LOCUS       NM_057161               1869 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens kelch domain containing 3 (KLHDC3), transcript variant
            1, mRNA.
ACCESSION   NM_057161
VERSION     NM_057161.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1869)
  AUTHORS   Liu,Y., Luo,Y., Yan,S., Lian,Y.F., Wu,S., Xu,M., Feng,L., Zhang,X.,
            Li,R., Zhang,X., Feng,Q.S., Zeng,Y.X. and Zhang,H.
  TITLE     CRL2KLHDC3 mediates p14ARF N-terminal ubiquitylation degradation to
            promote non-small cell lung carcinoma progression
  JOURNAL   Oncogene 41 (22), 3104-3117 (2022)
   PUBMED   35468939
  REMARK    GeneRIF: CRL2(KLHDC3) mediates p14ARF N-terminal ubiquitylation
            degradation to promote non-small cell lung carcinoma progression.
REFERENCE   2  (bases 1 to 1869)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1869)
  AUTHORS   Koren,I., Timms,R.T., Kula,T., Xu,Q., Li,M.Z. and Elledge,S.J.
  TITLE     The Eukaryotic Proteome Is Shaped by E3 Ubiquitin Ligases Targeting
            C-Terminal Degrons
  JOURNAL   Cell 173 (7), 1622-1635 (2018)
   PUBMED   29779948
REFERENCE   4  (bases 1 to 1869)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 1869)
  AUTHORS   Lin,H.C., Ho,S.C., Chen,Y.Y., Khoo,K.H., Hsu,P.H. and Yen,H.C.
  TITLE     SELENOPROTEINS. CRL2 aids elimination of truncated selenoproteins
            produced by failed UGA/Sec decoding
  JOURNAL   Science 349 (6243), 91-95 (2015)
   PUBMED   26138980
REFERENCE   6  (bases 1 to 1869)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   7  (bases 1 to 1869)
  AUTHORS   Ohinata,Y., Sutou,S. and Mitsui,Y.
  TITLE     Peas-Mea1-Ppp2r5d overlapping gene complex: a transposon
            mediated-gene formation in mammals
  JOURNAL   DNA Res 10 (2), 79-84 (2003)
   PUBMED   12755172
REFERENCE   8  (bases 1 to 1869)
  AUTHORS   Hermey,G., Keat,S.J., Madsen,P., Jacobsen,C., Petersen,C.M. and
            Gliemann,J.
  TITLE     Characterization of sorCS1, an alternatively spliced receptor with
            completely different cytoplasmic domains that mediate different
            trafficking in cells
  JOURNAL   J Biol Chem 278 (9), 7390-7396 (2003)
   PUBMED   12482870
REFERENCE   9  (bases 1 to 1869)
  AUTHORS   Ohinata,Y., Sutou,S. and Mitsui,Y.
  TITLE     A novel testis-specific RAG2-like protein, Peas: its expression in
            pachytene spermatocyte cytoplasm and meiotic chromatin
  JOURNAL   FEBS Lett 537 (1-3), 1-5 (2003)
   PUBMED   12606021
  REMARK    GeneRIF: cloned human and mouse Peas cDNAs (hPEAS/mPeas) and
            analyzed their tissue and stage-specific expressions; may be
            involved in meiotic recombination process
REFERENCE   10 (bases 1 to 1869)
  AUTHORS   Ohinata,Y., Sutou,S., Kondo,M., Takahashi,T. and Mitsui,Y.
  TITLE     Male-enhanced antigen-1 gene flanked by two overlapping genes is
            expressed in late spermatogenesis
  JOURNAL   Biol Reprod 67 (6), 1824-1831 (2002)
   PUBMED   12444059
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC395338.1 and BC001789.1.
            
            On Nov 22, 2018 this sequence version replaced NM_057161.3.
