LOCUS       NM_152366               1347 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens kelch domain containing 9 (KLHDC9), transcript variant
            1, mRNA.
ACCESSION   NM_152366
VERSION     NM_152366.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1347)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1347)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   3  (bases 1 to 1347)
  AUTHORS   Diederichs,S., Baumer,N., Ji,P., Metzelder,S.K., Idos,G.E.,
            Cauvet,T., Wang,W., Moller,M., Pierschalski,S., Gromoll,J.,
            Schrader,M.G., Koeffler,H.P., Berdel,W.E., Serve,H. and
            Muller-Tidow,C.
  TITLE     Identification of interaction partners and substrates of the cyclin
            A1-CDK2 complex
  JOURNAL   J Biol Chem 279 (32), 33727-33741 (2004)
   PUBMED   15159402
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL591806.16, BG718418.1, BC022077.1 and BC066896.1.
            
            On Nov 22, 2018 this sequence version replaced NM_152366.4.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC022077.1, SRR3476690.560645.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368011.9/ ENSP00000356990.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                AL591806.16        152363-152392
            31-33               BG718418.1         1-3
            34-89               BC022077.1         3-58
            90-90               BC066896.1         54-54
            91-1347             BC022077.1         60-1316
FEATURES             Location/Qualifiers
     source          1..1347
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.3"
     gene            1..1347
                     /gene="KLHDC9"
                     /gene_synonym="KARCA1"
                     /note="kelch domain containing 9"
                     /db_xref="GeneID:126823"
                     /db_xref="HGNC:HGNC:28489"
                     /db_xref="MIM:617375"
     exon            1..702
                     /gene="KLHDC9"
                     /gene_synonym="KARCA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             176..1225
                     /gene="KLHDC9"
                     /gene_synonym="KARCA1"
                     /note="isoform a is encoded by transcript variant 1;
                     kelch/ankyrin repeat-containing cyclin A1-interacting
                     protein"
                     /codon_start=1
                     /product="kelch domain-containing protein 9 isoform a"
                     /protein_id="NP_689579.3"
                     /db_xref="CCDS:CCDS30919.1"
                     /db_xref="GeneID:126823"
                     /db_xref="HGNC:HGNC:28489"
                     /db_xref="MIM:617375"
                     /translation="MAVAVPPGRAAGSGWAWRPVARDALLARAFHSCTELRGRFYLVG
                     GLLAGGAREPSSDTVVFDPARGQAVRLGARGSPPRSHHDAAPVDGRWLCVVGGWDGSR
                     RLATVTALDTERGVWEAWTGTPGDCPPAGLSSHTCTRISDRELQVAGREGGIHTQRRY
                     GSIYTLRLDPSARTYCYKQEGCHTASRSGHCAALLQTPGPHPGHQLLLFGGCNLAEPE
                     VAGHWSHGKIKEEPPVAPHLMEQLARLVSSGQGSQKGPHGLRHHSCSVVGPFAVLFGG
                     ETLTRARDTICNDLYIYDTRTSPPLWFHFPCADRGMKRMGHRTCLWNDQLYLVGGFGE
                     DGRTASPQVCILDFI"
     exon            703..862
                     /gene="KLHDC9"
                     /gene_synonym="KARCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            863..1061
                     /gene="KLHDC9"
                     /gene_synonym="KARCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1347
                     /gene="KLHDC9"
                     /gene_synonym="KARCA1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1324..1329
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLHDC9"
                     /gene_synonym="KARCA1"
                     /note="hexamer: ATTAAA"
     polyA_site      1347
                     /gene="KLHDC9"
                     /gene_synonym="KARCA1"
                     /note="major polyA site"
ORIGIN      
        1 gcagtggttg ctgggcgacc acggagagaa agccgggact tgaggtggga accccggctg
       61 gcgtccggta gggggaggtt cccggggaag cccgcggaag gcgaggtgcc tggcctgcca
      121 tgtaggggct cgttccaagc cgcagacccc accgccctcc ctctccccgg ggcccatggc
      181 ggtggccgtg cccccgggtc gggccgcagg ctcaggctgg gcctggaggc cagtggcgcg
      241 ggacgcgctt ttggctagag ctttccattc atgcaccgaa ctgcggggac ggttctatct
      301 cgtaggtggt ctcctagcag gaggagcgag agagcccagc agcgatacgg tggttttcga
      361 cccagctagg ggccaggccg tacgattggg agcccggggc agccccccgc gcagtcacca
      421 cgacgcggca cccgtggacg ggcgttggct ctgcgtggtg ggcggctggg acgggtctcg
      481 ccgcttggcc acagtgaccg cactggacac agagcgcggt gtgtgggagg cgtggacagg
      541 gacccctggt gactgccccc ccgccggcct cagtagtcac acctgcaccc gaatctctga
      601 ccgagagctg caggtggctg gccgggaggg cggtatccac actcagcgac gctatggaag
      661 catctacaca ttaaggctgg accccagcgc ccgcacctat tgctacaagc aagaaggctg
      721 ccacacagcc tcacgctcag gtcactgtgc ggccctgctc caaactcctg gaccccatcc
      781 aggtcatcag ctattgctct ttggaggttg caacttagct gaaccagaag tagctgggca
      841 ttggagtcat gggaaaatta aggaggaacc acctgttgct cctcatttga tggaacagct
      901 tgcaaggctt gtgagcagtg ggcaggggtc ccagaagggg ccccatggac tacggcatca
      961 ctcatgttct gtggtcgggc cctttgctgt gctgtttggt ggagaaactc tgaccagagc
     1021 tagagacacc atctgcaatg atctctacat ctatgatact cgcacatctc ctcctttgtg
     1081 gttccacttc ccctgtgcag atcgtgggat gaaacgcatg ggccatcgca cctgcctttg
     1141 gaatgatcag ctttacctgg ttgggggttt tggtgaggat ggcaggacag ccagtccaca
     1201 ggtttgcatc ctggacttta tctaaatagt gccaagacac atcactaagc ctcgttttgt
     1261 tttgctttgt tgcaaaccta taaagcgtta tcaccagagc tatctgcttc acttcaaatg
     1321 cttattaaat ttcaatctga gactcaa
//
