LOCUS       NM_018316               4351 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens kelch like family member 26 (KLHL26), transcript
            variant 2, mRNA.
ACCESSION   NM_018316
VERSION     NM_018316.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4351)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 4351)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 4351)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 4351)
  AUTHORS   Samudrala,S.S.K., North,L.M., Stamm,K.D., Earing,M.G.,
            Frommelt,M.A., Willes,R., Tripathi,S., Dsouza,N.R.,
            Zimmermann,M.T., Mahnke,D.K., Liang,H.L., Lund,M., Lin,C.W.,
            Geddes,G.C., Mitchell,M.E. and Tomita-Mitchell,A.
  TITLE     Novel KLHL26 variant associated with a familial case of Ebstein's
            anomaly and left ventricular noncompaction
  JOURNAL   Mol Genet Genomic Med 8 (4), e1152 (2020)
   PUBMED   31985165
  REMARK    GeneRIF: Novel KLHL26 variant associated with a familial case of
            Ebstein's anomaly and left ventricular noncompaction.
REFERENCE   5  (bases 1 to 4351)
  AUTHORS   Taipale,M., Tucker,G., Peng,J., Krykbaeva,I., Lin,Z.Y., Larsen,B.,
            Choi,H., Berger,B., Gingras,A.C. and Lindquist,S.
  TITLE     A quantitative chaperone interaction network reveals the
            architecture of cellular protein homeostasis pathways
  JOURNAL   Cell 158 (2), 434-448 (2014)
   PUBMED   25036637
REFERENCE   6  (bases 1 to 4351)
  AUTHORS   Dhanoa,B.S., Cogliati,T., Satish,A.G., Bruford,E.A. and
            Friedman,J.S.
  TITLE     Update on the Kelch-like (KLHL) gene family
  JOURNAL   Hum Genomics 7 (1), 13 (2013)
   PUBMED   23676014
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4351)
  AUTHORS   Shi,M., Murray,J.C., Marazita,M.L., Munger,R.G., Ruczinski,I.,
            Hetmanski,J.B., Wu,T., Murray,T., Redett,R.J., Wilcox,A.J.,
            Lie,R.T., Jabs,E.W., Wu-Chou,Y.H., Chen,P.K., Wang,H., Ye,X.,
            Yeow,V., Chong,S.S., Shi,B., Christensen,K., Scott,A.F., Patel,P.,
            Cheah,F. and Beaty,T.H.
  TITLE     Genome wide study of maternal and parent-of-origin effects on the
            etiology of orofacial clefts
  JOURNAL   Am J Med Genet A 158A (4), 784-794 (2012)
   PUBMED   22419666
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA453727.1, AK001940.1, AC004476.1 and BC026319.1.
            
            On Nov 23, 2018 this sequence version replaced NM_018316.2.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice junction compared to variant 1. The resulting isoform (2)
            has the same N- and C-termini but is shorter compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK001940.1, SRR1660805.96974.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000300976.9/ ENSP00000300976.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-496               DA453727.1         64-559
            497-3122            AK001940.1         497-3122
            3123-3127           AC004476.1         11780-11784
            3128-3129           BC026319.1         3122-3123
            3130-4351           AC004476.1         11787-13008
FEATURES             Location/Qualifiers
     source          1..4351
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.11"
     gene            1..4351
                     /gene="KLHL26"
                     /note="kelch like family member 26"
                     /db_xref="GeneID:55295"
                     /db_xref="HGNC:HGNC:25623"
     exon            1..110
                     /gene="KLHL26"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..1875
                     /gene="KLHL26"
