LOCUS       NM_001300               4590 bp    mRNA    linear   PRI 28-APR-2025
DEFINITION  Homo sapiens KLF transcription factor 6 (KLF6), transcript variant
            A, mRNA.
ACCESSION   NM_001300
VERSION     NM_001300.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4590)
  AUTHORS   Meng,Z., Yang,Y., Li,S., Huang,L., Yao,Z., Chen,Y., Wang,J.,
            Shen,Y., Liang,P., Zhang,H., Wang,W. and Wang,F.
  TITLE     GSE1 promotes the proliferation and migration of lung
            adenocarcinoma cells by downregulating KLF6 expression
  JOURNAL   Cell Biol Int 48 (10), 1490-1506 (2024)
   PUBMED   38886911
  REMARK    GeneRIF: GSE1 promotes the proliferation and migration of lung
            adenocarcinoma cells by downregulating KLF6 expression.
REFERENCE   2  (bases 1 to 4590)
  AUTHORS   Fang,M., Li,T. and Wu,Z.
  TITLE     WTAP-MEDIATED M6A MODIFICATION OF KLF6 AGGRAVATES
            HYPOXIA/REOXYGENATION-INDUCED HUMAN CARDIOMYOCYTE INJURY
  JOURNAL   Shock 62 (2), 201-207 (2024)
   PUBMED   38662610
  REMARK    GeneRIF: WTAP-MEDIATED M6A MODIFICATION OF KLF6 AGGRAVATES
            HYPOXIA/REOXYGENATION-INDUCED HUMAN CARDIOMYOCYTE INJURY.
REFERENCE   3  (bases 1 to 4590)
  AUTHORS   Shi,J., Jing,W., He,Y. and Huang,Y.
  TITLE     Decreased expression of KLF6 in ectopic endometrial stromal cells
            contributes to endometriosis progression by targeting CTNNB1
  JOURNAL   Cell Signal 120, 111230 (2024)
   PUBMED   38761988
  REMARK    GeneRIF: Decreased expression of KLF6 in ectopic endometrial
            stromal cells contributes to endometriosis progression by targeting
            CTNNB1.
REFERENCE   4  (bases 1 to 4590)
  AUTHORS   Bao,S., Zheng,W., Yan,R. and Xu,J.
  TITLE     miRNA-21 promotes the progression of acute liver failure via the
            KLF6/autophagy/IL-23 signaling pathway
  JOURNAL   Mol Med Rep 29 (5) (2024)
   PUBMED   38516774
  REMARK    GeneRIF: miRNA-21 promotes the progression of acute liver failure
            via the KLF6/autophagy/IL-23 signaling pathway.
REFERENCE   5  (bases 1 to 4590)
  AUTHORS   Eni-Aganga,I., Lanaghan,Z.M., Ismail,F., Korolkova,O.,
            Goodwin,J.S., Balasubramaniam,M., Dash,C. and Pandhare,J.
  TITLE     KLF6 activates Sp1-mediated prolidase transcription during
            TGF-beta1 signaling
  JOURNAL   J Biol Chem 300 (2), 105605 (2024)
   PUBMED   38159857
  REMARK    GeneRIF: KLF6 activates Sp1-mediated prolidase transcription during
            TGF-beta1 signaling.
            Erratum:[J Biol Chem. 2025 Mar;301(3):108214. doi:
            10.1016/j.jbc.2025.108214. PMID: 39952079]
REFERENCE   6  (bases 1 to 4590)
  AUTHORS   Narla,G., Difeo,A., Reeves,H.L., Schaid,D.J., Hirshfeld,J., Hod,E.,
            Katz,A., Isaacs,W.B., Hebbring,S., Komiya,A., McDonnell,S.K.,
            Wiley,K.E., Jacobsen,S.J., Isaacs,S.D., Walsh,P.C., Zheng,S.L.,
            Chang,B.L., Friedrichsen,D.M., Stanford,J.L., Ostrander,E.A.,
            Chinnaiyan,A.M., Rubin,M.A., Xu,J., Thibodeau,S.N., Friedman,S.L.
            and Martignetti,J.A.
  TITLE     A germline DNA polymorphism enhances alternative splicing of the
            KLF6 tumor suppressor gene and is associated with increased
            prostate cancer risk
  JOURNAL   Cancer Res 65 (4), 1213-1222 (2005)
   PUBMED   15735005
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 4590)
  AUTHORS   Suzuki,T., Yamamoto,T., Kurabayashi,M., Nagai,R., Yazaki,Y. and
            Horikoshi,M.
