LOCUS       NM_001003760            5776 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens kelch like family member 31 (KLHL31), mRNA.
ACCESSION   NM_001003760 XM_376508
VERSION     NM_001003760.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5776)
  AUTHORS   Dhanoa,B.S., Cogliati,T., Satish,A.G., Bruford,E.A. and
            Friedman,J.S.
  TITLE     Update on the Kelch-like (KLHL) gene family
  JOURNAL   Hum Genomics 7 (1), 13 (2013)
   PUBMED   23676014
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5776)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   3  (bases 1 to 5776)
  AUTHORS   Yu,W., Li,Y., Zhou,X., Deng,Y., Wang,Z., Yuan,W., Li,D., Zhu,C.,
            Zhao,X., Mo,X., Huang,W., Luo,N., Yan,Y., Ocorr,K., Bodmer,R.,
            Wang,Y. and Wu,X.
  TITLE     A novel human BTB-kelch protein KLHL31, strongly expressed in
            muscle and heart, inhibits transcriptional activities of TRE and
            SRE
  JOURNAL   Mol Cells 26 (5), 443-453 (2008)
   PUBMED   18719355
  REMARK    GeneRIF: These results suggest that KLHL31 protein may act as a new
            transcriptional repressor in MAPK/JNK signaling pathway to regulate
            cellular functions.
REFERENCE   4  (bases 1 to 5776)
  AUTHORS   Wu,Y.L. and Gong,Z.
  TITLE     A novel zebrafish kelchlike gene klhl and its human ortholog KLHL
            display conserved expression patterns in skeletal and cardiac
            muscles
  JOURNAL   Gene 338 (1), 75-83 (2004)
   PUBMED   15302408
REFERENCE   5  (bases 1 to 5776)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL157773.13 and EF633513.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001003760.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EF633513.1, DRR138518.242042.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN03267751,
                                           SAMN03267764 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370905.4/ ENSP00000359942.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                AL157773.13        45040-45087         c
            49-171              EF633513.1         1-123
            172-173             AL157773.13        34620-34621         c
            174-5776            EF633513.1         126-5728
FEATURES             Location/Qualifiers
     source          1..5776
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p12.1"
     gene            1..5776
                     /gene="KLHL31"
                     /gene_synonym="bA345L23.2; BKLHD6; KBTBD1; KLHL"
                     /note="kelch like family member 31"
                     /db_xref="GeneID:401265"
                     /db_xref="HGNC:HGNC:21353"
                     /db_xref="MIM:610749"
     exon            1..156
                     /gene="KLHL31"
                     /gene_synonym="bA345L23.2; BKLHD6; KBTBD1; KLHL"
                     /inference="alignment:Splign:2.1.0"
     exon            157..1361
                     /gene="KLHL31"
                     /gene_synonym="bA345L23.2; BKLHD6; KBTBD1; KLHL"
                     /inference="alignment:Splign:2.1.0"
     CDS             190..2094
