LOCUS       NM_153270               3641 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens kelch like family member 34 (KLHL34), mRNA.
ACCESSION   NM_153270
VERSION     NM_153270.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3641)
  AUTHORS   Dhanoa,B.S., Cogliati,T., Satish,A.G., Bruford,E.A. and
            Friedman,J.S.
  TITLE     Update on the Kelch-like (KLHL) gene family
  JOURNAL   Hum Genomics 7 (1), 13 (2013)
   PUBMED   23676014
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3641)
  AUTHORS   Bohm,D., Keller,K., Pieter,J., Boehm,N., Wolters,D., Siggelkow,W.,
            Lebrecht,A., Schmidt,M., Kolbl,H., Pfeiffer,N. and Grus,F.H.
  TITLE     Comparison of tear protein levels in breast cancer patients and
            healthy controls using a de novo proteomic approach
  JOURNAL   Oncol Rep 28 (2), 429-438 (2012)
   PUBMED   22664934
REFERENCE   3  (bases 1 to 3641)
  AUTHORS   Ross,M.T., Grafham,D.V., Coffey,A.J., Scherer,S., McLay,K.,
            Muzny,D., Platzer,M., Howell,G.R., Burrows,C., Bird,C.P.,
            Frankish,A., Lovell,F.L., Howe,K.L., Ashurst,J.L., Fulton,R.S.,
            Sudbrak,R., Wen,G., Jones,M.C., Hurles,M.E., Andrews,T.D.,
            Scott,C.E., Searle,S., Ramser,J., Whittaker,A., Deadman,R.,
            Carter,N.P., Hunt,S.E., Chen,R., Cree,A., Gunaratne,P., Havlak,P.,
            Hodgson,A., Metzker,M.L., Richards,S., Scott,G., Steffen,D.,
            Sodergren,E., Wheeler,D.A., Worley,K.C., Ainscough,R.,
            Ambrose,K.D., Ansari-Lari,M.A., Aradhya,S., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Ballabio,A., Banerjee,R., Barker,G.E.,
            Barlow,K.F., Barrett,I.P., Bates,K.N., Beare,D.M., Beasley,H.,
            Beasley,O., Beck,A., Bethel,G., Blechschmidt,K., Brady,N.,
            Bray-Allen,S., Bridgeman,A.M., Brown,A.J., Brown,M.J., Bonnin,D.,
            Bruford,E.A., Buhay,C., Burch,P., Burford,D., Burgess,J.,
            Burrill,W., Burton,J., Bye,J.M., Carder,C., Carrel,L., Chako,J.,
            Chapman,J.C., Chavez,D., Chen,E., Chen,G., Chen,Y., Chen,Z.,
            Chinault,C., Ciccodicola,A., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S., Clerc-Blankenburg,K., Clifford,K., Cobley,V., Cole,C.G.,
            Conquer,J.S., Corby,N., Connor,R.E., David,R., Davies,J., Davis,C.,
            Davis,J., Delgado,O., Deshazo,D., Dhami,P., Ding,Y., Dinh,H.,
            Dodsworth,S., Draper,H., Dugan-Rocha,S., Dunham,A., Dunn,M.,
            Durbin,K.J., Dutta,I., Eades,T., Ellwood,M., Emery-Cohen,A.,
            Errington,H., Evans,K.L., Faulkner,L., Francis,F., Frankland,J.,
            Fraser,A.E., Galgoczy,P., Gilbert,J., Gill,R., Glockner,G.,
            Gregory,S.G., Gribble,S., Griffiths,C., Grocock,R., Gu,Y.,
            Gwilliam,R., Hamilton,C., Hart,E.A., Hawes,A., Heath,P.D.,
            Heitmann,K., Hennig,S., Hernandez,J., Hinzmann,B., Ho,S., Hoffs,M.,
            Howden,P.J., Huckle,E.J., Hume,J., Hunt,P.J., Hunt,A.R.,
            Isherwood,J., Jacob,L., Johnson,D., Jones,S., de Jong,P.J.,
            Joseph,S.S., Keenan,S., Kelly,S., Kershaw,J.K., Khan,Z.,
