LOCUS       NM_001039548            2100 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens kelch like family member 35 (KLHL35), mRNA.
ACCESSION   NM_001039548
VERSION     NM_001039548.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2100)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 2100)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2100)
  AUTHORS   Dhanoa,B.S., Cogliati,T., Satish,A.G., Bruford,E.A. and
            Friedman,J.S.
  TITLE     Update on the Kelch-like (KLHL) gene family
  JOURNAL   Hum Genomics 7 (1), 13 (2013)
   PUBMED   23676014
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP000744.4 and KF510381.1.
            
            On Feb 11, 2021 this sequence version replaced NM_001039548.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038192.2030645.1,
                                           SRR14372080.3292940.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2154665, SAMN03465404
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000539798.3/
                                                ENSP00000438526.1
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-161               AP000744.4         123653-123813       c
            162-1043            AP000744.4         120359-121240       c
            1044-1228           AP000744.4         119052-119236       c
            1229-1347           AP000744.4         117130-117248       c
            1348-1479           AP000744.4         116060-116191       c
            1480-1536           KF510381.1         307-363             c
            1537-1725           AP000744.4         114301-114489       c
            1726-2100           AP000744.4         113003-113377       c
FEATURES             Location/Qualifiers
     source          1..2100
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.4"
     gene            1..2100
                     /gene="KLHL35"
                     /note="kelch like family member 35"
                     /db_xref="GeneID:283212"
                     /db_xref="HGNC:HGNC:26597"
     exon            1..161
                     /gene="KLHL35"
                     /inference="alignment:Splign:2.1.0"
     exon            162..1043
                     /gene="KLHL35"
                     /inference="alignment:Splign:2.1.0"
     CDS             163..1914
                     /gene="KLHL35"
                     /note="kelch-like 35"
                     /codon_start=1
                     /product="kelch-like protein 35"
                     /protein_id="NP_001034637.2"
                     /db_xref="CCDS:CCDS44685.2"
                     /db_xref="GeneID:283212"
                     /db_xref="HGNC:HGNC:26597"
                     /translation="MRQGHAPEESEPGCEAPCAGPCHAQRVLQALNAYRRSGTLTDVV
                     LRAGGRDFPCHRAALSAGSAYFRSLFAAGRPERGPAVVPVVPVAPEAPGTSPAGAAAA
                     LAVVLDYVYGAGVRLRAEDEAAAVLALAERLGVAGLREACVRFLEGRLRAANSLALRR
                     VAAAFSLAPLAERCGRVLRQAFAEVARHADFLELAPDEVVALLADPALGVAREEAVFE
                     AAMRWVRHDAPARRGQLRRLLEHVRLPLLAPAYFLEKVEADELLQACGECRPLLLEAR
                     ACFILGREAGALRTRPRRFMDLAEVIVVIGGCDRKGLLKLPFADAYHPESQRWTPLPS
                     LPGYTRSEFAACALRNDVYVSGGHINSHDVWMFSSHLHTWIKVASLHKGRWRHKMAVV
                     QGQLFAVGGFDGLRRLHSVERYDPFSNTWAAAAPLPEAVSSAAVASCAGKLFVIGGAR
                     QGGVNTDKVQCFDPKEDRWSLRSPAPFSQRCLEAVSLEDTIYVMGGLMSKIFTYDPGT
                     DVWGEAAVLPSPVESCGVTVCDGKVHILGGRDDRGESTDKVFTFDPSSGQVEVQPSLQ
                     RCTSSHGCVTIIQSLGR"
     exon            1044..1228
