LOCUS       NM_138433               5125 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens kelch domain containing 7B (KLHDC7B), mRNA.
ACCESSION   NM_138433
VERSION     NM_138433.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5125)
  AUTHORS   Hou,J., Huang,H., Xie,J., Yu,W., Hao,H. and Li,H.
  TITLE     KLHDC7B as a novel diagnostic biomarker in urine exosomal mRNA
            promotes bladder urothelial carcinoma cell proliferation and
            migration, inhibits apoptosis
  JOURNAL   Mol Carcinog 63 (2), 286-300 (2024)
   PUBMED   37888201
  REMARK    GeneRIF: KLHDC7B as a novel diagnostic biomarker in urine exosomal
            mRNA promotes bladder urothelial carcinoma cell proliferation and
            migration, inhibits apoptosis.
REFERENCE   2  (bases 1 to 5125)
  AUTHORS   Wang,J., Xiang,F., Liu,X., Ma,X., Cai,X., Yang,Y., Shen,X.,
            Yuan,C., Xiang,Y. and Xiao,H.
  TITLE     HPV E7 affects the function of cervical cancer cells via the
            TAL1/lnc-EBIC/KLHDC7B axis
  JOURNAL   Oncol Rep 45 (5) (2021)
   PUBMED   33760214
  REMARK    GeneRIF: HPV E7 affects the function of cervical cancer cells via
            the TAL1/lncEBIC/KLHDC7B axis.
REFERENCE   3  (bases 1 to 5125)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 5125)
  AUTHORS   Kim,T.W., Kim,Y.J., Lee,H.J., Min,S.Y., Kang,H.S. and Kim,S.J.
  TITLE     Hs.137007 is a novel epigenetic marker hypermethylated and
            up-regulated in breast cancer
  JOURNAL   Int J Oncol 36 (5), 1105-1111 (2010)
   PUBMED   20372783
  REMARK    GeneRIF: Hs.137007 gene is a novel gene specifically expressed in
            the breast that has a role in epigenetic regulation of breast
            cancer [Hs.137007]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            U62317.2 and AW014875.1.
            
            On May 17, 2019 this sequence version replaced NM_138433.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The extent of this transcript is
            supported by transcript alignments.
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000648057.3/ ENSP00000497256.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4870              U62317.2           89686-94555         c
            4871-5125           AW014875.1         17-271              c
FEATURES             Location/Qualifiers
     source          1..5125
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.33"
     gene            1..5125
                     /gene="KLHDC7B"
                     /note="kelch domain containing 7B"
                     /db_xref="GeneID:113730"
                     /db_xref="HGNC:HGNC:25145"
                     /db_xref="MIM:620521"
     exon            1..5125
                     /gene="KLHDC7B"
                     /inference="alignment:Splign:2.1.0"
     CDS             346..4053
                     /gene="KLHDC7B"
                     /codon_start=1
