LOCUS       NM_144711               4081 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens kelch like family member 23 (KLHL23), mRNA.
ACCESSION   NM_144711
VERSION     NM_144711.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4081)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 4081)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 4081)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 4081)
  AUTHORS   Taipale,M., Tucker,G., Peng,J., Krykbaeva,I., Lin,Z.Y., Larsen,B.,
            Choi,H., Berger,B., Gingras,A.C. and Lindquist,S.
  TITLE     A quantitative chaperone interaction network reveals the
            architecture of cellular protein homeostasis pathways
  JOURNAL   Cell 158 (2), 434-448 (2014)
   PUBMED   25036637
REFERENCE   5  (bases 1 to 4081)
  AUTHORS   Dhanoa,B.S., Cogliati,T., Satish,A.G., Bruford,E.A. and
            Friedman,J.S.
  TITLE     Update on the Kelch-like (KLHL) gene family
  JOURNAL   Hum Genomics 7 (1), 13 (2013)
   PUBMED   23676014
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4081)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   7  (bases 1 to 4081)
  AUTHORS   Wouters,M.M., Neefs,J.M., Kerchove d'Exaerde,Ad., Vanderwinden,J.M.
            and Smans,K.A.
  TITLE     Downregulation of two novel genes in Sl/Sld and W(LacZ)/Wv mouse
            jejunum
  JOURNAL   Biochem Biophys Res Commun 346 (2), 491-500 (2006)
   PUBMED   16765319
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC009967.8, BJ990781.1, BC010437.1 and BE326381.1.
            
            On Nov 22, 2018 this sequence version replaced NM_144711.5.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.50521.1,
                                           SRR1803612.227762.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000392647.7/ ENSP00000376419.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                AC009967.8         32013-32026
            15-180              BJ990781.1         1-166
            181-1673            BC010437.1         1-1493
            1674-4076           AC009967.8         47652-50054
            4077-4081           BE326381.1         23-27               c
FEATURES             Location/Qualifiers
     source          1..4081
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q31.1"
     gene            1..4081
                     /gene="KLHL23"
                     /gene_synonym="DITHP"
                     /note="kelch like family member 23"
                     /db_xref="GeneID:151230"
                     /db_xref="HGNC:HGNC:27506"
     exon            1..256
                     /gene="KLHL23"
                     /gene_synonym="DITHP"
                     /inference="alignment:Splign:2.1.0"
     exon            257..1471
                     /gene="KLHL23"
                     /gene_synonym="DITHP"
                     /inference="alignment:Splign:2.1.0"
     CDS             259..1935
                     /gene="KLHL23"
                     /gene_synonym="DITHP"
                     /note="kelch-like 23"
                     /codon_start=1
                     /product="kelch-like protein 23"
                     /protein_id="NP_653312.2"
                     /db_xref="GeneID:151230"
                     /db_xref="HGNC:HGNC:27506"
