LOCUS       NM_017644               7331 bp    mRNA    linear   PRI 06-OCT-2024
DEFINITION  Homo sapiens kelch like family member 24 (KLHL24), transcript
            variant 7, mRNA.
ACCESSION   NM_017644
VERSION     NM_017644.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7331)
  AUTHORS   Kosykh,A.V., Ryumina,I.I., Botkina,A.S., Evtushenko,N.A.,
            Zhigmitova,E.B., Martynova,A.A., Gurskaya,N.G. and Rebrikov,D.V.
  TITLE     EBS in Children with De Novo Pathogenic Variants Disturbing Krt14
  JOURNAL   Int J Mol Sci 25 (5), 2989 (2024)
   PUBMED   38474236
  REMARK    GeneRIF: EBS in Children with De Novo Pathogenic Variants
            Disturbing Krt14.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7331)
  AUTHORS   Vermeer,M.C.S.C., Al-Shinnag,M., Sillje,H.H.W., Gaytan,A.E.,
            Murrell,D.F., McGaughran,J., Melbourne,W., Cowan,T., van den
            Akker,P.C., van Spaendonck-Zwarts,K.Y., van der Meer,P. and
            Bolling,M.C.
  TITLE     A translation re-initiation variant in KLHL24 also causes
            epidermolysis bullosa simplex and dilated cardiomyopathy via
            intermediate filament degradation
  JOURNAL   Br J Dermatol 187 (6), 1045-1048 (2022)
   PUBMED   35975634
  REMARK    GeneRIF: A translation re-initiation variant in KLHL24 also causes
            epidermolysis bullosa simplex and dilated cardiomyopathy via
            intermediate filament degradation.
REFERENCE   3  (bases 1 to 7331)
  AUTHORS   Vermeer,M.C.S.C., Sillje,H.H.W., Pas,H.H., Andrei,D., van der
            Meer,P. and Bolling,M.C.
  TITLE     Keratin 14 Degradation and Aging in Epidermolysis Bullosa Simplex
            due to KLHL24 Gain-of-Function Variants
  JOURNAL   J Invest Dermatol 142 (8), 2271-2274 (2022)
   PUBMED   35031308
  REMARK    GeneRIF: Keratin 14 Degradation and Aging in Epidermolysis Bullosa
            Simplex due to KLHL24 Gain-of-Function Variants.
REFERENCE   4  (bases 1 to 7331)
  AUTHORS   Logli,E., Marzuolo,E., D'Agostino,M., Conti,L.A., Lena,A.M.,
            Diociaiuti,A., Dellambra,E., Has,C., Cianfanelli,V., Zambruno,G.,
            El Hachem,M., Magenta,A., Candi,E. and Condorelli,A.G.
  TITLE     Proteasome-mediated degradation of keratins 7, 8, 17 and 18 by
            mutant KLHL24 in a foetal keratinocyte model: Novel insight in
            congenital skin defects and fragility of epidermolysis bullosa
            simplex with cardiomyopathy
  JOURNAL   Hum Mol Genet 31 (8), 1308-1324 (2022)
   PUBMED   34740256
  REMARK    GeneRIF: Proteasome-mediated degradation of keratins 7, 8, 17 and
            18 by mutant KLHL24 in a foetal keratinocyte model: Novel insight
            in congenital skin defects and fragility of epidermolysis bullosa
            simplex with cardiomyopathy.
REFERENCE   5  (bases 1 to 7331)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   6  (bases 1 to 7331)
  AUTHORS   Dhanoa,B.S., Cogliati,T., Satish,A.G., Bruford,E.A. and
            Friedman,J.S.
  TITLE     Update on the Kelch-like (KLHL) gene family
  JOURNAL   Hum Genomics 7 (1), 13 (2013)
   PUBMED   23676014
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 7331)
  AUTHORS   Wu,W., Guo,Z., Zhang,X., Guo,L., Liu,L., Liao,Y., Wang,J., Wang,L.
            and Li,Q.