                     /product="kelch domain-containing protein 7B"
                     /protein_id="NP_612442.3"
                     /db_xref="CCDS:CCDS14097.3"
                     /db_xref="GeneID:113730"
                     /db_xref="HGNC:HGNC:25145"
                     /db_xref="MIM:620521"
                     /translation="MIQGTLEPDGPLWGWDWDSDNDWDSAVLALLALAVVAATALALH
                     WFGSGHDQEAAEPVSTALGAQPHQAGGAELALQPKSKVSDGSEGQSPGQGKPEPPGRG
                     QQSPVPAAAPGGGLAAMARLPLKTAVEEARREALGQQRGSATPAAPRAEGKEPPRPGT
                     ALLGRSEAGGMSAPLLIHFTPRSPGSEAEAETGGVRASSRQAAGPAGQQDTGPWQAGA
                     GPSGSMGRGRGRRRRMDAGSGDRARRPRKLDPLRLGAAGSVWDAVDGAAALDAHARGL
                     PTGPPLAQEPALPALPAPRALQPGSQTEGSGAKGGWSREASGVPAPGGGWPWVSREVP
                     GTRSFGPAPDSTRPWLESPPQGRPLSSQGPGATGAYDAGEAGADSSRDNSPAADLGPT
                     RPPEQAKPAAAGHSRAPSRSREPRPRSASPPAAPGPGFPPEALTLPSPSDFLPLEVTQ
                     DPSVGENLRAAPAPSSASAQVLTSAPASVLAPALASSPSSAPTSATTSTSSPTSAPAP
                     APTSAPTSTPAPAPSPAAAATPAPAPVPVPTLTPPSPALTPVPTPALSPAPTPALTPA
                     ASPALTPVPTPALSPAPTPAPTPAASPAPAPTSAPTPTPAASPAPADGSKPQESVALP
                     RRYQEGQVSASWGNLIAMVLRSHPFPRQDRPQGSVPRAVPGSPVGPSTSTHSEDRHGP
                     SSSVGTVIGTGTGGLVEAGGQPQPRSSETNGSPSPDPPPGLRGEGTREKSLDPLPQAA
                     MPRGPAQPPAQRPPGPAASSSARRSQPVPQLRKRSRCEIAPSSEQEVRPAASGDPQGE
                     APGEGGSPAGRSGALTEKQEEARKLMVFLQRPGGWGVVEGPRKPSSRALEPATAAALR
                     RRLDLGSCLDVLAFAQQHGEPGLAQETYALMSDNLLRVLGDPCLYRRLSAADRERILS
                     LRTGRGRAVLGVLVLPSLYQGGRSGLPRGPRGEEPPAAAPVSLPLPAHLHVFNPRENT
                     WRPLTQVPEEAPLRGCGLCTMHNYLFLAGGIRGSGAKAVCSNEVFCYNPLTNIWSQVR
                     PMQQARAQLKLVALDGLLYAIGGECLYSMECYDPRTDAWTPRAPLPAGTFPVAHEAVA
                     CRGDIYVTGGHLFYRLLRYSPVKDAWDECPYSASHRRSSDIVALGGFLYRFDLLRGVG
                     AAVMRYNTVTGSWSRAASLPLPAPAPLHCTTLGNTIYCLNPQVTATFTVSGGTAQFQA
                     KELQPFPLGSTGVLSPFILTLPPEDRLQTSL"
     regulatory      5101..5106
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLHDC7B"
                     /note="hexamer: AATACA"
     polyA_site      5125
                     /gene="KLHDC7B"
                     /note="major polyA site"
ORIGIN      
        1 agaagcaggt tggctgtgat gacagcacag agctcaggaa cgctgcctga ggaccctggg
       61 gcctacgagg aggagaagag ggcaggagct ggtggggtgc ttgcagagac cctgggctcc
      121 tatcctgcca taagcctcgc tgtctcctga tatctgcagc caggccctac tgacaccccc
      181 aggcctgagt gcaagcagag accccaccat tcccaggccc tggaggactg gtccacctta
      241 actgggcagc ccttggggca ggcgctggcc ggtgcctcag cccaggcctc tgtgctctgc
      301 atgcactgcc agcctgccat caggcctcta ttgcagccct gaaccatgat ccagggcacc
      361 ttggagccag atggtcccct ctggggctgg gactgggaca gtgacaatga ctgggatagt
      421 gctgtgctgg ccctcctggc gctggctgtg gtggctgcca cagcgctggc cttacactgg
