LOCUS       NM_025010               4622 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens kelch like family member 18 (KLHL18), mRNA.
ACCESSION   NM_025010
VERSION     NM_025010.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4622)
  AUTHORS   Lim,S.H., Snider,J., Birimberg-Schwartz,L., Ip,W., Serralha,J.C.,
            Botelho,H.M., Lopes-Pacheco,M., Pinto,M.C., Moutaoufik,M.T.,
            Zilocchi,M., Laselva,O., Esmaeili,M., Kotlyar,M., Lyakisheva,A.,
            Tang,P., Lopez Vazquez,L., Akula,I., Aboualizadeh,F., Wong,V.,
            Grozavu,I., Opacak-Bernardi,T., Yao,Z., Mendoza,M., Babu,M.,
            Jurisica,I., Gonska,T., Bear,C.E., Amaral,M.D. and Stagljar,I.
  TITLE     CFTR interactome mapping using the mammalian membrane two-hybrid
            high-throughput screening system
  JOURNAL   Mol Syst Biol 18 (2), e10629 (2022)
   PUBMED   35156780
REFERENCE   2  (bases 1 to 4622)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 4622)
  AUTHORS   Chaya,T., Tsutsumi,R., Varner,L.R., Maeda,Y., Yoshida,S. and
            Furukawa,T.
  TITLE     Cul3-Klhl18 ubiquitin ligase modulates rod transducin translocation
            during light-dark adaptation
  JOURNAL   EMBO J 38 (23), e101409 (2019)
   PUBMED   31696965
REFERENCE   4  (bases 1 to 4622)
  AUTHORS   Dhanoa,B.S., Cogliati,T., Satish,A.G., Bruford,E.A. and
            Friedman,J.S.
  TITLE     Update on the Kelch-like (KLHL) gene family
  JOURNAL   Hum Genomics 7 (1), 13 (2013)
   PUBMED   23676014
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4622)
  AUTHORS   Moghe,S., Jiang,F., Miura,Y., Cerny,R.L., Tsai,M.Y. and Furukawa,M.
  TITLE     The CUL3-KLHL18 ligase regulates mitotic entry and ubiquitylates
            Aurora-A
  JOURNAL   Biol Open 1 (2), 82-91 (2012)
   PUBMED   23213400
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC104447.2.
            
            On Nov 23, 2018 this sequence version replaced NM_025010.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX537953.1, SRR1660803.218762.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000232766.6/ ENSP00000232766.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-151               AC104447.2         129999-130149
            152-282             AC104447.2         166708-166838
            283-423             AC104447.2         169623-169763
            424-622             AC104447.2         177006-177204
            623-783             AC104447.2         180212-180372
            784-920             AC104447.2         181738-181874
            921-1143            AC104447.2         183590-183812
            1144-1248           AC104447.2         187627-187731
            1249-1360           AC104447.2         189774-189885
            1361-4622           AC104447.2         190610-193871
FEATURES             Location/Qualifiers
     source          1..4622
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..4622
                     /gene="KLHL18"
                     /note="kelch like family member 18"
                     /db_xref="GeneID:23276"
                     /db_xref="HGNC:HGNC:29120"
                     /db_xref="MIM:619926"
     exon            1..151
                     /gene="KLHL18"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..1747
                     /gene="KLHL18"
                     /codon_start=1
                     /product="kelch-like protein 18"
                     /protein_id="NP_079286.2"
                     /db_xref="CCDS:CCDS33749.1"
                     /db_xref="GeneID:23276"
                     /db_xref="HGNC:HGNC:29120"
                     /db_xref="MIM:619926"
                     /translation="MVEDGAEELEDLVHFSVSELPSRGYGVMEEIRRQGKLCDVTLKI
                     GDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGNLA
                     IDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLGVRQFAETMMCAVLYDAAN
