LOCUS       NM_014997               6398 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens kelch domain containing 10 (KLHDC10), mRNA.
ACCESSION   NM_014997 XM_045954 XM_379924
VERSION     NM_014997.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6398)
  AUTHORS   Patil,P.R., Burroughs,A.M., Misra,M., Cerullo,F., Costas-Insua,C.,
            Hung,H.C., Dikic,I., Aravind,L. and Joazeiro,C.A.P.
  TITLE     Mechanism and evolutionary origins of alanine-tail C-degron
            recognition by E3 ligases Pirh2 and CRL2-KLHDC10
  JOURNAL   Cell Rep 42 (9), 113100 (2023)
   PUBMED   37676773
  REMARK    GeneRIF: Mechanism and evolutionary origins of alanine-tail
            C-degron recognition by E3 ligases Pirh2 and CRL2-KLHDC10.
REFERENCE   2  (bases 1 to 6398)
  AUTHORS   Thrun,A., Garzia,A., Kigoshi-Tansho,Y., Patil,P.R., Umbaugh,C.S.,
            Dallinger,T., Liu,J., Kreger,S., Patrizi,A., Cox,G.A., Tuschl,T.
            and Joazeiro,C.A.P.
  TITLE     Convergence of mammalian RQC and C-end rule proteolytic pathways
            via alanine tailing
  JOURNAL   Mol Cell 81 (10), 2112-2122 (2021)
   PUBMED   33909987
REFERENCE   3  (bases 1 to 6398)
  AUTHORS   Koren,I., Timms,R.T., Kula,T., Xu,Q., Li,M.Z. and Elledge,S.J.
  TITLE     The Eukaryotic Proteome Is Shaped by E3 Ubiquitin Ligases Targeting
            C-Terminal Degrons
  JOURNAL   Cell 173 (7), 1622-1635 (2018)
   PUBMED   29779948
REFERENCE   4  (bases 1 to 6398)
  AUTHORS   Taipale,M., Tucker,G., Peng,J., Krykbaeva,I., Lin,Z.Y., Larsen,B.,
            Choi,H., Berger,B., Gingras,A.C. and Lindquist,S.
  TITLE     A quantitative chaperone interaction network reveals the
            architecture of cellular protein homeostasis pathways
  JOURNAL   Cell 158 (2), 434-448 (2014)
   PUBMED   25036637
REFERENCE   5  (bases 1 to 6398)
  AUTHORS   Sekine,Y., Hatanaka,R., Watanabe,T., Sono,N., Iemura,S.,
            Natsume,T., Kuranaga,E., Miura,M., Takeda,K. and Ichijo,H.
  TITLE     The Kelch repeat protein KLHDC10 regulates oxidative stress-induced
            ASK1 activation by suppressing PP5
  JOURNAL   Mol Cell 48 (5), 692-704 (2012)
   PUBMED   23102700
  REMARK    GeneRIF: Suggest that Slim/KLHDC10 is an activator of ASK1,
            contributing to oxidative stress-induced cell death through the
            suppression of PP5.
REFERENCE   6  (bases 1 to 6398)
  AUTHORS   Behrends,C., Sowa,M.E., Gygi,S.P. and Harper,J.W.
  TITLE     Network organization of the human autophagy system
  JOURNAL   Nature 466 (7302), 68-76 (2010)
   PUBMED   20562859
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC044884.1, AC087071.2, BC036464.2 and D87454.1.