                     /gene="KLHL35"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1347
                     /gene="KLHL35"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1536
                     /gene="KLHL35"
                     /inference="alignment:Splign:2.1.0"
     exon            1537..1725
                     /gene="KLHL35"
                     /inference="alignment:Splign:2.1.0"
     exon            1726..2100
                     /gene="KLHL35"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2037..2042
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLHL35"
                     /note="hexamer: AATAAA"
     polyA_site      2064
                     /gene="KLHL35"
                     /note="major polyA site"
     polyA_site      2100
                     /gene="KLHL35"
                     /note="major polyA site"
ORIGIN      
        1 gtcctcccgc agctgagccc gagcgaacag caaacgggag tctgggcaga gcagcatgaa
       61 cactggagct tgggctgcca ggggtgcggg cggcaggcac aaacgggagt gatacctgtg
      121 agagcagcag ctgcggagca cttgggagag ggtatggcca ggatgcggca aggccatgcg
      181 ccggaggagt cggagccggg ctgcgaagcg ccgtgcgcgg gtccgtgcca cgcgcagcgc
      241 gtgctgcagg ccctgaacgc ctaccggcgg agcggcaccc tcaccgacgt ggtgctgcgc
      301 gccggcgggc gcgactttcc gtgccaccgc gcggcgctca gcgcgggcag cgcctacttc
      361 cgcagcttgt tcgcggccgg gcggcccgag cgcggcccgg ccgtggtgcc agtggtgcca
      421 gtagctcccg aggcgccagg cacgagcccg gccggggcgg cggcggcgct ggccgtggtg
      481 ctcgactacg tgtacggagc gggcgtgcgg ctgcgcgcgg aggacgaggc ggcggccgtg
      541 ctggcgctgg cggagcggct gggcgtggcg ggcctgcgcg aggcctgcgt gcgctttctc
      601 gagggccgcc tgcgcgccgc caacagccta gcgctgcgcc gcgtggccgc cgccttctcg
      661 ctggccccgc tggccgagcg ctgcggccgc gtcctgcgtc aggccttcgc cgaggtggcg
      721 cgccacgccg acttcctgga gctggcgcct gacgaggtgg tggcgctgct ggcggacccc
      781 gcgctgggcg tggcgcgcga ggaggccgtg tttgaagcgg ccatgcgctg ggtgcgccac
      841 gacgcgccgg cccgccgcgg ccagctgcga cgcctgctgg agcacgtgcg cctgccgcta
      901 ctggcgcccg cttacttcct ggagaaggtg gaggcggacg agctgctgca ggcctgcggc
      961 gagtgccgcc cgctgctgct cgaggctcgc gcctgcttca tcctgggccg cgaggccggt
     1021 gcgctgcgga cccggccgcg gagattcatg gacctagctg aagtgatcgt ggtcatcggc
     1081 ggttgcgacc gcaaaggtct cctgaagctg cccttcgccg atgcctacca tccagagagc
     1141 cagcggtgga ccccactgcc cagcctgccc ggctacactc gctcagaatt cgccgcctgt
     1201 gctctccgca atgacgtcta cgtctccgga ggccacatca acagtcatga tgtgtggatg
     1261 tttagctccc atctgcacac ctggatcaag gtagcctctc tgcacaaggg caggtggagg
     1321 cacaagatgg cagttgtgca ggggcagctg ttcgcggtgg gtggcttcga cggcctgagg
     1381 cgcctgcaca gcgtggagcg ctacgacccc ttctccaaca cctgggcggc cgccgcgccc
     1441 ctcccggagg ccgtgagctc ggcggcggtg gcgtcctgcg cgggcaagct cttcgtgatt
     1501 gggggcgcca ggcagggcgg cgtcaacacg gacaaggtgc agtgctttga ccccaaggag
     1561 gaccggtgga gcctgcggtc accagcaccc ttctcacagc ggtgtctcga ggctgtctcc
     1621 cttgaggaca ccatctatgt catggggggt ctcatgagca aaatcttcac ctatgatcca
     1681 ggcacagatg tgtgggggga ggcagctgtc ctccccagcc ctgtggaaag ctgtggagtc
     1741 actgtgtgtg acgggaaggt ccacatcctt ggcgggcggg atgatcgcgg agaaagcacc
     1801 gataaggtct tcacctttga ccccagcagt gggcaggtgg aggtccagcc atccctgcag
     1861 cgctgcacca gctcccacgg ctgtgtcacc atcatccaga gcttgggcag gtgattcaga
     1921 tttggacagc ctgagccagg aggcggagag gcaggcggag ctcagatgca cactctgctc
     1981 cctcatggca cctccacgca aacagccctt aacttaatgg tcccttttct tgtataaata
     2041 aaatcttgtt gggtctgtgt tccagctgca gtctgccctg cctggagatg gaatgtctaa
//
