LOCUS       NM_152375               5045 bp    mRNA    linear   PRI 26-FEB-2021
DEFINITION  Homo sapiens kelch domain containing 7A (KLHDC7A), mRNA.
ACCESSION   NM_152375
VERSION     NM_152375.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5045)
  AUTHORS   Lin X, Wang J, Yun L, Jiang S, Li L, Chen X, Li Z, Lu Q, Zhang Y
            and Ma X.
  TITLE     Association between LEKR1-CCNL1 and IGSF21-KLHDC7A gene
            polymorphisms and diabetic retinopathy of type 2 diabetes mellitus
            in the Chinese Han population
  JOURNAL   J Gene Med 18 (10), 282-287 (2016)
   PUBMED   27607899
  REMARK    GeneRIF: Results suggest that LEKR1-CCNL1 and IGSF21-KLHDC7A gene
            polymorphisms influence the development of diabetic retinopathy
            (DR).
REFERENCE   2  (bases 1 to 5045)
  AUTHORS   Grassi MA, Tikhomirov A, Ramalingam S, Below JE, Cox NJ and Nicolae
            DL.
  TITLE     Genome-wide meta-analysis for severe diabetic retinopathy
  JOURNAL   Hum Mol Genet 20 (12), 2472-2481 (2011)
   PUBMED   21441570
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL591896.6.
            
            On Jul 31, 2020 this sequence version replaced NM_152375.2.
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000400664.3/ ENSP00000383505.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5045              AL591896.6         99217-104261
FEATURES             Location/Qualifiers
     source          1..5045
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.13"
     gene            1..5045
                     /gene="KLHDC7A"
                     /note="kelch domain containing 7A"
                     /db_xref="GeneID:127707"
                     /db_xref="HGNC:HGNC:26791"
     exon            1..5045
                     /gene="KLHDC7A"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..2386
                     /gene="KLHDC7A"
                     /codon_start=1
                     /product="kelch domain-containing protein 7A"
                     /protein_id="NP_689588.2"
                     /db_xref="CCDS:CCDS185.2"
                     /db_xref="GeneID:127707"
                     /db_xref="HGNC:HGNC:26791"
                     /translation="MFPRGAEAQDWHLDMQLTGKVVLSAAALLLVTVAYRLYKSRPAP
                     AQRWGGNGQAEAKEEAEGSGQPAVQEASPGVLLRGPRRRRSSKRAEAPQGCSCENPRG
                     PYVLVTGATSTDRKPQRKGSGEERGGQGSDSEQVPPCCPSQETRTAVGSNPDPPHFPR
                     LGSEPKSSPAGLIAAADGSCAGGEPSPWQDSKPREHPGLGQLEPPHCHYVAPLQGSSD
                     MNQSWVFTRVIGVSREEAGALEAASDVDLTLHQQEGAPNSSYTFSSIARVRMEEHFIQ
                     KAEGVEPRLKGKVYDYYVESTSQAIFQGRLAPRTAALTEVPSPRPPPGSLGTGAASGG
                     QAGDTKGAAERAASPQTGPWPSTRGFSRKESLLQIAENPELQLQPDGFRLPAPPCPDP
                     GALPGLGRSSREPHVQPVAGTNFFHIPLTPASAPQVRLDLGNCYEVLTLAKRQNLEAL
                     KEAAYKVMSENYLQVLRSPDIYGCLSGAERELILQRRLRGRQYLVVADVCPKEDSGGL
                     CCYDDEQDVWRPLARMPPEAVSRGCAICSLFNYLFVVSGCQGPGHQPSSRVFCYNPLT
                     GIWSEVCPLNQARPHCRLVALDGHLYAIGGECLNSVERYDPRLDRWDFAPPLPSDTFA
                     LAHTATVRAKEIFVTGGSLRFLLFRFSAQEQRWWAGPTGGSKDRTAEMVAVNGFLYRF
                     DLNRSLGIAVYRCSASTRLWYECATYRTPYPDAFQCAVVDNLIYCVGRRSTLCFLADS
                     VSPRFVPKELRSFPAPQGTLLPTVLTLPTPDLPQTRV"
     regulatory      4832..4837
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLHDC7A"
