LOCUS       NM_052920               5325 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens kelch like family member 29 (KLHL29), mRNA.
ACCESSION   NM_052920 XM_001717454 XM_001717533 XM_940375
VERSION     NM_052920.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5325)
  AUTHORS   Yao,L., Hao,Q., Wang,M., Chen,Y., Cao,H., Zhang,Q., Yu,K.,
            Jiang,Y., Shao,Z., Zhou,X. and Xu,Y.
  TITLE     KLHL29-mediated DDX3X degradation promotes chemosensitivity by
            abrogating cell cycle checkpoint in triple-negative breast cancer
  JOURNAL   Oncogene 42 (47), 3514-3528 (2023)
   PUBMED   37845393
  REMARK    GeneRIF: KLHL29-mediated DDX3X degradation promotes
            chemosensitivity by abrogating cell cycle checkpoint in
            triple-negative breast cancer.
REFERENCE   2  (bases 1 to 5325)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 5325)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 5325)
  AUTHORS   Sun,Z., Ke,X., Salzberg,S.L., Kim,D., Antonescu,V., Cheng,Y.,
            Huang,B., Song,J.H., Abraham,J.M., Ibrahim,S., Tian,H. and
            Meltzer,S.J.
  TITLE     The novel fusion transcript NR5A2-KLHL29FT is generated by an
            insertion at the KLHL29 locus
  JOURNAL   Cancer 123 (9), 1507-1515 (2017)
   PUBMED   28081303
  REMARK    GeneRIF: The fusion transcript NR5A2-KLHL29FT was identified in
            normal and cancerous colonic epithelia. It is due to an
            uncharacterized polymorphic germline insertion of the NR5A2
            sequence from chromosome 1 into the KLHL29 locus at chromosome 2,
            rather than a chromosomal rearrangement. NR5A2-KLH29FT expression
            levels were significantly lower in colon cancers than in matched
            normal colonic epithelia.
REFERENCE   5  (bases 1 to 5325)
  AUTHORS   Mychaleckyj,J.C., Havt,A., Nayak,U., Pinkerton,R., Farber,E.,
            Concannon,P., Lima,A.A. and Guerrant,R.L.
  TITLE     Genome-Wide Analysis in Brazilians Reveals Highly Differentiated
            Native American Genome Regions
  JOURNAL   Mol Biol Evol 34 (3), 559-574 (2017)
   PUBMED   28100790
  REMARK    GeneRIF: Brazilian Amerindian ancestry compared to Asian, European,
            and African Genomes.SNPs within or proximal to CIITA (rs6498115),
            SMC6 (rs1834619), and KLHL29 (rs2288697) were most differentiated
            in the Amerindian-specific branch. SNPs in ADAMTS9 (rs7631391),
            DOCK2 (rs77594147), SLC28A1 (rs28649017), ARHGAP5 (rs7151991), and
            CIITA (rs45601437) in the Asian comparison.
REFERENCE   6  (bases 1 to 5325)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   7  (bases 1 to 5325)
  AUTHORS   Murea,M., Lu,L., Ma,L., Hicks,P.J., Divers,J., McDonough,C.W.,
            Langefeld,C.D., Bowden,D.W. and Freedman,B.I.
  TITLE     Genome-wide association scan for survival on dialysis in
            African-Americans with type 2 diabetes
  JOURNAL   Am J Nephrol 33 (6), 502-509 (2011)
   PUBMED   21546767
REFERENCE   8  (bases 1 to 5325)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   9  (bases 1 to 5325)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   10 (bases 1 to 5325)
  AUTHORS   Trynka,G., Zhernakova,A., Romanos,J., Franke,L., Hunt,K.A.,
            Turner,G., Bruinenberg,M., Heap,G.A., Platteel,M., Ryan,A.W., de
            Kovel,C., Holmes,G.K., Howdle,P.D., Walters,J.R., Sanders,D.S.,
            Mulder,C.J., Mearin,M.L., Verbeek,W.H., Trimble,V., Stevens,F.M.,
            Kelleher,D., Barisani,D., Bardella,M.T., McManus,R., van Heel,D.A.
            and Wijmenga,C.
