LOCUS       NM_007250               9096 bp    mRNA    linear   PRI 05-JUN-2024
DEFINITION  Homo sapiens KLF transcription factor 8 (KLF8), transcript variant
            1, mRNA.
ACCESSION   NM_007250
VERSION     NM_007250.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9096)
  AUTHORS   Bai,Q., Jin,W., Chen,F., Zhu,J., Cao,L., Yang,Y., Zhong,F. and
            Li,L.
  TITLE     KLF8 Promotes the Survival of Lung Adenocarcinoma During Nutrient
            Deprivation by Regulating the Pentose Phosphate Pathway through
            SIRT2
  JOURNAL   Front Biosci (Landmark Ed) 29 (1), 27 (2024)
   PUBMED   38287804
  REMARK    GeneRIF: KLF8 Promotes the Survival of Lung Adenocarcinoma During
            Nutrient Deprivation by Regulating the Pentose Phosphate Pathway
            through SIRT2.
REFERENCE   2  (bases 1 to 9096)
  AUTHORS   Cherukunnath,A., Davargaon,R.S., Ashraf,R., Kamdar,U.,
            Srivastava,A.K., Tripathi,P.P., Chatterjee,N. and Kumar,S.
  TITLE     KLF8 is activated by TGF-beta1 via Smad2 and contributes to ovarian
            cancer progression
  JOURNAL   J Cell Biochem 123 (5), 921-934 (2022)
   PUBMED   35293014
  REMARK    GeneRIF: KLF8 is activated by TGF-beta1 via Smad2 and contributes
            to ovarian cancer progression.
REFERENCE   3  (bases 1 to 9096)
  AUTHORS   Wang,B., Yan,L., Shi,W., Xie,H., Chen,R., Shao,Y. and Liang,W.
  TITLE     CircRNA PVT1 promotes proliferation and chemoresistance of
            osteosarcoma cells via the miR-24-3p/KLF8 axis
  JOURNAL   Int J Clin Oncol 27 (4), 811-822 (2022)
   PUBMED   35171359
  REMARK    GeneRIF: CircRNA PVT1 promotes proliferation and chemoresistance of
            osteosarcoma cells via the miR-24-3p/KLF8 axis.
REFERENCE   4  (bases 1 to 9096)
  AUTHORS   Mao,M., Yang,L., Hu,J., Liu,B., Zhang,X., Liu,Y., Wang,P. and Li,H.
  TITLE     Oncogenic E3 ubiquitin ligase NEDD4 binds to KLF8 and regulates the
            microRNA-132/NRF2 axis in bladder cancer
  JOURNAL   Exp Mol Med 54 (1), 47-60 (2022)
   PUBMED   35031788
  REMARK    GeneRIF: Oncogenic E3 ubiquitin ligase NEDD4 binds to KLF8 and
            regulates the microRNA-132/NRF2 axis in bladder cancer.
REFERENCE   5  (bases 1 to 9096)
  AUTHORS   Zhao,M., Ma,W. and Ma,C.
  TITLE     Circ_0067934 promotes non-small cell lung cancer development by
            regulating miR-1182/KLF8 axis and activating Wnt/beta-catenin
            pathway
  JOURNAL   Biomed Pharmacother 129, 110461 (2020)
   PUBMED   32768951
  REMARK    GeneRIF: Circ_0067934 promotes non-small cell lung cancer
            development by regulating miR-1182/KLF8 axis and activating
            Wnt/beta-catenin pathway.
REFERENCE   6  (bases 1 to 9096)
  AUTHORS   Camacho-Vanegas,O., Till,J., Miranda-Lorenzo,I., Ozturk,B.,
            Camacho,S.C. and Martignetti,J.A.
  TITLE     Shaking the family tree: identification of novel and biologically
            active alternatively spliced isoforms across the KLF family of
            transcription factors
  JOURNAL   FASEB J 27 (2), 432-436 (2013)
   PUBMED   23134681
REFERENCE   7  (bases 1 to 9096)
  AUTHORS   Suske,G., Bruford,E. and Philipsen,S.