                     SFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDREQRGP
                     YLPELLSNIRLPLCRPQFLSDRVQQDDLVRCCHKCRDLVDEAKDYHLMPERRPHLPAF
                     RTRPRCCTSIAGLIYAVGGLNSAGDSLNVVEVFDPIANCWERCRPMTTARSRVGVAVV
                     NGLLYAIGGYDGQLRLSTVEAYNPETDTWTRVGSMNSKRSAMGTVVLDGQIYVCGGYD
                     GNSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIYVSGGHDGLQIFSSVEHY
                     NHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDGSGFLSIAEMYSSVADQWCLIV
                     PMHTRRSRVSLVASCGRLYAVGGYDGQSNLSSVEMYDPETDCWTFMAPMACHEGGVGV
                     GCIPLLTI"
     exon            152..282
                     /gene="KLHL18"
                     /inference="alignment:Splign:2.1.0"
     exon            283..423
                     /gene="KLHL18"
                     /inference="alignment:Splign:2.1.0"
     exon            424..622
                     /gene="KLHL18"
                     /inference="alignment:Splign:2.1.0"
     exon            623..783
                     /gene="KLHL18"
                     /inference="alignment:Splign:2.1.0"
     exon            784..920
                     /gene="KLHL18"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1143
                     /gene="KLHL18"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1248
                     /gene="KLHL18"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1360
                     /gene="KLHL18"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..4622
                     /gene="KLHL18"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4601..4606
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLHL18"
                     /note="hexamer: AATAAA"
     polyA_site      4622
                     /gene="KLHL18"
                     /note="major polyA site"
ORIGIN      
        1 gcagttgcag cggccgggga agatggtgga ggacggcgcg gaggagctgg aggatctggt
       61 gcacttctcc gtgtctgagt tgcctagtcg cggctacggc gtcatggagg agatccggcg
      121 gcagggcaag ctgtgcgacg tgaccctcaa gattggggac cacaaattca gtgcccaccg
      181 gattgtctta gcagcctcga tcccgtattt ccatgctatg tttacaaatg acatgatgga
      241 gtgcaagcag gatgagattg taatgcaagg aatggaccca agtgccctgg aggctctgat
      301 caactttgcc tacaacggca accttgccat tgaccagcaa aatgtccagt cattgctgat
      361 gggggcgagc ttcctgcagc tgcagagcat caaagacgcc tgctgcacat tccttcgaga
      421 acggcttcac ccaaaaaact gcctgggtgt gcgccagttt gctgagacaa tgatgtgtgc
      481 tgtgctgtac gacgctgcca acagcttcat ccaccagcac tttgtggagg tgtccatgtc
      541 agaagagttc ctggccctgc ccttggaaga cgtgcttgag ctggtgtctc gggatgagct
      601 gaatgtcaaa tctgaggagc aggtctttga agctgcattg gcctgggtca gatacgaccg
      661 ggagcagagg ggtccctacc tgcctgagct gctgtccaat atccgcctgc ccctctgtcg
      721 gccccagttc ctttcagaca gagtacagca ggatgacctg gtgcgttgct gccacaaatg
      781 cagggacctg gtagacgaag caaaggacta ccacctcatg ccagagcgcc ggccccacct
      841 gccagctttc agaacccggc cacgctgctg cacatccatc gctggactta tctacgctgt
      901 agggggcctc aactcagcag gtgattccct gaatgtggtg gaagtgttcg accccattgc
      961 caattgctgg gagagatgcc gtcccatgac aacagcccgc agccgcgttg gcgtggctgt
     1021 ggtgaacggg cttctctatg ccatcggagg atatgacggc cagctacggc tgagcactgt
     1081 ggaggcctac aacccggaga cagacacatg gaccagagtg gggagcatga atagcaagag
     1141 aagtgccatg gggacagtcg tgctggatgg gcagatctac gtctgtgggg gctacgatgg
     1201 caactcttcc ctcagctccg tggagaccta ctcacctgag acggacaaat ggacagtggt
     1261 gacctcgatg agctcgaatc gcagtgctgc tggggttaca gtctttgagg gcaggatata
     1321 tgtgtcaggc ggccatgatg gtttgcagat cttcagcagt gtggaacact acaaccacca
     1381 cacagccacc tggcaccctg cagctggcat gctcaacaag cgctgccggc acggagccgc
     1441 ctccctgggg agcaagatgt ttgtctgcgg gggctacgat ggctctggct tcctcagcat
     1501 tgccgagatg tacagctctg tggcagacca gtggtgcctg attgtcccca tgcacacgcg
