LOCUS       NM_022480               3650 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens kelch like family member 25 (KLHL25), mRNA.
ACCESSION   NM_022480 XM_001719329 XM_001721147 XM_001721166
VERSION     NM_022480.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3650)
  AUTHORS   Tian,M., Hao,F., Jin,X., Sun,X., Jiang,Y., Wang,Y., Li,D.,
            Chang,T., Zou,Y., Peng,P., Xia,C., Liu,J., Li,Y., Wang,P., Feng,Y.
            and Wei,M.
  TITLE     ACLY ubiquitination by CUL3-KLHL25 induces the reprogramming of
            fatty acid metabolism to facilitate iTreg differentiation
  JOURNAL   Elife 10, e62394 (2021)
   PUBMED   34491895
  REMARK    GeneRIF: ACLY ubiquitination by CUL3-KLHL25 induces the
            reprogramming of fatty acid metabolism to facilitate iTreg
            differentiation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3650)
  AUTHORS   Zhang,C., Liu,J., Huang,G., Zhao,Y., Yue,X., Wu,H., Li,J., Zhu,J.,
            Shen,Z., Haffty,B.G., Hu,W. and Feng,Z.
  TITLE     Cullin3-KLHL25 ubiquitin ligase targets ACLY for degradation to
            inhibit lipid synthesis and tumor progression
  JOURNAL   Genes Dev 30 (17), 1956-1970 (2016)
   PUBMED   27664236
  REMARK    GeneRIF: CUL3 interacts with ACLY through its adaptor protein,
            KLHL25 (Kelch-like family member 25), to ubiquitinate and degrade
            ACLY in cells
REFERENCE   3  (bases 1 to 3650)
  AUTHORS   Ikeda,M., Okahisa,Y., Aleksic,B., Won,M., Kondo,N., Naruse,N.,
            Aoyama-Uehara,K., Sora,I., Iyo,M., Hashimoto,R., Kawamura,Y.,
            Nishida,N., Miyagawa,T., Takeda,M., Sasaki,T., Tokunaga,K.,
            Ozaki,N., Ujike,H. and Iwata,N.
  TITLE     Evidence for shared genetic risk between methamphetamine-induced
            psychosis and schizophrenia
  JOURNAL   Neuropsychopharmacology 38 (10), 1864-1870 (2013)
   PUBMED   23594818
REFERENCE   4  (bases 1 to 3650)
  AUTHORS   Dhanoa,B.S., Cogliati,T., Satish,A.G., Bruford,E.A. and
            Friedman,J.S.
  TITLE     Update on the Kelch-like (KLHL) gene family
  JOURNAL   Hum Genomics 7 (1), 13 (2013)
   PUBMED   23676014
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3650)
  AUTHORS   Chung,S., Low,S.K., Zembutsu,H., Takahashi,A., Kubo,M., Sasa,M. and
            Nakamura,Y.
  TITLE     A genome-wide association study of chemotherapy-induced alopecia in
            breast cancer patients
  JOURNAL   Breast Cancer Res 15 (5), R81 (2013)
   PUBMED   24025145
REFERENCE   6  (bases 1 to 3650)
  AUTHORS   Yanagiya,A., Suyama,E., Adachi,H., Svitkin,Y.V., Aza-Blanc,P.,
            Imataka,H., Mikami,S., Martineau,Y., Ronai,Z.A. and Sonenberg,N.
  TITLE     Translational homeostasis via the mRNA cap-binding protein, eIF4E
  JOURNAL   Mol Cell 46 (6), 847-858 (2012)
   PUBMED   22578813
REFERENCE   7  (bases 1 to 3650)
  AUTHORS   Lunetta,K.L., D'Agostino,R.B. Sr., Karasik,D., Benjamin,E.J.,
            Guo,C.Y., Govindaraju,R., Kiel,D.P., Kelly-Hayes,M., Massaro,J.M.,
            Pencina,M.J., Seshadri,S. and Murabito,J.M.
  TITLE     Genetic correlates of longevity and selected age-related
            phenotypes: a genome-wide association study in the Framingham Study
  JOURNAL   BMC Med Genet 8 Suppl 1 (Suppl 1), S13 (2007)
   PUBMED   17903295
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3650)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA337553.1, DB063745.1 and AY764034.1.