  TITLE     Coeliac disease-associated risk variants in TNFAIP3 and REL
            implicate altered NF-kappaB signalling
  JOURNAL   Gut 58 (8), 1078-1083 (2009)
   PUBMED   19240061
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC012506.9, AC011239.5, DR002067.1, BC013982.1, AB067508.1 and
            BE142100.1.
            
            On Nov 22, 2018 this sequence version replaced NM_052920.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2146236,
                              SAMEA2148874 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000486442.6/ ENSP00000420659.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-602               AC012506.9         122932-123533
            603-710             AC011239.5         18009-18116
            711-1234            DR002067.1         102-625
            1235-1293           AC011239.5         184839-184897
            1294-2851           BC013982.1         35-1592
            2852-3827           AB067508.1         3907-4882
            3828-4562           BC013982.1         2569-3303
            4563-4580           BE142100.1         158-175
            4581-5325           AB067508.1         5636-6380
FEATURES             Location/Qualifiers
     source          1..5325
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p24.1"
     gene            1..5325
                     /gene="KLHL29"
                     /gene_synonym="KBTBD9"
                     /note="kelch like family member 29"
                     /db_xref="GeneID:114818"
                     /db_xref="HGNC:HGNC:29404"
     exon            1..602
                     /gene="KLHL29"
                     /gene_synonym="KBTBD9"
                     /inference="alignment:Splign:2.1.0"
     exon            603..710
                     /gene="KLHL29"
                     /gene_synonym="KBTBD9"
                     /inference="alignment:Splign:2.1.0"
     exon            711..1040
                     /gene="KLHL29"
                     /gene_synonym="KBTBD9"
                     /inference="alignment:Splign:2.1.0"
     CDS             756..3383
                     /gene="KLHL29"
                     /gene_synonym="KBTBD9"
                     /note="kelch repeat and BTB (POZ) domain containing 9;
                     kelch repeat and BTB domain-containing protein 9;
                     kelch-like 29"
                     /codon_start=1
                     /product="kelch-like protein 29"
                     /protein_id="NP_443152.1"
                     /db_xref="CCDS:CCDS54335.1"
                     /db_xref="GeneID:114818"
                     /db_xref="HGNC:HGNC:29404"
                     /translation="MSRHHSRFERDYRVGWDRREWSVNGTHGTTSICSVTSGAGGGTA
                     SSLSVRPGLLPLPVVPSRLPTPATAPAPCTTGSSEAITSLVASSASAVTTKAPGISKG
                     DSQSQGLATSIRWGQTPINQSTPWDTDEPPSKQMRESDNPGTGPWVTTVAAGNQPTLI
                     AHSYGVAQPPTFSPAVNVQAPVIGVTPSLPPHVGPQLPLMPGHYSLPQPPSQPLSSVV
                     VNMPAQALYASPQPLAVSTLPGVGQVARPGPTAVGNGHMAGPLLPPPPPAQPSATLPS
                     GAPATNGPPTTDSAHGLQMLRTIGVGKYEFTDPGHPREMLKELNQQRRAKAFTDLKIV
                     VEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGGREKLELVLSNLQADVLELLLEFV
