa cacagaaatt tctgtagtga
     2341 agcttgggcc tcaaagggtt ctcttaggcc acctagtcca agcctcccca aacctggctg
     2401 aacttttaag aatacagatg cgtgagcccc gctcagaatt atggaatcca aaaccaccag
     2461 gaacggggag gaggtggtgc ccagaagctg tattttaact agttcttgga attctgggta
     2521 ttagtcacat ctgggaatca ctggcaaggt ccagtgtgtt tgttttataa atgagtgcac
     2581 agagaccacc catgagggtg agtgagtgag tgaccagggg ccacgcagct cgctagactg
     2641 tcagatgaga catgatgact tcccgctggg gagctgttct ccgtatcagg tgaacgctgt
     2701 ttctgaataa ttccgtcttt cctcattgga aaccttcttg aattctaaaa cgttacaggt
     2761 aaccaaaaac gaaaaaaggt atgaagctct ttatacatat ttttttgtaa tttgtgcatt
     2821 tttttccttt tttttttttc tgaacccact gtcttttata ttactgatgt actgagctcc
     2881 caaatctgtt tatttctcag gaaagaaaaa gtgagtgcta tggaatttgc catcgttctc
     2941 tgtgactcta tcttgaggcg ctgttgaaag ttcctgcaca gaggagcaca tgtggatccc
     3001 tgagaaggca gtggagggct ccctaactcc cacgccaggt cctgccccag ttttctgctt
     3061 ctaagtagtt tcgtgctgct gggcaaattc tcgaacaagt ccgtgtgttc cctcatccac
     3121 cccgcttagc cacaggatta gatggaatac cctccaggct cctcccgggt gatagggcca
     3181 ttcagcctct gagctgttcg tacccggatg gcatcccctt caggatgtgg agctggcctg
     3241 cactgactcc tgcaaacagt tcctaaagca ggtgtcaggg tcgcttgccc tttaagaggg
     3301 ctcttagctg cccgagtgga tgagaaacgt gcagaactat gggaggatag gagtgtgatg
     3361 ggttttaagc atgagccaag gaaggcatga atgagctgta cctcacccag catccgatgg
     3421 cagagatcag taaacttcaa gatgtgcttc atcttcaatc ctagtctaac accagtcttc
     3481 ctgcagacag ttccgagagc aggtctcgat gtcacttgcc ctttaagagg gctctcagct
     3541 gctcgagtgg atgaggatca atgtgttaag attgatatta gactaggaaa aaaatcttag
     3601 ttaactttaa tttccatttc ttctgcttct ttgctgcccc tcctttccct tcccttcagg
     3661 gtttactgtg gttctcactg gtctgtttat gtagccatcc agaagagatg agagcatttt
     3721 ggggactgaa agcttcaata gccaacttac tgccctctgt ggttagtgag gagggcagtc
     3781 tgcatgttca gctagctagt tatttgcatg tgaagtccct ggaggcttac aaactgttga
     3841 gaggttctgc gaggcataca aacaaacaga ccaaaaggct ggaaactctg cttggagctc
     3901 tgcagcattc cggtgtatga aaggttccga gaagtctcaa cccagcattt ccaaacttct
     3961 ttgagcctaa aagtcgtttg tctcatacct agtcccagac ccccacaaaa catgttttgc
     4021 agaacttctg ccaactttgg gatagcttac ccccttccta ttcgggaaag gttttattgc
     4081 ttgtagaccc ctcagaaggc agggtagggt gtacgtgggc tgttctcccc atctcagcct
     4141 gggtcatgaa caaacgggca gttgtttggc ctgaatctcg gggcaagttg gggagagcac
     4201 atagaaagac tctgtgagtg atttggggag tgggatagct ttgaccttgg agagaggaga
     4261 gccattggtt ttcagcctaa gccagctctt ttatgttttg cttctgggac ttgtccctgg
     4321 aaatgtgtga gcttctggcc tctattctga ttttcttgtg cctcatgagt tacatacgac
     4381 gtcctgcgct tcatattttg tggtgtctct cctgatacta tgaaggtggt ttgtaattga
     4441 catggctttg accctaatat tactaaggtt gggaccaccc ttttaaaggg aggataaaca
     4501 agtttcatct tgtgggtcaa cttctaatat ttgatggtgg ctacactgtg acaagaaagg
     4561 tttttgagct tgttggggtc agtggatggg cacaagggca cccagtggtg gtgcccgggc
     4621 caggtttttg ttacttgtct ttttaagttg aaaattcacc ctactgtgca tgaaaatgga
     4681 actgaaaatg gaagagacca tgcctgggca acatggcaaa accccatctc tacaaaaaaa
     4741 ttacaaaaga ttagccaggg atggtggggc atgcagtagt cccagctgct taggaggctg
     4801 aggtgggaga atcacctgag cctgggaggt tgaggctgca gtgagctatg accacaccac
     4861 tgcactctaa cctgggtgac ggagtgagac cctgtctcaa aagaataaaa tgttttttaa
