LOCUS       NM_018143               7402 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens kelch like family member 11 (KLHL11), mRNA.
ACCESSION   NM_018143
VERSION     NM_018143.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7402)
  AUTHORS   Dubey,D., Wilson,M.R., Clarkson,B., Giannini,C., Gandhi,M.,
            Cheville,J., Lennon,V.A., Eggers,S., Devine,M.F., Mandel-Brehm,C.,
            Kryzer,T., Hinson,S.R., Khazaie,K., Hales,C., Kattah,J.,
            Pavelko,K.D., Andrews,P., Eaton,J.E., Jitprapaikulsan,J.,
            Mills,J.R., Flanagan,E.P., Zekeridou,A., Leibovich,B., Fryer,J.,
            Torre,M., Kaufman,C., Thoreson,J.B., Sagen,J., Linnoila,J.J.,
            DeRisi,J.L., Howe,C.L., McKeon,A. and Pittock,S.J.
  TITLE     Expanded Clinical Phenotype, Oncological Associations, and
            Immunopathologic Insights of Paraneoplastic Kelch-like Protein-11
            Encephalitis
  JOURNAL   JAMA Neurol 77 (11), 1420-1429 (2020)
   PUBMED   32744608
  REMARK    GeneRIF: Expanded Clinical Phenotype, Oncological Associations, and
            Immunopathologic Insights of Paraneoplastic Kelch-like Protein-11
            Encephalitis.
            Erratum:[JAMA Neurol. 2020 Nov 1;77(11):1453. doi:
            10.1001/jamaneurol.2020.3470.. PMID: 32926076]
REFERENCE   2  (bases 1 to 7402)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 7402)
  AUTHORS   Dhanoa,B.S., Cogliati,T., Satish,A.G., Bruford,E.A. and
            Friedman,J.S.
  TITLE     Update on the Kelch-like (KLHL) gene family
  JOURNAL   Hum Genomics 7 (1), 13 (2013)
   PUBMED   23676014
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7402)
  AUTHORS   Canning,P., Cooper,C.D.O., Krojer,T., Murray,J.W., Pike,A.C.W.,
            Chaikuad,A., Keates,T., Thangaratnarajah,C., Hojzan,V.,
            Marsden,B.D., Gileadi,O., Knapp,S., von Delft,F. and Bullock,A.N.
  TITLE     Structural basis for Cul3 protein assembly with the BTB-Kelch
            family of E3 ubiquitin ligases
  JOURNAL   J Biol Chem 288 (11), 7803-7814 (2013)
   PUBMED   23349464
  REMARK    GeneRIF: analysis of crystal structures of the BTB-BACK domains of
            KLHL11 both alone and in complex with Cul3
            Erratum:[J Biol Chem. 2013 Sep 27;388(39):28304. Ayinampudi, Vikram
            [added]]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI463857.1, AK001434.1 and AC125257.4.
