LOCUS       NM_001206               5201 bp    mRNA    linear   PRI 30-APR-2025
DEFINITION  Homo sapiens KLF transcription factor 9 (KLF9), mRNA.
ACCESSION   NM_001206
VERSION     NM_001206.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5201)
  AUTHORS   Guo,Y., Tian,S., Li,H., Zuo,S., Yu,C. and Sun,C.
  TITLE     Transcription factor KLF9 inhibits the proliferation, invasion, and
            migration of pancreatic cancer cells by repressing KIAA1522
  JOURNAL   Asia Pac J Clin Oncol 20 (3), 423-432 (2024)
   PUBMED   38520660
  REMARK    GeneRIF: Transcription factor KLF9 inhibits the proliferation,
            invasion, and migration of pancreatic cancer cells by repressing
            KIAA1522.
REFERENCE   2  (bases 1 to 5201)
  AUTHORS   Dong,C., Yao,J., Wu,Z., Hu,J., Sun,L., Wu,Z., Yan,J. and Yin,X.
  TITLE     PAFAH1B3 is a KLF9 target gene that promotes proliferation and
            metastasis in pancreatic cancer
  JOURNAL   Sci Rep 14 (1), 9196 (2024)
   PUBMED   38649699
  REMARK    GeneRIF: PAFAH1B3 is a KLF9 target gene that promotes proliferation
            and metastasis in pancreatic cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5201)
  AUTHORS   Lafontaine,N., Shore,C.J., Campbell,P.J., Mullin,B.H., Brown,S.J.,
            Panicker,V., Dudbridge,F., Brix,T.H., Hegedus,L., Wilson,S.G.,
            Bell,J.T. and Walsh,J.P.
  TITLE     Epigenome-wide Association Study Shows Differential DNA Methylation
            of MDC1, KLF9, and CUTA in Autoimmune Thyroid Disease
  JOURNAL   J Clin Endocrinol Metab 109 (4), 992-999 (2024)
   PUBMED   37962983
  REMARK    GeneRIF: Epigenome-wide Association Study Shows Differential DNA
            Methylation of MDC1, KLF9, and CUTA in Autoimmune Thyroid Disease.
REFERENCE   4  (bases 1 to 5201)
  AUTHORS   Shen,C. and Wang,H.
  TITLE     Age-Associated KLF9 Enhances the Inflammatory Response of Alveolar
            Macrophages Via Regulating TLR2 Expression
  JOURNAL   Rejuvenation Res 27 (1), 17-23 (2024)
   PUBMED   38062733
  REMARK    GeneRIF: Age-Associated KLF9 Enhances the Inflammatory Response of
            Alveolar Macrophages Via Regulating TLR2 Expression.
REFERENCE   5  (bases 1 to 5201)
  AUTHORS   Wu,S., Zhu,J., Jiang,T., Cui,T., Zuo,Q., Zheng,G., Li,G., Zhou,J.
            and Chen,X.
  TITLE     Long non-coding RNA ACTA2-AS1 suppresses metastasis of papillary
            thyroid cancer via regulation of miR-4428/KLF9 axis
  JOURNAL   Clin Epigenetics 16 (1), 10 (2024)
   PUBMED   38195623
  REMARK    GeneRIF: Long non-coding RNA ACTA2-AS1 suppresses metastasis of
            papillary thyroid cancer via regulation of miR-4428/KLF9 axis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5201)
  AUTHORS   Kobayashi,A., Sogawa,K., Imataka,H. and Fujii-Kuriyama,Y.
  TITLE     Analysis of functional domains of a GC box-binding protein, BTEB
  JOURNAL   J Biochem 117 (1), 91-95 (1995)
   PUBMED   7775404
REFERENCE   7  (bases 1 to 5201)
  AUTHORS   Imataka,H., Nakayama,K., Yasumoto,K., Mizuno,A., Fujii-Kuriyama,Y.
            and Hayami,M.
  TITLE     Cell-specific translational control of transcription factor BTEB
            expression. The role of an upstream AUG in the 5'-untranslated
            region
  JOURNAL   J Biol Chem 269 (32), 20668-20673 (1994)
   PUBMED   8051167
REFERENCE   8  (bases 1 to 5201)
  AUTHORS   Hashimoto,H., Toide,K., Kitamura,R., Fujita,M., Tagawa,S., Itoh,S.
            and Kamataki,T.
  TITLE     Gene structure of CYP3A4, an adult-specific form of cytochrome P450
            in human livers, and its transcriptional control
  JOURNAL   Eur J Biochem 218 (2), 585-595 (1993)
   PUBMED   8269949
REFERENCE   9  (bases 1 to 5201)
  AUTHORS   Imataka,H., Mizuno,A., Fujii-Kuriyama,Y. and Hayami,M.