            
            On Nov 22, 2018 this sequence version replaced NM_014997.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC036464.2, ERR279869.1249.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000335420.10/ ENSP00000334140.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                BC044884.1         28-88
            62-62               AC087071.2         38023-38023
            63-657              BC044884.1         90-684
            658-1996            BC036464.2         665-2003
            1997-5784           D87454.1           1764-5551
            5785-6398           AC087071.2         102520-103133
FEATURES             Location/Qualifiers
     source          1..6398
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q32.2"
     gene            1..6398
                     /gene="KLHDC10"
                     /gene_synonym="PNAS-138; slim"
                     /note="kelch domain containing 10"
                     /db_xref="GeneID:23008"
                     /db_xref="HGNC:HGNC:22194"
                     /db_xref="MIM:615152"
     exon            1..276
                     /gene="KLHDC10"
                     /gene_synonym="PNAS-138; slim"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..1439
                     /gene="KLHDC10"
                     /gene_synonym="PNAS-138; slim"
                     /note="scruin like at the midline homolog; PNAS-119"
                     /codon_start=1
                     /product="kelch domain-containing protein 10"
                     /protein_id="NP_055812.1"
                     /db_xref="CCDS:CCDS5815.1"
                     /db_xref="GeneID:23008"
                     /db_xref="HGNC:HGNC:22194"
                     /db_xref="MIM:615152"
                     /translation="MSAAQGWDRNRRRGGGAAGAGGGGSGAGGGSGGSGGRGTGQLNR
                     FVQLSGRPHLPGKKKIRWDPVRRRFIQSCPIIRIPNRFLRGHRPPPARSGHRCVADNT
                     NLYVFGGYNPDYDESGGPDNEDYPLFRELWRYHFATGVWHQMGTDGYMPRELASMSLV
                     LHGNNLLVFGGTGIPFGESNGNDVHVCNVKYKRWALLSCRGKKPSRIYGQAMAIINGS
                     LYVFGGTTGYIYSTDLHKLDLNTREWTQLKPNNLSCDLPEERYRHEIAHDGQRIYILG
                     GGTSWTAYSLNKIHAYNLETNAWEEIATKPHEKIGFPAARRCHSCVQIKNDVFICGGY
                     NGEVILGDIWKLNLQTFQWVKLPATMPEPVYFHCAAVTPAGCMYIHGGVVNIHENKRT
                     GSLFKIWLVVPSLLELAWEKLLAAFPNLANLSRTQLLHLGLTQGLIERLK"
     exon            277..363
                     /gene="KLHDC10"
                     /gene_synonym="PNAS-138; slim"
                     /inference="alignment:Splign:2.1.0"
     exon            364..585
                     /gene="KLHDC10"
                     /gene_synonym="PNAS-138; slim"
                     /inference="alignment:Splign:2.1.0"
     exon            586..740
                     /gene="KLHDC10"
                     /gene_synonym="PNAS-138; slim"
                     /inference="alignment:Splign:2.1.0"
     exon            741..889
                     /gene="KLHDC10"
                     /gene_synonym="PNAS-138; slim"
                     /inference="alignment:Splign:2.1.0"