                     YTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGVLAMAEAMQCSE
                     LYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKD
                     PATRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKSSEACRDLVNEAKRYHMLPHAR
                     QEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPLASLPFY
                     DREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNSLVYD
                     GKIYTLGGLGVAGNVDHVERYDTITNQWEAVAPLPKAVHSAAATVCGGKIYVFGGVNE
                     AGRAAGVLQSYVPQTNTWSFIESPMIDNKYAPAVTLNGFVFILGGAYARATTIYDPEK
                     GNIKAGPNMNHSRQFCSAVVLDGKIYATGGIVSSEGPALGNMEAYEPTTNTWTLLPHM
                     PCPVFRHGCVVIKKYIQSG"
     exon            1041..1182
                     /gene="KLHL29"
                     /gene_synonym="KBTBD9"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1695
                     /gene="KLHL29"
                     /gene_synonym="KBTBD9"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..1834
                     /gene="KLHL29"
                     /gene_synonym="KBTBD9"
                     /inference="alignment:Splign:2.1.0"
     exon            1835..2037
                     /gene="KLHL29"
                     /gene_synonym="KBTBD9"
                     /inference="alignment:Splign:2.1.0"
     exon            2038..2297
                     /gene="KLHL29"
                     /gene_synonym="KBTBD9"
                     /inference="alignment:Splign:2.1.0"
     exon            2298..2496
                     /gene="KLHL29"
                     /gene_synonym="KBTBD9"
                     /inference="alignment:Splign:2.1.0"
     exon            2497..2679
                     /gene="KLHL29"
                     /gene_synonym="KBTBD9"
                     /inference="alignment:Splign:2.1.0"
     exon            2680..2860
                     /gene="KLHL29"
                     /gene_synonym="KBTBD9"
                     /inference="alignment:Splign:2.1.0"
     exon            2861..3054
                     /gene="KLHL29"
                     /gene_synonym="KBTBD9"
                     /inference="alignment:Splign:2.1.0"
     exon            3055..3199
                     /gene="KLHL29"
                     /gene_synonym="KBTBD9"
                     /inference="alignment:Splign:2.1.0"
     exon            3200..5325
                     /gene="KLHL29"
                     /gene_synonym="KBTBD9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5302..5307
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLHL29"
                     /gene_synonym="KBTBD9"
                     /note="hexamer: AATAAA"
     polyA_site      5325
                     /gene="KLHL29"
                     /gene_synonym="KBTBD9"
                     /note="major polyA site"
ORIGIN      
        1 agacggtacc cggagcggag cgagccagaa gggagcatgg tccccgcgcc gcggccgcgc
       61 cagcccccgc gccgccgccg ccgtccccgc caccgcggat ctcgccgcag ctccagcccc
      121 ggccccggct ccgcagcgcc cgtccgcagc cccggcggtc gccgcgcttg agcgcagccc
      181 ccgcccggag cccgagccgc gagcccggag ccagccccag ccccgcggcc gccgcggctg
