LOCUS       NP_009177                593 aa            linear   PRI 19-SEP-2024
DEFINITION  kelch-like protein 2 isoform 1 [Homo sapiens].
ACCESSION   NP_009177
VERSION     NP_009177.3
DBSOURCE    REFSEQ: accession NM_007246.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 593)
  AUTHORS   Swaney,D.L., Ramms,D.J., Wang,Z., Park,J., Goto,Y., Soucheray,M.,
            Bhola,N., Kim,K., Zheng,F., Zeng,Y., McGregor,M., Herrington,K.A.,
            O'Keefe,R., Jin,N., VanLandingham,N.K., Foussard,H., Von Dollen,J.,
            Bouhaddou,M., Jimenez-Morales,D., Obernier,K., Kreisberg,J.F.,
            Kim,M., Johnson,D.E., Jura,N., Grandis,J.R., Gutkind,J.S.,
            Ideker,T. and Krogan,N.J.
  TITLE     A protein network map of head and neck cancer reveals PIK3CA mutant
            drug sensitivity
  JOURNAL   Science 374 (6563), eabf2911 (2021)
   PUBMED   34591642
REFERENCE   2  (residues 1 to 593)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (residues 1 to 593)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (residues 1 to 593)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 593)
  AUTHORS   Mena,E.L., Kjolby,R.A.S., Saxton,R.A., Werner,A., Lew,B.G.,
            Boyle,J.M., Harland,R. and Rape,M.
  TITLE     Dimerization quality control ensures neuronal development and
            survival
  JOURNAL   Science 362 (6411) (2018)
   PUBMED   30190310
REFERENCE   6  (residues 1 to 593)
  AUTHORS   Yu,H., Tardivo,L., Tam,S., Weiner,E., Gebreab,F., Fan,C.,
            Svrzikapa,N., Hirozane-Kishikawa,T., Rietman,E., Yang,X.,
            Sahalie,J., Salehi-Ashtiani,K., Hao,T., Cusick,M.E., Hill,D.E.,
            Roth,F.P., Braun,P. and Vidal,M.
  TITLE     Next-generation sequencing to generate interactome datasets
  JOURNAL   Nat Methods 8 (6), 478-480 (2011)
   PUBMED   21516116
REFERENCE   7  (residues 1 to 593)
  AUTHORS   Bennett,E.J., Rush,J., Gygi,S.P. and Harper,J.W.
  TITLE     Dynamics of cullin-RING ubiquitin ligase network revealed by
            systematic quantitative proteomics
  JOURNAL   Cell 143 (6), 951-965 (2010)
   PUBMED   21145461
REFERENCE   8  (residues 1 to 593)
  AUTHORS   Williams,S.K., Spence,H.J., Rodgers,R.R., Ozanne,B.W.,
            Fitzgerald,U. and Barnett,S.C.
  TITLE     Role of Mayven, a kelch-related protein in oligodendrocyte process
            formation
  JOURNAL   J Neurosci Res 81 (5), 622-631 (2005)
   PUBMED   16035103
REFERENCE   9  (residues 1 to 593)
  AUTHORS   Bu,X., Avraham,H.K., Li,X., Lim,B., Jiang,S., Fu,Y., Pestell,R.G.
            and Avraham,S.
  TITLE     Mayven induces c-Jun expression and cyclin D1 activation in breast
            cancer cells
  JOURNAL   Oncogene 24 (14), 2398-2409 (2005)
   PUBMED   15735724
  REMARK    GeneRIF: overexpression of Mayven may promote tumor growth through
            c-Jun and cyclin D1
REFERENCE   10 (residues 1 to 593)
  AUTHORS   Soltysik-Espanola,M., Rogers,R.A., Jiang,S., Kim,T.A., Gaedigk,R.,
            White,R.A., Avraham,H. and Avraham,S.
  TITLE     Characterization of Mayven, a novel actin-binding protein
            predominantly expressed in brain
  JOURNAL   Mol Biol Cell 10 (7), 2361-2375 (1999)
   PUBMED   10397770
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC055120.5, AL541403.3, BC036468.2, BC022503.1 and AI814691.1.
