LOCUS       NM_198582               3780 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens kelch like family member 30 (KLHL30), mRNA.
ACCESSION   NM_198582 XM_352496
VERSION     NM_198582.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3780)
  AUTHORS   Dhanoa,B.S., Cogliati,T., Satish,A.G., Bruford,E.A. and
            Friedman,J.S.
  TITLE     Update on the Kelch-like (KLHL) gene family
  JOURNAL   Hum Genomics 7 (1), 13 (2013)
   PUBMED   23676014
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC016757.10, BX280405.1, BC103703.1, BC105696.1 and AK125364.1.
            
            On Nov 22, 2018 this sequence version replaced NM_198582.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2142680,
                              SAMEA2147975 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000409223.2/ ENSP00000386389.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-54                AC016757.10        52887-52940
            55-184              BX280405.1         1-130
            185-1045            BC103703.1         1-861
            1046-1195           BC105696.1         862-1011
            1196-1344           BC103703.1         1012-1160
            1345-2107           AK125364.1         1163-1925
            2108-3252           AC016757.10        65494-66638
            3253-3739           AK125364.1         3069-3555
            3740-3780           AC016757.10        67126-67166
FEATURES             Location/Qualifiers
     source          1..3780
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q37.3"
     gene            1..3780
                     /gene="KLHL30"
                     /note="kelch like family member 30"
                     /db_xref="GeneID:377007"
                     /db_xref="HGNC:HGNC:24770"
     exon            1..91
                     /gene="KLHL30"
                     /inference="alignment:Splign:2.1.0"
     exon            92..935
                     /gene="KLHL30"
                     /inference="alignment:Splign:2.1.0"
     CDS             162..1898
                     /gene="KLHL30"
                     /note="kelch-like 30"
                     /codon_start=1
                     /product="kelch-like protein 30"
                     /protein_id="NP_940984.3"
                     /db_xref="CCDS:CCDS46555.2"
                     /db_xref="GeneID:377007"
                     /db_xref="HGNC:HGNC:24770"
                     /translation="MVRNVDDLDFHLPSHAQDMLDGLQRLRSQPKLADVTLLVGGREL
                     PCHRGLLALSSPYFHAMFAGDFAESFSARVELRDVEPAVVGQLVDFVYTGRLTITQGN
                     VEALTRTAARLHFPSVQKVCGRYLQQQLDAANCLGICEFGEQQGLLGVAAKAWAFLRE
                     NFEAVAREDEFLQLPRERLVTCLAGDLLQVQPEQSRLEALMRWVRHDPQARAAHLPEL
                     LSLVHLDAVPRPCVQQLLASEPLIQESEACRAALSQGHDGAPLALQQKLEEVLVVVGG
                     QALEEEEAGEEPTPGLGNFAFYNSKAKRWMALPDFPDYHKWGFSLAALNNNIYVTGGS
                     RGTKTDTWSTTQAWCFPLKEASWKPVAPMLKPRTNHASAALNGEIYVIGGTTLDVVEV
                     ESYDPYTDSWTPVSPALKYVSNFSAAGCRGRLYLVGSSACKYNALALQCYNPVTDAWS
                     VIASPFLPKYLSSPRCAALHGELYLIGDNTKKVYVYDPGANLWQKVQSQHSLHENGAL
                     VPLGDALYVTGGRWQGMEGDYHVEMEAYDTVRDTWTRHGALPRLWLYHGASTVFLDVS
                     KWTQPSGPTQEH"
     exon            936..1068
                     /gene="KLHL30"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1155
                     /gene="KLHL30"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1311
                     /gene="KLHL30"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1500
                     /gene="KLHL30"
                     /inference="alignment:Splign:2.1.0"
     exon            1501..1646
                     /gene="KLHL30"
                     /inference="alignment:Splign:2.1.0"
     exon            1647..3780
                     /gene="KLHL30"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3752..3757
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLHL30"
                     /note="hexamer: AATAAA"
     polyA_site      3780
                     /gene="KLHL30"
                     /note="major polyA site"
ORIGIN      
        1 ctgcaggcct ccgtgtcccc tggctgccgg ctaggcagtc ctgctctctc gggtctgtgt
       61 tctcagcttc gaggtccagg ctgagtgaga ggagctcggg cggctccagg cacttcttcc
      121 cttgagtggg tggactactg aggtcccctg ggcacggcgt catggtgcgg aacgtggatg
      181 acctggattt ccacctgccc tcgcatgccc aggacatgct ggatggcctg cagcgcctgc