  TITLE     Activation of the human immunodeficiency virus type 1 long terminal
            repeat by BTEB, a GC box-binding transcription factor
  JOURNAL   AIDS Res Hum Retroviruses 9 (9), 825-831 (1993)
   PUBMED   8257632
REFERENCE   10 (bases 1 to 5201)
  AUTHORS   Imataka,H., Sogawa,K., Yasumoto,K., Kikuchi,Y., Sasano,K.,
            Kobayashi,A., Hayami,M. and Fujii-Kuriyama,Y.
  TITLE     Two regulatory proteins that bind to the basic transcription
            element (BTE), a GC box sequence in the promoter region of the rat
            P-4501A1 gene
  JOURNAL   EMBO J 11 (10), 3663-3671 (1992)
   PUBMED   1356762
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL162390.9.
            
            On Nov 19, 2020 this sequence version replaced NM_001206.3.
            
            Summary: The protein encoded by this gene is a transcription factor
            that binds to GC box elements located in the promoter. Binding of
            the encoded protein to a single GC box inhibits mRNA expression
            while binding to tandemly repeated GC box elements activates
            transcription. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D31716.1, SRR14038196.310685.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377126.4/ ENSP00000366330.2
            RefSeq Select criteria :: based on single protein-coding transcript
            regulatory uORF        :: PMID: 8051167
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1799              AL162390.9         178630-180428       c
            1800-5201           AL162390.9         150375-153776       c
FEATURES             Location/Qualifiers
     source          1..5201
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q21.12"
     gene            1..5201
                     /gene="KLF9"
                     /gene_synonym="BTEB; BTEB1"
                     /note="KLF transcription factor 9"
                     /db_xref="GeneID:687"
                     /db_xref="HGNC:HGNC:1123"
                     /db_xref="MIM:602902"
     exon            1..1799
                     /gene="KLF9"
                     /gene_synonym="BTEB; BTEB1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      682..840
                     /regulatory_class="uORF"
                     /gene="KLF9"
                     /gene_synonym="BTEB; BTEB1"
                     /experiment="DESCRIPTION:regulatory uORF[PMID:8051167]"
                     /note="this uORF is predicted to encode a 52 aa peptide
                     (PMID:8051167)"
     CDS             1295..2029
                     /gene="KLF9"
                     /gene_synonym="BTEB; BTEB1"
                     /note="Kruppel like factor 9; BTE-binding protein 1;
                     GC-box-binding protein 1; transcription factor BTEB1;
                     basic transcription element-binding protein 1"
                     /codon_start=1
                     /product="Krueppel-like factor 9"
                     /protein_id="NP_001197.1"
                     /db_xref="CCDS:CCDS6633.1"
                     /db_xref="GeneID:687"
                     /db_xref="HGNC:HGNC:1123"
                     /db_xref="MIM:602902"
                     /translation="MSAAAYMDFVAAQCLVSISNRAAVPEHGVAPDAERLRLPEREVT
                     KEHGDPGDTWKDYCTLVTIAKSLLDLNKYRPIQTPSVCSDSLESPDEDMGSDSDVTTE
                     SGSSPSHSPEERQDPGSAPSPLSLLHPGVAAKGKHASEKRHKCPYSGCGKVYGKSSHL
                     KAHYRVHTGERPFPCTWPDCLKKFSRSDELTRHYRTHTGEKQFRCPLCEKRFMRSDHL
                     TKHARRHTEFHPSMIKRSKKALANAL"
