LOCUS       NM_032775               2528 bp    mRNA    linear   PRI 18-NOV-2024
DEFINITION  Homo sapiens kelch like family member 22 (KLHL22), transcript
            variant 1, mRNA.
ACCESSION   NM_032775
VERSION     NM_032775.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2528)
  AUTHORS   Teng,F., Wang,Y., Liu,M., Tian,S., Stjepanovic,G. and Su,M.Y.
  TITLE     Cryo-EM structure of the KLHL22 E3 ligase bound to an oligomeric
            metabolic enzyme
  JOURNAL   Structure 31 (11), 1431-1440 (2023)
   PUBMED   37788672
REFERENCE   2  (bases 1 to 2528)
  AUTHORS   Liu,B.Q., Liu,R.B., Li,W.P., Mao,X.T., Li,Y.N., Huang,T.,
            Wang,H.L., Chen,H.T., Zhong,J.Y., Yang,B., Chai,R.J., Cao,Q.,
            Jin,J. and Li,Y.Y.
  TITLE     XAF1 prevents hyperproduction of type I interferon upon viral
            infection by targeting IRF7
  JOURNAL   EMBO Rep 24 (1), e55387 (2023)
   PUBMED   36394357
REFERENCE   3  (bases 1 to 2528)
  AUTHORS   Swaney,D.L., Ramms,D.J., Wang,Z., Park,J., Goto,Y., Soucheray,M.,
            Bhola,N., Kim,K., Zheng,F., Zeng,Y., McGregor,M., Herrington,K.A.,
            O'Keefe,R., Jin,N., VanLandingham,N.K., Foussard,H., Von Dollen,J.,
            Bouhaddou,M., Jimenez-Morales,D., Obernier,K., Kreisberg,J.F.,
            Kim,M., Johnson,D.E., Jura,N., Grandis,J.R., Gutkind,J.S.,
            Ideker,T. and Krogan,N.J.
  TITLE     A protein network map of head and neck cancer reveals PIK3CA mutant
            drug sensitivity
  JOURNAL   Science 374 (6563), eabf2911 (2021)
   PUBMED   34591642
REFERENCE   4  (bases 1 to 2528)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 2528)
  AUTHORS   Zhou,X.A., Zhou,J., Zhao,L., Yu,G., Zhan,J., Shi,C., Yuan,R.,
            Wang,Y., Chen,C., Zhang,W., Xu,D., Ye,Y., Wang,W., Shen,Z., Wang,W.
            and Wang,J.
  TITLE     KLHL22 maintains PD-1 homeostasis and prevents excessive T cell
            suppression
  JOURNAL   Proc Natl Acad Sci U S A 117 (45), 28239-28250 (2020)
   PUBMED   33109719
  REMARK    GeneRIF: KLHL22 maintains PD-1 homeostasis and prevents excessive T
            cell suppression.
REFERENCE   6  (bases 1 to 2528)
  AUTHORS   Taipale,M., Krykbaeva,I., Koeva,M., Kayatekin,C., Westover,K.D.,
            Karras,G.I. and Lindquist,S.
  TITLE     Quantitative analysis of HSP90-client interactions reveals
            principles of substrate recognition
  JOURNAL   Cell 150 (5), 987-1001 (2012)
   PUBMED   22939624
REFERENCE   7  (bases 1 to 2528)
  AUTHORS   Bennett,E.J., Rush,J., Gygi,S.P. and Harper,J.W.
  TITLE     Dynamics of cullin-RING ubiquitin ligase network revealed by
            systematic quantitative proteomics
  JOURNAL   Cell 143 (6), 951-965 (2010)
   PUBMED   21145461
REFERENCE   8  (bases 1 to 2528)
  AUTHORS   Maerki,S., Olma,M.H., Staubli,T., Steigemann,P., Gerlich,D.W.,
            Quadroni,M., Sumara,I. and Peter,M.
  TITLE     The Cul3-KLHL21 E3 ubiquitin ligase targets aurora B to midzone
            microtubules in anaphase and is required for cytokinesis
  JOURNAL   J Cell Biol 187 (6), 791-800 (2009)
   PUBMED   19995937
REFERENCE   9  (bases 1 to 2528)
  AUTHORS   Sumara,I., Quadroni,M., Frei,C., Olma,M.H., Sumara,G., Ricci,R. and
            Peter,M.