            
            Summary: The protein encoded by this gene contains six repeated
            kelch motifs that are structurally similar to recombination
            activating gene 2, a protein involved in the activation of the
            V(D)J recombination. In mouse, this gene is found to be expressed
            specifically in testis. Its expression in pachytene spermatocytes
            is localized to cytoplasma and meiotic chromatin, suggesting that
            this gene may be involved in meiotic recombination. [provided by
            RefSeq, Jun 2012].
            
            Transcript Variant: This variant (1) encodes the functional
            protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1302.1, SRR1163655.6325.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000326974.9/ ENSP00000313995.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                DC395338.1         147-165
            20-1869             BC001789.1         1-1850
FEATURES             Location/Qualifiers
     source          1..1869
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.1"
     gene            1..1869
                     /gene="KLHDC3"
                     /gene_synonym="dJ20C7.3; PEAS"
                     /note="kelch domain containing 3"
                     /db_xref="GeneID:116138"
                     /db_xref="HGNC:HGNC:20704"
                     /db_xref="MIM:611248"
     exon            1..100
                     /gene="KLHDC3"
                     /gene_synonym="dJ20C7.3; PEAS"
                     /inference="alignment:Splign:2.1.0"
     exon            101..313
                     /gene="KLHDC3"
                     /gene_synonym="dJ20C7.3; PEAS"
                     /inference="alignment:Splign:2.1.0"
     CDS             160..1308
                     /gene="KLHDC3"
                     /gene_synonym="dJ20C7.3; PEAS"
                     /note="testis intracellular mediator protein"
                     /codon_start=1
                     /product="kelch domain-containing protein 3"
                     /protein_id="NP_476502.1"
                     /db_xref="CCDS:CCDS4880.1"
                     /db_xref="GeneID:116138"
                     /db_xref="HGNC:HGNC:20704"
                     /db_xref="MIM:611248"
                     /translation="MLRWTVHLEGGPRRVNHAAVAVGHRVYSFGGYCSGEDYETLRQI
                     DVHIFNAVSLRWTKLPPVKSAIRGQAPVVPYMRYGHSTVLIDDTVLLWGGRNDTEGAC
                     NVLYAFDVNTHKWFTPRVSGTVPGARDGHSACVLGKIMYIFGGYEQQADCFSNDIHKL
                     DTSTMTWTLICTKGSPARWRDFHSATMLGSHMYVFGGRADRFGPFHSNNEIYCNRIRV
                     FDTRTEAWLDCPPTPVLPEGRRSHSAFGYNGELYIFGGYNARLNRHFHDLWKFNPVSF
                     TWKKIEPKGKGPCPRRRQCCCIVGDKIVLFGGTSPSPEEGLGDEFDLIDHSDLHILDF
                     SPSLKTLCKLAVIQYNLDQSCLPHDIRWELNAMTTNSNISRPIVSSHG"
     exon            314..490
                     /gene="KLHDC3"
                     /gene_synonym="dJ20C7.3; PEAS"
                     /inference="alignment:Splign:2.1.0"
     exon            491..606
                     /gene="KLHDC3"
                     /gene_synonym="dJ20C7.3; PEAS"
                     /inference="alignment:Splign:2.1.0"
     exon            607..678
                     /gene="KLHDC3"
                     /gene_synonym="dJ20C7.3; PEAS"
                     /inference="alignment:Splign:2.1.0"
     exon            679..892
                     /gene="KLHDC3"
                     /gene_synonym="dJ20C7.3; PEAS"