      241 gctctcagcc caagctggcc gacgtcacac tgctggtggg cggccgggag ctgccatgcc
      301 accgcggcct cctggcgctc agcagcccct acttccatgc catgtttgcg ggtgacttcg
      361 ccgagagctt ctctgcgcgc gtggagctgc gggacgtgga gcccgccgtg gtgggacaac
      421 tggtggactt cgtgtacaca ggccggctga ccatcacgca gggcaacgtg gaggcgctga
      481 cacgcacggc tgcgcgcctg cacttcccct cggtgcagaa ggtctgcggc cgctacctgc
      541 agcagcaact ggatgccgcc aactgcctgg gcatctgtga gttcggggag cagcaagggc
      601 tgctgggcgt ggctgccaag gcctgggcct tcctgcgaga gaactttgag gctgtggcac
      661 gtgaggacga gttcctgcag cttccccgag agcggctggt cacttgtctg gccggcgacc
      721 tgctgcaggt acagccggag caaagccgac tcgaggccct gatgcgctgg gtgcgccatg
      781 acccgcaggc ccgggccgcc cacctgcccg agctgctcag cctagtgcac ctggacgccg
      841 tgcccaggcc ctgcgtgcag caactgctgg cctcagagcc cctgatccag gagtcagagg
      901 catgccgggc agccctgtcc cagggccatg atggggcacc actcgccctc cagcagaagc
      961 tggaggaggt cctggtggtg gtgggcgggc aggcgctgga ggaggaggag gcaggtgagg
     1021 agcccacccc cggccttggg aactttgcct tctacaacag caaggccaag aggtggatgg
     1081 cacttccaga cttccccgac tatcacaagt ggggtttctc cctggcggcc ctgaacaaca
     1141 acatctatgt cacaggtggc tctcggggca caaagacaga cacctggtca accacccagg
     1201 cctggtgctt ccccctgaag gaggcctcct ggaagcccgt ggcgcccatg ctgaagcccc
     1261 gcaccaacca cgccagcgcg gccctcaatg gggagatcta cgttatcggc ggcaccaccc
     1321 tggacgtggt ggaggtggag agctatgacc cctacacgga cagctggacg cccgtcagcc
     1381 cggccctcaa atacgtcagc aacttctcgg ctgccggctg ccggggccgg ctctacctgg
     1441 tgggctccag cgcctgcaag tacaacgccc tggccctgca gtgctacaac cctgtcacag
     1501 atgcgtggag tgtgatcgcc tcgcccttcc tgcccaagta cctgtcctcg cctcgctgtg
     1561 ctgcactgca cggggagctc tacctcattg gggacaacac caagaaggtc tacgtgtacg
     1621 accccggggc caacctgtgg cagaaggtgc agtcacagca cagcctgcat gagaatggcg
     1681 cgctggtgcc actgggtgat gcgctgtacg tgacgggcgg ccgctggcag ggcatggaag
     1741 gtgactacca cgtggagatg gaggcctacg acacggttcg ggacacctgg acccgccacg
     1801 gcgccctgcc ccggctctgg ctctaccacg gggcctccac cgtcttcctg gatgtctcca
     1861 agtggaccca gccctccggc cccacccagg agcactaaac cagggccagg gtccccgggg
     1921 aggagtcccc acagcggccc ctcatcagcc tgtggaacgg cccctttcat tttcgcttat
     1981 ttgttcactc ggagctacca ttccttccaa gctgcgctca ggccaccagg ggtgatcaga
     2041 cggcatggct tggaggacac agccttggtc tctgtggcca ccacactaaa ctctgagctg
     2101 agcagtgaca agggcctgag tgccagacgc tggcataaca gggacaggaa gctctgctgc
     2161 ccctggggtt cccgagacct cagagagggg agccgggggc cgggccagca ttcccagagc
     2221 ttgcgagccc cactcctgcc cctggacccc agcaggggct tttggagcag ttgcatgaat
     2281 gtggggtgaa cacggagcgt cccagaaagc tgaggctgct ggggaaggca ggccccggag
     2341 atgggatcag caccaggtcc tcgtgggcct gcttctgccc agctcacggc agcgtaactg
     2401 tggccagcca cctcccctct ctgggcttca agctccgcgt ccaccacaca cggggctggc
     2461 tgtgtgggct ttgggtcccc actcaggctt tgcatgttgg tgctgtgttt ctgcttctgt
     2521 ggacaaagga ggcccccacc catctcttgc acccagaggg cggtgcccac agaggcacca
     2581 ggaaggaggg aggcagggcg tggggcgggg ctggagggtc ccagggaggt gagcagtttt
     2641 gctctcagaa gggattgcct ccgtctctgt gtgtcagaac aaaggctctt cattagaatg
     2701 gaatttccca ccaggggacg actcttgggt gcattggtgg cagcctcctg agggtgaggg
     2761 gtagcatccg atgggcccct gccagcatgc agcccgactc cggctggctc aggctccgag
     2821 tggcttctcc ctcatcctga atgaggcacc cacctttgca gctaaggaga caatgaagga
     2881 ctctccctgg gtgcccaatg gcgtgtccct cctgtcacag gctccgccct gggacatggg
     2941 gctagaagtc aggagtcggg cccggccagg cacaggccct ggtgttgccc cagaggccct
     3001 gggcagctcc ggtctcccgc cggatccagg cttcctctcc aggaccagcc cctgggttcc
     3061 tccttaacac cccccgcccc tggggaccag aggggcctct gacatccttg ggttctgagg
     3121 acggaaaccc ctgagcctct tgagcttctg taggtaggga tctgctttgc tcccagacct
     3181 gcctctcata gctttttttt tttttttttt ttttttttga gacggagtct cgctcttgtc
     3241 gtccaggctg gagtgcaatg ctgagatctt ggctcactgc aacctccacc tcccgggttc
     3301 aagagattct cctgccttag cctctcaagt agctgggatt acaggcactc gccaccacgc
     3361 ctgactaatt tttgtatttt tagtagaaac agggtttcac catgttgacc aggctggtct
     3421 tgaactcctg acctcaggtg atccgcccgc ctcagcctcc caaagtgctg ggattacaag
     3481 gtgtgggaga agtgagttga ccctggaggg ccagacagag tggggcctct gggtgctacc
     3541 aaaggaacaa gagcccagag ctgaggagac cttcggtggc agatggattg gatgaagcaa
     3601 gggtgagggt ttctggggcc ctgggctctg tttccatgtg gaaatctgaa atgttttcta
     3661 gacagtgatg gaaggaggtc agccaaaggg ctgtttaaaa acaaagcctc catgtaaacc
     3721 atttctgcaa gaatatttta aaataaataa aaataaaact gaagacatga aatgtcaaaa
//