            
            On Nov 22, 2018 this sequence version replaced NM_018143.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.72019.1,
                                           SRR1660805.47769.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000319121.4/ ENSP00000314608.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                BI463857.1         14-60
            48-1192             AK001434.1         1-1145
            1193-1193           AC125257.4         19416-19416         c
            1194-2373           AK001434.1         1147-2326
            2374-7402           AC125257.4         13207-18235         c
FEATURES             Location/Qualifiers
     source          1..7402
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.2"
     gene            1..7402
                     /gene="KLHL11"
                     /note="kelch like family member 11"
                     /db_xref="GeneID:55175"
                     /db_xref="HGNC:HGNC:19008"
                     /db_xref="MIM:619078"
     exon            1..598
                     /gene="KLHL11"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..2180
                     /gene="KLHL11"
                     /note="kelch-like protein 11"
                     /codon_start=1
                     /product="kelch-like protein 11 precursor"
                     /protein_id="NP_060613.1"
                     /db_xref="CCDS:CCDS11411.1"
                     /db_xref="GeneID:55175"
                     /db_xref="HGNC:HGNC:19008"
                     /db_xref="MIM:619078"
                     /translation="MAAAAVAAAAAAAAAASLQVLEMESMETAAAGSAGLAAEVRGSG
                     TVDFGPGPGISAMEASGGDPGPEAEDFECSSHCSELSWRQNEQRRQGLFCDITLCFGG
                     AGGREFRAHRSVLAAATEYFTPLLSGQFSESRSGRVEMRKWSSEPGPEPDTVEAVIEY
                     MYTGRIRVSTGSVHEVLELADRFLLIRLKEFCGEFLKKKLHLSNCVAIHSLAHMYTLS
                     QLALKAADMIRRNFHKVIQDEEFYTLPFHLIRDWLSDLEITVDSEEVLFETVLKWVQR
                     NAEERERYFEELFKLLRLSQMKPTYLTRHVKPERLVANNEVCVKLVADAVERHALRAE
                     NIQSGTCQHPTSHVSLLPRYGQNMDVIMVIGGVSEGGDYLSECVGYFVDEDRWVNLPH
                     IHNHLDGHAVAVTESYVYVAGSMEPGFAKTVERYNPNLNTWEHVCSLMTRKHSFGLTE
                     VKGKLYSIGGHGNFSPGFKDVTVYNPELDKWHNLESAPKILRDVKALAIEDRFVYIAA
                     RTPVDRDTEDGLKAVITCYDTETRQWQDVESLPLIDNYCFFQMSVVNSNFYQTASCCP
                     KSYCLENEEAVRKIASQVSDEILESLPPEVLSIEGAAICYYKDDVFIIGGWKNSDDID
                     KQYRKEAYRYCAERKRWMLLPPMPQPRCRATACHVRIPYRYLHGTQRYPMPQNLMWQK
                     DRIRQMQEIHRHALNMRRVPSSQIEC"
     exon            599..7402
                     /gene="KLHL11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7383..7388
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLHL11"
                     /note="hexamer: AATAAA"
     polyA_site      7402
                     /gene="KLHL11"
                     /note="major polyA site"
ORIGIN      
        1 accaacagcc gcatcgttcc gaggctgtgg aggccgggcg cagcggcgtc aagatggcgg
       61 ctgcggcagt ggcggcggcg gcggcggcgg ccgcggctgc atctcttcag gtactggaga