            
            On Nov 23, 2018 this sequence version replaced NM_022480.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY764034.1, AK092231.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN04284274 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000337975.6/ ENSP00000336800.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-163               DA337553.1         34-196
            164-544             DB063745.1         164-544
            545-3650            AY764034.1         560-3665
FEATURES             Location/Qualifiers
     source          1..3650
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q25.3"
     gene            1..3650
                     /gene="KLHL25"
                     /gene_synonym="ENC-2; ENC2"
                     /note="kelch like family member 25"
                     /db_xref="GeneID:64410"
                     /db_xref="HGNC:HGNC:25732"
                     /db_xref="MIM:619893"
     exon            1..160
                     /gene="KLHL25"
                     /gene_synonym="ENC-2; ENC2"
                     /inference="alignment:Splign:2.1.0"
     exon            161..1964
                     /gene="KLHL25"
                     /gene_synonym="ENC-2; ENC2"
                     /inference="alignment:Splign:2.1.0"
     CDS             171..1940
                     /gene="KLHL25"
                     /gene_synonym="ENC-2; ENC2"
                     /note="ectodermal-neural cortex 2; ectoderm-neural cortex
                     protein 2; BTB/POZ KELCH domain protein; kelch-like 25"
                     /codon_start=1
                     /product="kelch-like protein 25"
                     /protein_id="NP_071925.2"
                     /db_xref="CCDS:CCDS10339.1"
                     /db_xref="GeneID:64410"
                     /db_xref="HGNC:HGNC:25732"
                     /db_xref="MIM:619893"
                     /translation="MSVSVHETRKSRSSTGSMNVTLFHKASHPDCVLAHLNTLRKHCM
                     FTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQDNLHPEVLELLL
                     DFAYSSRIAINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLFPSNCLGMMLLSDAHQ
                     CRRLYEFSWRMCLVHFETVRQSEDFNSLSKDTLLDLISSDELETEDERVVFEAILQWV
                     KHDLEPRKVHLPELLRSVRLALLPSDCLQEAVSSEALLMADERTKLIMDEALRCKTRI
                     LQNDGVVTSPCARPRKAGHTLLILGGQTFMCDKIYQVDHKAKEIIPKADLPSPRKEFS
                     ASAIGCKVYVTGGRGSENGVSKDVWVYDTVHEEWSKAAPMLIARFGHGSAELENCLYV
                     VGGHTSLAGVFPASPSVSLKQVEKYDPGANKWMMVAPLRDGVSNAAVVSAKLKLFVFG
                     GTSIHRDMVSKVQCYDPSENRWTIKAECPQPWRYTAAAVLGSQIFIMGGDTEFTAASA
                     YRFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVGGYFGTQRCKTLDCYDPTSDTWN
                     CITTVPYSLIPTAFVSTWKHLPA"
     exon            1965..3650
                     /gene="KLHL25"
                     /gene_synonym="ENC-2; ENC2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3631..3636
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLHL25"
                     /gene_synonym="ENC-2; ENC2"
                     /note="hexamer: AATAAA"
     polyA_site      3650
                     /gene="KLHL25"
                     /gene_synonym="ENC-2; ENC2"
                     /note="major polyA site"
ORIGIN      
        1 agaaactagt ttgttggcgg cgcctaggct gtatcgcagc gagagcgttt ttgcctgtgg
       61 agagccggcc gacgggagcc gcggcggagc ctgttgagct cgcgcgggct gccgggagtg
      121 gtctctgagg cggcggcggc ggcggggatc gtctccggca ctgacgcacc atgtcggtca
      181 gtgtccatga gacccgcaag tcgcggagca gcacggggtc catgaacgtc accctcttcc
      241 acaaggcctc ccacccggac tgtgtgctgg cccacctcaa cacgcttcgc aagcactgca
      301 tgttcaccga cgtcacactc tgggcgggcg accgtgcctt cccctgtcac cgtgccgtgc
      361 tggccgcctc tagccgctat tttgaggcca tgttcagcca tggccttcgg gagagccggg
      421 atgacactgt caacttccag gacaacctgc acccggaggt gctggagctg ctgctggact
      481 ttgcctactc ctcacgcatc gccatcaacg aggagaacgc tgagtcactg ctggaggcag
