LOCUS       NM_001365790            5478 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens kelch like family member 33 (KLHL33), transcript
            variant 1, mRNA.
ACCESSION   NM_001365790 XM_005267347
VERSION     NM_001365790.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5478)
  AUTHORS   Dhanoa,B.S., Cogliati,T., Satish,A.G., Bruford,E.A. and
            Friedman,J.S.
  TITLE     Update on the Kelch-like (KLHL) gene family
  JOURNAL   Hum Genomics 7 (1), 13 (2013)
   PUBMED   23676014
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5478)
  AUTHORS   Choy,K.W., Wang,C.C., Ogura,A., Lau,T.K., Rogers,M.S., Ikeo,K.,
            Gojobori,T., Lam,D.S. and Pang,C.P.
  TITLE     Genomic annotation of 15,809 ESTs identified from pooled early
            gestation human eyes
  JOURNAL   Physiol Genomics 25 (1), 9-15 (2006)
   PUBMED   16368877
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL355075.6.
            
            On May 17, 2019 this sequence version replaced NM_001365790.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DRR138518.508330.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2158800, SAMN03465413
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000636854.3/ ENSP00000490040.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                AL355075.6         83799-83866
            69-835              AL355075.6         84135-84901
            836-1760            AL355075.6         89246-90170
            1761-1928           AL355075.6         90296-90463
            1929-5478           AL355075.6         90564-94113
FEATURES             Location/Qualifiers
     source          1..5478
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q11.2"
     gene            1..5478
                     /gene="KLHL33"
                     /note="kelch like family member 33"
                     /db_xref="GeneID:123103"
                     /db_xref="HGNC:HGNC:31952"
     exon            1..68
                     /gene="KLHL33"
                     /inference="alignment:Splign:2.1.0"
     exon            69..835
                     /gene="KLHL33"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..2481
                     /gene="KLHL33"
                     /note="isoform 1 is encoded by transcript variant 1;
                     kelch-like protein 33"
                     /codon_start=1
                     /product="kelch-like protein 33 isoform 1"
                     /protein_id="NP_001352719.1"
                     /db_xref="CCDS:CCDS91847.1"
                     /db_xref="GeneID:123103"
                     /db_xref="HGNC:HGNC:31952"
                     /translation="MSVSDTPHYPPELESVSHPVQRDCLGLLVHAQRTPSWPPSPDED
                     PRLPSFPLEEPGSRPLVPRNLPFPALSLEEEEEEEEDEDAAEPEWLRSEEHPSQFFAE
                     AQRLREQRLLLDEEVSVAGRVYGVHRVILAAISSLFRDRLLGGGGPRPPFSLEVSPGG
                     WEAVLTFAYEGVLGPASQGDVLAAAEALGAPRVKAAAQQTCERAGNAREDVKKPSQAE
                     ELRENLRGIELLYREGVGCDLKLEAGGCQLSVHRAALACGSEFFGAMLLSGMRESQGT
                     EVSLRTISTQDLRLLVSFAYSGVVRARWPGLLRAAQAALQYQSSSCLDLCQKGLARGL
                     SPARCLALFPMAEAPGLERLWSKARHYLLTHLPAVALCPAFPSLPAACLAELLDSDEL
                     HVQEEFEAFVAARCWLAANPETQESEAKALLRCVRFGRMSTRELRRVRAAGLLPPLTP
                     DLLHQLMVEADVPGQERRREPDRALVVIGGDGLRPDMALRQPSRAVWWARAFRCGVGL
                     VRTVEWGQLPALPAPGRFRHGAASLAGSELYVCGGQDFYSHSNTLASTLRWEPSQEDW
                     EEMAPLSQARSLFSLVALDGKLYALGGRHNDVALDSVETYNPELNVWRPAPALPAPCF
                     AHAAAILEGQLYVSGGCGGTGQYLASLMHYDPKLEKPGTFLSPMGVPRAGHVMAALGG
                     RLYVAGGLGETEDLLSFEAYELRTDSWTHLAPLPSPHVGAASAVLQGELLVLGGYSHR
                     TYALSHLIHAYCPGLGRWLCLGTLPRPRAEMPACILTLPAVQHIALVPTPHQTKPAG"