  TITLE     A microRNA encoded by HSV-1 inhibits a cellular transcriptional
            repressor of viral immediate early and early genes
  JOURNAL   Sci China Life Sci 56 (4), 373-383 (2013)
   PUBMED   23512275
  REMARK    GeneRIF: Data show that a miRNA, hsv1-mir-H27, encoded within the
            genome of herpes simplex virus 1 (HSV-1), targets the mRNA of the
            cellular transcriptional repressor Kelch-like 24 (KLHL24).
REFERENCE   8  (bases 1 to 7331)
  AUTHORS   Laezza,F., Wilding,T.J., Sequeira,S., Craig,A.M. and Huettner,J.E.
  TITLE     The BTB/kelch protein, KRIP6, modulates the interaction of PICK1
            with GluR6 kainate receptors
  JOURNAL   Neuropharmacology 55 (7), 1131-1139 (2008)
   PUBMED   18692513
  REMARK    GeneRIF: KRIP6 regulates kainate receptors by inhibiting PICK1
            modulation via competition or a mutual blocking effect
REFERENCE   9  (bases 1 to 7331)
  AUTHORS   Laezza,F., Wilding,T.J., Sequeira,S., Coussen,F., Zhang,X.Z.,
            Hill-Robinson,R., Mulle,C., Huettner,J.E. and Craig,A.M.
  TITLE     KRIP6: a novel BTB/kelch protein regulating function of kainate
            receptors
  JOURNAL   Mol Cell Neurosci 34 (4), 539-550 (2007)
   PUBMED   17254796
REFERENCE   10 (bases 1 to 7331)
  AUTHORS   So,J.Y. and Teng,J.
  TITLE     Epidermolysis Bullosa Simplex
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301543
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY422472.1 and AC068769.19.
            
            On Apr 22, 2005 this sequence version replaced NM_017644.2.
            
            Summary: The protein encoded by this gene is a ubiquitin ligase
            substrate receptor and is regulated by autoubiquitination.
            Variations in the translation initiation codon of this gene have
            been found, which result in an N-terminally truncated but more
            stable protein due to loss of the autoubiquitination function. The
            more stable mutant protein causes an increased ubiquitin and
            degradation of keratin 14, which leads to skin fragility and the
            potentially life-threatening disease epidermolysis bullosa. The
            encoded protein is also involved in the regulation of kainate
            receptors. [provided by RefSeq, Mar 2017].
            
            Transcript Variant: This variant (7), as well as variants 8-15,
            encodes isoform b.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY422472.1, SRR1660809.211238.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000242810.11/ ENSP00000242810.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2290              AY422472.1         1-2290
            2291-7331           AC068769.19        109133-114173       c
FEATURES             Location/Qualifiers
     source          1..7331
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q27.1"
     gene            1..7331
                     /gene="KLHL24"
                     /gene_synonym="CMH29; DRE1; EBS6; EBSSH; KRIP6"
                     /note="kelch like family member 24"
                     /db_xref="GeneID:54800"
                     /db_xref="HGNC:HGNC:25947"