                     /translation="MALKGQEDYIYLFKDSTHPVDFLDAFRTFYLDGLFTDITLQCPS
                     GIIFHCHRAVLAACSNYFKAMFTADMKEKFKNKIKLSGIHHDILEGLVNYAYTSQIEI
                     TKRNVQSLLEAADLLQFLSVKKACERFLVRHLDIDNCIGMHSFAEFHVCPELEKESRR
                     ILCSKFKEVWQQEEFLEISLEKFLFILSRKNLSVWKEEAIIEPVIKWTAHDVENRIEC
                     LYNLLSYINIDIDPVYLKTALGLQRSCLLTENKIRSLIYNALNPMHKEISQRSTATMY
                     IIGGYYWHPLSEVHIWDPLTNVWIQGAEIPDYTRESYGVTCLGPNIYVTGGYRTDNIE
                     ALDTVWIYNSESDEWTEGLPMLNARYYHCAVTLGGCVYALGGYRKGAPAEEAEFYDPL
                     KEKWIPIANMIKGVGNATACVLHDVIYVIGGHCGYRGSCTYDKVQSYNSDINEWSLIT
                     SSPHPEYGLCSVPFENKLYLVGGQTTITECYDPEQNEWREIAPMMERRMECGAVIMNG
                     CIYVTGGYSYSKGTYLQSIEKYDPDLNKWEIVGNLPSAMRSHGCVCVYNV"
     exon            1472..1624
                     /gene="KLHL23"
                     /gene_synonym="DITHP"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..4081
                     /gene="KLHL23"
                     /gene_synonym="DITHP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4062..4067
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLHL23"
                     /gene_synonym="DITHP"
                     /note="hexamer: AATAAA"
     polyA_site      4081
                     /gene="KLHL23"
                     /gene_synonym="DITHP"
                     /note="major polyA site"
ORIGIN      
        1 gccccgctcg ccgcacggcc cggcgacggg ggagttcccg cgagtggcct cgcgcccaga
       61 ccgtgcgggg ggctgttcgg gtggaggcgg gggagccgcc gggacaccaa aataggagct
      121 gcttgtgggg tggagcggca ctagctggcg gcttccgagc gcctcttcca aagatggtca
      181 gaggggccgg aggcgtcccc gctcccgctc gctactagcc cgcgggccag cgccgcgtcc
      241 cgagccccgg cgggagccat ggctctaaaa ggacaagaag attatattta tcttttcaag
      301 gattcaacac atccagtgga ttttctggat gcattcagaa cattttactt ggatggatta
      361 tttactgata ttactcttca gtgtccttca ggcataattt tccattgtca ccgagccgtt
      421 ttagctgctt gcagcaatta ttttaaggca atgttcacag ctgacatgaa agaaaaattt
      481 aaaaataaaa taaaactctc tggcatccac catgatattc tggaaggcct tgtaaattat
      541 gcatacactt cccaaattga aataactaaa agaaatgttc aaagcctgct tgaggcagcg
      601 gatctgctac agttcctttc agtaaagaag gcttgtgagc ggtttttggt aaggcacttg
      661 gatattgata attgtattgg aatgcactcc tttgcagaat ttcatgtgtg tccagaacta
      721 gagaaggaat ctcgaagaat tctatgttca aagtttaagg aagtgtggca acaagaagaa
      781 tttctggaaa tcagccttga aaagtttctc tttatcttgt ccagaaagaa tctcagtgtt
      841 tggaaagaag aagctatcat agagccagtt attaagtgga ctgctcatga tgtagaaaat
      901 cgaattgaat gcctctataa tctactgagc tatatcaaca ttgatataga tccagtgtac
      961 ttaaaaacag ccttaggcct tcaaagaagc tgcctgctca ccgaaaataa gatccgctcc
     1021 ctaatataca atgccttgaa tcccatgcat aaagagattt cccagaggtc cacagccaca
     1081 atgtatataa ttggaggcta ttactggcat cctttatcag aggttcacat atgggatcct
     1141 ttgacaaatg tttggattca gggagcagaa ataccagatt ataccaggga gagctatggt
     1201 gttacatgtt taggacccaa catttatgta actgggggct acaggacgga taacatagaa
     1261 gctcttgaca cagtgtggat ctataacagt gaaagtgatg aatggacaga aggtttgcca
     1321 atgctcaatg ccaggtatta ccactgtgca gtcaccttgg gtggctgtgt ctatgcttta
     1381 ggtggttaca gaaaaggggc tccagcagaa gaggctgagt tctatgatcc tttaaaagag
     1441 aaatggattc ctattgcaaa catgattaaa ggtgtgggaa atgctactgc ctgtgtctta