            
            On Jun 12, 2009 this sequence version replaced NP_009177.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC022503.1, SRR1660809.13095.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000226725.11/ ENSP00000226725.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..593
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q32.3"
     Protein         1..593
                     /product="kelch-like protein 2 isoform 1"
                     /note="kelch-like protein 2; actin-binding protein Mayven;
                     kelch-like 2, Mayven"
                     /calculated_mol_wt=65844
     Region          1..28
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O95198.2)"
     Region          35..155
                     /region_name="BTB_POZ_KLHL2_Mayven"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in Kelch-like
                     protein 2 (KLHL2); cd18338"
                     /db_xref="CDD:349647"
     Region          56..573
                     /region_name="PHA03098"
                     /note="kelch-like protein; Provisional"
                     /db_xref="CDD:222983"
     Site            order(79..80,83..84,88..89,91,98..101,131,134..135,137,
                     142)
                     /site_type="other"
                     /note="cullin binding site [polypeptide binding]"
                     /db_xref="CDD:349647"
     Region          153..282
                     /region_name="BACK_KLHL2_Mayven"
                     /note="BACK (BTB and C-terminal Kelch) domain found in
                     Kelch-like protein 2 (KLHL2); cd18512"
                     /db_xref="CDD:350587"
     Site            order(166..169,171)
                     /site_type="other"
                     /note="putative cullin binding site [polypeptide binding]"
                     /db_xref="CDD:350587"
     Region          308..353
                     /region_name="Kelch 1"
                     /note="propagated from UniProtKB/Swiss-Prot (O95198.2)"
     Region          343..386
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          354..400
                     /region_name="Kelch 2"
                     /note="propagated from UniProtKB/Swiss-Prot (O95198.2)"
     Region          390..434
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          402..447
                     /region_name="Kelch 3"
                     /note="propagated from UniProtKB/Swiss-Prot (O95198.2)"
     Region          449..496
                     /region_name="Kelch 4"
                     /note="propagated from UniProtKB/Swiss-Prot (O95198.2)"
     Region          486..530
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          497..543
                     /region_name="Kelch 5"
                     /note="propagated from UniProtKB/Swiss-Prot (O95198.2)"
     Region          533..579
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          545..591
                     /region_name="Kelch 6"
                     /note="propagated from UniProtKB/Swiss-Prot (O95198.2)"
     CDS             1..593
                     /gene="KLHL2"
                     /gene_synonym="ABP-KELCH; MAV; MAYVEN"
                     /coded_by="NM_007246.4:317..2098"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS34094.1"
                     /db_xref="GeneID:11275"
                     /db_xref="HGNC:HGNC:6353"
                     /db_xref="MIM:605774"
ORIGIN      
        1 metpplppac tkqghqkpld skddntekhc pvtvnpwhmk kafkvmnelr sqnllcdvti
       61 vaedmeisah rvvlaacspy fhamftgems esrakrvrik evdgwtlrml idyvytaeiq
      121 vteenvqvll paagllqlqd vkktccefle sqlhpvnclg irafadmhac tdllnkanty
      181 aeqhfadvvl seeflnlgie qvcslissdk ltisseekvf eaviawvnhd kdvrqefmar
      241 lmehvrlpll preylvqrve eealvknssa ckdylieamk yhllpteqri lmksvrtrlr
      301 tpmnlpklmv vvggqapkai rsvecydfke erwhqvaelp srrcragmvy maglvfavgg
      361 fngslrvrtv dsydpvkdqw tsvanmrdrr stlgaavlng llyavggfdg stglssveay
      421 niksnewfhv apmntrrssv gvgvvgglly avggydgasr qclstvecyn attnewtyia
      481 emstrrsgag vgvlnnllya vgghdgplvr ksvevydptt nawrqvadmn mcrrnagvca
      541 vngllyvvgg ddgscnlasv eyynpttdkw tvvsscmstg rsyagvtvid kpl
//