     exon            836..1760
                     /gene="KLHL33"
                     /inference="alignment:Splign:2.1.0"
     exon            1761..1928
                     /gene="KLHL33"
                     /inference="alignment:Splign:2.1.0"
     exon            1929..5478
                     /gene="KLHL33"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5455..5460
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLHL33"
                     /note="hexamer: AATAAA"
     polyA_site      5478
                     /gene="KLHL33"
                     /note="major polyA site"
ORIGIN      
        1 gccacgcagc cccaagcaca gcgggcgctt aagtgagagg gcaagcggaa cgctggtgtc
       61 tcctgaggct atccagcaaa cctcggcatg agcgtctcgg acaccccaca ttatccccct
      121 gagctggaga gtgtctctca tcccgtccag agggactgcc ttggactcct tgtgcacgcc
      181 cagagaaccc cttcctggcc tccctccccc gacgaggatc ccagattgcc ttcctttcct
      241 ctggaggagc ctggttccag gcccctggtc ccaaggaacc ttccctttcc agccttgtcc
      301 ctagaggaag aagaggaaga ggaagaagat gaagatgcgg cagagcccga gtggctgcgc
      361 agcgaggagc atccgagcca gtttttcgcc gaggcccagc ggctgcggga gcagagactg
      421 ttgctggacg aagaggtgtc agtcgcgggg cgggtatacg gggtgcatcg ggtgatcctg
      481 gccgcaatca gcagcctctt ccgagacagg ctgctgggcg gcggaggtcc gcggcccccc
      541 ttcagcctcg aggtgtcccc agggggctgg gaggccgtgc tgacctttgc ctatgagggg
      601 gtgctgggcc ccgcctcgca gggggatgtg ctggccgcag cagaggcgct gggagcgccc
      661 cgggtgaagg ctgctgccca gcagacatgc gagagggctg gaaatgccag ggaagatgta
      721 aagaagccca gccaggcaga ggagctgagg gagaacctgc gcggaatcga gctcctctac
      781 cgagagggcg tcgggtgtga cttgaagctg gaggcaggcg gctgccagct gtcggtgcac
      841 cgagccgccc tggcctgtgg cagtgagttc tttggggcca tgctcctgag cgggatgagg
      901 gaatcccagg gcacagaggt atctctgcgg acgatctcca cccaggacct gcgactcctc
      961 gtctcttttg cttactccgg agttgtgcgg gcaaggtggc cagggctact gagagctgcc
     1021 caggctgctc tgcagtacca gagctcttcc tgcttggatt tgtgtcagaa aggcttggca
     1081 cggggcctca gccctgcccg ttgcctggcc ctgttcccca tggcggaagc ccctgggttg
     1141 gagaggctct ggagcaaagc ccgtcactac ctcctcaccc acctgcctgc tgtagccttg
     1201 tgtcctgctt tcccttcttt accagctgcc tgcttggctg agctcctgga tagtgatgag
     1261 ctccatgtgc aggaggagtt tgaggccttt gtggctgcac ggtgttggct ggctgccaac
     1321 cccgagaccc aggagtcaga ggccaaggcc ctgctgcgat gtgtccgctt tggccgcatg
     1381 tccaccaggg agttgcggag ggtgcgggca gccgggctac ttccacccct gaccccagat
     1441 ctgttgcacc agctgatggt agaggctgat gttccaggcc aagagagacg gagggagcct
     1501 gaccgggcac tggtagtgat tggcggggat gggctcagac cagacatggc cctaagacaa
     1561 ccatcccgag cagtgtggtg ggcccgggcc ttccgctgtg gcgtgggact ggtacgaact
     1621 gttgagtggg ggcagctgcc tgccctgcct gcccccggac gcttccggca tggggctgca
     1681 agcctggcag gaagtgaact ctatgtgtgt gggggacaag atttctacag tcactccaac
     1741 accctggctt caactctcag gtgggagccc agtcaagagg actgggagga gatggctcct
     1801 ttgtcccagg ctcgaagcct tttctccttg gtggcactgg atggaaaact ttatgccctg
     1861 ggtggaagac acaatgatgt tgccctggac tctgtggaga cctacaaccc tgagctcaat
     1921 gtctggaggc cagcacctgc acttccagca ccatgttttg cccacgcagc tgcgattttg
     1981 gagggccagt tgtacgtgag cggtggctgt ggtgggactg gccaatacct ggcctcactg
     2041 atgcactatg accccaaact tgagaagcca gggacgtttc tgagccctat gggggtacct
     2101 cgggctggcc atgtcatggc tgcattgggt gggaggttgt atgtggcagg tgggctgggt
     2161 gagactgagg acctgctaag ctttgaggcc tatgaactaa ggactgatag ctggactcac
     2221 ctggcacccc taccctcccc ccatgtgggg gctgcaagtg ctgtgctgca gggggagcta
     2281 ctggtgctcg ggggctacag tcaccgtact tatgccctct ctcaccttat ccatgcctac
     2341 tgtcctggcc tgggccgatg gctctgcctg ggaactctgc caaggcctcg ggctgagatg
     2401 cctgcctgca tcctgacact gcccgctgtg cagcacatag ctttggttcc caccccacac
     2461 caaaccaaac ctgctgggtg aagagggagc aacagtgtat ggggagagga gggcataaga