      481 tttggctccg ggcacgatca agaggcggca gaaccggtgt ccacagccct cggggctcaa
      541 cctcatcagg caggaggagc tgagctggcc ctgcaaccga agtctaaggt cagtgatggc
      601 agcgaggggc agagcccagg gcaggggaaa ccagagcccc caggacgcgg ccagcagagc
      661 cctgtccctg ctgcagcgcc gggcgggggc ctggccgcca tggcccggct tccactcaag
      721 acggctgtcg aggaggcccg cagagaggca ttaggacagc aacggggcag tgccaccccc
      781 gcggcccccc gagcggaagg aaaggagcct cccaggccag gcactgccct cctgggcagg
      841 agcgaagcag gggggatgtc cgcccccctc ctgatccact tcactcctcg gagccctggc
      901 agcgaagcgg aggcggagac aggtggtgtc agggcgtcct ctcgccaggc cgcaggcccc
      961 gcggggcaac aggacactgg cccctggcag gcgggcgcgg ggccctcggg ctcgatgggg
     1021 agaggccggg gccggcggcg gcggatggac gctggctcgg gagacagagc ccgccgcccc
     1081 cggaaactgg acccgctccg cctgggcgcc gcggggagcg tgtgggacgc ggtggacggg
     1141 gccgccgccc tggacgccca cgcgcgcggc ctccccacag gacccccact cgcccaggag
     1201 cccgcactcc cggcgctgcc cgctccccgc gccctgcagc ctgggtctca gacggaaggc
     1261 tctggggcca agggtggctg gagcagggag gcctcggggg tccctgcccc cggaggaggc
     1321 tggccctggg tcagcaggga ggtcccgggc acccggagct ttggcccagc cccagactcc
     1381 acgcgcccct ggctagagag tccgcctcaa ggtcgcccac tctcgtccca agggccgggt
     1441 gccacagggg cctacgatgc cggcgaggcc ggggctgaca gctcccgaga taacagtcct
     1501 gccgctgacc tggggcccac ccggcccccg gagcaagcaa agccggctgc agccggccac
     1561 agccgcgcgc cctcccggag ccgtgagcct cgcccgcgct ccgcctcccc gcccgcagct
     1621 cccggcccgg ggttcccacc tgaagccctg actctcccct ctccttcaga ctttttgccc
     1681 ctggaggtta cccaggatcc ttccgtgggc gaaaatctca gagcggcgcc agccccaagt
     1741 tcagcctcag cccaagtctt aacttcagct ccagcctcag tcctagcccc agccctggct
     1801 tcatccccca gctcagcacc aacctcagcc accacctcaa cctcatcccc cacctcagcc
     1861 ccagccccag ctccaacctc agctccaact tcaaccccag ccccagcccc aagtccagct
     1921 gcagccgcaa ctccagcccc agccccagtc ccagtcccaa ccctcacacc cccatcccca
     1981 gccctaaccc cagtcccaac cccagcccta agcccagctc caactccagc cctaacccca
     2041 gccgcatccc cagccctaac cccagtccca accccagccc taagcccagc tccaactcca
     2101 gccccaaccc cagccgcatc ccctgcccca gcccccacct cagccccaac cccaacccca
     2161 gccgcatccc ctgccccagc tgacgggtca aagcctcagg agagtgtggc tctccccagg
     2221 cgctaccagg aggggcaggt ctcagccagc tggggaaacc ttattgccat ggttcttaga
     2281 agccacccct tccccaggca agacaggccc caagggagtg tcccgagggc ggttcccggg
     2341 agccccgtgg gtcccagcac ttccacacac tctgaggaca gacacggccc ctcttcttca
     2401 gtggggacag tcatagggac aggtacaggg ggcctggttg aggctggagg tcagccacag
     2461 ccaagaagct ccgagaccaa cggatcgccc agcccagacc ctcccccagg cctaagagga
     2521 gagggaacca gggagaaaag tctagacccg ctgccccaag ccgcgatgcc caggggcccc
     2581 gcacagcccc ccgcgcagag gccgcctggc cccgcggcct cctcctctgc gaggcgctca
     2641 cagccggtac cccagctacg gaaacgcagc aggtgcgaaa tcgccccgag ctcggagcag
     2701 gaggtcaggc cggccgcctc gggggaccct caaggggagg cgccggggga ggggggcagc
     2761 cctgccggcc gcagcggggc gctcacggaa aagcaggagg aggcccggaa gctcatggtg