  TITLE     Mammalian SP/KLF transcription factors: bring in the family
  JOURNAL   Genomics 85 (5), 551-556 (2005)
   PUBMED   15820306
REFERENCE   8  (bases 1 to 9096)
  AUTHORS   Zhao,J., Bian,Z.C., Yee,K., Chen,B.P., Chien,S. and Guan,J.L.
  TITLE     Identification of transcription factor KLF8 as a downstream target
            of focal adhesion kinase in its regulation of cyclin D1 and cell
            cycle progression
  JOURNAL   Mol Cell 11 (6), 1503-1515 (2003)
   PUBMED   12820964
REFERENCE   9  (bases 1 to 9096)
  AUTHORS   Lossi,A.M., Laugier-Anfossi,F., Depetris,D., Gecz,J., Gedeon,A.,
            Kooy,F., Schwartz,C., Mattei,M.G., Croquette,M.F. and Villard,L.
  TITLE     Abnormal expression of the KLF8 (ZNF741) gene in a female patient
            with an X;autosome translocation t(X;21)(p11.2;q22.3) and
            non-syndromic mental retardation
  JOURNAL   J Med Genet 39 (2), 113-117 (2002)
   PUBMED   11836360
  REMARK    GeneRIF: The gene KLF8 is abnormally expressed in a female patient
            with X;autosome translocation t(X;21)(p11.2;q22.3) and
            non-syndromic mental retardation.
REFERENCE   10 (bases 1 to 9096)
  AUTHORS   van Vliet,J., Turner,J. and Crossley,M.
  TITLE     Human Kruppel-like factor 8: a CACCC-box binding protein that
            associates with CtBP and represses transcription
  JOURNAL   Nucleic Acids Res 28 (9), 1955-1962 (2000)
   PUBMED   10756197
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL050309.4, BC105130.1 and
            BX322609.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Apr 27, 2016 this sequence version replaced NM_007250.4.
            
            Summary: This gene encodes a protein which is a member of the
            Sp/KLF family of transcription factors. Members of this family
            contain a C-terminal DNA-binding domain with three Kruppel-like
            zinc fingers. The encoded protein is thought to play an important
            role in the regulation of epithelial to mesenchymal transition, a
            process which occurs normally during development but also during
            metastasis. A pseudogene has been identified on chromosome 16.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Apr 2009].
            
            Transcript Variant: This variant (1) encodes isoform 1. Variants 1
            and 5 encode the same isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.14649.1,
                                           SRR1803611.157844.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000468660.6/ ENSP00000417303.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-691               AL050309.4         41737-42427         c
            692-2234            BC105130.1         1-1543
            2235-9096           BX322609.3         11888-18749
FEATURES             Location/Qualifiers
     source          1..9096
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.21"
     gene            1..9096
                     /gene="KLF8"
                     /gene_synonym="BKLF3; ZNF741"