     exon            1800..5201
                     /gene="KLF9"
                     /gene_synonym="BTEB; BTEB1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5180..5185
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLF9"
                     /gene_synonym="BTEB; BTEB1"
                     /note="hexamer: AATAAA"
     polyA_site      5201
                     /gene="KLF9"
                     /gene_synonym="BTEB; BTEB1"
                     /note="major polyA site"
ORIGIN      
        1 cttactcatt tgtgtttatt cttggactta tcctgacata atggggtttt tttaattata
       61 gattcacact gcatttattc atcacccctg tcctctcatc cataactcaa atttactacc
      121 agcaacacaa aatacaaaga tgtgtccagt ttcactacag ctcttcgcgt ttacaagtgt
      181 cgagcgcttg ctttcggaac gcccttgtga ttggccgagc caatgccagt gacatcaacc
      241 aacttacttt tgattggaag gctggttgct gggactgtag cgtttgcagg aagtcactta
      301 actgtttggg agctggaaaa ccgaagctga agttctcttt tgccatagga acgagcgcaa
      361 ctgactagga aagatgtgtc ccaaagctcc gcaagctgga acgtgagcca ggaggcccgg
      421 accggccacg ggaccgcgag gcactccgaa agtgtgcggc tgccccttcc ctgcctccca
      481 gctgttaccc ttttaaatgt cagtgttcga ggctgtaggg gtagcacgag gcagcgaaac
      541 ggaacagtcg gattggccgc acgcctcagt tctagacgca cctctccacc gaaggccgtt
      601 ctgactggca gggggagaaa gtaaacagag ttgaatcacc ctccccactg gccaattgga
      661 gggggtttgg tttgtgacgt gatgggattc tgcgaaattg ttactgagca agagaatgcc
      721 ggaacggtgc ggaccggccg gagcaggggt tcagaagccg tcagtggact cgggaaaaag
      781 tgtctcttag acctggcgct cggcgggacc ctcgccaccc gcgtcggggt gatcgggtga
      841 atgtcctggg gctttggctc gacggcgagg cggccgaggg cgtgcacctc tcttgcagtt
      901 tcctctccca gcgcctcggg ggcgttttca gtcgaataaa cttgcgaccg ccacgtgtgg
      961 catctttcca agggagccgg ctcagagggg ccggcgcgcc cgtcggggga tcgcggccgg
     1021 cgcggggcag gggcggcggc tagaggcggc ggcgcggcgg agcccggggc cgtggatgct
     1081 gcgtgcggag gcgctgccgg ttacgtaaag atgaggggct gaggtcgcct cggcgctcct
     1141 gcgagtcgga agcgccccgc gcccccgccc ccttggccgc cgcgccgtgc cgcgccgcgc
     1201 cgcgctcgtc gtccgaggcc agggcagggc gagccgaacc tccgcagcca ccgccaagtt
     1261 tgtccgcgcc gcctgggctg ccgtcgcccg caccatgtcc gcggccgcct acatggactt
     1321 cgtggctgcc cagtgtctgg tttccatttc gaaccgcgct gcggtgccgg agcatggggt
     1381 cgctccggac gccgagcggc tgcgactacc tgagcgcgag gtgaccaagg agcacggtga
     1441 cccgggggac acctggaagg attactgcac actggtcacc atcgccaaga gcttgttgga
     1501 cctgaacaag taccgaccca tccagacccc ctccgtgtgc agcgacagtc tggaaagtcc
     1561 agatgaggat atgggatccg acagcgacgt gaccaccgaa tctgggtcga gtccttccca
     1621 cagcccggag gagagacagg atcctggcag cgcgcccagc ccgctctccc tcctccatcc
     1681 tggagtggct gcgaagggga aacacgcctc cgaaaagagg cacaagtgcc cctacagtgg
     1741 ctgtgggaaa gtctatggaa aatcctccca tctcaaagcc cattacagag tgcatacagg
     1801 tgaacggccc tttccctgca cgtggccaga ctgccttaaa aagttctccc gctcagacga
     1861 gctgacccgc cactaccgga cccacactgg ggaaaagcag ttccgctgtc cgctgtgtga
     1921 gaagcgcttc atgaggagtg accacctcac aaagcacgcc cggcggcaca ccgagttcca
     1981 ccccagcatg atcaagcgat cgaaaaaggc gctggccaac gctttgtgag gtgctgcccg
     2041 tggaagccag ggagggatgg accccgaaag gagaaaagta ctcccaggaa acagacgcgt
     2101 gaaaactgag ccccagaaga ggcacacttg acggcacagg aagtcactgc tctttggtca
     2161 atattctgat tttcctctcc ctgcattgtt tttaaaaagc acattgtagc ctaagatcaa
     2221 agtcaacaac actcggtccc cttgaagagg caactctctg aacccgtctc tgactgttgg
     2281 agggaaggca aatgcttttg ggttttttgg tttttgtttt tgtttttttt tctcctttta
     2341 tttttttgcg ggggagggta gggagtgggt gggggggagg ggggtaaggc caagactggg