            Kioschis,P., Klages,S., Knights,A.J., Kosiura,A., Kovar-Smith,C.,
            Laird,G.K., Langford,C., Lawlor,S., Leversha,M., Lewis,L., Liu,W.,
            Lloyd,C., Lloyd,D.M., Loulseged,H., Loveland,J.E., Lovell,J.D.,
            Lozado,R., Lu,J., Lyne,R., Ma,J., Maheshwari,M., Matthews,L.H.,
            McDowall,J., McLaren,S., McMurray,A., Meidl,P., Meitinger,T.,
            Milne,S., Miner,G., Mistry,S.L., Morgan,M., Morris,S., Muller,I.,
            Mullikin,J.C., Nguyen,N., Nordsiek,G., Nyakatura,G., O'Dell,C.N.,
            Okwuonu,G., Palmer,S., Pandian,R., Parker,D., Parrish,J.,
            Pasternak,S., Patel,D., Pearce,A.V., Pearson,D.M., Pelan,S.E.,
            Perez,L., Porter,K.M., Ramsey,Y., Reichwald,K., Rhodes,S.,
            Ridler,K.A., Schlessinger,D., Schueler,M.G., Sehra,H.K.,
            Shaw-Smith,C., Shen,H., Sheridan,E.M., Shownkeen,R., Skuce,C.D.,
            Smith,M.L., Sotheran,E.C., Steingruber,H.E., Steward,C.A.,
            Storey,R., Swann,R.M., Swarbreck,D., Tabor,P.E., Taudien,S.,
            Taylor,T., Teague,B., Thomas,K., Thorpe,A., Timms,K., Tracey,A.,
            Trevanion,S., Tromans,A.C., d'Urso,M., Verduzco,D., Villasana,D.,
            Waldron,L., Wall,M., Wang,Q., Warren,J., Warry,G.L., Wei,X.,
            West,A., Whitehead,S.L., Whiteley,M.N., Wilkinson,J.E.,
            Willey,D.L., Williams,G., Williams,L., Williamson,A.,
            Williamson,H., Wilming,L., Woodmansey,R.L., Wray,P.W., Yen,J.,
            Zhang,J., Zhou,J., Zoghbi,H., Zorilla,S., Buck,D., Reinhardt,R.,
            Poustka,A., Rosenthal,A., Lehrach,H., Meindl,A., Minx,P.J.,
            Hillier,L.W., Willard,H.F., Wilson,R.K., Waterston,R.H., Rice,C.M.,
            Vaudin,M., Coulson,A., Nelson,D.L., Weinstock,G., Sulston,J.E.,
            Durbin,R., Hubbard,T., Gibbs,R.A., Beck,S., Rogers,J. and
            Bentley,D.R.
  TITLE     The DNA sequence of the human X chromosome
  JOURNAL   Nature 434 (7031), 325-337 (2005)
   PUBMED   15772651
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA395149.1, BC109031.2, AI792176.1 and AL772392.4.
            
            On May 17, 2019 this sequence version replaced NM_153270.2.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK092279.1, BC109031.2 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000379499.3/ ENSP00000368813.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                DA395149.1         58-88
            32-2663             BC109031.2         1-2632
            2664-2982           AI792176.1         178-496
            2983-3641           AL772392.4         48945-49603         c
FEATURES             Location/Qualifiers
     source          1..3641
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp22.12"
     gene            1..3641
                     /gene="KLHL34"
                     /note="kelch like family member 34"
                     /db_xref="GeneID:257240"
                     /db_xref="HGNC:HGNC:26634"
     exon            1..3641
                     /gene="KLHL34"
                     /inference="alignment:Splign:2.1.0"