     2521 aatagcctga gagaaggaca gagattgtgg ggagtgaaaa gaggctttat tcttggtagt
     2581 attttattct cacactgtgc attgtaaact gcttttgtac gtatgatctc cgttgaggaa
     2641 atggtggttc cagaactcct agggaaaaca tatagggaaa ggggaggcag ctgaataccc
     2701 aggtgaggaa aggagactcg ggagcaactc cacaaggctt agggattctt agggaaaggg
     2761 catctagttt gaaagagagt taagaagctt cagtagccaa agtgtagaga ccatgggagg
     2821 acagttggaa aaatggttct gacccatgga tcatgggaaa aatgtggaat ggccatccat
     2881 gaaagagttt gaggagtgta ggagtaagga ctgtaaatcg ttcagccctt tttttcctgg
     2941 aacttgctcc tttctcctct cccacccctg ggatgcctaa accttcttaa caatattctc
     3001 tcccgggtaa ctttgtaggc ctggtctagc gtttcccagc gagacaccac aggctgcccc
     3061 tgagaacctc ttggtttcct tctgaggcag aagctcccac atggacatgc acggcacagg
     3121 ggcctgagag gcctgacggg ccccccaggg ccatgtggca ggagtgttgt gtgggaaaga
     3181 tgatgggggc agaggccaag gagggagagg cccacagtgg aaaaacagat gatctgaggt
     3241 ttaaggagat ggggtggaag aagtcagaag cctgtgtgcc ttctttcttt tgggcaaact
     3301 gaggaatcag gagtgaaaat gagaccgttg ttgcctgagg tctcaagtgg tgagaggatg
     3361 tggggggaga gaagagtgag aagcagacaa gactcagaaa agtcatttcc ccctttcagt
     3421 tcctttcccc cagagttatt tttaaatcca tttcccttta tcttggccag ggaaggtagt
     3481 caggtgcttc ctctttctct cttcccccat cctgctctcc ccactgcctc tcttttttct
     3541 ttctcttctt tctccctcac acagttatta attacctact gtgtggcagg cactgtagga
     3601 ggcaccaaga tacagaggtc agagagctcc tgaccagcag atagacataa acaaatacaa
     3661 attttgagtg gacttacatg tatggacgag tcttgcgaga gcccagagga tagagcagtg
     3721 aactctgctc aggaaggctt ctgttaggaa aggtgtcatc cgatgggtgt attttgaact
     3781 ggatcttaaa ggctgcctag agtctcaccc attagagaag ggggaatgca tttgaaacag
     3841 aaagaagtgg ggcatgccat gccctgtttc tccatagcaa agaggaagtg ggtattccag
     3901 aggcttttca gataattctg ctgctcttgc cacctactct cttctctgga gccttcctga
     3961 ggataatggc tttcacttaa tgattgtgta ttcccgccct ctatgactca cctctatcct
     4021 tcctgtctgc tctttccatt tctgcctact ggacagctga gagcaaaaaa gggtcagttt
     4081 ttttgtgtgt gtttaggtca attttctttt tctttttttt tttttaattt attttatttt
     4141 attattatta tactttaagt tttagggtac atgtgcccaa tgtgcaggtt agttacatat
     4201 gtatacatgt gccatgctgg tgtgctgcac ccattaactc gtcatttagc attaggtata
     4261 tctcctaatg ctatccttcc cccctccccc caccccacaa cattctccag agtgtgatgt
     4321 tccccttcct gtgtccacgt gttctcattg ttcaattccc acctatgagt gagaacatgc
     4381 ggtgtttggt ttttttgtcc ttgcgatagt ttactgagaa tgatgatttc caatctcatc
     4441 catgtcccta caaaggacat gaactcatca ttttttatgg ctgcatagta ttccatggtg
     4501 tatatgtgcc acattttctt aatccggtct atcattgttg gacatttggg ttggttccaa
     4561 gtctttgcta ttgtgaatag tgatgcaata aacatatgtg tgcatgtgtc tttatagcgg
     4621 catgatttat attcctttgg gcatataccc agtaatggga tggctgggtc aaatggtatt
     4681 tctagttcta ggtccctgag gaatcgccac actgacttcc acaatggttg aactagttta
     4741 cagtcccacc aacagtgtaa aagtgttcct atttctccac atcctctcca gcacctgttg
     4801 tcaattttct ttttcttttt tttttttttt tttttgagac agagttttac tctgttgccc
     4861 aggctggagt gcaatggcgt gatctcagct caccgcaaac tcttcctcct gagttcaagt
     4921 gattctcctg cctcagcctc cctgagttgc tgggattaca gctattacat ctggctaatt
     4981 ttgtattttt agtagagacg gggtttctcc atgttggtca ggctggtctt gaactcccga
     5041 cctcaggtga tccacccacc tcgacctccg aaagtgctgg gattacaggc gtgagccaca
     5101 atgcccggcc tgtgtaggtc agttttctat taccattgtt tattaagatt ttcatgtttc
     5161 taagggtgat gatggagtct cccttgcacc cttcttcatt ctggccccag aagtacttgg
     5221 catgtatttt atttatttat ttttagattt cgttatttta gtaagatctt tttctgtatc
     5281 tctatttaag atagactagg aatgtaattg aaaatgagaa ggggtaagta ggatgtataa
     5341 gagaaaagag aaggaagaat aaagaacggg aagaaggaaa ttgaaggaga tgacaagctc
     5401 tctggatgaa cttctatgaa cattttttgt gatttgtacc taaaggcaga cttaaataaa
     5461 ggtttcatag tgactgaa
//