                     /note="KLF transcription factor 8"
                     /db_xref="GeneID:11279"
                     /db_xref="HGNC:HGNC:6351"
                     /db_xref="MIM:300286"
     exon            1..986
                     /gene="KLF8"
                     /gene_synonym="BKLF3; ZNF741"
                     /inference="alignment:Splign:2.1.0"
     CDS             980..2059
                     /gene="KLF8"
                     /gene_synonym="BKLF3; ZNF741"
                     /note="isoform 1 is encoded by transcript variant 1;
                     krueppel-like factor 8; zinc finger protein 741; basic
                     kruppel-like factor 3; basic krueppel-like factor 3;
                     Kruppel like factor 8"
                     /codon_start=1
                     /product="Krueppel-like factor 8 isoform 1"
                     /protein_id="NP_009181.2"
                     /db_xref="CCDS:CCDS14373.1"
                     /db_xref="GeneID:11279"
                     /db_xref="HGNC:HGNC:6351"
                     /db_xref="MIM:300286"
                     /translation="MVDMDKLINNLEVQLNSEGGSMQVFKQVTASVRNRDPPEIEYRS
                     NMTSPTLLDANPMENPALFNDIKIEPPEELLASDFSLPQVEPVDLSFHKPKAPLQPAS
                     MLQAPIRPPKPQSSPQTLVVSTSTSDMSTSANIPTVLTPGSVLTSSQSTGSQQILHVI
                     HTIPSVSLPNKMGGLKTIPVVVQSLPMVYTTLPADGGPAAITVPLIGGDGKNAGSVKV
                     DPTSMSPLEIPSDSEESTIESGSSALQSLQGLQQEPAAMAQMQGEESLDLKRRRIHQC
                     DFAGCSKVYTKSSHLKAHRRIHTGEKPYKCTWDGCSWKFARSDELTRHFRKHTGIKPF
                     RCTDCNRSFSRSDHLSLHRRRHDTM"
     exon            987..1060
                     /gene="KLF8"
                     /gene_synonym="BKLF3; ZNF741"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1625
                     /gene="KLF8"
                     /gene_synonym="BKLF3; ZNF741"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..1737
                     /gene="KLF8"
                     /gene_synonym="BKLF3; ZNF741"
                     /inference="alignment:Splign:2.1.0"
     exon            1738..1877
                     /gene="KLF8"
                     /gene_synonym="BKLF3; ZNF741"
                     /inference="alignment:Splign:2.1.0"
     exon            1878..9096
                     /gene="KLF8"
                     /gene_synonym="BKLF3; ZNF741"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2635..2640
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLF8"
                     /gene_synonym="BKLF3; ZNF741"
                     /note="hexamer: AATAAA"
     polyA_site      2662
                     /gene="KLF8"
                     /gene_synonym="BKLF3; ZNF741"
                     /note="major polyA site"
     regulatory      5423..5428
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLF8"
                     /gene_synonym="BKLF3; ZNF741"
                     /note="hexamer: AATAAA"
     polyA_site      5450
                     /gene="KLF8"
                     /gene_synonym="BKLF3; ZNF741"
                     /note="major polyA site"