      121 tggagagcat ggagacggcc gccgccggct cggcaggact ggccgccgag gtccgaggca
      181 gcggcacggt ggacttcggg cctgggccgg ggatctctgc aatggaggcg agcgggggcg
      241 atccgggccc agaagccgag gatttcgagt gcagctctca ctgctcagag ctgtcctggc
      301 ggcagaacga gcagcggcgc cagggcctct tctgcgacat taccctgtgc ttcggcgggg
      361 ctggaggccg cgagttccgg gcccaccgct cggtactggc tgccgccacc gagtacttca
      421 cgcccctgct ctcgggccag ttttccgagt cccgctcggg acgggtggag atgcgcaagt
      481 ggagctccga gccggggccc gaacccgaca cagtggaagc cgtaatcgag tacatgtaca
      541 ccgggcgcat ccgcgtcagc acgggcagcg tgcacgaggt gctggagttg gccgacaggt
      601 tcctactcat tcgtttaaaa gaattttgtg gagaatttct caagaaaaaa cttcatctct
      661 caaattgtgt ggcaattcat agcttagcac acatgtacac cctgagccaa cttgctctga
      721 aggctgctga tatgatacgg agaaatttcc acaaagtgat tcaggatgaa gaattttata
      781 cgttaccttt ccatctcatt agagactggc tttcagattt ggaaattaca gttgattctg
      841 aagaggttct ctttgaaacc gttttgaaat gggttcagag aaatgctgaa gagagagaga
      901 gatactttga agaacttttt aaattgctca ggttgtccca gatgaaacct acctacctta
      961 ctcgacatgt caaaccagag aggctggtag ccaataatga agtttgtgtc aagttggtcg
     1021 ctgacgcagt ggagagacat gctctgagag ctgagaatat acaatctggc acatgccagc
     1081 accccacttc tcatgtgtca ctattgcctc gttatgggca aaacatggat gtgatcatgg
     1141 ttattggagg tgtgtcagaa ggaggggact atttaagtga atgtgtggga tactttgttg
     1201 atgaggacag atgggtaaat ctgccacata ttcataatca cctcgatgga catgctgttg
     1261 cagtaacaga atcctacgtg tatgttgctg gatcaatgga gccagggttt gctaaaactg
     1321 tagaaaggta taacccaaat ttgaatacat gggaacatgt ttgtagtctg atgacaagaa
     1381 agcattcttt tggactaaca gaagtcaaag ggaagctcta tagcattgga ggacatggca
     1441 actttagtcc tggttttaaa gatgtgactg tttataatcc tgagcttgat aaatggcaca
     1501 acttggaatc ggcaccaaag attcttcgag atgtcaaagc actagccatt gaagaccggt
     1561 ttgtatacat tgccgcccgc actcctgtag accgggacac tgaagatgga ttaaaggctg
     1621 taattacttg ctatgataca gagactcgac agtggcaaga tgtggaatct ttgccgctta
     1681 ttgacaatta ctgctttttc caaatgtctg tggtcaattc aaacttttat cagacagcat
     1741 catgttgtcc caagagttat tgtttagaaa acgaagaggc agtaagaaaa attgccagcc
     1801 aagtgtctga tgagatcctt gaaagcttgc ctccagaagt cctaagcatc gaaggagcag
     1861 ccatttgcta ttacaaagat gatgtcttca ttataggagg ctggaaaaac agtgatgata
     1921 ttgataaaca gtatcggaaa gaagcctacc gatattgtgc ggagaggaag aggtggatgc
     1981 ttcttcctcc tatgccacaa cctcgttgta gagccactgc ttgtcacgtg aggatcccat
     2041 accggtactt gcatggcaca cagagatacc ctatgcctca aaacctgatg tggcagaagg
     2101 accgcatcag acagatgcaa gagatacatc gtcacgccct gaacatgagg cgagtgccaa
     2161 gctctcagat tgaatgctag gttctctcaa gcgtgccgat taaaactgtt acacccgttt
     2221 cgtgaagctg aagataccca ggctgttatt taaaaaagta tgtcgataac ttattttcta
     2281 catgaactga ttattacccc atataaagga aatagagtta aaaactaaag aatgggagac
     2341 tcagttcaat acatggtcat tttgttagct tgcaattttt gtctttggtt tgtttgtttg
     2401 tgctagctaa ataagatctt attaaggaca agtggaaaaa tcaggtgtag ttgcttagct
     2461 gttttcctgc caacgagtta tgactccttt gtcttgagga cttacgtttt gaacatgctt