      241 cggggagagg gcgggggcga tgctgccgga gccgccgccg ccgccgccgc ctcgatgaga
      301 gccgcgccgc accgctcata gccgcacagg ctgacaggca ggaggaccga cttccctctc
      361 ccgggcatcc tccctgggct gccgggaggc ggcggcggcg gaggaggagg aggaacgagg
      421 ggagaaggcg gagagcagga acgcgaggag gaggacctgg atccgtttcc tccggccagg
      481 acccgagcgg ccccagccac cgctacccgc cggcgctgtc cgctctccat cagccctcct
      541 gcgcccaccc gcgaccccgg gctctctgcg cgtcgggccg gggccggagc cgcgcgccgg
      601 agactatctg gcttcctggt gatgctcacg ctttgctaag tgttggcggc catcgtggtt
      661 ttcgcatcct ggggacgaat cctgagcttg ccagagacgg gcggcgcaag gtccgggctc
      721 tgtttccctg tgagaagccg cctcggccca ccgagatgtc ccggcaccat agccgcttcg
      781 aaagagatta ccgggtgggc tgggaccgcc gcgaatggag cgtcaacggg acgcatggga
      841 ccaccagcat ctgcagtgtc acctcggggg ccggtggcgg cacagccagc agcctcagcg
      901 tccggcccgg cctcctgccg ctgcccgtgg tgccctcccg gctgcccacc ccggctacag
      961 ctcctgctcc ctgcaccacc ggcagcagcg aggccatcac cagcctcgtg gccagctctg
     1021 cgtctgcggt caccaccaag gctcccggca tctccaaagg ggacagtcag tcccagggac
     1081 tggcgaccag catccggtgg gggcagacgc ctatcaatca gtccacaccc tgggacactg
     1141 atgagccacc ctccaaacag atgagagaga gtgacaatcc aggcacaggg ccatgggtga
     1201 ccacggtggc cgccgggaac cagcccaccc tgattgcaca ctcctatgga gtggcccagc
     1261 ctcccacctt cagcccggct gtgaacgtcc aggccccggt cattggggtg accccctcac
     1321 tgcctcccca cgtggggccc cagctcccgc tgatgccagg ccactactcg ctccctcagc
     1381 cgccctctca gccactgagc agcgtggtgg tcaacatgcc tgcccaggcc ctgtatgcca
     1441 gccctcagcc cctggccgtg tccacactgc ccggtgtggg gcaggtggcc cgcccaggac
     1501 ccaccgctgt gggcaacggc cacatggcag ggcccctgct gcctccaccg ccgccagccc
     1561 agccgtccgc cactctcccc agtggtgccc ctgccaccaa tgggcccccc acaaccgact
     1621 cggcccacgg gctgcagatg ctgcggacca ttggcgtggg gaagtatgag ttcaccgacc
     1681 cggggcaccc cagagaaatg ttgaaggaat tgaaccagca acgcagagcg aaagcgttta
     1741 cagacctgaa aattgttgtt gaaggcagag agtttgaagt ccaccaaaat gttctagctt
     1801 cctgcagctt gtatttcaag gacctgattc aaaggtccgt gcaagacagc ggccagggcg
     1861 gccgggagaa gctggagctc gtcctgtcga acctgcaggc agacgtcctg gagttgctgc
     1921 tggagtttgt ctacacgggc tccctggtca tcgactcggc caacgccaag acactgctgg
     1981 aggcggccag caagttccag ttccacacct tctgcaaagt ctgcgtgtcc tttctcgaga
     2041 agcagctgac ggccagcaac tgcctgggcg tgctggccat ggccgaggcc atgcagtgca
     2101 gcgagctcta ccacatggcc aaggccttcg cgctgcagat cttccccgag gtggccgccc
     2161 aggaggagat cctcagcatc tccaaggacg acttcatcgc ctacgtctcc aacgacagcc
     2221 tcaacaccaa ggctgaggag ctggtgtacg agacagtcat caagtggatc aagaaggacc
     2281 ccgcgacacg cacacagtac gcggctgagc tcctggccgt ggtccgcctc cccttcatcc
     2341 accccagcta cctgctcaat gtggttgaca atgaagagct gatcaagtca tcagaagcct
     2401 gccgggacct ggtgaacgag gccaaacgct accatatgct gccccacgcc cgccaggaga
     2461 tgcagacgcc ccgaacccgg ccgcgcctct ctgcaggtgt ggctgaggtc atcgtcttgg
     2521 ttgggggccg tcagatggtg gggatgaccc agcgctcgct ggtggccgtc acctgctgga
     2581 acccgcagaa caacaagtgg taccccttgg cctcgctgcc cttctatgac cgcgagttct
     2641 tcagtgtagt gagtgcaggg gacaacatct acctctcagg tgggatggaa tcaggggtga
     2701 cgctggctga tgtctggtgc tacatgtccc tgcttgataa ctggaacctc gtctccagaa
     2761 tgacagtccc ccgctgtcgg cacaatagcc tcgtctacga tgggaagatt tacaccctcg
