LOCUS       NM_030624               6272 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens kelch like family member 15 (KLHL15), mRNA.
ACCESSION   NM_030624 XM_040383
VERSION     NM_030624.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6272)
  AUTHORS   Zhang,C., Zhou,B., Gu,F., Liu,H., Wu,H., Yao,F., Zheng,H., Fu,H.,
            Chong,W., Cai,S., Huang,M., Ma,X., Guo,Z., Li,T., Deng,W.,
            Zheng,M., Ji,Q., Zhao,Y., Ma,Y., Wang,Q.E., Tang,T.S. and Guo,C.
  TITLE     Micropeptide PACMP inhibition elicits synthetic lethal effects by
            decreasing CtIP and poly(ADP-ribosyl)ation
  JOURNAL   Mol Cell 82 (7), 1297-1312 (2022)
   PUBMED   35219381
REFERENCE   2  (bases 1 to 6272)
  AUTHORS   Wang,C., Tang,M., Chen,Z., Nie,L., Li,S., Xiong,Y.,
            Szymonowicz,K.A., Park,J.M., Zhang,H., Feng,X., Huang,M., Su,D.,
            Hart,T. and Chen,J.
  TITLE     Genetic vulnerabilities upon inhibition of DNA damage response
  JOURNAL   Nucleic Acids Res 49 (14), 8214-8231 (2021)
   PUBMED   34320214
  REMARK    GeneRIF: Genetic vulnerabilities upon inhibition of DNA damage
            response.
REFERENCE   3  (bases 1 to 6272)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 6272)
  AUTHORS   Song,J., Merrill,R.A., Usachev,A.Y. and Strack,S.
  TITLE     The X-linked intellectual disability gene product and E3 ubiquitin
            ligase KLHL15 degrades doublecortin proteins to constrain neuronal
            dendritogenesis
  JOURNAL   J Biol Chem 296, 100082 (2021)
   PUBMED   33199366
REFERENCE   5  (bases 1 to 6272)
  AUTHORS   Ferretti,L.P., Himmels,S.F., Trenner,A., Walker,C., von Aesch,C.,
            Eggenschwiler,A., Murina,O., Enchev,R.I., Peter,M., Freire,R.,
            Porro,A. and Sartori,A.A.
  TITLE     Cullin3-KLHL15 ubiquitin ligase mediates CtIP protein turnover to
            fine-tune DNA-end resection
  JOURNAL   Nat Commun 7, 12628 (2016)
   PUBMED   27561354
  REMARK    GeneRIF: Study identifies the KLHL15 as a new interaction partner
            of CtIP and show that KLHL15 promotes CtIP protein turnover via the
            ubiquitin-proteasome pathway.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6272)
  AUTHORS   Taipale,M., Tucker,G., Peng,J., Krykbaeva,I., Lin,Z.Y., Larsen,B.,
            Choi,H., Berger,B., Gingras,A.C. and Lindquist,S.
  TITLE     A quantitative chaperone interaction network reveals the
            architecture of cellular protein homeostasis pathways
  JOURNAL   Cell 158 (2), 434-448 (2014)
   PUBMED   25036637
REFERENCE   7  (bases 1 to 6272)
  AUTHORS   Dhanoa,B.S., Cogliati,T., Satish,A.G., Bruford,E.A. and
            Friedman,J.S.
  TITLE     Update on the Kelch-like (KLHL) gene family
  JOURNAL   Hum Genomics 7 (1), 13 (2013)
   PUBMED   23676014
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 6272)
  AUTHORS   Oberg,E.A., Nifoussi,S.K., Gingras,A.C. and Strack,S.
  TITLE     Selective proteasomal degradation of the B'beta subunit of protein
            phosphatase 2A by the E3 ubiquitin ligase adaptor Kelch-like 15
  JOURNAL   J Biol Chem 287 (52), 43378-43389 (2012)
   PUBMED   23135275
  REMARK    GeneRIF: KLHL15 can interact with the PP2A/B'beta heterotrimer, it
            only degrades B'beta, thus promoting exchange with other regulatory
            subunits.
REFERENCE   9  (bases 1 to 6272)
  AUTHORS   Yoshida,K.