                     /note="isoform 2 is encoded by transcript variant 2;
                     kelch-like protein 26; kelch-like 26"
                     /codon_start=1
                     /product="kelch-like protein 26 isoform 2"
                     /protein_id="NP_060786.1"
                     /db_xref="CCDS:CCDS12384.1"
                     /db_xref="GeneID:55295"
                     /db_xref="HGNC:HGNC:25623"
                     /translation="MAESGGSSGGAGGGGAFGAGPGPERPNSTADKNGALKCTFSAPS
                     HSTSLLQGLATLRAQGQLLDVVLTINREAFPAHKVVLAACSDYFRAMFTGGMREASQD
                     VIELKGVSARGLRHIIDFAYSAEVTLDLDCVQDVLGAAVFLQMLPVVELCEEFLKAAM
                     SVETCLNIGQMATTFSLASLRESVDAFTFRHFLQIAEEEDFLRLPLERLVFFLQSNRL
                     QSCAEIDLFRAAVRWLQHDPARRPRASHVLCHIRFPLMQSSELVDSVQTLDIMVEDVL
                     CRQYLLEAFNYQVLPFRQHEMQSPRTAVRSDVPSLVTFGGTPYTDSDRSVSSKVYQLP
                     EPGARHFRELTEMEVGCSHTCVAVLDNFVYVAGGQHLQYRSGEGAVDACYRYDPHLNR
                     WLRLQAMQESRIQFQLNVLCGMVYATGGRNRAGSLASVERYCPRRNEWGYACSLKRRT
                     WGHAGAASGGRLYISGGYGISVEDKKALHCYDPVADQWEFKAPMSEPRVLHAMVGAGG
                     RIYALGGRMDHVDRCFDVLAVEYYVPETDQWTSVSPMRAGQSEAGCCLLERKIYIVGG
                     YNWRLNNVTGIVQVYNTDTDEWERDLHFPESFAGIACAPVLLPRAGTRR"
     exon            111..293
                     /gene="KLHL26"
                     /inference="alignment:Splign:2.1.0"
     exon            294..4351
                     /gene="KLHL26"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3105..3110
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLHL26"
                     /note="hexamer: AATAAA"
     polyA_site      3144
                     /gene="KLHL26"
                     /note="major polyA site"
     polyA_site      4351
                     /gene="KLHL26"
                     /note="major polyA site"
ORIGIN      
        1 actcgaacgc gcgacggcgg ggggaagatg gcggagtccg gcggtagcag cggtggtgct
       61 ggtggcggcg gcgctttcgg cgcgggcccg ggccccgagc gcccgaacag cacggccgac
      121 aagaacgggg ccctcaagtg caccttctcg gcacccagcc acagcaccag cctcctgcag
      181 ggcctggcca ccctccgcgc tcagggccag ctcctcgatg ttgtgctgac tattaacaga
      241 gaggcctttc ctgcacacaa ggtcgtcctg gctgcctgca gcgactactt cagggccatg
      301 ttcaccggcg gcatgcggga ggcaagccag gacgtcatcg agctgaaggg cgtgtcggcc
      361 cgtggcctgc ggcacatcat cgacttcgcc tacagcgccg aggtgacact ggacctggac
      421 tgcgtgcagg acgtgctggg cgcggccgtg ttcttgcaga tgctgcccgt ggtggagctg
      481 tgcgaggagt tcctgaaggc ggccatgagc gtggagacct gcctcaacat cggccagatg
      541 gccaccacct tcagcctggc ctcgctgcga gagtcggtgg atgccttcac cttccggcac
      601 ttcctgcaga tcgccgagga ggaggatttc ctgcgcctgc cactggagcg cctggtcttc
      661 ttcctgcaga gcaaccggct gcagagctgt gccgagatcg acctgttccg cgcggccgtc
      721 cgctggctgc agcatgaccc ggcccggcgg ccgcgcgcca gccacgtgct ctgccacatt
      781 cgcttcccgc tcatgcagtc gtccgagctg gtggacagcg tgcagacgct ggacatcatg
      841 gtggaggacg tgctgtgccg ccagtatctg ctggaggcct tcaactacca ggtgctgccc
      901 ttccggcagc acgagatgca gtctccgcgc accgccgtgc gctcggatgt gccctcgctc
      961 gtcaccttcg gcggcacgcc ctacaccgac agcgaccgct cggtcagcag caaggtctac
     1021 cagctgcctg agccgggagc ccgccacttc cgcgagctca cggagatgga ggtaggctgc
     1081 agccacacgt gcgtggccgt gctggacaat tttgtgtacg tggccggggg gcagcacctg
     1141 cagtaccgca gcggcgaggg cgcagtggac gcctgctacc gctacgaccc ccacctgaat
     1201 cgctggctgc gcctgcaggc catgcaggaa agccgcatcc agttccagct gaacgtgctg
     1261 tgcggcatgg tgtacgccac gggcggccgc aaccgagccg gcagcctggc ctccgtggag
     1321 cggtactgcc cccggcgcaa tgagtggggc tacgcctgct cgctgaagcg ccgtacctgg
     1381 ggccatgctg gggccgcctc agggggccgc ctctacatct cgggtggcta cgggatctca