                     /db_xref="MIM:611295"
     exon            1..171
                     /gene="KLHL24"
                     /gene_synonym="CMH29; DRE1; EBS6; EBSSH; KRIP6"
                     /inference="alignment:Splign:2.1.0"
     exon            172..234
                     /gene="KLHL24"
                     /gene_synonym="CMH29; DRE1; EBS6; EBSSH; KRIP6"
                     /inference="alignment:Splign:2.1.0"
     exon            235..1215
                     /gene="KLHL24"
                     /gene_synonym="CMH29; DRE1; EBS6; EBSSH; KRIP6"
                     /inference="alignment:Splign:2.1.0"
     CDS             296..2098
                     /gene="KLHL24"
                     /gene_synonym="CMH29; DRE1; EBS6; EBSSH; KRIP6"
                     /note="isoform b is encoded by transcript variant 7;
                     kainate receptor interacting protein for GluR6; kelch-like
                     protein 24; kelch-like 24"
                     /codon_start=1
                     /product="kelch-like protein 24 isoform b"
                     /protein_id="NP_060114.2"
                     /db_xref="CCDS:CCDS3246.1"
                     /db_xref="GeneID:54800"
                     /db_xref="HGNC:HGNC:25947"
                     /db_xref="MIM:611295"
                     /translation="MVLILGRRLNREDLGVRDSPATKRKVFEMDPKSLTGHEFFDFSS
                     GSSHAENILQIFNEFRDSRLFTDVIICVEGKEFPCHRAVLSACSSYFRAMFCNDHRES
                     REMLVEINGILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLE
                     EQLDPCNCLGIQRFADTHSLKTLFTKCKNFALQTFEDVSQHEEFLELDKDELIDYICS
                     DELVIGKEEMVFEAVMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVEVDQLIQ
                     NSPECYQLLHEARRYHILGNEMMSPRTRPRRSTGYSEVIVVVGGCERVGGFNLPYTEC
                     YDPVTGEWKSLAKLPEFTKSEYAVCALRNDILVSGGRINSRDVWIYNSQLNIWIRVAS
                     LNKGRWRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVT
                     SCVGKLFVIGGGPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSLNNLIYVAG
                     GLTKAIYCYDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGGRRENGEATDTILCYD
                     PATSIITGVAAMPRPVSYHGCVTIHRYNEKCFKL"
     exon            1216..1400
                     /gene="KLHL24"
                     /gene_synonym="CMH29; DRE1; EBS6; EBSSH; KRIP6"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1519
                     /gene="KLHL24"
                     /gene_synonym="CMH29; DRE1; EBS6; EBSSH; KRIP6"
                     /inference="alignment:Splign:2.1.0"
     exon            1520..1708
                     /gene="KLHL24"
                     /gene_synonym="CMH29; DRE1; EBS6; EBSSH; KRIP6"
                     /inference="alignment:Splign:2.1.0"
     exon            1709..1897
                     /gene="KLHL24"
                     /gene_synonym="CMH29; DRE1; EBS6; EBSSH; KRIP6"
                     /inference="alignment:Splign:2.1.0"
     exon            1898..7331
                     /gene="KLHL24"
                     /gene_synonym="CMH29; DRE1; EBS6; EBSSH; KRIP6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7310..7315
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLHL24"