     regulatory      6380..6385
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLF8"
                     /gene_synonym="BKLF3; ZNF741"
                     /note="hexamer: AATAAA"
     polyA_site      6404
                     /gene="KLF8"
                     /gene_synonym="BKLF3; ZNF741"
                     /note="major polyA site"
     regulatory      9071..9076
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLF8"
                     /gene_synonym="BKLF3; ZNF741"
                     /note="hexamer: AATAAA"
     polyA_site      9096
                     /gene="KLF8"
                     /gene_synonym="BKLF3; ZNF741"
                     /note="major polyA site"
ORIGIN      
        1 actttgcact ctcctctagc ggccgcctgt cctttttaag gaactccacc ctaggtggag
       61 tcctcacgat agtcacacct ctcctttggg cctagcaggg ccagagaaag acggaatcac
      121 tctacccact caggttgccc agagagcact ttaggttctg actcgcgtgg ggcgcgaggt
      181 accccgtggg gcagctaggt gcctccaaga aaccccgccc cagaggaccc gcacgagttg
      241 ctgccatttt tcgctgaagc ccctgccctg gggctggtgt tcttctctat gattctacca
      301 atcgtcggca tttttttcct cccttctttc tttttaggaa ggcgctgggg tgtgcggcgg
      361 caacggcggc ggtgaaggga tcctcttgtg gtatctcctc gtgggttcct gtcttgaagg
      421 atttcttctc cgcctcaact ttatgttcaa gtagcgcttt gggggttggg ttggttttca
      481 tagcccccac ccccggccct ctccttttaa agggtgtgtg gagttcagag gatgggtgga
      541 gagcgggctt ggccggaact gaattggtag aggtaaaagg ggaacggagg accttaagct
      601 ctggccactt cggcccagcg aacccacttt atttttgtcc aaggaaaagc tgcagggggg
      661 aggattcttt ttaggaagtc tactctgccg gcccctgatt tttgggttgg atgcttgaga
      721 gctttgtttc ccttgttccg agagtggccc agctgggtct gaatcgactc cctccccttt
      781 cgaccccctc ctcattttcc agcccggaga aataggggag tgggggccca agaacgagaa
      841 gacgagaacg cgtcgccctg cgctatgtca gaatggggcg ggtgtgaggg gaacagctct
      901 cttgcgatca gctcaggagt atgagcctcc cggaggacgg catgagttct ggacacttca
      961 ggagtcctca gctagtgaca tggtcgatat ggataaactc ataaacaact tggaggtcca
     1021 acttaattca gaaggtggct caatgcaggt attcaagcag gtcactgctt ctgttcggaa
     1081 cagagatccc cctgagatag aatacagaag taatatgact tctccaacac tcctggatgc
     1141 caaccccatg gagaacccag cactgtttaa tgacatcaag attgagcccc cagaagaact
     1201 tttggctagt gatttcagcc tgccccaagt ggaaccagtt gacctctcct ttcacaagcc
     1261 caaggctcct ctccagcctg ctagcatgct acaagctcca atacgtcccc ccaagccaca
     1321 gtcttctccc cagacccttg tggtgtccac gtcaacatct gacatgagca cttcagcaaa
     1381 cattcctact gttctgaccc caggctctgt cctgacctcc tctcagagca ctggtagcca
     1441 gcagatctta catgtcattc acactatccc ctcagtcagt ctgccaaata agatgggtgg
     1501 cctgaagacc atcccagtgg tagtgcagtc tctgcccatg gtgtatacta ctttgcctgc
     1561 agatgggggc cctgcagcca ttacagtccc actcattgga ggagatggta aaaatgctgg
     1621 atcagtgaaa gttgacccca cctccatgtc tccactggaa attccaagtg acagtgagga
     1681 gagtacaatt gagagtggat cctcagcctt gcagagtctg cagggactac agcaagaacc
     1741 agcagcaatg gcccaaatgc agggagaaga gtcgcttgac ttgaagagaa gacggattca
     1801 ccaatgtgac tttgcaggat gcagcaaagt gtacaccaaa agctctcacc tgaaagctca
