LOCUS       NM_014851               4487 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens kelch like family member 21 (KLHL21), transcript
            variant 1, mRNA.
ACCESSION   NM_014851 XM_375685
VERSION     NM_014851.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4487)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 4487)
  AUTHORS   Chen,J., Song,W., Du,Y., Li,Z., Xuan,Z., Zhao,L., Chen,J., Zhao,Y.,
            Tuo,B., Zheng,S. and Song,P.
  TITLE     Inhibition of KLHL21 prevents cholangiocarcinoma progression
            through regulating cell proliferation and motility, arresting cell
            cycle and reducing Erk activation
  JOURNAL   Biochem Biophys Res Commun 499 (3), 433-440 (2018)
   PUBMED   29574153
  REMARK    GeneRIF: KLHL21 plays an essential role in the tumorigenesis and
            progression of cholangiocarcinoma.
REFERENCE   3  (bases 1 to 4487)
  AUTHORS   Shi,L., Zhang,W., Zou,F., Mei,L., Wu,G. and Teng,Y.
  TITLE     KLHL21, a novel gene that contributes to the progression of
            hepatocellular carcinoma
  JOURNAL   BMC Cancer 16 (1), 815 (2016)
   PUBMED   27769251
  REMARK    GeneRIF: Our study suggests that KLHL21 is a potential target for
            therapeutic intervention. Our findings also provide novel candidate
            genes on a genome-wide scale, which may have significant impact on
            the design and execution of effective therapy of HCC patients.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4487)
  AUTHORS   Mei,Z.Z., Chen,X.Y., Hu,S.W., Wang,N., Ou,X.L., Wang,J., Luo,H.H.,
            Liu,J. and Jiang,Y.
  TITLE     Kelch-like Protein 21 (KLHL21) Targets IkappaB Kinase-beta to
            Regulate Nuclear Factor kappa-Light Chain Enhancer of Activated B
            Cells (NF-kappaB) Signaling Negatively
  JOURNAL   J Biol Chem 291 (35), 18176-18189 (2016)
   PUBMED   27387502
  REMARK    GeneRIF: data clearly demonstrate that KLHL21 negatively regulates
            TNFalpha-activated NF-kappaB signaling via targeting IKKbeta,
            providing new insight into the mechanisms underlying NF-kappaB
            regulation in cells.
REFERENCE   5  (bases 1 to 4487)
  AUTHORS   Dhanoa,B.S., Cogliati,T., Satish,A.G., Bruford,E.A. and
            Friedman,J.S.
  TITLE     Update on the Kelch-like (KLHL) gene family
  JOURNAL   Hum Genomics 7 (1), 13 (2013)
   PUBMED   23676014
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4487)
  AUTHORS   Maerki,S., Olma,M.H., Staubli,T., Steigemann,P., Gerlich,D.W.,
            Quadroni,M., Sumara,I. and Peter,M.
  TITLE     The Cul3-KLHL21 E3 ubiquitin ligase targets aurora B to midzone
            microtubules in anaphase and is required for cytokinesis
  JOURNAL   J Cell Biol 187 (6), 791-800 (2009)
   PUBMED   19995937
  REMARK    GeneRIF: KLHL21 localizes to midzone microtubules in anaphase &
            recruits aurora B & Cul3 to this region; results suggest that
            different Cul3 adaptors nonredundantly regulate aurora B during
            mitosis, possibly by ubiquitinating different pools of aurora B
REFERENCE   7  (bases 1 to 4487)
  AUTHORS   Furukawa,M., He,Y.J., Borchers,C. and Xiong,Y.
  TITLE     Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin
            ligases
  JOURNAL   Nat Cell Biol 5 (11), 1001-1007 (2003)
   PUBMED   14528312
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB007938.1 and BC064980.1.