                     /gene_synonym="CMH29; DRE1; EBS6; EBSSH; KRIP6"
                     /note="hexamer: ATTAAA"
     polyA_site      7331
                     /gene="KLHL24"
                     /gene_synonym="CMH29; DRE1; EBS6; EBSSH; KRIP6"
                     /note="major polyA site"
ORIGIN      
        1 gttgtgagct gcggcagaga ctggtggctg gaggagacgc cggcgctgga gagtgcgctg
       61 cgccgcccgc cgctgaggga ccgcggggtt agccactgct ggctgcttcc agtgttcgcc
      121 gagaggtacc gggggtgaca gctccgggac cggccgaaag gcgaggaacc ggtgtggaaa
      181 ttaaaagaac acacatattt tgactggggc tttgatcaac caaatgctaa aaagccacat
      241 aaagaagatc cctaatagtc atttctcaac aattatatag tcaactgatg taacaatggt
      301 actaatattg ggacgcagac taaacagaga ggatcttggg gtgcgtgatt ccccagcaac
      361 taagcgaaaa gtttttgaaa tggaccccaa atctctgaca ggtcatgagt tttttgactt
      421 ctcttcagga tcatcccatg ccgaaaacat actccagata tttaatgaat ttcgtgatag
      481 ccgcttattc acagatgtta tcatttgtgt ggaaggaaaa gaatttcctt gccatagagc
      541 tgtgctctca gcctgtagca gctacttcag agctatgttt tgtaatgacc acagggaaag
      601 ccgagaaatg ttggttgaga tcaatggtat tttagctgaa gctatggaat gttttttgca
      661 gtatgtttat actggaaagg tgaagatcac tacagagaat gtacagtatc tctttgagac
      721 atcaagcctc tttcagatta gtgttctccg tgatgcatgt gccaagttct tggaggagca
      781 acttgatcct tgtaattgct taggaatcca gcgctttgct gatacccatt cactcaaaac
      841 actcttcaca aaatgcaaaa attttgcgtt acagactttt gaggatgtat cccagcacga
      901 agaatttctt gagcttgaca aagatgaact tattgattat atttgtagtg atgaacttgt
      961 tattggtaaa gaggagatgg tttttgaagc cgtcatgcgt tgggtctatc gtgccgttga
     1021 tctgagaaga ccactgttac acgagctcct gacacatgtg agactccctc tgttgcatcc
     1081 caactacttt gttcaaacag ttgaagtgga ccaattgatc cagaattctc ctgagtgtta
     1141 tcagttgttg catgaagcaa gacggtacca catacttggg aatgaaatga tgtccccaag
     1201 gactaggcca cgcaggtcca ctggctattc tgaggtgata gttgtcgttg gaggatgtga
     1261 gcgagttgga ggatttaatc ttccatacac tgagtgctac gatcctgtaa caggagaatg
     1321 gaagtctttg gctaagcttc cagaatttac caaatcagag tatgcagtct gtgctctaag
     1381 gaatgacatt cttgtttcag gtggaagaat caacagccgt gatgtctgga tttataactc
     1441 acagttaaat atttggatca gagttgcctc tctcaataaa ggcagatggc gtcacaaaat
     1501 ggctgtcctc cttggtaaag tatatgttgt cggtggctat gatgggcaaa acagacttag
     1561 cagcgtagaa tgttatgatt ccttttcaaa tcgatggact gaagttgctc cccttaagga
     1621 agccgtgagt tctcctgcag tgactagctg tgtaggcaaa ctgtttgtga ttggtggagg
     1681 acctgatgat aatacttgtt ctgataaggt tcaatcttat gatccagaaa ccaattcttg
     1741 gctacttcgt gcagctatcc caattgccaa aaggtgtata acagctgtat ccctaaacaa
     1801 cctgatctat gttgccggtg gactgaccaa ggcaatatac tgttacgatc cagttgaaga
     1861 ttactggatg cacgtacaga atacattcag ccgtcaggaa aactgtggta tgtctgtgtg
     1921 taatggtaaa atatatatcc tgggcggaag acgggaaaat ggagaagcca cagacactat
     1981 tctctgttat gatcctgcaa caagtatcat cacaggggta gctgcaatgc ccaggccagt
     2041 gtcctatcat ggctgtgtga ctattcatag atacaatgag aaatgcttta aactctgaag
     2101 acaggatacc tcaccgaaga agccacactg atccaagatg ggaggtttta aaaactctac
     2161 agtgggaact tcacatatct cctttgtgcc atatgcaaaa aatagtaaaa ataataattt
     2221 ggtgcctttc tcctcaaaat atcaatcttt caaactataa taaagccttt cctataattg