     1861 ccgcagaatc catacaggag agaagcctta taaatgcacc tgggatggct gctcctggaa
     1921 atttgctcgc tcagatgagc tcactcgcca tttccgcaag cacacaggca tcaagccttt
     1981 tcggtgcaca gactgcaacc gcagcttttc tcgttctgac cacctgtccc tgcatcgccg
     2041 tcgccatgac accatgtgag ccgcacaggt cacactagag aagctgcgct ggtatctttc
     2101 ctggtcgtgt gctgaggttg ggacaatttt ttcctctttg acttcagctt gcatatgggg
     2161 ttgaagcagc ccactgagcc aagttgagga gactggagga aaagagagct ggtctcccgt
     2221 ggggctcttc atattctacc ttcacttctc cactgtccag acccgttttt ttcaacctcc
     2281 acatgggttg aattccagtg tggcacccat ggctgccttc ccatcccccc ctgctctgaa
     2341 ataggacatt tttcctacag taacaaaaca ggaatcaaac tcaaggctgt gaacaaacat
     2401 acgctgcttt attctttcca atttttctct tgttttctag aactcttatc catatgtttt
     2461 taaaataagt acctaaaagt ggtttgatag tgtcctaaac gactttttta acttcctaaa
     2521 tggaaagagc ataacaatgt agttgattgg taagatttac agggatttgg tttctgagtt
     2581 tgaggcacat tcccagtgaa taagctgagt cccataccac actcaaaagg ttttaataaa
     2641 tctaatccta tttcttctta aagtttggtt ttcagacagt gctggtgctt ctgcttctta
     2701 agttcatcaa gggaatgagg agttcttgtc cttctcctcc tctttttttt cttttccact
     2761 ttctccttca ggattaaaga ttttgctgca caattgttat ttgttaggtt aaatttggac
     2821 aaatattcaa agcacacata gacatataag taaggagaaa aatgttccag gagagtaggt
     2881 tgggcagtga caggaacaaa cagacctagg atgatcctga gaacaaatag aggggttcct
     2941 ttacttgtat aggatatcaa aagtgctgtt aatcacaaac ctcattcaaa tggcaggctg
     3001 tcgagacagt gtcttgaggg gctggctgta ctgtttattt tttcgtttac acaaagaagc
     3061 aattgagtat attgcatgat gagaaatcac acactagggt catgttatac agaagtaagg
     3121 ggttggaaaa atggaatgtt gttcactcca tggaattatt ggcattcatt cctgtgtttc
     3181 aaatgaaaca tagatgcttt tcatgaaaac tgacctacaa aaagcaattt gatgttctgc
     3241 aactgctatg aaaacctaag ccatttattt tagctgatag cagattgcat aatatactca
     3301 tttagctgcc caatcagatt gttttataat attacctggg gtacaaaatc ctctgttcct
     3361 ggccctggac cacagatcta cctccacatg gcatatttcc tttctggggt caggggtagg
     3421 ggagggggct ttgcatcact tgaatttaga ctcagcctct ctttaaaaga ttgtctttat
     3481 attgaacacc tttttctttt caaccctgct tgaatacttt aggttactat ttcctgaggc
     3541 tgtccattct cactatattg tagaattcta gcaccaagaa gggatcccgt taaccatcta
     3601 gtcctatcca tccctcatat tttacagatg agacaaatac gggtcagatt tttttctcca
     3661 gatgtttctt tgagccctta tacacctgca cgcttattct cctggggatc acataatttt
     3721 atttatttat tttttgagag acggtttcac tccatcaccc aggctggagt gcagtggcgt
     3781 aatcttggct cactgcaacc tccgcctcct gggttcaagt gattctcctg cctcagcctc
     3841 ccaaatagct tggattacag gtgcgtgcca ccacacctag ctaagttttg tattattagt
     3901 agagatgggg tttcgccatg ttggccaggc tggtctcaaa ctcctgacct caagtgatcc
     3961 ccccacctcg gcctcccaaa gtgctgggat cacaggtgtg agtcaccaca cctggccagg
     4021 atcacattat taaaccaaat taaagtttat gtgattggtt gcaatatttg tctaatttta
     4081 tatgttttct tcaggaaaac tttagaactc aaaaatcatt tacagctgat taaatagcaa
     4141 gtaaaatgta cttgtggtca ttgccgtata acattaggca cacgcttcta acacttctat
     4201 aatatctaga ttttatttac ctcattttaa cttgcaatgt ctgtctatct catgaactct