      541 gcgacatgct gcagttccac gatgtgcggg atgctgccgc cgagttcctg gagaagaacc
      601 ttttcccctc caactgcctg ggcatgatgc tgctctcgga cgcccaccag tgccgccggc
      661 tgtatgagtt ctcctggcgc atgtgcctgg tgcactttga gacggtgagg cagagcgagg
      721 acttcaacag cctgtccaag gacacactgc tggacctcat ctcgagtgat gagctggaga
      781 ccgaggacga gcgggtggtc ttcgaggcca tcctccagtg ggtgaagcac gacctggagc
      841 cacggaaggt ccacttgccc gagctcctcc gcagcgtgcg tctggccttg ctgccgtccg
      901 actgcctgca ggaggccgtc tccagcgagg ccctcctcat ggcagacgag cgcaccaagc
      961 ttatcatgga tgaggccctg cgctgcaaga ccaggatcct gcagaatgat ggcgtggtca
     1021 ccagcccctg tgcccggcca cgcaaggcgg gccacacgct actcatcctg gggggccaga
     1081 ccttcatgtg tgacaagatc taccaggtgg accacaaggc caaggagatc atccccaagg
     1141 ccgacctgcc cagcccccgg aaggagttca gcgcctcagc gatcggctgc aaggtctatg
     1201 tgacgggggg caggggctcc gagaacgggg tctccaagga tgtctgggtg tacgacaccg
     1261 tacatgagga atggtccaag gcggcgccca tgctgattgc ccgctttggc catggctcag
     1321 ctgagctgga gaactgcctc tatgtggtgg ggggacacac atccctggca ggggtcttcc
     1381 cggcctcgcc ttctgtctcc ctgaaacaag tggagaaata cgaccctggg gccaacaagt
     1441 ggatgatggt ggcccccttg cgggatggcg tcagcaatgc cgcagtggtg agtgccaagc
     1501 tgaagctctt tgttttcgga ggaaccagca tccaccggga catggtgtcc aaggtccagt
     1561 gctatgaccc ctcggagaac aggtggacga tcaaggccga gtgcccccag ccttggcggt
     1621 acacagccgc tgccgtcctg ggcagccaga tcttcatcat gggaggtgac acggaattca
     1681 cagccgcctc ggcctaccgc tttgactgtg agaccaacca gtggacgcgg attggggaca
     1741 tgactgccaa gcgcatgtcc tgccatgccc tggcttccgg caacaagctc tatgtggtcg
     1801 ggggctactt tgggacccag aggtgtaaga ctctggactg ctatgacccc acttcagata
     1861 catggaactg catcaccaca gtgccctact cacttatccc cacggccttt gtcagcacct
     1921 ggaagcacct gcccgcgtga ggagcacctg ctgagcccag ccagaccgcg gccttcagtg
     1981 tcacagcgtg gccttgcttg tctgccacag cgggagctaa gccggccctg ggccagcact
     2041 ccgagaggtg gaaggggccc tgccagctct ggggagcagc agccttgggc tgttctgagc
     2101 tttaggcaag agaagagaag catctcttgc atccgtgccc ctgggggcct cttcagcttt
     2161 gcagtggttt gtgggaagac atacctccca gaggggcatg gactgccacc aggactgacc
     2221 ctggcgtcgg ggagaaggac acttgcagag ccttgagatc acctgtttgg caggtcctgg
     2281 actggggccg ggcaggcagg ggcagggagg cgccccgggt gggctttggg gctgcggcac
     2341 tgccacacat cctttccctc ctggcctgcc ctgctggggc tctactgcca tctatagatg
     2401 gtgtcctggg cctgggaaac taggttccca ggggttgaga ccagaaaggt gaccaagaca
     2461 gattttttaa ggtgcagaaa ctgcaggggg gcctcagtga catccatgag gccttattag
     2521 caaaggacac ccagacctcc aaggtttgtg ggccccttcc acaaagctgt aagtcccagc
     2581 ccacctactc agggccttgc tcagtgctgt ggcccggtgg ggacacagtt gctcgtggcc
     2641 actcagtgga gctgggcctg cagcagactc aaggctccga gtgccctggg ggtcacccct
     2701 cccctcccct cctcagagcc caccctgaga ggcagcagtg acccccatgg cacacacctg
     2761 ccaacagcac tgggggcttc tccccaggag accacgctgc cctccaagac caggagcagc
     2821 tgtgagctgg agacagcaga gggaccccag ggtgtcccct gcagatccca ccagggccgc
     2881 atccatctca gtgtggagga cagtgacggg accctcacca tcctcttgcg ttttggcccc
     2941 catttgctcc ctgagctcca agataagaat ggccccgaga gaactgctga acatttgttc
     3001 attgctgtca cctcctgagt cactggggtc cctcaccagc acctccctga cacctgggct
     3061 atggagaggt tggcgcctgt cagtgaccat cctaatgcct ctcgctcact cccaagccac
     3121 catttgagag ggaggggtgt tggtgccctg acagggactg ggcagggtgt ccaaacttgg
     3181 ggcttcccag gcacctgcag tgtgaacact gcttggctgg ctcaagatta gggccgcgga
     3241 gggggctgtg cacataccag ttacttaagc agccacgagt gtcccccatg ccttggtgcg
     3301 ggtcctggag gcctcttggg ggtgggacct ttgggcaggg tttgcccact gacacgcccg
     3361 ccatggggca ctggctgcat ggggctcctt ggaccctgta gacccagcag accccgcctg
     3421 tgtcaggcca gctgcccgaa ggcacttggc tgtggtccca ggggacggct ctgctggcac
     3481 actcaggagc ctggccgcgg ggactgcagg gagggtgcct ggacccgtgg ggttgcttca
     3541 ttgagataaa gcacacttat cacatagcac aaaggacgtg ccatggtgct ttccccaaaa
     3601 gttgtgttgc ttttatcagt tttctaactt aataaaaaga gttgagaaaa
//