                     /inference="alignment:Splign:2.1.0"
     exon            893..979
                     /gene="KLHDC3"
                     /gene_synonym="dJ20C7.3; PEAS"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1088
                     /gene="KLHDC3"
                     /gene_synonym="dJ20C7.3; PEAS"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1162
                     /gene="KLHDC3"
                     /gene_synonym="dJ20C7.3; PEAS"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1241
                     /gene="KLHDC3"
                     /gene_synonym="dJ20C7.3; PEAS"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1869
                     /gene="KLHDC3"
                     /gene_synonym="dJ20C7.3; PEAS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1855..1860
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLHDC3"
                     /gene_synonym="dJ20C7.3; PEAS"
                     /note="hexamer: ATTAAA"
     polyA_site      1869
                     /gene="KLHDC3"
                     /gene_synonym="dJ20C7.3; PEAS"
                     /note="major polyA site"
ORIGIN      
        1 gtttatctcg ttggggacta aggcgtcggt tggcgcgcaa cgggttctag gctgcaggca
       61 gctcgaggac ccgcggcccc gccccggctc ggcctggcag atagcagagg cagcaggccg
      121 tgccgggggg gcatgttgct gtaaccagtg gcccagggga tgttacggtg gacagtgcac
      181 ctggagggcg ggccccgcag ggtgaaccat gctgcagtgg ctgtcgggca tcgggtatac
      241 tccttcgggg gttactgctc tggtgaagac tatgagacac tgcgtcagat agatgtgcac
      301 attttcaatg cagtgtcctt gcgttggaca aagctgcccc cggtgaagtc tgccatccgt
      361 gggcaagctc ctgtggtacc ctacatgcgc tatggacact caaccgtcct catcgacgac
      421 acagtcctcc tttggggcgg gcggaatgac accgaagggg cctgcaatgt gctctatgcc
      481 tttgacgtca atacgcacaa gtggttcaca ccccgagtgt cagggacagt tcctggggcc
      541 cgggatggac attcagcctg tgtcctaggc aagatcatgt acatttttgg gggctacgag
      601 cagcaggcgg actgtttttc caatgacatt cacaagctag ataccagcac catgacatgg
      661 actcttatct gtacaaaggg cagccctgca cgctggaggg acttccactc agccacaatg
      721 ctgggaagtc acatgtatgt ctttgggggc cgtgccgacc gctttgggcc attccattcc
      781 aacaatgaga tttactgcaa ccgcattcga gtctttgaca ccagaactga ggcttggctg
      841 gactgtcccc cgactccagt gctgcctgag gggcgccgga gccactcggc ctttggctac
      901 aatggggagc tgtacatctt tggtggttat aatgcaaggc tgaaccggca cttccatgac
      961 ctctggaagt ttaatcctgt gtcctttacc tggaaaaaga ttgaaccgaa ggggaagggg
     1021 ccatgtcccc gccggcgcca gtgctgctgt attgttggtg acaagattgt cctctttggg
     1081 ggtaccagtc catctcctga ggaaggcctg ggagatgaat ttgaccttat agatcattct
     1141 gacttacaca ttttggactt tagccctagt ctgaagactc tgtgcaaact ggccgtgatt
     1201 cagtataacc tagaccagtc ctgtttgcct catgatatca ggtgggagct gaatgccatg
     1261 accaccaaca gcaatatcag tcgccccatc gtctcctccc atgggtagga ggaagtttct
     1321 gccacctccc ctcctgagcc tgctgtcatc ttcactgccc ctgcccatct gtcacccacc
     1381 tgctcctttg acccctggac ttggtatacc tccatgtgga gttgttgggc gagaggtgtt
     1441 ctctgtgctg tgaattcagt ggggagctgt agcggggtgg gggctaggtt cctcccccct
     1501 tgggccgagg gccccttccc cttggtgctc tgtccccatc cacctccttt cagctgctcc
     1561 tgggcctcag ctctgcccag ggccagccag gttctgctgg gaagggaagg gaatggggag
     1621 aagggagaag caagcagtgt ctgagcctca ggagcttccc cctccccctt tgcctatccc
     1681 ctcccctctg cttgagcctt gagccttgac tgggagctga aaggagttgc agctgttggc
     1741 atgagacctc cttctccccg tcttggggag gtggggacca gcagataaat cccacccttc
     1801 cttgagctgt cgctgtactc tgaagttcag ccagctcaga ttttataaaa attaattaaa
     1861 atctccaaa
//