                     /gene="KLHL31"
                     /gene_synonym="bA345L23.2; BKLHD6; KBTBD1; KLHL"
                     /note="kelch repeat and BTB (POZ) domain containing 1;
                     kelch-like protein KLHL; BTB and kelch domain-containing
                     protein 6; kelch repeat and BTB domain-containing protein
                     1"
                     /codon_start=1
                     /product="kelch-like protein 31"
                     /protein_id="NP_001003760.2"
                     /db_xref="CCDS:CCDS34478.1"
                     /db_xref="GeneID:401265"
                     /db_xref="HGNC:HGNC:21353"
                     /db_xref="MIM:610749"
                     /translation="MAPKKKIVKKNKGDINEMTIIVEDSPLNKLNALNGLLEGGNGLS
                     CISSELTDASYGPNLLEGLSKMRQENFLCDLVIGTKTKSFDVHKSVMASCSEYFYNIL
                     KKDPSIQRVDLNDISPLGLATVIAYAYTGKLTLSLYTIGSIISAAVYLQIHTLVKMCS
                     DFLIREMSVENCMYVVNIAETYSLKNAKAAAQKFIRDNFLEFAESDQFMKLTFEQINE
                     LLIDDDLQLPSEIVAFQIAMKWLEFDQKRVKYAADLLSNIRFGTISAQDLVNYVQSVP
                     RMMQDADCHRLLVDAMNYHLLPYHQNTLQSRRTRIRGGCRVLVTVGGRPGLTEKSLSR
                     DILYRDPENGWSKLTEMPAKSFNQCVAVMDGFLYVAGGEDQNDARNQAKHAVSNFCRY
                     DPRFNTWIHLASMNQKRTHFSLSVFNGLVYAAGGRNAEGSLASLECYVPSTNQWQPKT
                     PLEVARCCHASAVADGRVLVTGGYIANAYSRSVCAYDPASDSWQELPNLSTPRGWHCA
                     VTLSDRVYVMGGSQLGPRGERVDVLTVECYSPATGQWSYAAPLQVGVSTAGVSALHGR
                     AYLVGGWNEGEKKYKKCIQCFSPELNEWTEDDELPEATVGVSCCTLSMPNNVTRESRA
                     SSVSSVPVSI"
     exon            1362..5776
                     /gene="KLHL31"
                     /gene_synonym="bA345L23.2; BKLHD6; KBTBD1; KLHL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5750..5755
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLHL31"
                     /gene_synonym="bA345L23.2; BKLHD6; KBTBD1; KLHL"
                     /note="hexamer: AATAAA"
     polyA_site      5776
                     /gene="KLHL31"
                     /gene_synonym="bA345L23.2; BKLHD6; KBTBD1; KLHL"
                     /note="major polyA site"
ORIGIN      
        1 aaaaattgct gcagccgggt cttgtcaggt ggctgctggt ggctccccac cggattttcc
       61 ttctccctct ctctatctcc acagatccct tcccaagagg agtctcctgc taaaacttca
      121 tcatctcaag ttgacctgcc acttcaccca aggaggcaag ctcttgcctg taacagtgta
      181 tttgccaaca tggcacccaa aaagaagatt gtcaaaaaga acaaaggaga tatcaatgag
      241 atgactataa tcgtagaaga tagcccccta aacaaactga atgctttgaa tgggctccta
      301 gagggaggca atggccttag ctgcatttct tctgaactaa cagatgcttc ttatggcccc
      361 aacctcttgg aaggtttaag taaaatgcgg caggagaact tcctatgtga cttagtcatt
      421 ggtaccaaaa ccaaatcctt tgatgttcat aagtcagtca tggcttcatg cagtgagtat
      481 ttttacaaca tcctaaaaaa agacccgtca attcagaggg tggatctcaa tgatatctca
      541 ccactaggcc tggccactgt cattgcatat gcctacactg gaaagctcac tctctccttg
      601 tatacaatag gaagcattat ttctgctgct gtttatcttc agatccatac tcttgtaaag
      661 atgtgcagtg attttctgat acgggagatg agtgttgaga attgcatgta tgttgttaat
      721 attgctgaaa catactccct aaaaaatgca aaagcagcag cccagaaatt tattcgggat