     1561 caggagccgg gtctccctgg tggccagctg tgggcgcctc tacgctgttg ggggctacga
     1621 cggacagtca aacctaagct cagtggagat gtatgaccca gagacagact gctggacatt
     1681 catggccccc atggcgtgcc atgagggagg ggtcggtgtg ggctgcatcc ctctcctcac
     1741 catctaaggc agaggatggg atgtggtggg gcagggatct ggtacagaca taggcgcttc
     1801 cttccaggaa cagtccctca ggagaggcag tggaccagaa gagatggcga aacgtgagct
     1861 cgccggaggt acagtttttc caggtgctta agccctcccc cactgtgcca cccttgtgac
     1921 cttcaggctt gggtcatcaa gatgcacagc atggaacaca agctcctctg gatcctgcag
     1981 ctggtgacat ggaactgttt tctggtccac atgaacacag gctccatcca ggcccagctc
     2041 ctacccaccg cctctctgtg ggccagctgt tcacagaagg ccttccatct gatgctcccc
     2101 atcgcctgct tgctctccag ccgagtctgg ccaatttgcc atggggaggc tgcagtgtcc
     2161 aagcctgctg gaaactggga tgtagctggg gacgaaagga cagacccaag cgttctccct
     2221 gcctgagatg gtgtggccac agcagtggaa ggctgcacac aggcacattc cttcttccac
     2281 agtggggcac caaggattct gtcctcattg ctgggtaagc agggagaaga gaagttttcc
     2341 ccatgtctaa ttttgggatt tcagtgaggc cttttgatct gtccaggaga acagaaggga
     2401 aaaaaagata cttgaaagaa actgaaggaa atttaaacaa agaaacactt gaaagaaact
     2461 ggaaagaaaa ataatttttt tatgtgaaca aattttgcaa gaagaaaaaa gcataaaaga
     2521 cactaacggc aaatctatgt ttaaatggaa aatcgtctaa ctggagaagg gcggtatcca
     2581 ccccacattc ggatcccagg gtcctgaggc ctcgcattga gctgggggtt ccctctgagc
     2641 cccagtgtgt gtggaatcag tgcactcttg actgggcctg tagtaaggtg ctcatggggt
     2701 ttgtcttctc acccaccatc agaggacttt taaaatcata ggcgtagaga gttaggctat
     2761 ctgctgaatt actgccactc ttcttggtgg gggctcctag ctgtggctgg gggctccagg
     2821 cgcccctgtg attacctcct actgccacca tggcgctcat tcagattccc cactctcact
     2881 aacattgctt ccttttttga ccagcaggaa acagcaggtc tggccagatt ctcacttgcc
     2941 catcaatctc gttcttggat gatttccctc attgtgatgc ttctggggca cgttgaccat
     3001 atgcacctct agaacctaac cagggcttcc ttctaccagc tgtgggcggg cttggtctgg
     3061 taaccttgtc tgctctgcca ttccactgct cctccatcca ctcgccaatc ccaagagtct
     3121 ggcctccctc cagccctggg cagactgacc agcaaggtgg acctttacat tcaagcacag
     3181 ctggctttta tgacataaag aactaaaggc cgaaagaatc tcttgctgct gcaaagaaca
     3241 gattttatat ttcttcctct aatcttggca aatgaccttt accttttgga aagatttcat
     3301 attgcttcct cctccctgga taggacctaa tgtagcacag cgggactcaa agaggaggac
     3361 attttctctt gccagtgcac tgggcagtgg ggctgtcctt caactgctgc tgccaaaatt
     3421 ggttttctaa aattcttcca gtagagacta aaagaagatt caattcctgt aacccaagac
     3481 tgagtcttag ggctccagtc tccacctgct tggtttccta tcctttgctg cctgcctggg
     3541 gtggcctgga agcctgttca gaaaggcaca atgtggagcc tggggtgtct cccccacccc
     3601 aggaccgtca ggtttaccag tgtgtgcaat cgccatgtat tcagagggaa gtacctttgt
     3661 tacctacaac ttaggagcta ggcctctgct acaagcactt gaaaatgata tttttatttt
     3721 taacgtctca acaatctgat atcggatgtc gtttaacctg ggctcgtggt agggctccag
     3781 catttctccc tccttcctgg tttgcctgta ggggtagact cggaaggtgg gtggggtgtg
     3841 catttcctgt taggagtgta tcagtgcttg tcttattata agcccctttc ttttgtgaat
     3901 ttgaagtagc accaacaagc ctggattgtg aaggtattaa gaatcggtct gtgggctact
     3961 gagtgggtcc ttaggatact ggcccagatt ttgccactgg gtatggcaga tcattttcta
     4021 ccatggcctg ctgctcttgt agtggacttc ctgagtccaa tcccacctcc tggtgtagaa
     4081 tttacactgc tgcacctgag gtcgatgttt caaagtaaga tcaagccagt gttttgatct
     4141 gggctctgag cacaagtcag gaaacaccaa catattcaca ctctcccagt aggttcctca
     4201 gtccgatggt gaatggctat tcgtaaatgg ctggtctggc tctttggtgt tggagccttt
     4261 ccaatagccc catgaaaaga agcatcaccc aaggatattg taaaaaggat gtaacaagga
     4321 gatagggtag acattgtact cagtgggcct tggggcctag cccagctctg agcagaggac
     4381 tgtggcattc actgtccttg agtgtttcac cttcttggat aacacacggg ccttctcttc
     4441 tggatttcat cagagattac agccagatgg gggctgaaga ccatcctctt gaccacagag
     4501 gtgtgactgt gggaattcct cccaatttat ggtttcccag aaaatcttag ttccttttat
     4561 ttatagaatg catgtctttt gtgttaagaa accaaagaga aataaagaga acactcctaa
     4621 ta
//