     1441 gtggaggaca agaaggccct gcactgctac gaccccgtgg ccgaccagtg ggagttcaag
     1501 gcgcccatga gcgaaccccg cgtgctacac gccatggtgg gtgccggcgg ccgcatctat
     1561 gccctcgggg gccgcatgga ccacgtggac cgctgcttcg acgtgctggc tgtggagtac
     1621 tatgtgccgg agacggacca gtggaccagc gtgagcccca tgcgggccgg ccagtcagag
     1681 gccggctgct gcctgctgga gaggaagatc tacatcgtcg ggggctacaa ctggcgtctc
     1741 aacaacgtca cgggcatcgt acaggtgtac aacacggaca ccgacgagtg ggagcgggac
     1801 ctgcacttcc cggagtcctt cgcaggcata gcctgcgccc ccgtcctgct gccccgggcc
     1861 gggaccagga ggtagccccc aagacccccg ggaccctggc ctgaccgcat gttgtctcca
     1921 agtggggctt ggcgaatgca cgtctgcctg agaaccccag tgcccccctt cgcccgggct
     1981 gcccttgagg ggcctgctgc gttgataagc ccccctccca ggggtccctc cctccctcct
     2041 tcccaaagca gatcctggct gcgagtccat ccgagggagc ctgccggcaa agcgtctgac
     2101 atgtggtggc agcaaattcg tccccggggt ggtttcctcg cctggccccc gagtccccac
     2161 gggctggcgg gtggaatccc aggtctccag ggggtccctg tgcagctcca tctcacttct
     2221 ctactgcctc ccagccccac ggtttcaggc attcagatgt gagctcatca acattgaacc
     2281 caaagtcggt ggtatatgac tcaccctcct tccaagtctc ctgcgcgcgt gtttttaaaa
     2341 taaactcacc cgaaacgtcc gtaacacacg gacctccagg agcagtgaga ggtggcttag
     2401 aagcccctgg tttggggtgg gtggaggagg agggcacgtg tctgcctccc ctggggtgcc
     2461 ctccttcccc catcccaagc tgctgagggg aggccctggt catgcctcag ttcctgcctt
     2521 catctgcttt ccggaggaaa aaccatatca actcctagaa acgctcctta ggggcttggg
     2581 accttccatt tggcactgag catcttgtgg ggccttaact ggctgagaca tcccggccct
     2641 ctacatttgc cctgttggcc aggcagtccc cttcccgcaa ttggagggcg acgctaactt
     2701 cagaatccca tagtggcgct tgccgcaggt ctggtggggt gtcttttttc tcctccctcc
     2761 tttccacccc tccgcgccct gccactccct ggcctgccct gtttttgggt caacattgct
     2821 acggagccag cagtgaggcc tttcccttca agggctctgt ggtatctctg gccacatttg
     2881 ttctaatgtc tgaacctcta aatcttttct ttttgattgg ttttactgtt tttaagaagc
     2941 cagcactgct gtctcataga tgggatttgt actcttgggg caacttaaag tgtctctctc
     3001 gctgctaaca gacgattgat gtcttgtctc tgtgacccac tcaccatgta aagaattaac
     3061 ctcctatctt agcagacatc gtctcctaat atttcccttt atttaataaa aatgttatgg
     3121 tgaagagatg gagccggccc agcactgagc ttgtgcggct tgggtctgat tggtcacaga
     3181 ttcctcgtgt gtcctccgcg tgtctggggg ctcctctccc ccgcctcaac cttttccagc
     3241 ctttcagagg agtcggcagt gggctgggct ttggctcagg ggcgcagagg cagcaggaag
     3301 cgtggccagg actttcaccc tggcgttttt tgttgttggt ttttttgttt ttttgagacg
     3361 gagcctcgct ctgtcaccca ggctggagtg cagtggcgtg atctcggctc actgcaacct
     3421 ctgcctcctg ggttcaagca attcacctgc ctcagcctcc caagtagcca ggattacaga
     3481 cgcagacaca caccaccaca cccggctaat ttttgtattt ttagtacaga cggggtttca
     3541 ccatgttggc caggctggcc ttgaactctt gacctcaggt gatccacctg cctctgcctc
     3601 ccaaagtgct gggattacag gtgtgagcca ccatgcccgg accaaccttg gcactttgga
     3661 agagccttca gccccctatt ctcatcatgg ccggccaaac tatgaactgg gctgcccaga
     3721 gcaggccact tatcagttgc aggttagcag agaaagcctg atgttcccgg acggccttcc
     3781 cagaagggag gccctgggat atcacacaca catggatctc cataagttgc tgtgcctgca
     3841 tgcctggcgc tcctgtgtgg cagccatcgg ggctggggta acactagagg ctgagggggt
     3901 gggcagtgct aaaataggaa catggttggg aacctaaaag aagcccacac tgtcaggggc
     3961 atcgagacaa aagccgagtt ccctggggac ttaccagaac attccagccc cacccccgac
     4021 ctgagctccc ccaaagagaa cccttcccca ctggaggcat ggccccttca ggggagcagt
     4081 gagaagcttt gccagctgca agtcccctgg atcagctcac acctcagaac atcttgtccc
     4141 cagtgagctg gcaggggcgc cggcccaggg cggggggcgc tgctgtatct aaccggatcg
     4201 attgtgcata accgtctagg ccggttcgtg gaatgttcgt ggggccccct gcccctccct
     4261 cagcctcccc ccgcatcccc ccaagaaagg aaaattattt ttcgtattgt aaactttaaa
     4321 catgaaaaag ctgtttttaa tttagcagaa a
//