  TITLE     Identification and characterization of a novel kelch-like gene
            KLHL15 in silico
  JOURNAL   Oncol Rep 13 (6), 1133-1137 (2005)
   PUBMED   15870933
REFERENCE   10 (bases 1 to 6272)
  AUTHORS   Furukawa,M., He,Y.J., Borchers,C. and Xiong,Y.
  TITLE     Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin
            ligases
  JOURNAL   Nat Cell Biol 5 (11), 1001-1007 (2003)
   PUBMED   14528312
  REMARK    GeneRIF: KLHL15 (KIAA1677) binds Cul3
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK057298.1, BC109059.2 and
            AL834313.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 31, 2019 this sequence version replaced NM_030624.2.
            
            Summary: This gene encodes a member of the kelch-like family of
            proteins that share a common domain structure consisting of an
            N-terminal broad-complex, tramtrack, bric-a-brac/poxvirus and zinc
            finger domain and C-terminal kelch repeat motifs. The encoded
            protein may be involved in protein ubiquitination and cytoskeletal
            organization. [provided by RefSeq, Apr 2009].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK057298.1, SRR14372080.731025.1
                                           [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000328046.8/ ENSP00000332791.8
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1144              AK057298.1         1-1144
            1145-2071           BC109059.2         889-1815
            2072-6272           AL834313.1         557-4757
FEATURES             Location/Qualifiers
     source          1..6272
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp22.11"
     gene            1..6272
                     /gene="KLHL15"
                     /gene_synonym="HEL-S-305; XLID103"
                     /note="kelch like family member 15"
                     /db_xref="GeneID:80311"
                     /db_xref="HGNC:HGNC:29347"
                     /db_xref="MIM:300980"
     exon            1..47
                     /gene="KLHL15"
                     /gene_synonym="HEL-S-305; XLID103"
                     /inference="alignment:Splign:2.1.0"
     exon            48..249
                     /gene="KLHL15"
                     /gene_synonym="HEL-S-305; XLID103"
                     /inference="alignment:Splign:2.1.0"
     exon            250..961
                     /gene="KLHL15"
                     /gene_synonym="HEL-S-305; XLID103"
                     /inference="alignment:Splign:2.1.0"
     CDS             257..2071
                     /gene="KLHL15"
                     /gene_synonym="HEL-S-305; XLID103"
                     /note="kelch-like 15; epididymis secretory protein Li 305;
                     epididymis secretory sperm binding protein"
                     /codon_start=1
                     /product="kelch-like protein 15"
                     /protein_id="NP_085127.2"
                     /db_xref="CCDS:CCDS35217.1"
                     /db_xref="GeneID:80311"
                     /db_xref="HGNC:HGNC:29347"
                     /db_xref="MIM:300980"