  TITLE     Isolation and initial characterization of GBF, a novel DNA-binding
            zinc finger protein that binds to the GC-rich binding sites of the
            HIV-1 promoter
  JOURNAL   J Biochem 124 (2), 389-395 (1998)
   PUBMED   9685731
REFERENCE   8  (bases 1 to 4590)
  AUTHORS   Onyango,P., Koritschoner,N.P., Patrito,L.C., Zenke,M. and Weith,A.
  TITLE     Assignment of the gene encoding the core promoter element binding
            protein (COPEB) to human chromosome 10p15 by somatic hybrid
            analysis and fluorescence in situ hybridization
  JOURNAL   Genomics 48 (1), 143-144 (1998)
   PUBMED   9503030
REFERENCE   9  (bases 1 to 4590)
  AUTHORS   Koritschoner,N.P., Bocco,J.L., Panzetta-Dutari,G.M., Dumur,C.I.,
            Flury,A. and Patrito,L.C.
  TITLE     A novel human zinc finger protein that interacts with the core
            promoter element of a TATA box-less gene
  JOURNAL   J Biol Chem 272 (14), 9573-9580 (1997)
   PUBMED   9083102
REFERENCE   10 (bases 1 to 4590)
  AUTHORS   El Rouby,S. and Newcomb,E.W.
  TITLE     Identification of Bcd, a novel proto-oncogene expressed in B-cells
  JOURNAL   Oncogene 13 (12), 2623-2630 (1996)
   PUBMED   9000136
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP357332.1, BC000311.2,
            AL450322.17 and BQ017028.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001300.5.
            
            Summary: This gene encodes a member of the Kruppel-like family of
            transcription factors. The zinc finger protein is a transcriptional
            activator, and functions as a tumor suppressor. Multiple transcript
            variants encoding different isoforms have been found for this gene,
            some of which are implicated in carcinogenesis. [provided by
            RefSeq, May 2009].
            
            Transcript Variant: This variant (A) represents the longest
            transcript and encodes the longest isoform (A).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.209705.1,
                                           SRR1660809.195613.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142586
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000497571.6/ ENSP00000419923.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                BP357332.1         73-133
            62-1450             BC000311.2         53-1441
            1451-3976           AL450322.17        86365-88890         c
            3977-4590           BQ017028.1         18-631              c
FEATURES             Location/Qualifiers
     source          1..4590
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p15.2"
     gene            1..4590
                     /gene="KLF6"
                     /gene_synonym="BCD1; CBA1; COPEB; CPBP; GBF; PAC1; ST12;
                     ZF9"
                     /note="KLF transcription factor 6"
                     /db_xref="GeneID:1316"
                     /db_xref="HGNC:HGNC:2235"
                     /db_xref="MIM:602053"
     exon            1..297
                     /gene="KLF6"
                     /gene_synonym="BCD1; CBA1; COPEB; CPBP; GBF; PAC1; ST12;
                     ZF9"
                     /inference="alignment:Splign:2.1.0"
     CDS             196..1047
                     /gene="KLF6"
                     /gene_synonym="BCD1; CBA1; COPEB; CPBP; GBF; PAC1; ST12;
                     ZF9"
                     /note="isoform A is encoded by transcript variant A;
                     GC-rich binding factor; suppression of tumorigenicity 12
                     (prostate); Kruppel-like zinc finger protein Zf9;
                     krueppel-like factor 6; protooncogene B-cell derived 1;
                     proto-oncogene BCD1; core promoter element binding
                     protein; B-cell-derived protein 1; transcription factor
                     Zf9; GC-rich sites-binding factor GBF; suppressor of
                     tumorigenicity 12 protein; Kruppel like factor 6"
                     /codon_start=1