            
            On Nov 23, 2018 this sequence version replaced NM_014851.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC034039.1, AK075305.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377658.8/ ENSP00000366886.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                AB007938.1         133-167
            36-4487             BC064980.1         18-4469
FEATURES             Location/Qualifiers
     source          1..4487
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.31"
     gene            1..4487
                     /gene="KLHL21"
                     /note="kelch like family member 21"
                     /db_xref="GeneID:9903"
                     /db_xref="HGNC:HGNC:29041"
                     /db_xref="MIM:616262"
     exon            1..1073
                     /gene="KLHL21"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..1846
                     /gene="KLHL21"
                     /note="isoform 1 is encoded by transcript variant 1;
                     kelch-like protein 21"
                     /codon_start=1
                     /product="kelch-like protein 21 isoform 1"
                     /protein_id="NP_055666.2"
                     /db_xref="CCDS:CCDS30575.1"
                     /db_xref="GeneID:9903"
                     /db_xref="HGNC:HGNC:29041"
                     /db_xref="MIM:616262"
                     /translation="MERPAPLAVLPFSDPAHALSLLRGLSQLRAERKFLDVTLEAAGG
                     RDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSYTGRVAVS
                     GDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLANCLDMQDFAEAFSCSGLASAAQRF
                     ILRHVGELGAEQLERLPLARLLRYLRDDGLCVPKEEAAYQLALRWVRADPPRRAAHWP
                     QLLEAVRLPFVRRFYLLAHVEAEPLVARCPPCLRLLREARDFQAARYDRHDRGPCPRM
                     RPRPSTGLAEILVLVGGCDQDCDELVTVDCYNPQTGQWRYLAEFPDHLGGGYSIVALG
                     NDIYVTGGSDGSRLYDCVWRYNSSVNEWAEVAPMLKAREYHSSSVLDGLLYVVAADST
                     ERYDHTTDSWEALQPMTYPMDNCSTTACRGRLYAIGSLAGKETMVMQCYDPDTDLWSL
                     VDCGQLPPWSFAPKTATLNGLMYFVRDDSAEVDVYNPTRNEWDKIPSMNQVHVGGSLA
                     VLGGKLYVSGGYDNTFELSDVVEAYDPETRAWSVVGRLPEPTFWHGSVSIFRQFMPQT
                     FSGGRGFELDSGSDDMDPGRPRPPRDPDELH"
     exon            1074..1479
                     /gene="KLHL21"
                     /inference="alignment:Splign:2.1.0"
     exon            1480..1552
                     /gene="KLHL21"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..4487
                     /gene="KLHL21"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4467..4472
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLHL21"
                     /note="hexamer: AATAAA"
     polyA_site      4487
                     /gene="KLHL21"
                     /note="major polyA site"
ORIGIN      
        1 gtctctccgc aggccccggc cgcggcgtcc tcgacaacct atcgaaggcg ccatggagcg
       61 accggcgccc ctggccgtgc ttcccttctc ggaccccgcg cacgccctga gcctgctgcg
      121 cggcctgagc cagctgcgcg ccgagcgcaa gttcctggac gtgaccctgg aggcggcggg
      181 cgggcgcgac ttcccggcgc accgtgcggt gctggccgcc gccagcccct acttccgcgc
      241 catgttcgcg gggcagctgc gcgagagccg cgccgagcgg gtgcgcctgc acggagtgcc
      301 tcccgacatg ctgcagctgc tgctggactt cagctacacg ggccgcgtgg cggtaagcgg
      361 cgacaacgct gagccgctgc tgcgcgccgc cgacctgctg cagttcccgg ccgtgaagga
      421 ggcgtgcggg gccttcctgc agcagcagct cgacctggcc aactgcctgg acatgcagga
      481 cttcgctgag gccttcagct gctcgggact ggcgagcgcg gcgcagcggt tcattctgcg
      541 ccacgtgggc gagctgggcg ccgagcagct ggagcggctg ccactggcgc gcctgctgcg
      601 ctacctgcgg gacgacgggc tgtgtgtgcc caaggaggag gccgcctacc agctggcgct
      661 gcgctgggtc cgcgctgacc cgccgcgccg cgccgcgcac tggccgcagc tgctggaggc
      721 cgtgcgcctg cccttcgtgc gccgcttcta cctgttggcg cacgtcgagg ccgagccgct
      781 ggtggcgcgc tgcccaccct gcctgcgcct gctgcgcgag gcgcgcgact tccaggcggc
      841 gcgctacgac cgccacgacc gcgggccctg tccccgaatg cgtcctcgcc cgtccaccgg
      901 tctcgccgag atcctcgtgc tcgtgggcgg ctgcgaccag gactgtgacg agctggtcac
      961 tgtcgactgc tacaacccgc agacgggtca gtggcgctac ctggccgagt tcccagacca
     1021 cctgggcgga ggctacagca tcgtggcgct gggcaatgac atctacgtga cgggtgggtc
     1081 cgatggctcc cggctctatg actgcgtgtg gaggtacaac tcaagcgtga atgagtgggc