                     /translation="MAGDVEGFCSSIHDTSVSAGFRALYEEGLLLDVTLVIEDHQFQA
                     HKALLATQSDYFRIMFTADMRERDQDKIHLKGLTATGFSHVLQFMYYGTIELSMNTVH
                     EILQAAMYVQLIEVVKFCCSFLLAKICLENCAEIMRLLDDFGVNIEGVREKLDTFLLD
                     NFVPLMSRPDFLSYLSFEKLMSYLDNDHLSRFPEIELYEAVQSWLRHDRRRWRHTDTI
                     IQNIRFCLMTPTSVFEKVKTSEFYRYSRQLRYEVDQALNYFQNVHQQPLLDMKSSRIR
                     SAKPQTTVFRGMIGHSMVNSKILLLKKPRVWWELEGPQVPLRPDCLAIVNNFVFLLGG
                     EELGPDGEFHASSKVFRYDPRQNSWLQMADMSVPRSEFAVGVIGKFIYAVAGRTRDET
                     FYSTERYDITNDKWEFVDPYPVNKYGHEGTVLNNKLFITGGITSSSTSKQVCVFDPSK
                     EGTIEQRTRRTQVVTNCWENKSKMNYARCFHKMISYNGKLYVFGGVCVILRASFESQG
                     CPSTEVYNPETDQWTILASMPIGRSGHGVTVLDKQIMVLGGLCYNGHYSDSILTFDPD
                     ENKWKEDEYPRMPCKLDGLQVCNLHFPDYVLDEVRRCN"
     exon            962..6272
                     /gene="KLHL15"
                     /gene_synonym="HEL-S-305; XLID103"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6248..6253
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLHL15"
                     /gene_synonym="HEL-S-305; XLID103"
                     /note="hexamer: AATAAA"
     polyA_site      6272
                     /gene="KLHL15"
                     /gene_synonym="HEL-S-305; XLID103"
                     /note="major polyA site"
ORIGIN      
        1 gtttcaactc ttgcttgaat caagaacaga agcctctctt tagacaggac ttatccagag
       61 ggggctgcag gcgagcactc tcgtgccccg ccggagcgac ccggctcgtg ccgggagcgg
      121 ctgctcgtag acgtccgagg agcctgccga gtgccgtccc ggcgcccgac cgcccaccca
      181 tcggcccgct ggcccggttc ttcctgatgc agactgccgt ccactagagg ctggacagga
      241 ccccccgagg tgattcatgg caggggacgt ggaaggattc tgttcctcca tccacgacac
      301 cagtgtctct gctgggttca gagcactgta tgaggaggga ttgcttcttg atgtcactct
      361 ggttattgaa gatcatcagt tccaggccca taaagcactc ttggccaccc agagtgatta
      421 cttcagaatt atgtttactg cagacatgag ggaacgagat caggacaaaa ttcatttaaa
      481 aggtctaaca gctaccggtt tcagccatgt cctgcaattt atgtactatg gaactataga
      541 gctgagtatg aataccgttc atgagattct tcaggctgcc atgtatgttc aacttataga
      601 agtggtgaag ttctgctgct cttttctctt agcgaagatc tgcctagaaa attgtgcaga
      661 aattatgaga ctcttagatg atttcggcgt aaacatcgag ggagtcaggg agaagttaga
      721 cacctttctg ctagacaact ttgtgccact catgtctagg cctgactttc tgtcctatct
      781 gagctttgag aagctcatgt cttacttgga taatgatcat ctgagcaggt tcccagagat
      841 agagctgtac gaggctgtgc agtcttggct gcggcatgat agaagacgct ggagacatac
      901 cgataccatc attcagaata tccggttttg cttgatgacc ccaaccagcg tttttgagaa
      961 ggttaagaca tcagaatttt atagatactc ccgacagctc cgttacgaag ttgaccaagc
     1021 attgaattac tttcagaatg ttcaccagca gcctttgttg gatatgaagt caagccgcat
     1081 ccgttctgca aaaccgcaaa ctacagtatt tcgaggaatg attggacata gcatggttaa
     1141 cagtaaaata cttctcttaa agaaaccaag agtctggtgg gagctagaag gcccacaagt
     1201 acctctgcga cctgactgcc ttgctatcgt caataatttt gtgttcctgt taggcgggga
     1261 agagctgggc ccggatggtg aattccatgc ttcttccaaa gtattcaggt atgacccgag
     1321 acagaactcc tggctgcaga tggcagatat gtctgtacca cgctctgaat ttgctgtagg