     2401 gtagaatttt aaagattcaa cactggtgta catatgtccg ctgggtgagt tgacctgtgg
     2461 cctcgcacag tgattctggg ccctttatgc ttgctgtctc tcagaattgt tttcttacct
     2521 tttaatgtaa tgacgagtgt gcttcagttt gtttagcaaa accactctct tgaatcacgt
     2581 taacttttga gattaaaaaa aaaaacgcca tagcacagct gtctttatgc aagcaagagc
     2641 acatctactc cagcatgatc tgtcatctaa agacttgaaa acaaaaaaca gttacttata
     2701 gtcaatgggt aagcagagtc tgaatttata ctaatcaaga caaacctttg aaaggttaca
     2761 ctaagtacag aacttttaaa ccttgctttg tatgagttgt actttttgaa cataagctgc
     2821 acttttattt tctaatgcag aggatgaata agttaaatac atgctttgag gatagaagca
     2881 gatgttctgt ttggcaccac gttataatct gcttatttta caatatacac gtttccctaa
     2941 gaaatcatgg cagagatgtg agggcagaat atacacaaca gatgctgaag gagaaggagg
     3001 gtagtgtttt gcaaaagaaa aagaaaagaa ccaacagaat tttaactcta ttaacttttc
     3061 caaattttcc tatgctttta gttaacatca ttattgtatc ctaatgccac taggggagag
     3121 agcttttgac tctgttgggt tttatttgaa tgtgtgcata acagtaatga gatctggaaa
     3181 cacctatttt ttggggaaaa aggtttgttg gtctccttcc tgtgttccta caaaactccc
     3241 actctcaggt gcaagagtta tgtagaagga aagggagctg aaataggaac agaaaaatca
     3301 acccctataa ctagtgaaca ccaagggaaa ataccacaat gatttcagag gagactctgc
     3361 aaaatcgtcc cttgtggaga atgcaggcaa catggaatac taggaatgaa atcacatcac
     3421 tgtatctttt acatcaatag cctcaccact aatatatctt gtatctaggt gtctataatg
     3481 gctgaaacca ctacatccat ctatgccatt tacctgaaaa cttaactgtg gcctttatga
     3541 ggccagaaaa gtgaactgag ttttcgtagt taagacctca aatgagggga gtcagcagtg
     3601 atcatggggg aaatgtttac attttttttt tcttcagaag taacgctttc tgatgatttt
     3661 atctgatatt taaaacaggg agctatggtg cactctagtt tatacttgcg ctctgaaatg
     3721 tgtaaacata gggtgcctac ctatttcacc tgacccatac tcgtttctga ttcagaatca
     3781 gtgtgggctc ctgcagtggg cgcgggtcac ggctgactcc aacttccaat acaacagcca
     3841 tcactagcac agtgtttttt tgtttaacca acgtagttgt attagtagtt ctataaagag
     3901 aactgctttt aacattaggg actgggagca gtccatggga taaaaaggaa agtgttttct
     3961 cacgagaaaa catgtcagga aaaataaaga acactttcta cctctgtttc agatttttga
     4021 aacacttatt ttaaaccaaa ttttaatttc tgtgtccaaa ataagtttta aggacatctg
     4081 ttcttccata cgaaataggt taggctgcct atttctcact gagctcatgg aatggttctg
     4141 cttatgatac tctgcacgct gccttttagt gagtgaggag tttggggttg cctagcaact
     4201 tgctaacttg taaaaagtca tctttccctc acagaaagaa acgaaagaaa gcaaagcaaa
     4261 gtcagtgaaa gacaatcttt atagtttcag gagtaaatct aaatgtggct tttgtcaagc
     4321 acttagatgg atataaatgc agcaacttgt tttaaaaaaa tgcacaattt acttcccaaa
     4381 aaagttgtta cttgcctttt caagttgttg acaaacacac atttgatatt ctcttatatg
     4441 ttatagtaat gtaacgtata aactcaagcc tttttattct ttgtgattaa atcctgtttt
     4501 aaaatgtcac aaaacaggaa ccagcattct aattagattt actatatcaa gatatggttc
     4561 aaataggact actagagttc attgaacact aaaactatga aacaattact ttttatatta
     4621 aaaagaccat ggatttaact tatgaaaatc caaatgcagg atagtaattt ttgtttactt
     4681 ttttaaccaa actgaatttt tgaaagacta ttgcaggtgt ttaaaaagaa agaaaagttg
     4741 ttttatctaa tactgtaagt agttgtcata ttctggaaaa tttaatagtt ttagagttaa
     4801 gatatctcct ctctttggtt agggaagaag aaagcccttc accattgtgg aatgatgccc
     4861 tggctttaag gtttagctcc acatcatgct tctcttgaga attctatttg gtagttacaa
     4921 ttacagaaac tgattagttt gtcagtttgc agatagattt agcacagtac tcatcactcg
     4981 gatagattga gatgttcttt cacatcagat gatctgtaac actgtaagat actgatcttt
     5041 acaactgttt aatcagtttt atttttgtac agtattagtg acctaagtta ttttgctgtc
     5101 ccgtttttgt aaatcaaatg aaattataaa agaggattct gacagtaggt attttgtaca
     5161 tatgtatata tgttgtccaa ataaaaataa taaatgataa a
//