     CDS             543..2477
                     /gene="KLHL34"
                     /note="kelch-like 34; RP11-450P7.3"
                     /codon_start=1
                     /product="kelch-like protein 34"
                     /protein_id="NP_695002.1"
                     /db_xref="CCDS:CCDS14199.1"
                     /db_xref="GeneID:257240"
                     /db_xref="HGNC:HGNC:26634"
                     /translation="MSYFLSYCKAHGGALLTGYQALRAEGFLCDVTLETEGSEFPAHR
                     SLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRLLDFIYTAWLSLSMDTVEDT
                     LEAASYLQVTEALGLCGRYLERQLAPENCCFAANVAARFGLAHTLDAAERCIVSHLQE
                     LLARGAGPAGLLELNPTSLRAVLGAPDVARVPEARLLGLALAWLRQEPTTERLAHCTE
                     LLERVRFGLVPADVLRRVYSGSGLVLPARVKGLIIQALNYHTTPSRQPLMQGEQTSIR
                     SPQTRILLVGGRRAREVVIEEVAAPQRAARGQVAAPEPEEEEEELEEEEEEEEWELTQ
                     NVVAFDVYNHRWRSLTQLPTPLLGHSVCTAGNFLFVLGGESPSGSASSPLADDSRVVT
                     AQVHRYDPRFHAWTEVPAMREARAHFWCGAVGERLLAVGGLGAGGEVLASVEMYDLRR
                     DRWTAAGALPRALHGHAGAVGDRGVVYISGGKAGRGEGGASSLRDLYVLGPEEQVWSK
                     KAPMGTARFGHHMAVLRGAVFAFLGRYEPFSEIERYDPGADQWTRLRPLPYDRFCYGL
                     AVVEETALLLGGLKWRDSRQVPTRNVVGYDLDLDRWEDIGCALPWAWSGLRCAVLQLA
                     EGGDDEREGEVGEALDLVLG"
     regulatory      3618..3623
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLHL34"
                     /note="hexamer: AATAAA"
     polyA_site      3641
                     /gene="KLHL34"
                     /note="major polyA site"
ORIGIN      
        1 agttgtcccc ggccttcgcg ggtgcccgca gaacccgtcc tcctcgtcca ccccggagag
       61 gtcagagtcc tcgccctgca ctcccgggac gccgcatctg cgccgtcgga catccagcac
      121 ccccggagtc caccggcaac tcggttcttc caggtgatgg tgtgcagcca ccgccgcccc
      181 tggcgtgcag gtgtgggctc tccacattgg gccggggagg ggacttcggg caacgcgctg
      241 gaagcctcgg cagtcgtgga aaccaagccc cacactcccg ggaagcctcc aaattccgcg
      301 ccctccgtta ctaggggcct ccgaaaaccg tttccagact ggatttgctc tgagaggggc
      361 actgggcgat ctgcaggtct ggatgaagga gccctgggct ttaaactgag caggcagaaa
      421 tgggcccctg ctaggggctc tgtggcttac gcgggggtcc cgggagtgtt gtgccccggg
      481 atgcctccgg ccctgcccag caggcctctg gtcccaccag gctgcttcca gccctgggta
      541 gaatgagtta cttcctgtct tactgcaaag ctcatggcgg cgcgctgctc accggctacc
      601 aggccctgcg cgccgagggc ttcctgtgcg acgtgacact ggagaccgag ggcagcgaat
      661 tcccggcgca caggtcgctc ctggcgtgct ccagtgacta cttcagggcc ctgttcaaga
      721 gccacaccca ggaatcccgg gcgcgcgtga tccacctgca cgtgccatcg gcagccggcc
      781 tgcagcgcct gctggacttc atctacactg cctggctgtc gctttccatg gacactgtag
      841 aggacactct ggaggccgcc agctacctgc aggtcactga ggccctgggg ctctgtgggc
      901 gctacttgga gcgccagctg gctccagaga actgctgctt cgccgccaac gtggcagcgc
      961 gctttggcct ggctcacacg ctggacgcgg ccgagcgctg catcgtgagc cacttgcagg
     1021 agctgctggc gcggggcgcg ggccccgcgg gactcctgga gctcaaccct acatcgctga
     1081 gggctgtact gggtgccccc gacgtggcgc gggtgcccga ggcccggcta ctgggcctgg
     1141 cgttagcttg gttgcggcag gagcccacaa ctgagcgcct ggcacactgt acagagttgc