      781 aacttccttg aatttgcaga atcggatcag tttatgaaac ttacatttga acaaattaat
      841 gaacttctta tagatgatga cttacagttg ccttctgaga tagtagcatt ccagattgca
      901 atgaaatggt tagaatttga ccaaaagaga gtaaaatacg ctgcagatct tttgagcaat
      961 attcgctttg gtaccatctc tgcacaagac ctggtcaatt atgttcaatc cgtaccaaga
     1021 atgatgcaag atgctgattg tcacagactt ctcgtagatg ctatgaacta ccacttgctt
     1081 ccatatcatc aaaacacatt gcaatctagg cgaacaagaa tccgaggtgg ctgccgagtc
     1141 ctcgtcactg ttgggggacg cccaggcctt actgagaagt cccttagcag agacatcttg
     1201 tatagagacc ctgaaaatgg atggagcaag cttacggaaa tgccagccaa aagttttaat
     1261 cagtgtgtgg ctgtgatgga tggatttctt tatgtagccg gtggtgaaga ccagaatgat
     1321 gcaagaaatc aagccaagca tgcagtcagc aatttctgca gatacgatcc ccgcttcaac
     1381 acctggatac acctggccag catgaaccag aagcgcacgc acttcagcct gagcgtgttc
     1441 aacgggctcg tgtacgccgc gggcggccgc aacgcagaag gaagcctggc ctcgctggag
     1501 tgctacgtgc cctccaccaa tcagtggcag ccgaagacgc ccctggaggt ggcgcgctgc
     1561 tgccacgcta gcgcggtcgc cgacggccgc gtgctggtga ccggaggcta catagccaac
     1621 gcctactcgc gctctgtgtg cgcctacgac ccggccagcg actcgtggca ggagctgccg
     1681 aacctcagca caccccgggg ctggcactgc gcggtcacgc tgagcgacag agtgtacgtg
     1741 atgggcggca gccagctggg gccgcgcggg gagcgcgtgg acgtgctcac cgtggagtgc
     1801 tacagccccg cgaccggcca gtggagctac gcggcgccgc tgcaggtggg agtgagcact
     1861 gcgggcgtct cggcgctgca tggccgcgcc tacctggtgg ggggctggaa cgagggcgag
     1921 aagaagtaca agaagtgcat ccagtgcttc agccccgagc tcaacgagtg gacggaggac
     1981 gacgagctac ccgaggccac tgtcggcgtg tcctgctgca ccctctcgat gcccaacaac
     2041 gtgactcggg aatcccgggc cagttcggta tcttctgtgc cagtcagtat ctgagcccag
     2101 gtagatgcag ggacgcagga agaacacgtt atttattcgt agagccacgt ggttaacctc
     2161 tgagttcgcg aaaaggaaaa tatttaacat ttactacact gattgtattg taaaatatgt
     2221 cgaggcacat gtcctgatgg ctttaaattc ctggtatggc ataatctacc tctttttttt
     2281 tttttttttt ttagcaaaat acagggcaat ggccaacaaa agaaacaatt tatttcagcg
     2341 gccactgggt ggcagacgga attcgttata ggcactctcc caaggcggca tgtttcctaa
     2401 atgtatagcg gttacaccca catttgagat tttttcctct acacgttagt acacttgagg
     2461 tttatgtaag tgatttcatg ttcaaaagtt tattttcctc tctctctttt ttctttagga
     2521 agttgaagat attcatatag attttattta tttaaaaatg gaaattgtcg atctccataa
     2581 agacttaaga tttaattctg tatttcaacg caattttccc cccatatgtg attgagtaaa
     2641 ggattttgaa agatatccca tgacaacgta ataaagctta aaacaagatc tgaccgaaaa
     2701 ggaataggga ttccacccag ggaccctaaa tttgataacc tttgtgttag cggacattcc
     2761 tcttcctcca tgcctcaggc cccagtttat tttctaccat aaaatcatgc tctcaatgaa
     2821 gtaattgata tgaatcattt aatttatagc ataaatttaa gtcatttggt tgtttcaact
     2881 agaaggattt gcattttatc ccttgtcctc tattaaagaa gaatttcaca taccctggga
     2941 gccttaccct caccctaaaa actacaccaa cctggttaaa ggcaaccttg gccctaatgt
     3001 acaccccgcg aagatcacca aataaaacta tgtccctaag gaccattagc cttaagctta
     3061 gagagcttga agtttacaca accaataaca ataattttat ttgccccaat cttttatatg
     3121 ataagaatga tagaaacatt tggaatttgt agatttggta gtaactggat gaatgggttc
     3181 tcctgttgat aaatgccatt gtttcccatt taatatggat cctcctgatt tcttaagtaa
     3241 aaatcaagca ctcatctcac gtatataaaa atatatactc attctgtcct atttttatta