     2521 taagcaccaa ttttatttgc acatttactt tgatattctt tttcattttt tattaaatga
     2581 ttggttttgg caagatctga cttctgcatt gagccctcat ctgcaggagg catgtgcaat
     2641 agtgagactg aaatttgaat gaaaacactc aatatttcag caagataatt tgagaatgtt
     2701 tgcattgata ttttcttatg tttatctaga aatgccagtt tccttcctag aagatgtgac
     2761 tgatgagaaa ttttttactg gctcatgcat tttttgaata tttttcatta gcagctgttt
     2821 atagacttta agccttcaat ctgaggtgac ggtagttggc aaaagtatag atctttagct
     2881 aattgactaa atacagagca agttacatgt gtgaactttg tttctctaag aagaaaagta
     2941 ttagtgtaga ctgggaaatc aaaggcattt aaaatttttt caacattttt ttcaggagtt
     3001 gcaggattat ttgaggatat gttaatgagt gtaaataatg cctatgacaa tcgacactca
     3061 atgccttcca ttttaatttt tgctctaatg catattatat agaatcttca ttattccttt
     3121 tctctttttt tttttttttt tgctcatgtt gcccaggctg gagtgcagtg gtgcaatctc
     3181 ggctcactgc aacctctgcc tgccaggttc gagtgattct cttgcctcag catcccgagt
     3241 agctgggatt acaggtaccc accatcacgc ctggctaatt tttgtgcttt tagtagagac
     3301 agggtttcac catgttgacc aggctggtct tgaactcctg acctcaggtg atacgcccgc
     3361 ctcagcctcc caaagtgctg ggattacagg catgagccac cgtgcccagt ccattattct
     3421 tttctacaag aaactgtttt tttccaaaat gggaaggaag tcacaattta gagaaatgtt
     3481 gctaaagaga agccttatta tttctgattg ttatatttta tccagttgcc ccacactttc
     3541 aaactttgcc tgagcctagg ataccaaatt tgggtacata attttggctt ttaaaggttt
     3601 atgggctggg cacggtggct catgactgta atcccaacac tttggaggag gctgaggtgg
     3661 gcagattttg agcccaagag ttcaagacca gcctgggaaa catagcaaga tcctgtctct
     3721 acaaaaagta gaaaaattag ctgagtgtgg tagctggcac gtgcctgtag tccttcctac
     3781 ttgaagccaa ggtgggagga tcaccagagc ctgggaaggt tgaggctgaa atgagctgtg
     3841 atcatgccac tctaccttgg gtgacagaga gacggtgtct caaataaaaa ttaaaaagat
     3901 cactgaagct atcttttatt tagttttata cgttattcga attatcttat gtctcctgag
     3961 ctttataaaa gttagcactc aaattgactt tttttttttt ttgggccagg ggatggggtc
     4021 ccactttgtc acccaggttg gagtacagtg gtatgatctc ggctcactac aacctccacc
     4081 tcctggatgc aagccatcct gccacctcag catacggagt agctgggact atgggcacgc
     4141 gccaccacgc ccagctaatt ttttttttgt atttttggta gagatggggt ttctccatgt
     4201 tgccgaggct ggtctccaac tcctgggctc aggagatcca cccgtatcag cctcccaggg
     4261 tgctaggatt aggtgtgagc caccacgccc ggcctcaaaa taactttttt tttttttttt
     4321 gaaacagtca cgctttgtcg ccctggctgg agtgcagttg cgcagtctca gctcactgca
     4381 acctccacct cccgggttca tgtgattctc ctgcctcagc ctgctgagta gctgggattg
     4441 caggtgtgta ccaccacgcc cggctaattt ttgtattttt aatagagatg gggtttcacc
     4501 atgttggtta ggctggtctc gaactcctga cctcgtgatc cgcccacctc agcctctcaa
     4561 agcgctggga ttacaggcat gagccaccat gcccagccct caaatttact cttaatgctc
     4621 agttaatata aaggattcct aacagtttac aatgtggttt tcttgttttt gttgttgttt
     4681 tggtttttta agatgtgagg tctcacctta ttggccaggc tggtctcaag ctcctttcct
     4741 caagcaatcc tcccaccttg gcctcccaaa gagccacctg tccaatgatt tatcctgttt
     4801 cttaagaact gtctttacct tcttagacat tttgtcatac cattctagaa gtcaaattcc
     4861 aagtgcagtg attttttttt tccctagtcc attatagtta atcttcttgt tagtgatcaa
     4921 ataccaaaag agaaaagcac aaccagaaat tttggctatt tgctgcaagt tgtaggtctt