  TITLE     A Cul3-based E3 ligase removes Aurora B from mitotic chromosomes,
            regulating mitotic progression and completion of cytokinesis in
            human cells
  JOURNAL   Dev Cell 12 (6), 887-900 (2007)
   PUBMED   17543862
REFERENCE   10 (bases 1 to 2528)
  AUTHORS   Collins,J.E., Wright,C.L., Edwards,C.A., Davis,M.P., Grinham,J.A.,
            Cole,C.G., Goward,M.E., Aguado,B., Mallya,M., Mokrab,Y.,
            Huckle,E.J., Beare,D.M. and Dunham,I.
  TITLE     A genome annotation-driven approach to cloning the human ORFeome
  JOURNAL   Genome Biol 5 (10), R84 (2004)
   PUBMED   15461802
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC015923.1.
            
            On Nov 22, 2018 this sequence version replaced NM_032775.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the functional protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC015923.1, SRR3476690.264520.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000328879.9/ ENSP00000331682.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2528              BC015923.1         41-2568
FEATURES             Location/Qualifiers
     source          1..2528
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q11.21"
     gene            1..2528
                     /gene="KLHL22"
                     /gene_synonym="KELCHL"
                     /note="kelch like family member 22"
                     /db_xref="GeneID:84861"
                     /db_xref="HGNC:HGNC:25888"
                     /db_xref="MIM:618020"
     exon            1..36
                     /gene="KLHL22"
                     /gene_synonym="KELCHL"
                     /inference="alignment:Splign:2.1.0"
     exon            37..296
                     /gene="KLHL22"
                     /gene_synonym="KELCHL"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..1974
                     /gene="KLHL22"
                     /gene_synonym="KELCHL"
                     /note="kelch-like 22"
                     /codon_start=1
                     /product="kelch-like protein 22"
                     /protein_id="NP_116164.2"
                     /db_xref="CCDS:CCDS13780.1"
                     /db_xref="GeneID:84861"
                     /db_xref="HGNC:HGNC:25888"
                     /db_xref="MIM:618020"
                     /translation="MAEEQEFTQLCKLPAQPSHPHCVNNTYRSAQHSQALLRGLLALR
                     DSGILFDVVLVVEGRHIEAHRILLAASCDYFRGMFAGGLKEMEQEEVLIHGVSYNAMC
                     QILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCDFLMSWVDEENILDVYRLAE
                     LFDLSRLTEQLDTYILKNFVAFSRTDKYRQLPLEKVYSLLSSNRLEVSCETEVYEGAL
                     LYHYSLEQVQADQISLHEPPKLLETVRFPLMEAEVLQRLHDKLDPSPLRDTVASALMY
                     HRNESLQPSLQSPQTELRSDFQCVVGFGGIHSTPSTVLSDQAKYLNPLLGEWKHFTAS
                     LAPRMSNQGIAVLNNFVYLIGGDNNVQGFRAESRCWRYDPRHNRWFQIQSLQQEHADL
                     SVCVVGRYIYAVAGRDYHNDLNAVERYDPATNSWAYVAPLKREVYAHAGATLEGKMYI
                     TCGRRGEDYLKETHCYDPGSNTWHTLADGPVRRAWHGMATLLNKLYVIGGSNNDAGYR
                     RDVHQVACYSCTSGQWSSVCPLPAGHGEPGIAVLDNRIYVLGGRSHNRGSRTGYVHIY
                     DVEKDCWEEGPQLDNSISGLAACVLTLPRSLLLEPPRGTPDRSQADPDFASEVMSVSD
                     WEEFDNSSED"
     exon            297..462
                     /gene="KLHL22"
                     /gene_synonym="KELCHL"
                     /inference="alignment:Splign:2.1.0"
     exon            463..1181
                     /gene="KLHL22"
                     /gene_synonym="KELCHL"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1374
                     /gene="KLHL22"
                     /gene_synonym="KELCHL"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1608
                     /gene="KLHL22"
                     /gene_synonym="KELCHL"