     1381 tgttattggg aagtttattt acgccgtagc aggcagaacc agagatgaga ctttctattc
     1441 aactgagaga tatgacatca ccaacgataa atgggaattt gtggatcctt atccagttaa
     1501 caaatatgga catgagggga cagtgctcaa taacaaattg tttatcaccg gtggaatcac
     1561 ctcatcttcc acctccaagc aagtgtgcgt gtttgacccc agcaaagaag ggaccataga
     1621 acaacggacc aggagaactc aagtggttac caactgttgg gagaataaga gcaagatgaa
     1681 ttacgcgaga tgctttcaca agatgatttc ttacaatggc aagctttatg tcttcggtgg
     1741 tgtctgtgtg atcttgaggg cctctttcga atctcaggga tgcccttcta cagaagtata
     1801 caacccagag actgatcagt ggaccatctt ggcatccatg ccgattggta gaagtggcca
     1861 tggtgtgact gtgctggaca aacaaataat ggttcttgga ggcctttgtt ataatggtca
     1921 ttacagcgat tccatcctca cttttgatcc ggatgaaaac aagtggaagg aagatgagta
     1981 ccctcggatg ccctgcaagc tggatggttt acaagtatgc aacctgcatt ttccggacta
     2041 tgtactggat gaggtcaggc gttgcaacta atgacatcct cctccctaaa aaaagaggca
     2101 aacaaagtat ttgtttgcac agagtaatta attaaaacat ataaagaaaa acctcaccag
     2161 ttttactatc aaagccattg gtctaacatt gtaagaattt ttcattctgt gctagcatcc
     2221 tttttttctt ttcagtggcc tcaaactcat gcaataagtt aattctaagt gctagctctt
     2281 gaaactactt ccagaagcag ttgaatagaa tgctccactt atctgggata ttgattttct
     2341 gctttaaaca tttctttcag atgttagcgt aggagtcatg tgtcttctaa gagaagaccc
     2401 gataagtgtc actggatgtg atttcagtct ctgtctctat ctgaaacctt tttgaagatt
     2461 tatttcagtg tatttcagtc tgttatactt tttagtttta ttatttaaaa gtttaaaact
     2521 cttgaccttt ttgcatggct ttttgctgaa aatgcaaaaa tataaatttt ctacaaaatt
     2581 aactttttat attcaaaaca ctatttctaa gctgccttct cttatccgca ttgtgttagt
     2641 gaaagcatat tcatactcgc atacaaccta taaatacaca aggcacatcc cttttatgcg
     2701 tggttaggat tctatatttt taagctagtg cacttacttg cacacacagt tcgccatact
     2761 tgttgaattt tagatgtaac gtcttttcac atattaacat ttttagaaag ttgaaataac
     2821 tggagtcctc atttgctatc aaagtagcct atcttcagtc catactgatt cagtaatatt
     2881 tgaactcctt atatttctga aacatgtatg gttatgaaaa ctaacacttt atattttatt
     2941 ttcaaaagta aatgttagtg ttctttgtcg atgtatgtct tttctttttg aaaatgtttt
     3001 tctttgcagt ctgtttaacg ttaccctgtt tttagtgaga atcggagtgg tatatgacaa
     3061 gttctggccc tgcagcatgc aagcactttt aaagagcatt taggtaatac cagactccta
     3121 aatcaaggcc ccttaaaagt aagtgcaact cccatttttt acattcagta aggctgctgc
     3181 atttgttatt gaatggaagg tagaaactct tagaaaattt gacctcagtt ttgacttaga
     3241 ggtaagaaat agaattataa tgttactggt tttatctact tgtttatttt gtacaaaata
     3301 cccagcgaca ctagggatgt aagccctcag tttttgtttt atttactgaa agctattagc
     3361 atgaaggata gtaaccacaa agttcagaat ggatcaagaa tagctgttta aaagcattta
     3421 taataagtgt tttaggatta gctgcacctt tcaactcttt aaatgcagag gaaaaaacat
     3481 agttgacaaa gttaagcaag aataacctgg gagtggatca ttgaaattga tgccatttgc
     3541 gcatgagtag tctatatctg atacagacta gatctatact ggcaaaactt gccagatctt
     3601 agaatattgg tgcaatattg caatgccttc tatatggctg ctgatgtata aattttctag
     3661 tttcactttg tttggtgttt tttgtttttt tgtttgtttg tttgtttttt tgctgctgcc
     3721 accattgaac ataaaatgga agtgtgaagt catggaaatg tgaagacttt ggtttttggg
     3781 ggttttttgg gcagttatta gacatactat gagattaaac ctgatcttca aactccagaa