     exon            890..974
                     /gene="KLHDC10"
                     /gene_synonym="PNAS-138; slim"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1041
                     /gene="KLHDC10"
                     /gene_synonym="PNAS-138; slim"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1089
                     /gene="KLHDC10"
                     /gene_synonym="PNAS-138; slim"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1229
                     /gene="KLHDC10"
                     /gene_synonym="PNAS-138; slim"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..6398
                     /gene="KLHDC10"
                     /gene_synonym="PNAS-138; slim"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6378..6383
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLHDC10"
                     /gene_synonym="PNAS-138; slim"
                     /note="hexamer: AATAAA"
     polyA_site      6398
                     /gene="KLHDC10"
                     /gene_synonym="PNAS-138; slim"
                     /note="major polyA site"
ORIGIN      
        1 gcccccttcc cctgtctcct gggtctctgg aggagcccag gaaggaggct ccgctggttc
       61 cgctgggtca ggcgctgacg ggaccgggct gcggcaatcg ttagcgggtc atgtcggccg
      121 cccagggctg ggacaggaac cgccggaggg gaggaggcgc cgccggcgct ggtggcggag
      181 gtagcggggc cggcgggggc agtgggggca gcgggggtcg ggggactggc cagctcaacc
      241 gcttcgtgca actctccggg cggccgcacc tgccaggtaa gaagaaaata cgatgggacc
      301 cagttaggag gcgcttcatt cagtcctgtc ccatcataag gatccctaac aggtttttga
      361 gaggccacag acctccacca gcacgaagtg gacatcgttg tgtggcagat aataccaacc
      421 tatatgtgtt tggaggttat aacccagatt atgatgaatc gggagggcct gataatgaag
      481 actatcctct cttcagggaa ctctggaggt atcattttgc tacaggagta tggcaccaga
      541 tgggcacaga tggctacatg ccccgggaat tggcatctat gtcacttgtg ctgcatggaa
      601 acaacctgtt agtatttgga ggtacgggca tcccatttgg agagagcaac ggcaatgacg
      661 tccatgtgtg taatgtgaag tataagagat gggctttgct cagctgtcgg gggaagaaac
      721 ccagtcgtat atatggacag gctatggcca tcatcaatgg ctccctttat gtctttggag
      781 gtacaaccgg ctatatttac agcacagacc tgcacaagtt agatctcaat accagagagt
      841 ggacacaact gaaaccaaac aacctatcct gtgatctacc agaagagaga taccgacatg
      901 aaattgcaca tgacgggcag aggatttaca tcttgggagg tggtacttcc tggacagcat
      961 attccttaaa caagatccat gcatacaacc ttgaaacgaa tgcctgggag gaaattgcaa
     1021 caaaacccca tgaaaaaata ggctttcctg cagcccgaag gtgtcacagt tgtgttcaaa
     1081 taaaaaatga tgtatttatt tgtgggggct ataatggaga ggtgatcctg ggagatatct
     1141 ggaagttgaa tctgcagact ttccaatggg tgaagctccc agctaccatg ccagagccag
     1201 tttattttca ctgtgcagct gttacaccag ctggttgcat gtacattcat ggaggagtgg
     1261 tgaacatcca tgaaaacaaa cggactgggt cattgtttaa gatctggctg gtggtaccta
     1321 gcctgctgga actggcatgg gagaagctgc ttgcggcctt ccctaacctt gcaaacctct
     1381 cccgaacaca acttctgcac cttggactca cacagggact catcgaacgc ttgaaatgag
     1441 gatttctgga ctgttcattg atactggaaa tgttaattta aagagactcc tttatttatg
     1501 ggcagtgtag aatgtgctac aaagaggatt ggttaccctg atcaaggcct tatttagaaa