     2281 aaaaaaaaaa cttttttgtt aaaggtaatg gtggttgtta cttggccttt gaagagtgta
     2341 cctttgtaag tatttgtaag aagtctatgt gaattaggaa atgtctgtct gcataccttt
     2401 taggagcgtg tgaatggtgt cttcacttat tatgtatgtt tatctgtatg tatattcctt
     2461 attttgtcat atatgtagag aaaattgcat gacttgaggc atcatttagg ttgaagaagt
     2521 taatgcttag gatgcattct aggagaaaaa atcagtttta aaaacctttg ttgttaacaa
     2581 agtatatcca gattggttaa ttttattgaa gggttttttt ctgtaattga taaaaatgta
     2641 atgacaacaa ttcaggcatc ataaaatact gaactattgt gactttattc ttagaattgc
     2701 tgtcttacat taaacatgtt tttaggggga agttaggtag gagatagaaa aataagtgcc
     2761 cctacaaggg ggattaaaat tacaagttaa ttcctaagag aaaaatggaa tggcctttga
     2821 aggaaaaatg acccactatg gctctcaaag tttttatgca tcatctcttc aatcctctaa
     2881 gaaagcctct tttcttaact tgataaagca gtggaaaccc attttgcaat attgttttgt
     2941 gaaaaacagg gacagacagc caggtacaga gactcacacc tgtactccca actactcagc
     3001 aggctggggc aggaggattg cttgagccca ggagtctgag gctacagtga gctatgaacg
     3061 cacacggcac cctagcctgg gcaacaggtt gcgacactgt ctcaagagaa aagaaaaaga
     3121 aaaataggga taggttttcc ttcctagccc agtagagttt gacctcatta gtatggtgct
     3181 ttgggtgagg acctcttcct tgattatccc actttctagt gaacagctaa aattcctgag
     3241 agtctctact gttaaggtac ctttaatagg ataaagcagg gaccacctat ctcagtgggt
     3301 ccatttttct tttaaaatta gttatctgaa aaaacttagc agtagttccc atctttaagg
     3361 taagtctttc atttggtccc cattgtgtaa aatactaatc aacattttca agcttctgta
     3421 caacagactg cttttgtcta gatttctcaa ctccacttta taaagcttat cagttttcag
     3481 agaggaatgt gaattttttt tctaatgcaa ataaatggat atggcaggaa ctacagcata
     3541 agtgattatt gtgattctgg gtggacggat ataatttaca acatttaggg atgttctagg
     3601 tagcctgctg tagtttgact tccagtcact gttgtctttc acattataat ttgtatattt
     3661 cttgtgatag aagggatgat gcaaatatgt aattaaagtg tcaccagatt tctgttaaaa
     3721 ccaaggttga aataaaaagc ctaacattgg taagctacat tgttttctca ttttagaatg
     3781 attcagagat ttcagataga cattttttaa actttaatgc ttagctagaa tctacattct
     3841 gaggaaaact ctaaaaaact taaaaatttt tagggaattt ttatttttca aatcataatt
     3901 ttaaaatgat agataccatt ttgtgataac aacaattcag aaaacaattt tctatcctct
     3961 tagttgaaag aatgtaggta cagtttggat acttgtactt taattttaga gtaaacatct
     4021 gcattatact cttatagata atagaattat ttagttaaga aattctttac agtaaatgag
     4081 ataatgtgtg aaaaagtatt ttgtaaatgc tgaggattct acaaatgata gttgttattt
     4141 tcatgtgtat ttgtaagatc atgtccattt catgaatata ggacttcaca taaaaaaaga
     4201 ctttctcaag acaactttat attctagtat ttttctgttg taaaaagtat taactattta
     4261 cttttatttt gttatacatt tattttaata tccatgtgtt tattatagta aatttgaaat
     4321 gaaatcctga aaaacagaat ttttttaaac acagacctca caccaatatt aattttttct
     4381 ctacataatt taaaactaca taaattaagt acttaaaatt tatattgaag gccaccaaga
     4441 acttaggttg aatcttagaa aatttaaata actattttta aagttaccca acttaatatt
     4501 ttaatttttt aatatttatc ttcctttact aattcttgat aaataatagc attagacttg
     4561 ataaaataaa aaagaatttt agagtagaat taatatatca aaaggggtat atcaaccaaa
     4621 ttggtgtcag attgtattca ttctctcatc acataaagat ttttcttttg ataggtgatg
     4681 ctcatatgaa cctttggttt agaatctata tatgtacatg tgtatgtatg tagatagtat
     4741 ggttgtatac acacatatat accaaacacc atgaatttta gcagtctgtg atgatcagca