     3841 ttggaggcat ttgggtttaa gaaaccaggt acataagtag cttttgaaaa aaccattggc
     3901 attgatttca aaaatcaata ataatcttat tttatatatg agacttatat tttcattaac
     3961 tagtcctgtc atttacttac agtttccaaa catgaaattt ggtatcttgt ttcccatggt
     4021 aatatgggta aaagtctttt tctacattta aaaaatacat tattttattt ttgaaagtta
     4081 ggaataagtt agccatttaa tttttttcta cattagttta gtggctttgt atgtgtgcta
     4141 ttttgcttta aagaaaataa cgtcttcatt attttcctca ttgatgtctt ttgctagaaa
     4201 agaccaagaa agagccatca ggccaggtat ccacatcaaa gcctttacac tatagtggtg
     4261 gttctcttta attgcttaga tatgacttca tgaccctagt cagggtgaca tctgggcaaa
     4321 catttgagta ttcttggtct tccattttaa agacagaggc caagatcaaa gttcatgttt
     4381 tgtaaaattc gtaaaatctt aacttgaact aactctgggt tcagctttac gtaagtcacg
     4441 tcggacctga tgttagctgt aatcagtttt gagctttaag gatagttgct gttgcttggg
     4501 ttctgaatgt atgagaaaac tccctgttta tatgtagttc taatttaggt tattttaaat
     4561 ccatgattaa cttacattcc cttttaaaat tatggtttta ttgctgcaag agatttattt
     4621 ttgttatact aaactatgga aaagtttttc atagcatttt tttcaagttt attttttgtg
     4681 tgcttcattt ggagtttttg tttatataca ttgcgctcaa aaaagtagtt ttttgaaaaa
     4741 ttcagtaaga tttgaatcta tacagtttaa ctgttatgac ctttatgcgt gttgttttca
     4801 ctttatatct caaatgccag agttcacaaa aatagctgat cttcattaat tacatcttaa
     4861 ttagaaccat ttgttctctt ccgtgtcttt gaccttctaa gttttgattt taaagaaatt
     4921 ccttgcacta cagccttttc ttaaaatgca agattctcac tttgaaggtt ttgtgttgga
     4981 agaaatgcta ctggttttta aaaagcaaag cttaactaat agaattatta gcttttcttg
     5041 agacagcttt ctgtgtcctc attactctgc tctgtgtgag tgttactaga atttgtgaaa
     5101 tactgactga gcccttcact tatcttttct aaagcagcac ctttggacac ctcattctgg
     5161 gaagcctgct cgagtcatag taaaggacac acgctttatg tggggagaag tggtaaaaat
     5221 ggagttttgt cttaattaca tgaaactaag ctttaaaata ttttataaca gattatttga
     5281 gctgcataat ctaaacatgt caaacgttca gtgggactat ttttatatat gtatatgtgg
     5341 gtgtaggtca taacatttca gtttataata taaattgtta tttcagttta taagctatct
     5401 ctcagaggag actagctctt ttgagaattc ataatttaaa gttttagact gaagtaaaat
     5461 gcaacataga taatagtgta aatcagatat aattgagggc tatatggcag taaaactgct
     5521 agtgccagtt ttcttgtttg cctgttatac atttttgatt tttgtttttg tattctgaac
     5581 attttgagag atcatatgtt tgttcaatta catttagagt tggtttggga ataaatatct
     5641 tctaaaaaga gatttatctt aaaaatggaa gtcctaaaaa ttagtttatc cagagtttat
     5701 aaagtcaaat attcagtagg catagactgg aatagataaa ttcatggaaa tcatatcctt
     5761 tcagtacacc gtataacttc aatattacac aagtaacatt gaggagaatg ccatcagctt
     5821 tgttctccct taaattcttt ggttttcttt ttacattttg ggaacaactg catttaaaat
     5881 gttattagtc agtatatagt aaggattagg tgtttgcttt ctgaaggaat ggtccagtga
     5941 ggtgattggg agaggttatt ttctacctaa cttgtatatg ccctatacct cttgggcata
     6001 ctttgtctat agaaaaatat tttgaccttt aggtacattt tgggccagta gtcaaataat
     6061 cctagggccg atataaaaat cttagaataa tttaaggttt gccttttata cctgttttga
     6121 aagcctttac atttttgtca ggtaattttt cccaagccgt ggatataatc tattcaaaca
     6181 tgtttatgct atccattctg tttttaaatt gaaaaaaatg ttaaaagtgt ttatgaagaa
     6241 aagtttaaat aaaatatttt taatctttaa aa
//