     2821 ggggacttgg cgtggcaggc aacgtggacc acgtggagag gtacgacacc atcaccaacc
     2881 aatgggaggc ggtggcccct ctgcccaagg cagtacactc tgctgcagcc acagtgtgtg
     2941 gcggcaagat ctacgtgttt ggtggggtga acgaggcagg ccgagctgcc ggcgtcctcc
     3001 agtcttacgt tcctcagacc aacacgtgga gcttcatcga gtccccaatg attgacaaca
     3061 agtatgcccc cgctgtcacg ctcaatggct tcgttttcat cctgggcggg gcttatgcca
     3121 gagctaccac catctacgac cctgagaaag gaaacattaa ggcgggccca aacatgaacc
     3181 actctcgcca gttctgcagt gctgtggtgc ttgatggcaa gatttatgca actggaggta
     3241 ttgtcagcag tgaagggccc gcgctgggca acatggaggc ctacgagccc acaaccaaca
     3301 catggaccct cctcccccac atgccctgcc ctgtgttcag acacggctgc gtcgtgataa
     3361 agaaatatat tcaaagcggc tgacatcagc agaaagccca cgataagact gtggacaagt
     3421 ctggtgaggc aagtgccacg caatgataat tttccagcga caccaacaag aggccaacaa
     3481 aacacaatca aggaactcac tgcgctcaac atgttgaata ttctctacat tgaatgtaga
     3541 aaatcatcct cgcctttgga tgaaacggag gcaccgcgct tggagccgca ggaaccacga
     3601 tcccgccatg gggctggctg cctcctgaac aggggcgctc gctctgccag gtgcaataga
     3661 gtttcacgta tttttcaact gggagagaga agctgttttt tccttcctgc agagcaagct
     3721 tgatccctaa acaaccatag atcagttatc ttatgacaac attaggcatc aggctctctt
     3781 ggaataagat caaagtgtcc ttatcacttt gattcctact tttgtttttt aaccgatcta
     3841 cactttcagt ggccgacaga aaacgaggga caatactgtg catcacaagg cctaggaggc
     3901 tgctggtccc cactggggct gaagagaagc ccagctgccc acgcggagcc aggggtggca
     3961 gctgtgggac agccggggag cagggacagc ggtctgtcct tcacaggttt ttctactgtg
     4021 tttttgctgg agaaggacag tgattgcgct agctttctct tacccggtat gaattattta
     4081 gatttctgag gcattttctt gataaacaaa aggctatttt taagtactga gaggaggagc
     4141 aggccacaag agggataatg ttgtgggaat tcccaaagct ctttgtaggt agtgccagag
     4201 gggggctttt gctctcattt ttctatgtgc agaatagagg atctctcctg gggtgggcga
     4261 tgcccccatt ttatttttag aaaaagtaac tcccagacag ccccataaaa gctgtgccca
     4321 aggaagaaga gtctgctcta gaaggagccc ggttctggct caggacaccg gcccagctcc
     4381 ctccatgagg tcaagctgag gaccaggcca gtgggaaggg aaggagggag aattagcgtc
     4441 tataaagcac aggagactat ttttgatatt catagctata tattaaggca cctgccacaa
     4501 gagctctcag gatggggaca gccttcttag tggagccatg gcagcaaggc ctgagggcat
     4561 gaacagaacc actcttcttg tcacatacga acctgagaaa agggaagcca ggagggaggt
     4621 cacaccatgg ctcaaaaggg aaaggccttc ccacttgtcc ttagcccctc aaacctcaca
     4681 cggtcaacag tttccattcc agggcaggag aatgctgccg ccactgcgct gttgagttga
     4741 agttggtacc aaatacacat ttaccacttt tatatctggg aagtcaactt gccatcgttt
     4801 catgataaca accatttata agagaaaaag acaggacacg ctttccatcg ttcagtattt
     4861 gatgacacaa aattccagtt ctaacgttgg gcatcaactt ctagcactac gagtgtggct
     4921 cccacttgga caagataccg agcttcgtta tgcagttttt aatattattt attattttaa
     4981 aaagtaataa gcacaaaact acatacattg tatgtcattt aaagtattta tgtcaaacag
     5041 ggtgcaagtg tgaacccaag gactggagca caaattccta actgcctggg gcagggctaa
     5101 tgttagcatt ggtgtgcgtc tgcctccaaa ggaggttcta gttgtcagcg agactcaaca
     5161 cagatgacat tgaaattcgt ttctctcctc atctatcaca ctggagcaaa actggctatt
     5221 tctgtgaatg atataaaaca gggttctctg taatggtatt gtacatagta tatgtttact
     5281 gttaagttct tgttatatta taataaatat atttatagat ctaga
//