                     /inference="alignment:Splign:2.1.0"
     exon            1609..2528
                     /gene="KLHL22"
                     /gene_synonym="KELCHL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2497..2502
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLHL22"
                     /gene_synonym="KELCHL"
                     /note="hexamer: AATAAA"
     polyA_site      2528
                     /gene="KLHL22"
                     /gene_synonym="KELCHL"
                     /note="major polyA site"
ORIGIN      
        1 agctgcgagt gcggcctcgg ctggcggcgg caccaggcca cagttgtaag ggatcttgtg
       61 gctgtcagga tggcagagga gcaggagttc acccagctct gcaagttgcc tgcacagccc
      121 tcacacccac actgcgtgaa caacacctac cgcagcgcac agcactccca ggctctgctc
      181 cgagggctgc tggctctccg ggacagcgga atcctcttcg atgttgtgct ggtggtggag
      241 ggcagacaca tcgaggccca tcgcatcctg ctggctgcgt cctgcgatta cttcagagga
      301 atgtttgctg ggggattgaa ggagatggaa caggaagagg tcctgatcca cggtgtgtcc
      361 tacaatgcta tgtgccaaat cctacatttc atatacacct ccgagctgga gctcagcctg
      421 agcaatgtac aagagacact ggtggctgcc tgccagcttc agatcccaga aattatccat
      481 ttctgctgtg atttcctcat gtcctgggtg gacgaagaga acattctcga tgtctaccgg
      541 ctggcagagc tgtttgactt gagccgcctg actgagcaac tggacaccta tatcctcaaa
      601 aactttgtgg ccttctctcg gactgacaag taccgccagc ttccattgga gaaggtctac
      661 tccctcctca gcagcaatcg cctggaggtc tcctgcgaga ccgaggtata tgagggggcc
      721 cttctctacc attatagcct ggagcaggtg caggctgacc agatctcgct gcacgagccc
      781 ccaaagctcc ttgagacagt gcggtttccg ctgatggaag ctgaggtcct gcagcggctg
      841 catgacaagc tggaccccag ccctttgagg gacacagtgg ccagcgccct catgtaccac
      901 cggaacgaga gcctacagcc cagcctgcag agcccgcaaa cggagctgcg gtcggacttc
      961 cagtgcgttg tgggcttcgg gggcattcac tccacgccgt ccactgtcct cagcgaccag
     1021 gccaagtatc taaacccctt actgggagag tggaagcact tcactgcctc cctggccccc
     1081 cgcatgtcca accagggcat cgcggtgctc aacaacttcg tatacttgat tggaggggac
     1141 aacaatgtcc aaggatttcg agcagagtcc cgatgctgga ggtatgaccc acggcacaac
     1201 cgctggttcc agatccagtc cctgcagcag gagcacgccg acctgtccgt gtgtgttgta
     1261 ggcaggtaca tctacgctgt ggcgggccgt gactaccaca atgacctgaa tgctgtggag
     1321 cgctacgacc ctgccaccaa ctcctgggca tacgtggccc cactcaagag ggaggtgtat
     1381 gcccacgcag gcgcgacgct ggaggggaag atgtatatca cctgcggccg cagaggggag
     1441 gattacctga aagagacaca ctgctacgat ccaggcagca acacttggca cacactggct
     1501 gatgggcctg tgcggcgcgc ctggcacggc atggcaaccc tcctcaacaa gctgtatgtg
     1561 atcgggggca gcaacaacga tgccggatac aggagggacg tgcaccaggt ggcctgctac
     1621 agctgcacgt ctggacagtg gtcatctgtc tgcccactcc ctgctgggca cggtgagcct
     1681 ggcattgctg tgctggacaa caggatctat gtgttaggtg gccgctcaca caaccgcggc
     1741 agccgcacag gctacgtgca catttacgat gtggagaagg actgctggga ggaagggccc
     1801 cagctggaca actccatctc aggcctggcg gcctgtgtgc tcaccctgcc ccgctccctg
     1861 ctccttgagc cgccccgcgg gacccctgac cgcagccagg ccgacccgga ctttgcctct
     1921 gaggtgatga gtgtgtctga ctgggaggag tttgacaact ccagtgagga ctaggctccc
     1981 tgtgcctggc atcagaggga agggaggctg gggctgcagg gcagtgaaac ccacgcagcc
     2041 taggccagag cactttactc caggcagggc ccctgcccct gttggccaca gcttatgggc
     2101 cctgccctct ttcttcacac cagccccttg gccagcctgc cgcaggcatc tcagggccat
     2161 gcagatccca ggctgtggat tacgtcactg caggaactgc ttctgaaagg ctttggcctt
     2221 cctcagtgag ccctggaggg gttggccttc tctcctccct gcctagatca gtccttctcc
     2281 aaaaggacct gggagctggc agcctgggca ggggggctga ggcacgtggt agccctcttt
     2341 ctgtgaatgg ggtggggctg tgggggcagc tggggttgga ggatgagagc tcctgagggg
     2401 cagaggagca gagatgcatc agctcgcctg ggactggctc tgtgataaaa agacccctcc
     2461 cgctgggttt tcagacccca tgttgttggt caatgaaata aagcatctta cagaaggtgt
     2521 taactgtt
//