     4261 ccataaatcc aagaactgcc tgtagttttc aaaatgacat gtgggttttt actgttatca
     4321 ttgttatttc gatagggctt tttcctgatt ttgggtatac aagttccaaa cttgcataat
     4381 aattgctaac gcactaggcg atatctaggg ccagtctgtt aaaggggacc tctaatgtag
     4441 ctataagaca ggttggtaaa gatgaactaa cataagttta agctaataat tcagtagttg
     4501 atgcagtatt tcacagtaga gcccgagctt actcattttt ttcaaaattt ggatcctgat
     4561 actccttttt cagagttcag aactgaactg ctcccctaag acctcagaat cttttgcatt
     4621 gagacatatg atctatttat aaataaaggt tatcaaatat cttgttgaac taattaggtt
     4681 gatcaaatta ggatcccaaa tattggggtc cctgacatct gagcctttat ctaaaaatgt
     4741 ttctgtaaca taatgacagc ctttatgttt gttaattgcc tatagtaaag aagcaatttt
     4801 aagcctattc tcatttccct ctcccctaca aaaaatgata aaagctttcc aattacttac
     4861 atatgctcta acaagtgtct caggattcat taacagaatt ttatagagta cagtaattca
     4921 aatatagcac agtacagagt ttaccaaaaa cacataaaac tttgctagat agacagtgag
     4981 gtggaaagga actaaaatgt atctctcttg aatagcattt ggggttcaat tgaatttgtt
     5041 gtgtttacaa cagcaaagca ccgttagcct ggacagttgc ttatggcatc gatagggttg
     5101 gataatattc tgggatttgt tgcagcagaa ttcctctatc tgatgatcag cagttgaaca
     5161 taaacttcat aattatagta aaatttagga aaaactatga gtgtgaagag tatgaactga
     5221 ttgggtagat taggcagagt gcattatggg caagacaaag gttttcgata ttaacttctt
     5281 ttaaaataaa ctttttattt tcaaacagtt tcagttttac agaaaaaatg tgaagctagt
     5341 acagagaggt ctcatttacc ccacacccag tttctcctgt tattagcatc tcacattaat
     5401 atgtggtata tttgttacaa ttaataaaac acattgatat gttaatatta ttaactgaag
     5461 tccatacttt attcaggttt ctttagtttt tacctaagat cctttttaaa gaattgtttc
     5521 ggccaggcac tgtggctcac acctgtaatc ccagcacttt gggaggccaa gacgggcgga
     5581 tcacgaagtc aggagttcga gaccaacctg gacaacatgg tgaaaccacg tctctattaa
     5641 aaatacaaaa aattagccag gcgtagtggt gggtgcctgt aatcccagca atacttgaga
     5701 ggctgaggca agagaattgc ttgaacctgg gaggcggagg ttgcagtgag ctgagatcat
     5761 gccacttcac tccagcctgg gtgacagagc gacacacttg atctcaaaaa aaaaaaaatt
     5821 gtttcagcat cttgttcagg attccacatt acatctaata gtcatatctc cttaggatcc
     5881 ttttgattgt gacagtttct cagactttcc ttgttttcag tgaccttgac acttttgaga
     5941 gagattttcc tcaactggga tttgtcagtt gtctttctca tgattagact gaggttatga
     6001 gtttttgaaa gtaggaccac ggagaagaag tgccattttc atcacatcat acaggcatac
     6061 tttggagaca atgcagattt ggttccagat cactgcaatg aagcaaatat tacaataaag
     6121 caagtcacac aaattttttg gtttcccagt gcatataaaa ttttatgttt acactatcct
     6181 gtagtctggt aaatgtgcaa tagcattatg tctaaaaaac aatgtacata ccttatttta
     6241 aaatacttta ttgctaacat gttactggca caaacacgaa gtgagcacat gctgttggaa
     6301 aaatggtgcc aatagacttg ttggtcacag ggttgccaca aacttttaat ttgtaaaaaa
     6361 tgcaatatca gcaaagtgca ataaagtgaa gcacaataaa acgaggtatg cctgtattta
     6421 catgactcat cactgttgtt taaccttgat cacctggctg aaatagttgt tgtcaggttt
     6481 ctcccctgta ctcttttttt cctcccctcc atactgtact ctctgaaagg aaatcactat
     6541 gtgcagccca tgcttctgga gtggtaagtt atatgccaca cccttcagag catgtatctt
     6601 acataaatta tttggaatta ttctctaagg gagattgtct cttctccccc atttatttat