                     /note="hexamer: AATAAA"
     polyA_site      4851
                     /gene="KLHDC7A"
                     /note="major polyA site"
     regulatory      5002..5007
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLHDC7A"
                     /note="hexamer: ATTAAA"
     polyA_site      5031
                     /gene="KLHDC7A"
ORIGIN      
        1 aattattaat cagattcttg acattcctca gccccaggtt ggctggagaa gcatgttccc
       61 cagaggagca gaggcccagg actggcattt ggatatgcag ctgaccggca aggtggtgct
      121 gtcagccgct gccctgctcc tggtgactgt ggcctacagg ctgtacaagt cgaggcctgc
      181 cccagcccag cggtggggtg ggaatggcca ggcagaagcc aaggaggaag cagagggctc
      241 agggcagcct gctgtacagg aggcttctcc tggggtgctc ctgagggggc caagacgtcg
      301 gaggagcagc aagcgggctg aagcaccaca gggctgcagc tgtgagaatc caagaggccc
      361 ctatgtcctg gtcacggggg ccacttccac agacaggaag ccccagagaa aaggctcagg
      421 tgaggagcgg ggcgggcagg gctcggactc tgagcaggtg cctccttgct gccccagcca
      481 ggaaaccaga acagctgttg gcagtaaccc tgaccctccc catttccccc gcttgggcag
      541 cgaaccgaag agctccccag ctggactcat tgcagcagcc gacggcagct gtgccggtgg
      601 tgagccttct ccatggcagg acagtaaacc ccgtgagcat ccaggactgg ggcaactaga
      661 acctccccac tgtcactacg tggctccctt gcaaggcagc agtgacatga accagagctg
      721 ggtcttcacc cgtgtgatag gggtcagcag agaagaggct ggggctctcg aggctgcctc
      781 cgatgttgac ctgaccctgc atcagcagga gggcgccccc aactcctcct ataccttctc
      841 atccatagcc cgcgtccgaa tggaggagca tttcatacag aaggcggagg gggttgagcc
      901 ccggctcaag ggcaaggtgt acgactacta tgtggaatct acctctcagg ccatcttcca
      961 gggcaggctg gctcccagga cagcagccct gactgaggtt ccatccccta ggccaccgcc
     1021 agggtccctg ggaacagggg ctgcctcggg aggccaagcc ggtgacacaa agggtgcagc
     1081 cgaaagagcc gcctccccgc agacagggcc gtggccctcc acccgaggct tcagccggaa
     1141 ggagagcctt ctgcagatag cggagaaccc agagctgcag ctgcagccag atggcttccg
     1201 gctccccgct ccaccctgcc cagacccggg cgccctgcct ggcttaggca gaagcagccg
     1261 ggagccccat gtgcagccgg tggccgggac caatttcttc catatcccgc tcacccctgc
     1321 ttcagcccca caggtccgcc tggatctggg caattgctat gaggtgctga ccttggccaa
     1381 gaggcagaac ctggaggccc tgaaagaggc ggcctacaag gtgatgagcg aaaactacct
     1441 gcaggtgctg cgcagcccgg acatctacgg gtgcctgagc ggggcagagc gcgagctgat
     1501 cctgcagcgc cggctccggg gccgccagta cctggtggtg gctgacgtgt gccccaagga
     1561 agactccggc ggcctctgtt gctatgacga tgagcaggat gtctggcgcc cgctggctcg
     1621 catgcccccc gaggccgtgt cccggggctg tgccatctgc agtctcttca attatctctt
     1681 cgtggtgtcc ggctgccagg ggcccgggca ccagccctcc agccgcgtct tctgctacaa
     1741 cccgctcacg gggatctgga gcgaggtgtg cccgctgaac caggcccggc cgcactgccg
     1801 gctggtggcc ctggacgggc acctgtatgc catcggcgga gagtgtctga actcggtgga
     1861 gcgttacgac ccccgcctgg accgctggga ctttgccccg ccgctcccca gtgacacgtt
     1921 cgccctggcg cacacggcca cggtgcgtgc caaggaaatc ttcgtcaccg gcggctcgct
     1981 gcgcttcctg ctgttccgct tctctgcgca ggagcagcgc tggtgggccg gccccaccgg
     2041 gggcagcaag gaccgcacgg ccgagatggt ggcggtcaac ggctttctct accgctttga
     2101 cctcaaccgc agcctgggca tcgccgtgta ccgctgcagc gccagcaccc ggctctggta
     2161 cgagtgcgcc acgtaccgga cgccttaccc ggatgccttc cagtgcgccg tggtggacaa
     2221 cctcatctac tgcgtgggac gccggagcac cctctgcttc ctagcagact ctgtctcacc
     2281 caggtttgtg cccaaggagc tgcggagttt cccggccccg cagggcaccc tcctgcccac
     2341 cgtcctgacc ttgcccaccc ccgatttgcc tcagaccagg gtctagcagt ccctcaactg