     4921 ctcagatggg cagagtttgg gctgtgctta tgcagtggcc atttgaaccg cacagtcacg
     4981 aatgtggggt tttaaactag agtgatgaag gcacaggtgc ttgcaggctg ccattttgag
     5041 agggaaacag ccacacatgt catcatgtta aactttcagt gtttcaagct attctgcttg
     5101 aattttgaag acacctggat cttttttttt ttttaacatt tcaaaataag catggcaggc
     5161 ttctattgag gtttggactt ctctcatttc taaagaatta gagttgtaac ttcatattag
     5221 ttgtaagttt ggggtttggt cctcacccaa gttggaaagc tgtttgctta agacatagat
     5281 gtattataat aatagaaggg agggagtaga aagctgatga acccttgtta cttatagcaa
     5341 acttcctgct gttttaaatg cacagagatt attttatcaa ctgtggttag cacgcaattg
     5401 gtatttttat tgttctgcca ttttattgag gctatcaagt gggacttcag acctggctct
     5461 gagcaggacc acacgtgtgt atttatattg agtgccctca ctcatgataa ggtgacttca
     5521 tggagaccca gaaactcacc ctaaggggtg ttcacctttg aggtgggcat ccagatgctg
     5581 aggggaagtg gggtccatcc tctgaggtcc aggggcctac tttgtgagct cagttgtgtt
     5641 cacctgtggt tcagtgtacc tcggccccta agccaagtga tcgttcagtg acttgcagca
     5701 atgtgggaag tgaggggacc cctgccacac cccccaccac cccctgtaga gtcactgacc
     5761 ttcatccttc accctggtcc tccatggtgc agcagcatct catgggcctt gtggctgtca
     5821 gagcccgtgg ttggaacccc gtccactggt cccaaacctg gaggggcagc tgcagatgag
     5881 gtttagacct cctggtgtct ccgtggattc tgagtgccca ggaggggagg ggagggggtg
     5941 gcatcctggc ctctaggata aatgcctgga gtatagggca gcgccacggg cacttggaga
     6001 ccctgtcctg cgcatctgcc aagcctggca gtttttagag ttttttgaaa tgttttgata
     6061 ctttttgata caatttgcta ataactgttt tgtagaatgc ctgccggggt tttccacctc
     6121 atccctttcc tccggcccct tgatttgtgc tggacaacaa atggcagcac caggacctcg
     6181 cctcatgtgg ctttgtcttg gatcttgccc ttctccatcg ctgatgtgat acagctctag
     6241 aatttcgtga agttgcatgc aaagttgcat gcagcccgtg ggtatgactg tctcaggccc
     6301 ccagctcatt tgccaagagg aaaccttaac ccccctgaga gggtctgcgt ttcttctaga
     6361 gctcctacct cagtggtgtg cacagagttg gagacacctg agggctggtc cacgtctcac
     6421 ctttgccata cgggtcattt cttgatcaaa tatatgactg gggtcctggt ttactcccgc
     6481 ccaccctttc ttttaaagta ttcttaacat gaaatccaca aaagcggaaa caatgaacca
     6541 ttcttgcact ttacagaatc attgtcctta gctttagagg ttgttaattt cttgttttta
     6601 acatgaacag aatgtgtggt tctgaaggtg tgtgggggtc tcaagaaatt gtcctttggg
     6661 gccgggcgca gtggctcacg cctgtactcc cagcactctg ggaggccaag ggggacggat
     6721 cacctgaggt caagagtttg agaccaccct gaccaacatg gtgaaacccc gtctctacta
     6781 aaatacaaaa attaggcagt cgtggtcgcc tgtaatctca gctcttccgg aggctgaggc
     6841 aggagaatcg cttgaaccca ggaggcagag gttgcagtga gccgaggttg cgccactgca
     6901 ctccagcctg ggtgaccgag taagactgtc tcaaaaaaaa aaaaaaaaaa gaaaagaaat
     6961 tgtcctttgg ttgccttagt taccagagtt gaatgaatgt acacatttcg gtagtggggg
     7021 ggcagagcgg ataacccctt ccttgtctgt ttcctttgag aaaggacact ccaccttttc
     7081 aaaggtactt aaagccatct ttacagattg cttgtaatgt aaggaaagag tcatgtcctt
     7141 tggattgatt gaggttaaat catcaaccac tagccccctt tcaaaatcag cgagatattt
     7201 gatgattaag tgattcattg ggtatgttct ggctactgat gttactgaaa tctgcaatcg
     7261 tgtatgtttt ttaatttgtt gcttttgtat ttgtaatttt atgacatttc gaagtttctg
     7321 tgtcttaact ctttttaatt aattttctgc acgttgcttt tttctctttg tttttaattc
     7381 catacagagt attcaattct tgaaacacat taaaataatt tgcttgctag ggtatggttt
     7441 attttataat tacattccta gtcttgtgtg gttattgtaa tgatgtctgg tcctaatttc
     7501 tctgcccgta tgaaaaagaa ccccttgcct gttgatccta aatataattt ggaaattaa
//