     2821 tttctgcaga ggcccggggg ttggggggtg gtggaggggc cccggaagcc cagctcccgg
     2881 gccctggagc ccgccacggc ggcagccctg cggcggcggc tggacctggg cagttgcctg
     2941 gacgtgctgg cctttgccca gcagcacgga gagcccggcc tggcgcagga gacctacgcg
     3001 ctgatgagcg acaacctgct gcgagtgctg ggagacccgt gcctctaccg ccggctgagc
     3061 gcggccgacc gcgagcgcat cctcagcctg cggaccggcc ggggccgggc ggtgctgggc
     3121 gtcctcgtac tgcccagcct ctaccagggg ggccgctcag ggctccccag gggccctcgt
     3181 ggcgaggagc ctcctgcggc ggcccctgtg tccctgcctc tacctgcgca cctgcatgtg
     3241 ttcaaccccc gggagaacac ctggcggccc ctgacccagg tgcccgagga ggccccgctt
     3301 cggggctgcg gtctctgcac catgcacaac tacctgtttc tggcgggggg catccgtggc
     3361 tccggtgcca aggccgtctg ctccaacgag gtcttctgct acaaccctct gaccaacatc
     3421 tggagccagg ttcggcccat gcagcaggcc cgagcccagc tcaagctggt ggccctggac
     3481 gggctgctct atgccatcgg tggcgaatgc ctgtacagca tggagtgcta cgacccgcga
     3541 acagacgcct ggaccccacg cgcgccactc cccgcaggca ccttccctgt ggcccacgag
     3601 gctgtggcct gccgtgggga catctacgtc accgggggtc acctcttcta ccgcctgctc
     3661 aggtacagcc ccgtgaagga tgcttgggac gagtgcccat acagtgccag ccaccggcgt
     3721 tccagcgaca tcgtggcact ggggggcttc ctgtaccgct tcgacctgct gcggggcgtg
     3781 ggcgccgccg tgatgcgcta caacacagtg accggctcct ggagcagggc tgcctccctg
     3841 cccctgcccg cccccgcccc actgcactgc accaccctgg gcaacaccat ttactgcctc
     3901 aacccccagg tcactgccac cttcacggtc tctgggggga ctgcccagtt ccaggccaag
     3961 gagctgcagc ccttcccctt ggggagcacc ggggtcctca gtccattcat cctgactctg
     4021 ccccctgagg accggctgca gacctcactc tgagtggcag gcagagaacc aaagctgctt
     4081 cgctgctctc cagggagacc ctcctgggat gggcctgaga ggccggggct cagggaaggg
     4141 gctgggatcg gaacttcctg ctcttgtttc tggacaactt tccccttctg ctttaaaggt
     4201 tgtcgattat tttgaagccc agactccctc agcctctttc tgcccctcac tccacaccca
     4261 gactgtttcc tgactcaatt ccgtacctac ttacagaccc tctcagcttg ctgacacccc
     4321 cctgtctgtg ggactcccta ttccctagag ccagggactg atgcgtctcc acagacaagg
     4381 acttggctcg ctggagctct gctgagccga gagaggaggg ggtagaaaac attcacactt
     4441 cctatgctct gtcagcagga cagggagcaa aaacgtcccc aggcaacgcc ctcgcctctg
     4501 ggactttctg cctgtcctaa ggcctcccca ggtaccaacc ccgtagctat ctgggtctgt
     4561 ttggcactgt ggattctcaa gggcctagaa cccttgcctc tgaaactggt ccgctggtgc
     4621 agccctgctg tctgcagctc ctgcccatac ccccagccca caccaggcca ggcccactcc
     4681 gggctcacca ccctctgcag ccttgtgggg ctctcccagc ccctccagaa gcccacccca
     4741 cttctcgcca acccccgatc tctaaatgag gcctgagcgt caccctagtt ctgccccttt
     4801 ttagctgtgt agacttggac gagacatttg acttcccttt ctccttgtct ataaaatgtg
     4861 gacagtggac gtctgtcacc caagagagtt gtgggagaca agatcacagc tatgagcacc
     4921 tcgcacggtg tccaggatgc acagcacaat ccatgatgcg ttttctcccc ttacgcactt
     4981 tgaaacccat gctagaaaag tgaatacatc tgactgtgct ccactccaac ctccagcctg
     5041 gatgtccctg tctgggccct ttttctgttt tttattctat gttcagcacc actggcacca
     5101 aatacatttt aattcaccga aagca
//