     6661 ttatacaata ctttatttat atcagcatgg actcatgggt atttatttta tacttcgagt
     6721 tataatctaa tactactact ttattttatt gctcgaattg ttccagcttt ggccattggg
     6781 agctcttttg ggtgattctc aagttctttt gacacacccc catcattttt ttttagcacg
     6841 tccttacttt ctgccactgc aagatcttcc aggctcatct tgtatatttt gtggcctact
     6901 cctataatca gccatttctt caagaagtcc tggtttcttt tactggaaaa ttgtattaga
     6961 aaccaatatc tgggcattag gtatgttcat tgttactggg ctattgttgc ttctagggtg
     7021 tctcagctaa cagcaaggaa acatatgtgt gtatactatc ctatgtatat gcacattcta
     7081 taaatatttc tatatgtaat cacccagatt tttatttagc taaacatgag ttcatattga
     7141 tgttttcaac tctaacctgt taccacgtga atcattctag cttcttcctg ttagttacat
     7201 gaagcctccc acactaatac tgagaaacct ggctctcaac ctctgtcatc tatttactta
     7261 atttttcaaa ttcagtgtgc acatatagca gtatctgaat tgttaacctg tatacccatg
     7321 ggaaacaact ttatcaacta cagcacagtg tgtatgtaca taaaaatagt aatattttta
     7381 gaactccaac agctctttga aacaaagtgg tctgcaaaat tctggaatta gggatttctg
     7441 tgatctgagt tccaagattc tggggtctat cctgccccca aaaagttttc tcatgaacca
     7501 aaccatcaag aatgtaccta accttaaata agccaaggga acttactgat gctccacagt
     7561 ttgctaattc ttgtatgagg tactgtagag ggatggatac agaaggaact gggtgggcca
     7621 aatttaaata aacacatagc actatctttt ctcactgtta aatatggctc tctgacaaca
     7681 gtgatgctac cctgagttac ctctcttctg tattttccca gatctcactt ggttgacctt
     7741 aggcaagtca tatcacctct ctgtgcctca attaatccat ttgcaaaatg gggatctcaa
     7801 tatctacctc acaggaatgt tgtgaggctt ctcataaatt gattttggca aaaatgaaag
     7861 atctttaagt gaacaaccaa gtattataac cattgttata atgatagtta tagtacctta
     7921 tatttaccct atgtaaaaga gaagattagg cttcctaggt gataaacaga taaatttgag
     7981 taagaaggat aattaaagag tggccactgg aagcaatatt atttattctc ttactttcac
     8041 tttccctata tcttctttgt tactaacaat acgattatca tctgtttcca tacttgaaat
     8101 gtattaggac ctaaaggaag aggtaggcaa aattcattgc ttcagaagct gtattcttcc
     8161 ccctttgtaa ctctgcttgg accacattcc atgtcacatt ctcagaagca caaaggcaat
     8221 tttccagagc cctttaagct ttggccagtt cagtttcacc acttatattt tctctttccc
     8281 aacttacttt actctgaata gtataggtag gaggagggaa gttgggtagg gtggttgggg
     8341 gtgggagtgg gttggaagag gatgggattt ataccagtgg caggatattt ctctgttttc
     8401 caaacactgg ttttaatttc catttccttt tctggtgttg gggtggggtc aggggaagag
     8461 atactatttt gttaactgtt aaaagctctc cttcctttcc tagagtcgct acaagtagct
     8521 gtgttggaca ttactttata actatgctgt atgccatgct gttttcattg tatcacagaa
     8581 ttaaaagggg aagagagttc ctagtggtgt ccatccctgt tttttgacag gcagtcacac
     8641 aggtgagcag tgccagaaac tggttctctt ttttgtgttg gggaaaggag cctgcagtga
     8701 aaggatcagt tggatttttt gtcattgtta gtttgtttaa ataaattata agacagtata
     8761 ttaagcttta gtctctgtaa ctcttatgtt tgtgccccat tattttagtg ctttagagca
     8821 acaccttgtt tttcctctat tttatactag ttcttgctcc agaggcatgg ctttgaggct
     8881 agaatcatga gcaatctctc ataaacaagt ctgttatgca cctggagata ctcaagattt
     8941 gcctctgtta gcatggccac ttagagatta ctctgttcta cttcagagac cctccactat
     9001 ggcatccatg cagggtgtgt gcttggggac taagcaatct tgttcagttt aattattgta
     9061 cttttttatt aataaaaagg tcttaaactt cagaaa
//