     1501 catgatgtta tctacgtcat tggtggccac tgtggctaca gaggaagctg cacctatgac
     1561 aaagttcaga gctacaattc cgatatcaac gaatggagcc tcatcacctc cagtccacat
     1621 ccagaatatg gattgtgctc agttccgttt gaaaataagc tctatctagt cggcggacaa
     1681 actacaatca cagaatgcta tgaccctgaa caaaatgaat ggagagagat agctcccatg
     1741 atggaaagga ggatggagtg cggtgccgtc atcatgaatg gatgtattta tgtcactgga
     1801 ggatactcct actcaaaggg aacgtatctt cagagcattg agaaatatga tccagatctt
     1861 aataagtggg aaatagtggg taatcttccc agtgccatgc ggtctcatgg gtgtgtttgt
     1921 gtgtataatg tctaattgaa tctgcagaaa tgaccaagca atcacttttt tggagtatag
     1981 ttttataaaa aaagaatgca gggtttgaag ttccttacct gataattgtg tctggcacat
     2041 gataggggat cagtaaattg taattcctaa ccctactgta ctcccaaaca tggtgattca
     2101 tggtcaagaa aaatcttata tatatatata tatacacaca cacatatatg tgttcatata
     2161 tatgtataca tatatatgtg tatatatacg tatgtataca tatatgtgta tatatacgta
     2221 tgtatgtata catatgtgta tatatagtat gtatgtatac atgtatgtgt atatatacgt
     2281 atgtatgtat acatatatgt gtatacatat atatgtgtgt atatatatac acatatatac
     2341 gtatatatgt gtatatatat acacagttga atcagtggga ttaataccta taatctctgg
     2401 ttttcaaagg taatatagaa tatttgacac ttggtaaaag gtgaactacc tttgtagtga
     2461 atcttttcct cttggtagca tcaacactgg ggataaatca gaaccattct gtggaatgaa
     2521 atgtttctca agagcctata atatagtaga tagtgcatat taagatgtct ggctgggcat
     2581 ggtggctcat gcctgtaatc ccagcacttt gggaggctga ggcgggagga tcacttgagc
     2641 ctagaagttg gagactaacc tggcgagacc ctgtctcaaa aaaaaaaaaa aatcaattta
     2701 gctagcagga atttgacatt taaagaggga atcttctcta cctctacaaa atcaaccctt
     2761 aacacttttt tcaccttcag aattatttag aatgtggatt tactttgtct agttttttcc
     2821 tttatagtgt aatttattgt tactctctat ttactgacta ccagagatat acaaaatact
     2881 gtgcaaaaga ttgttactgt tcaaagagct tacaaactaa atttaaaaga atagcaagtc
     2941 tgaaaaatag aagatagtca aatatttgtt tatgctaaga actgttttta attttcagct
     3001 ttgatgtaaa ttgctagctt agttgtcttt agttcaagca tgttaggaaa tcctctttat
     3061 tcttaaatat agatacatgt ctgcatatat gattgaattt tagagccaga aagcatgtag
     3121 agcagttgtg attagtagaa aatacactga caagaagata tttgcattta tttcccaaag
     3181 ctgccagtaa ctagattttg tgacttaagt catttaacct ctccttgatt agagcttcct
     3241 gagccatgca cactggcact gcaaatcaca gacaggccta gatacagatc ccctcacccc
     3301 ttgctacatc caaaggtggc ctgggtggct ggagcctctg ggccagaacc acctttgtcc
     3361 attttcctca gtgtgcctac agcatcgctt tccatgtgtg ccataacttg ggaatagttg
     3421 ggatgtgttg cttaactcct ttacaccatt agttatctgt gagaccatct attccacact
     3481 cttcattttt taaaaagaga caataattat ttttaactca ctgaagttta aaactaccta
     3541 gcatttctga ttaaaaaaaa tttagaagga aaattttaat gcatttattt cagatggcgt
     3601 tttaaataga tacaaccctt tggaaacaca atatggtact acatagcaag ggctgtaaaa
     3661 atgaccatat cctttgcccc ataaattcta cttctatact tttaacctta aaaataattc
     3721 agaaaaaaga taaatgcatg aagacattta tgtctgcatt ctttataata acaaaaattg
     3781 gggaaaaaaa ctccatgtca agaaagtggg ataagaaaaa tagtgaagta ttatactgcc
     3841 attaaaataa ttatttggaa gactgtagaa acgtggacat gtttgatatg gtaagtaaaa
     3901 tgagcacaat acaaaatagt atgcatacta tgattgtgac tttgtaaaat ctttatgcat
     3961 gtggaaggta atctgcaaaa caaattcatt gtgttagtgt agcgggatat ggaatgactt
     4021 tatttattta aatcttttct ttaatattac tttgtatttt caataaaaat aaatcactgt
     4081 a
//