     1141 ggaggtggcg cccatgctga aggcccgcga gtaccacagc tcctctgtgc tggacggact
     1201 gctgtacgtg gtggccgccg acagcaccga gcgctatgac cacaccactg actcctggga
     1261 ggccctgcag cccatgacct accccatgga caactgctcc accactgcgt gccgtggccg
     1321 gctctatgcc atcggctccc tggctggcaa ggagaccatg gtgatgcagt gctacgaccc
     1381 ggacaccgac ctgtggtcgc tggtggactg cggccagctc ccgccctggt ccttcgcccc
     1441 caagactgcg actctaaacg gactcatgta ctttgtcagg gatgactccg ctgaggtgga
     1501 cgtgtacaac ccgacgagga acgaatggga caagatcccg tccatgaatc aggtacatgt
     1561 ggggggcagc ctggccgtcc ttggggggaa gctgtacgtc tctgggggat acgacaatac
     1621 atttgaactc tcggacgtgg tagaggccta tgacccagag actcgcgcgt ggagcgtggt
     1681 ggggcggctc ccagaaccca ccttctggca tggcagtgtc agcatcttcc gccagttcat
     1741 gccccagacc ttctcgggtg ggcgtggctt cgagttggac agtggcagcg atgacatgga
     1801 cccaggccga ccccggccgc cgcgggaccc cgatgagctg cactagcccc agtctggccc
     1861 ggcacgggcc tcggtgcagg taactggcac ctctgcgggg cagtgcccca ctcctttgtg
     1921 cacaaggaca cgttgggctc acaggaggag cacaggctct tgggtggcga agccagccca
     1981 ggatccatta cctggaaggt ttctgtacct tgagagcctg aatcagaggc cgtcgggaac
     2041 gccctccctg cagttgagga agagccactt tcctgccagc acatgtttct gggtcttgga
     2101 ggtcaccccc accccgcgga tcacagctca cccacgcggc gcacacccct cctgccgttg
     2161 tcatctgcac ctacttgttc ccaccttggg agaggacgat gacttgggag ggacgcgtga
     2221 agggagaagg ggtcctccca tgaggctgag gatggcctga acctggagca gcggaccagg
     2281 cagacgggct gaagtggggt cccaaattcc atgtccagag gtgtggggag cctgcctccc
     2341 tagctcctgg cccctgccag gggcttacat caaaacacct cagagggctg ccctccagag
     2401 gctgcaccca gaacagtggg acatgagcag gggtgtgggc ttggagggtg aagaggatgt
     2461 ggtcctatca gatgctgggc ctcctcagcc atagccccct gctcctaccc cctgactggc
     2521 tcttgcgtcc tcacctctca ccctctcctt cccgggaggc cctgggaggt gatcattgac
     2581 acccagccaa gcagacagct gcgggtgccc aagcccttgc tgggcctgcg cgtgaggagt
     2641 cccactgctt ctaaaggaag tcctgggcag gaggtggctt tggtggttgg ttccaaagtt
     2701 gaaaatgctt gcagtttgac cttagaagaa gtgggaagaa gaaggagctc tacagggtca
     2761 gctttgtttg atttgtccag tctaagaagt cccattgcca aagctttctg caggagggtg
     2821 aatgccgcag cttggcagcc cctgggtttc tcttggaaat ggtcagtttc ccctcaaagt
     2881 acccaaagta gccttggctt gagtttttgt ccttgcctcc tttttagaga agagggcatt
     2941 tagactgcat tttcctggtt aaagaaggtt aaagcaaatg tttattgcct tttctagtga
     3001 actaactcgt agagatgttc tcagcaggaa gacagtctta gcactgtcac ttagcagatt
     3061 gcacttaagt cccttgtgct ggccagatgg cgtggctggt tgccttaata tgtcccagga
     3121 cccctgacag ggctgcctgg cctctccctc gtgctcctca agagcccagt ccatacactg
     3181 tggatgtcat tgctgtcggg ttaggaagtc ttgtcctaga acgccctggc tggtatgacc
     3241 acagttcatg gcggctcttc tcgcttgggt catggtcatc ttccagcacc tgctgtgctg
     3301 ggaaggccga ggatgggggc ccagcactgt ccaggcctgc tggggcctgg ctgggagtcc
     3361 tgtgggcagc atggaacatg cagctgggct tcctgtgacc aggcaccctc tggcactgtt
     3421 gcttgccctg tgccctggac cttttcctgc ccttctcctt cctctgctcc cttggggcta
     3481 ccccttggcc cctcctggtc tgtgcaaact ccctcaggga gcccccctgc cctgtagctc
     3541 tcgcttaact tcctaggggc tgctgagccc acccagaggt tgttggagtt cagcggggca
     3601 gcttgtctcc cttgtcagca ggggcgtaag ggctgggttt ggccatacaa ggttggctac
     3661 gccctcaatc cctgaccgtt ccaggcactg agctgggcac ccacggaagg acatgctgtc
     3721 cagactgtga tgactgccag cacagggcat ctcgggcttg gctggtctgc gaggccttgc
     3781 ccctgtggaa ctctgggttc ctgttttctc agtctttttt gcggctttgc tgtggttggc
     3841 agctgccgta ctccaggctt gtgtcggcca ctcagatgag ggctgtggtg cgagccagtg
     3901 caggagagct gcgcttggga ttgtgccctc tcctgtgtct gtcctccgga cctacccagg
     3961 tctccaccat caggaccctg tctttgggtt tagaagacca agtatgggga aaaccaggca
     4021 ccagcctctg cagcaatggg tccctctagc ctgtggacac cagctggggg atccagggtc
     4081 aggccccctc ctctccccag tttccctctg ctgtgggttc tgggctgtca tgtctccacc
     4141 acttaaggat gtctttacac tgacttcagg atagatgctg ggatgcctgg gcatggccac
     4201 atgttacatg tacagaactt tgtctacagc acaaattaag ttatataaac acagtgactg
     4261 gtatttaatg ctgatctact ataaggtatt ctatatttat atgacttcag agacgcgtat
     4321 gtaataaagg acgccctccc tccagtgtcc acatccagtt caccccagag ggtcgggcag
     4381 gttgacatat ttatttttgt ctattctgta ggcttccatg tccagaatcc tgcttaaggt
     4441 tttagggtac cttcagtact ttttgcaata aaagtatttc ctatcca
//