     3301 atctcatctg ctccaaatga gctttggatt tataatcaaa gtgtacccac ttgatagcac
     3361 ttttcctata tgtttgccaa gttttgggga aagggaatga ctgtagtaaa tgatacatat
     3421 tttccttttt tataatttat cactttattc tttgacagtt tatttgtttt ggagaggaag
     3481 tggcctatca attatgggtt atgtgcaatt ggattttgaa aaataaaaca agctatttag
     3541 gaattgaaca tgagatatat ggaaatataa tttggttttt gttaatctca tcctctccac
     3601 cttgtgtaga taggttattg ctagttatga tatttatttc taaaatatgt tatttgaact
     3661 gtgaaaagtg gttcatatag tacactttgt ggaacaattt tatatcatta ccccgatgaa
     3721 aagttcaatc tctggatatt taatgataac actcaggtaa gggctacaaa cgctgtaaat
     3781 taagaacaag atattattaa tgtaaaagcg ctgggctgtt tccttatccc acacaaagaa
     3841 tcttttacct tggtatatgt ggatatggta tattaccttg gtgtatgtat atgtgtgtat
     3901 acgcacacac tcatacaact gagaagccta tagtatatgg ttaatttttg gagaaaaggg
     3961 tgttttattg tgggttacag atcataagtg agtgaataga tgtaattcct tgatgcacac
     4021 caatagatgt gttcccattg acatcttaga agtattgtat gaagaggagg acctagggct
     4081 tgaaatgaaa tgagaatcaa tcaattgcaa cattacatga tggaataatg agaagagata
     4141 ctgaaactag aggatttttc atctatcaaa gcttgataaa ttaggttgtg caaaaacttg
     4201 gcagtggctt tctagagatg aaactggaga catgttagtg ctggataaat catttaaaat
     4261 taccatttaa tttattttct acattgttta tctgaagact cagaaaatcc acatatttga
     4321 gcttaccaga ctcttgggtg cattgctgtt ctatcttctg cttcaacagt taggaaaata
     4381 aagaccaata tgaatttgga atgtcagaat ttctgacata acacattggc gaggagtatg
     4441 gaatgtaagg gtcggtgaaa gtttcatatc ctggaacatc ttgcattgcc aattgaaaga
     4501 cataaaagta tgcagaatca aaataatatg tgtccacttt catgtgtaag tgaaacatat
     4561 tctttacacc aactattgaa gcagttgctc ctagaaacct agtttctcca gatttcccaa
     4621 gtggaaaata tttagtatgt tttaagctta cattcaatta ctccagagtc ttaggaccca
     4681 accatatact tccttttatt ttttattaaa gaaaatgact tgttattttt gtaacggctg
     4741 agtcctgtga tcaaataaaa gcatcagttc aatatatcag ggaaattgca tgttacccag
     4801 caactgaaat aataaaattc aagctctctt tttctaaatg ggccagagac ctgatgagaa
     4861 agtctccagg aagccaaact ttaacatact ttgtccattt ttagttaggt tcttggtgcc
     4921 aagttgtcat ccctgatgca ttagttgctt tcagtgcatt gaatgaattt tatttttact
     4981 tcctatgttg taagaatggt tttgaataga aggtcagtga tggtacagat tcgtataatt
     5041 ttaaaacatg attagatggt agtgaagtgt tatgagtgag gaggtataat tgatgtcatg
     5101 aggaagtgag tactgaatgg ttctatgatt taaggtaaag cagcagttgt agtaagtgta
     5161 ttttacaaat acacatgtaa atagaggttt acctggaaat atgtacgttc taaaaggtca
     5221 attttttaat tttatttttt tgctggttat cctggccaag tgtcttcaga actcatccaa
     5281 gttacgagac gaaataaact aaaatcacct cattaatttt tttcccttag ttacaaccaa
     5341 atgaatttat gtaatctctg aatgaactac atccctattc cagccgctga tgaatatgtt
     5401 ctccagcaca aggcagcatt aaaaggaaat acttttcagt atttcttttc atgccaaaaa
     5461 acctacagaa taattttcca aacagtcctt tattcgtaat tataagaatt aaacaatcta
     5521 aaatattaaa gatttaccct ccagcacatt cactgggtaa agaccattta atttgccctc
     5581 tcagggaatt tgaaataaat tatttgtcct ggatattctt taaaaacttt ttatttattc
     5641 agcaaatttt ggcaaaaaaa tttctttctt tgcttaaaac attctggtac tatataagga
     5701 acaacaaact aaaatgtatg tagtgttatt ttgtaatctc atcactatca ataaagctgc
     5761 attcaataag acctta
//