     4981 gggctctata ctaagaactt gaaattttta aattagtatc cctgcctagg tgaaaagttt
     5041 ttaataaatg tgttgaaaat caactttaaa tccatttaat ttagactgga gtgggcgtga
     5101 gaaactgcaa gtctatttct acatataagg atatattatt atattgtccc atcccaccac
     5161 tacctttttc tcaatttcta tttctttgta gttattttag taaaagccat ttggattctg
     5221 agaagcacta attcttagct gtgataggtc tatgcaagta agacagaatc attaaatgaa
     5281 gctcactaaa tgaagttctc atttctctcc aacagactgt gctagcaaac ttcgttttct
     5341 tgattgtatt taaataattt agtatctcac tacgataata gtttttaact ggaagggtgt
     5401 gatgtgtttt ttgttttttg ttctcagagt tgtcttctga gataattatt accaagtcat
     5461 ttgtggggtt gtgttttttt cacatcatgt gacagaaatt ataactcata agatttaggc
     5521 ataatctggt tttaaaacct tgattgaaac tgttgttttt taacttagca ggcagcctag
     5581 gccatggctg aaaagaaggg gtaagtcctt cattgcatga tgatgtgtgc aggttttcct
     5641 gattttctaa tttttatttt tgaattcaca tgtgtaattt cacatcaata acttgtgttt
     5701 ctgaaatatc ctaactaact tgttaataag gaaagaaacc agatttgctt aaatctgttc
     5761 aaggctgaca ttctgaaatt ctaaactgga aataacttcc cagagtattt ggaaaggttc
     5821 taagtacaag gatcaggcct aaaatagctc cttgggaaag aaatttcctt tttgatgaga
     5881 aaacttaaaa tattgttttt ggtaatgtaa gcagttaaaa acatgacttt agaaagacag
     5941 cttaatgcgt attcaagcaa acctttgttt tgttgctttt gcttttgttt gtagaagaga
     6001 gaggaagtta ttataccaaa aagtaatagt atatgtaact ttgagtgagg ctacttatat
     6061 cttagaatgg gtatccttga actatatcta ccccaccatg gcttaaaaaa atcagtggta
     6121 tatattgaga atgtcagtca tgagcttagt gtttaagtaa cacatcccac ttacagttgt
     6181 ttgcatgatt agtcttgtgt atcatgatgt tcaactttgc ttttgctgtg ccagttcaaa
     6241 aatatctttt ttgctaaaaa ctcttaaaat tcatgacata agttttgttt tgatcacccg
     6301 gttttatata gtatttctgg gaccaaaaaa tttaaatata cctttttaat ataaaacaga
     6361 agtttgaagc tggaaagata gtgtttatgg aagatttgtg tgcttttgtg ttttttaaac
     6421 ccgtcaggct gctggtaagg cagtttctag ggctcacttt tcctccttac ctcttgacta
     6481 gtgtagcatg tggtatgttt aaaatatttc attttctgct ttgtaattct aaagtcaaca
     6541 ctatactgta tgtagacagg agagctgatt tgtatatttt agttatttgg tctaatcaag
     6601 cataactaaa gggacttctt ttttgatact tttctcaaat taagtttaaa tatagtatac
     6661 gggccacatt tcatgtcttt gaaagtgttg tacattactg taaaccaagt actctgtcta
     6721 caccagaggg tgctttaact gcaaaatatt tgagaaacaa ttcagtctct caaacatttt
     6781 ggcacagttc atcactccag tttgttactt tcttgagaat agtccatttt ttgtttttgt
     6841 tattgtaccg tatgttctgg tcattggaaa cagaacagct catagttggg tgatgtaata
     6901 taataacagt aatataacct agtagtcatt ttgcttcaag taatttaatt agatagcaaa
     6961 atcactgcgg tttgtttatt acacttgtag ggctttttat cttactcagt gaccatcact
     7021 acgaatgtct tacattgaag cacagactgc agagcacttg ttaacttagt cctcctgcat
     7081 aatgcactcg tgaaaagtag tgcttgctag gtgtttgaag attttatgat ccgtgtgctt
     7141 gggctcgttg agttatttgt aaaataaaca tttagtttga gttgatgcag taagtttttt
     7201 ggactagtag tatccaggtc cctactctac tgaaaatata atcttcacta tctcccctta
     7261 actcagagga gatgtagcat ttagaacacc ttgagacatg acattgtaaa atagcttgtt
     7321 ttatgttcct gaagctatct tgttctctgt taaagctact aattgtctca gtgtaagttt
     7381 taaataaaca tatttcttta aa
//