     4801 aaaaagcaca taaagtaaaa attagttgac catgctaaat tcaattctgg aatttttttt
     4861 tatttgggca tttctagaac tttttacatt tgaaagtaca tgatgagtat tagtaacgat
     4921 gacttatgta taatcagaat ctttatgaca atttagtttt acaaggtcag aagagatgag
     4981 tttgctaaac ccagctgtga tacctcagtt ggaaagggaa ttcaaaggta tgctttgtag
     5041 aacagaaaag tatagttttt ttttcatgaa ctttaatcat tttctgtttt tcctctatgt
     5101 gagtcagcta caaaagtggt ctaattttta caacagtaga acttcctcct tttctactgt
     5161 aatcttccca ctgactttac tgcacaggta tgaaatacta gtgtattgga tcttcagtaa
     5221 cctttttatt tcctagatga ttgaaatata ggtatttact ccatttaaac caggtgataa
     5281 gatgatgtaa atactcaggg agggtattaa cttgttactt ttgctcgttt ggggtgtaaa
     5341 gtgccatgac tgaataatct tcaattcatg attctagagt aagtttaatt tggaaaaagg
     5401 ggcttcacac atggtggtgg ttgaacattg attcttttat acttaaaaag atgaaaatgt
     5461 tttgtggact gatacatttt atcttactga atatgaattg tttatgtatc tctactgtca
     5521 aatagccttt ttgaaactca ggaaagacaa aggttcaatt acaccacttt tgtcaataag
     5581 caaaccaggt attttttttt tctcctgttg tctggatatg gcaatagatt ttttaaattg
     5641 ctgtgagaac ccatatatga aaagagagga gttgaattgt gtgtgccttt tatgtcttga
     5701 gatttatatg tggaaaagac gacatctact tcaaactgta tttttttcgt tttttttttt
     5761 ttttggggaa ggggggagaa cggggtcttg ctctgtcgcc caggctggag tgcagtggcg
     5821 cgatctcagc tgactgcaac ctccacctcc cgggttcaag ggattctgcc tcagcctccc
     5881 gagtagctga gaccacaggt gcgtgccacc acacccggct aatttttttg tatttttagt
     5941 agagacgggg tttagtagag acggatcact cctgaccacg tgatccgccc acctcggcct
     6001 cccaaagtgc tgggattaca ggcgtgagcc accacccccg gcctgtattt tcagagagga
     6061 gagcttggtg tttttgtggt gccaagtggt aagataatgt ctctttgagg cttcctatgg
     6121 actgccttta ttttagtaaa ctcaagacac cagttaacct caacagagtt ttggccttat
     6181 tagaatttgt tgtgcatctt attgaaagcc aggtttacat cacctcaccc cattattctt
     6241 tttagttaaa taaatttacc atgccaagta accagaatgg agcaaattgg ttgatcttta
     6301 aggcagtagg tttgactagc tagctatcat tattgtcaca tctaatgcta ggcaccagaa
     6361 accatttgag ccaggagtgt gaatgaataa ttccagagac actttagaca ttttttaatg
     6421 ttttatatga acattttaca tttgtgtgat tgccttagat attaaatttt cctagtgctg
     6481 ataaaaacag caacattcat aacttatttt atatattgtt ccaaagaaaa gaatttgttt
     6541 taatggtttc aaaataactg cacctgaatt tgtttatgtg ccttaagttc tctagtgcta
     6601 tttcaacttt tttttcaatc taaatgaagc ttaccttaga taaggttcat atttgtttcc
     6661 tatagagtaa ataaacttcc ccttcttaaa ttgtgtaata agcaccaacg tgtggttgct
     6721 tggcagaatg agaatgttaa gggagattgt tggatgtttg gagtttcatt atattttttg
     6781 tttttatttt ttgataccta ggtgcttttt aaaatattca gacaaatatc tatcttacat
     6841 tgattaaacc cgtgtaaatt catttgcagt atctacatcg aatgtcaaaa aagtatactt
     6901 atttttgttc catacttatg tacaattttt tccctcttca ggctttttca tttacctttt
     6961 tgaaaaagca cttactctcc ccttccctat cacccctccc ccaaggtttc tttatttaaa
     7021 tttttattga gagttgttgg agctctaaga caatacaaat ttagagttga acaaaagtat
     7081 aatctgcttt acaactagta tagacctaag gtcatttgct ttcaattaga ggctccagag
     7141 tcttcatagt ggaaagaatg ctttgtattt aattgttctt agttaagttg tagcacgtga
     7201 atacttactt acatgttttg tttaaatata cttcttgcat agtttaattt tttaaaagtt
     7261 gtatctaata aaatgtcttt taaccattat tacttgacta tatggttgta ttaaattttg
     7321 tttacgaaaa a
//