     1201 tggagcgtgt ccgctttggc ctggttcccg ccgacgtact gcggcgcgtg tactcgggct
     1261 ctggcctcgt gctgcccgcc cgggtcaagg gcctcatcat ccaggccctc aactaccaca
     1321 cgacgccctc ccgccagccg ctcatgcagg gcgagcagac cagcatccgg agcccccaga
     1381 cccgcatctt gttggtgggg gggcgcaggg cacgggaggt ggtgattgag gaggtcgcgg
     1441 ccccgcagag ggcagctagg ggccaggtcg ccgccccaga gcccgaggaa gaagaggaag
     1501 agttggagga agaggaggag gaggaggagt gggagctcac ccagaacgtg gtggccttcg
     1561 atgtgtacaa tcaccgctgg cgcagcctta cgcagctacc cacaccactg ctggggcaca
     1621 gcgtgtgcac cgcgggcaac ttcctgtttg tcctgggtgg ggagagccct tccggcagtg
     1681 catcctctcc cctggccgac gactcgcggg tggtcacggc ccaagtgcac cgttacgacc
     1741 cgcgcttcca cgcttggacg gaagtgcccg ccatgcggga agcgcgggcc cacttctggt
     1801 gcggcgcggt gggcgagagg ctcctggccg tcgggggcct gggtgcgggc ggtgaggtgc
     1861 tggcctcggt ggagatgtac gacctgcgtc gggaccgctg gacggcggct ggggcactac
     1921 cgcgggctct gcacggtcac gcgggggccg tcggggaccg cggtgttgtg tacatctcgg
     1981 ggggcaaggc agggagaggc gagggcggag cgagcagcct ccgggactta tacgtcctgg
     2041 gccctgagga gcaggtttgg agcaagaagg cacccatggg caccgcacgt ttcgggcacc
     2101 acatggcagt gctgcgcggc gctgtgtttg cttttctggg gcgatacgag cccttctctg
     2161 agatcgagcg ctacgacccc ggcgccgacc agtggactcg gttgcggccg ctgccctacg
     2221 accgcttctg ctatgggctg gccgtggtcg aggagacagc gttgctgctg ggcggcctca
     2281 agtggcggga ctcgcgccag gtgcctaccc gcaacgtagt gggctacgac ctcgacctgg
     2341 accgttggga ggacatcggc tgcgcgttgc cctgggcctg gagcggcctg cggtgcgcag
     2401 tgctgcagct ggccgagggt ggggacgacg agagggaggg agaggttgga gaggcgctag
     2461 atttggtgct gggctgaatg ggtcagtccg gtttccttcc gcaatggagg agaaagtcgc
     2521 gcttggttag tcttacagag caacggatgg gctttttcta agaaagggat tctgggagca
     2581 gagtggcttc tgaaggttaa caggcaaaca aggccttgag caaagagaaa catttctcct
     2641 tgagctgaga atgggagaca gcggggcggg gggtcaaata gaaggctata tgaatcaact
     2701 tcagtgagct ggtgaaagaa aatttttaga aaggctcacg caaggctaga gaaggacttt
     2761 cacaaataaa atatgacctt attttccctc ttacagttaa agtgtttccc taggtgcaaa
     2821 acagtgatta cttatgtgcc aaaaaaaaaa aaaaaaaaaa aaggccaaaa aatgtaccac
     2881 aggaagttta tacaaaactc agaaaattgt tggctataaa ggctgtaatt aagtcctagg
     2941 agatggcatt atctgaataa atagtgaaag gagagtgcct tggttaaata ccatgaaatc
     3001 attgtaagga gaactatgat tttatgatcc ggagccatgg ttacagttct gctctgatgg
     3061 tttgatataa atatggaact gagaaggaaa aaaaaaatct ctaagcactt ttttttaatc
     3121 tagaaagtat ccttaaattt ttctgtcacc ggtgtcaccc taggctgctt ttgccctgac
     3181 tttagacagc tcactggttt taagtcacat ttcatcaacc cttagccata ataatcagga
     3241 tcctctggtt aagtggaatg tctaaccaaa acaaaacaaa aactgatttc tttcatactc
     3301 ttttaaatgt tcattctgca gacatactgt agattatatt tgtaaaaaaa aatcaatttt
     3361 tggtggttac ccccacttcc cccaaaagaa tcacagagaa aggaaagagg aataggtaaa
     3421 gttttaaact tcgtctcagg taaatgggaa acgagcttga tttttcaggg tcttagataa
     3481 gacacttgta tatactgaac aggtgctgct tttggcttgt atcaccaatg aggcagcaaa
     3541 gttagaactc gaaactaggg tggggggtgg tggctgtata attaggtcac aaagaaatgt
     3601 ggtaaggact ttgcatgaat aaagtaggtg ctttataagg a
//