     1561 atacatcaga tgcctttctg taaattggtt tttcagttta tggacatctc actttcccac
     1621 gtgcttcctt ctttgcttct gttcctcctg acccattaca tgcacatgta ctcacatact
     1681 ccctcttcct tctcgatgga gttaagggaa agcctgaaag taccttaata atgttattaa
     1741 tcaagacaga ttccttttta aaggaattct gaatagttcc atgtcataca atattctaga
     1801 aattaaaaca tcatcaacat aaagaaaaat gaaattaaaa aatttttaca tctagcaaca
     1861 gcaacaacca caaatttagg ggaagctgag aaggctaacc ttgggaatct tgcaggttat
     1921 acttaaacct agatgtttaa cttagtgttt tcaagatgtg tctaactgag tagtagctgg
     1981 gtctgatggc agcagtgctt gccatcttgt tgcacagata actcaaacct accctttggc
     2041 tttgaaggaa ggttaagcag cccagcaact cttggttagt gatttctttc tcatcctcat
     2101 ggtgccagca gtggttagag ttggtttgtc aaaagactta cgtgtgtgtc gtggtcgtgc
     2161 tctttgttgt tgctcttaga aattatggca ccaagaatgt ttcaaacgga aaaacttgtg
     2221 gtggccaaag ttcttcattc tggcagtttt gaaactctct tatgcttatt aatggtttta
     2281 aatatctctt tgacttcttc atggggaatt gtagacccta agtatgtggt gtaaatgcca
     2341 tgtaacatga acacaagctc ccgagggagg ccagagaaga gccaggcaga gaaaacctgc
     2401 atcctctggg cttgttaact tggcttccac tcgggctgtg gtctttggct atcatcttgg
     2461 ccatttcctt ttgagaactt gtttcttttc taatctctgg gccaggtacc tgccattttc
     2521 tcaggcagtt ggtccttgat ttttccctta gcttgttgcc ttcttttccg tctgctttaa
     2581 tgtgcatggt gctgtgaata attgtctagt aattggatac aaggtcttgg gggtaaagcc
     2641 acaggtcatc cttcctgaag aaccaagtat catttaaaaa ctagcatgag gaaggaatga
     2701 aactgagtag cattcatttt gtgtgtgtga aattttagtt ctggtttgtt tgatttgttt
     2761 tttttttaat tctaaaaaga atgacataaa ttttcactcg ctttgccatc tggctgctag
     2821 gggagctgag caagaggctc accatgcgca tgtgtaagcc gcaggtgtac tcaaggtgct
     2881 gaaggcgtgc aaggggcagc gctggtcctc ccggggccaa ctcacagcag gagactcgca
     2941 tgggagagtt ggaacacatc tttcctttaa gtgcctcttt tttcacctag cttttaaagt
     3001 tattctttgt ccttcatctc agaagggatc tctttagctt atgtgtggat ttaaaatgac
     3061 ctttgagcta cggttaaaaa gctaccatct ggtgttcagt tctgggaaag agaaaaccgt
     3121 agcctccaga catgctcctg atttctaggc cttatcatac catcccctct gtgatgggtt
     3181 gagttcatgg agcctgtatt ctgggaagtc ttataataac cacgcacctg tgaacgtggg
     3241 tcctttctgg ggagtgagga atgtgggaga gaggcagaaa aaggagcagc tcctctaggg
     3301 gcccatcctc ccacatcttg ccattaccag tctgtgtagc acttaacctc ctgccaccac
     3361 tgccaggctt gctcctccgt tctctcccag agcaagtcag tctgagcagc tccattagtc
     3421 caaaacagag ctttgctgca tgacttcagc ctggcctctg gatatttggt ggaaatatat
     3481 tctaaattga acaagccagg ctgtccaggg tggcaagagg atttttgacc tggatttata
     3541 cagggaccaa agactgaatg ctcagcctct gtgcttagac tttcatggtc cttaggatag
     3601 aagtgagtct ctagccctgc tacaccagag agctgaagag agatgtggtc tggttccatc
     3661 catacttgct ggcatccttt gttaagcctt ctgagggcag tcttctttga ggtagacctt
     3721 ggaggcctga catcgaagac ctgtgtgttt tattttcata aaagtatata tccttggtct
     3781 aaagtgtctt cttttaatat aacactagta aaaatgacat ggtatgacca gcactgagtg
     3841 ctatagaacc acacatgtgt acatgttctg gatgccaaat gagactgtgt gtaaatgact
     3901 aagtgtagat aactagaaat tagatagggg tcatcaggcg tttcggtata cctataacca