     2401 agctcctcat gcaaagctgg gggccaccgg gctccactgc cagccgtccc tctgggggcc
     2461 atttctaggc aaacaggcaa cccaggaatg tggccatcaa gaggtgaatt ccggtccttt
     2521 ctcctcccct agctggggag agagggatct tagatgagtc ttacccttca tgggctgcag
     2581 aggccccact gcagaaaaga ggaccaggag ctggtgttcc aaggcagaag gcattcatgt
     2641 cttcagggat gaccgccctt gcttcaactc tgaattcttg gggggataca ccgggacccc
     2701 accaaagctt agggggcata gtctttttgc aatcacaatt ctaggagcca gttgacccca
     2761 gcagcccctc gctagttgct ctggagaggg gttggctctc tgagccatca gtgccccttc
     2821 ctaaacatca gccactgggc cccacctcca cagttcccag aagcaccggg acacacaggt
     2881 gggaaagatg gaggcaggtg acttgggcag ggccaggaag gagccgaggg agccccaggg
     2941 gccctggcca gagggagtgg tggtttgaaa agtagaacag ctgaagctgg ggccagccta
     3001 ggagactctt gcttgcgaga aaatatacca aagcccacat tacttttctc cttattggaa
     3061 gaaagagaag cagccattgt accaagctat cttctggtgg aggtctgcta aggatacacg
     3121 gaggtctcag caaagggaag aaactatgtg atccaagggc caccctgctc ctcggccctg
     3181 cccatgttaa ctgaccattg cactcattct cagatctgta gccgtcttcc tgtctggaag
     3241 ctggggcaac caccaccagt cagcacttca gggtgacagc ataatttgcc ctccttgtgc
     3301 caggtacggt cacctggttt gccgcattca cattttcagg tggatgacca agcggaggaa
     3361 ctagaagagt ctagtgaagc atccagagac tggatctcct ttcacatctg gtttgataaa
     3421 ctccgaatga aggagacccc cagcctcagg aaagcacctg tccttccagg agggacggga
     3481 gagagcctga cccagtgtat taccacagcc cttgttccac ctctgaggga gacagtgaca
     3541 gatgggaagg cagtgatgct cttggtccca gccagaagcc aggggagatg ggaggtacac
     3601 cagagcaggg cctgacaagg aagaaaataa ggatgctttg gacctcagtg tccttgtctt
     3661 gaaaatggga aggacaattc atgtccctgt ctgccctggg gataaatgag aggataaaag
     3721 agaaagttct tcccagtttc ccaggtggtc ccagctagat cctgtgtcca cggaagctgc
     3781 tggtgcccag gctgtgggtc ttgttggaag aagcaggact ggaacaaagg atgaaaagga
     3841 ggttggcatg gacataagag gagagcttgc actggaccac cgaagaccac catccctggt
     3901 ctgggctctg gcaccaggct ctgccagtgg cagctcagag gccacagggt gacattggcc
     3961 acacccccac cccacttccc tggcctgggc ctcgaaagat gaagcaactg aatttattct
     4021 taaatcagag accaggaagg gaaagtcagc tggggccatg gctaccttct tgggagagtg
     4081 acccctgaac ccagccaagg ccacattcaa gctcagtgtc aacactaggc atgaacctcc
     4141 aagggacctg tgggctgggg cagaatggct tcagtgacaa gactcaaagg aggcactagc
     4201 attgtgctgc tggactgggg gaaggacttg cttgggagga gaactctaca taggagctgg
     4261 gggcaggtgg acctagatcc aaccttcaac ccctagtgag gggccaggca gaggacaagg
     4321 caacaactaa gctaggtaaa gttctggaaa gtttccaagc ccaggaggaa caaggaccac
     4381 tctggaaaaa cattccaaag cccattgcat acctgtggta gagactaggg gagtgattcc
     4441 agggataaga cggacaaatg tgttccaggc cccagctgat ggtgggtgtg gtcttcataa
     4501 tgagaggtgg agctgagatt tgggcctggg ctgggaagag gagtacacag tccatctgat
     4561 ccacctctct tatggttcca ttggcaaaat cattcatcag tcgtcctatc ttttcctggc
     4621 gagcgctcac aatggcttca taagtgtttc aatacagtgt cccaggcagt cactacctat
     4681 agattagagc tgatgtgctg gcctggggct ctagagctgg gcttcaggaa gaatgtggtc
     4741 agggccatca gggtggaaca aggtagctca agaccttgga aagacaccct gagggcacaa
     4801 tcgtccttgc agtttaagat gacactttaa aaataaattc tttcctaatg atggcttgag
     4861 tcctgccact caatgggagc atcagcggaa cccgtagcat cttatttgga attgacattc
     4921 tctattgtaa ttttgttcct gtttattttt aagttttctt tttgtttcac tggaaaggaa
     4981 agatgatgct ctgttttaaa cattaaaagt atacaagttg ctttgttaca ataaaactaa
     5041 atatg
//