     3961 gcactcggaa ttcctgacac tgtttacttg atttaggaaa gtttatgcct gctgcttctc
     4021 tgcctctttg aggtactccc agccgtctta ctacagtcct gtaaatttaa gtgcaatata
     4081 tagaaacata tggatatata cagattatat atagggtgta actataaagc aggtagacta
     4141 cttttttgca tcttggggaa gtgagctcat tactttaggt tcaaattatg ccaagaattt
     4201 tagatgtgat cagctggctt aagccaactc atgtcatgat aaagctggat tttcaagtcc
     4261 atgttttctt actccaactc ttagagactc attgttcctt aggtttgtta gagttgagat
     4321 tttttttctc cctgtcatct ttgtactctc tcatgtttgc atgtcttaca ttttgttgcc
     4381 ggagaacaag gaagtccatc tgtaaggagt ttcctaaacg gagaattaaa acctagtatt
     4441 taacactaac cattctccta tgtatatact aatttatctg ggaatgtaat actttattaa
     4501 atgaagaaaa tgatgctttc ttcatttaat attttccaca tcctggaaaa actataaact
     4561 gacacagaat aggttgaaat cttaactggg gctaaacaaa accctttcca ttggcagaat
     4621 ctcctttttt cagggccata atgacatgat gtaaaaattt gctttaaacc attcatgccc
     4681 ttaaatagct agattttaaa gcataataag catattaaca tttttaagca aaagatacgt
     4741 taacagtgac ctttggttat ccacagtagc aagagtaaag cacagatcat tgaaatccat
     4801 agataatcag tgaatcaact ttcctaccaa acaatagatt catttacatt tctttttcct
     4861 ccctatcctt tcctgtaagc acctgttttt ccatggaatg gggttaatga gtaggtagaa
     4921 aaggaaaagg aataatcagt aggagctgac aaccagtgac catataagca gctgattgcc
     4981 tgtaattagt caggctgaac aattagagtt gaatgctgaa attaggaacc acaggtggta
     5041 atcctgagta gatgtagctc ttcagcgtca tctcctgccc tgagctccag gccatctctc
     5101 taaccaccaa agaactctta gtacctacgg gaaggaaaag ctgtgtgcga cacagaggaa
     5161 actccattat ttgaacacat ttctttggct cttgacaaat acttgctttt cctctaatct
     5221 tgcaagagct atggctcttc tattttccaa tcacacagct tggcatgtag gaaaggttga
     5281 atgatcctct aagactgtgt tggtcttcgt attctgtaaa acccattttt tttttgtggt
     5341 cttacagatg tttagaaagt ggcacaggtt actgaattgt ctacctgcca gcattctgat
     5401 atagcacaaa aagctatttt cctttatttt ttgtattatt ttttattttt ctggcattga
     5461 gctctagggt ggatgagggt ttatggtcct ctgatcataa gctccattct aaaaactggt
     5521 cactgttagc tgaaattgct ttggttcccc aaatgccttg gaactccaga cgcacccgca
     5581 gggcctgagg taggcttcat agagttctag gacttccgtg tgcgttgcca ccagatcctg
     5641 cccagcaatg gcctttccct tctaaggtca ttagattcag ccaaaagcga cctcttctct
     5701 agtccggtgt tacgaacaga agttctgagt tgtgctacaa aagtagttcc atctttttgg
     5761 tgtaattttc atgtttttaa tttgaaaaaa aaaaaaaaaa aaaaacaact ttttataagt
     5821 tttttaaggg ccctgcttag tcagtgtaca gggtggagtc agaggcagtt ttcagaaaaa
     5881 aacaaaaaac aatttcacca agcggtagta attgttgttt tactagttat acatttagaa
     5941 tataaaggag gcatcagaaa acacactctc taaagccact tccttgtgca cagagtctgc
     6001 acagggagag cacaggcatc tccctggaaa agcacctgcc aatgacgaat ttcatggaag
     6061 aacctaggca agaaaggaag cctctttctg agacacagtc tctgagaggt gagcctagct
     6121 ttgctcttcc tacagggtat gcttgggcca tacacaatgc tcgccttact ttaaagctat
     6181 tttgccacag tcctgttaaa tagtgtggac gtccttttgc agtctggtgt gcatgccata
     6241 tgatcaggac agcttttcca ctttactcgg tttcctacaa gcaagtagga aatacagtga
     6301 atttacccta aaatgtccaa tctgtattta tgtaccttgt cagtgttttg ctgttggttt
     6361 tctaaaacaa tctgatcaat aaatcttatc caaatcaa
//