                     /product="Krueppel-like factor 6 isoform A"
                     /protein_id="NP_001291.3"
                     /db_xref="CCDS:CCDS7060.1"
                     /db_xref="GeneID:1316"
                     /db_xref="HGNC:HGNC:2235"
                     /db_xref="MIM:602053"
                     /translation="MDVLPMCSIFQELQIVHETGYFSALPSLEEYWQQTCLELERYLQ
                     SEPCYVSASEIKFDSQEDLWTKIILAREKKEESELKISSSPPEDTLISPSFCYNLETN
                     SLNSDVSSESSDSSEELSPTAKFTSDPIGEVLVSSGKLSSSVTSTPPSSPELSREPSQ
                     LWGCVPGELPSPGKVRSGTSGKPGDKGNGDASPDGRRRVHRCHFNGCRKVYTKSSHLK
                     AHQRTHTGEKPYRCSWEGCEWRFARSDELTRHFRKHTGAKPFKCSHCDRCFSRSDHLA
                     LHMKRHL"
     exon            298..871
                     /gene="KLF6"
                     /gene_synonym="BCD1; CBA1; COPEB; CPBP; GBF; PAC1; ST12;
                     ZF9"
                     /inference="alignment:Splign:2.1.0"
     exon            872..995
                     /gene="KLF6"
                     /gene_synonym="BCD1; CBA1; COPEB; CPBP; GBF; PAC1; ST12;
                     ZF9"
                     /inference="alignment:Splign:2.1.0"
     exon            996..4590
                     /gene="KLF6"
                     /gene_synonym="BCD1; CBA1; COPEB; CPBP; GBF; PAC1; ST12;
                     ZF9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4012..4017
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLF6"
                     /gene_synonym="BCD1; CBA1; COPEB; CPBP; GBF; PAC1; ST12;
                     ZF9"
                     /note="hexamer: CATAAA"
     polyA_site      4033
                     /gene="KLF6"
                     /gene_synonym="BCD1; CBA1; COPEB; CPBP; GBF; PAC1; ST12;
                     ZF9"
                     /note="major polyA site"
     regulatory      4568..4573
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLF6"
                     /gene_synonym="BCD1; CBA1; COPEB; CPBP; GBF; PAC1; ST12;
                     ZF9"
                     /note="hexamer: AATAAA"
     polyA_site      4590
                     /gene="KLF6"
                     /gene_synonym="BCD1; CBA1; COPEB; CPBP; GBF; PAC1; ST12;
                     ZF9"
ORIGIN      
        1 gcagtcagtc cggtgtttgc aaatattgtg tgggctccgc gcgctgcggg ctgcgggagg
       61 gtccggccgg gcgtctctgc gagcctggag tttgcatgaa actttcacct gcgctccggg
      121 gagactttcg gctccggctc ccaccgcgcg cctcgccgcc ctcgcgaccg cgggctccgt
      181 ccaacccggc ccgacatgga cgtgctcccc atgtgcagca tcttccagga gctccagatc
      241 gtgcacgaga ccggctactt ctcggcgctg ccgtctctgg aggagtactg gcaacagacc
      301 tgcctagagc tggaacgtta cctccagagc gagccctgct atgtttcagc ctcagaaatc
      361 aaatttgaca gccaggaaga tctgtggacc aaaatcattc tggctcggga gaaaaaggag
      421 gaatccgaac tgaagatatc ttccagtcct ccagaggaca ctctcatcag cccgagcttt
      481 tgttacaact tagagaccaa cagcctgaac tcagatgtca gcagcgaatc ctctgacagc
      541 tccgaggaac tttctcccac ggccaagttt acctccgacc ccattggcga agttttggtc
      601 agctcgggaa aattgagctc ctctgtcacc tccacgcctc catcttctcc ggaactgagc
      661 agggaacctt ctcaactgtg gggttgcgtg cccggggagc tgccctcgcc agggaaggtg
      721 cgcagcggga cttcggggaa gccaggtgac aagggaaatg gcgatgcctc ccccgacggc
      781 aggaggaggg tgcaccggtg ccactttaac ggctgcagga aagtttacac caaaagctcc
      841 cacttgaaag cacaccagcg gacgcacaca ggagaaaagc cttacagatg ctcatgggaa
      901 gggtgtgagt ggcgttttgc aagaagtgat gagttaacca ggcacttccg aaagcacacc
      961 ggggccaagc cttttaaatg ctcccactgt gacaggtgtt tttccaggtc tgaccacctg
     1021 gccctgcaca tgaagaggca cctctgaggg agcagagagg tggatcctgt aggctaaaag
     1081 gcttccaggc tgagagccgg ccgtggaagg agggatgcgt gttccagcca aagcatgccg
     1141 ttctgcaccc tacccagttg cctccagggc ctctccttgg aaggtctttt gagggctaaa
     1201 aaggtcctgt aagaagcggc atagcacccg tggtgcatgg tatgtgggtg accctggact
     1261 cgccactggt acccgccctt ccgagcggcg cctaagcctt tgccgtgagc atgcacactg
     1321 agaatgctaa tggttgggtt gattgtatgt tgaggatcta ttactgaccg tatgatgagg
     1381 ccaacttttt ttccttgtgg ttagcaagac tgcaagagat ggaaaaaaag tagtttgaat
     1441 gttttgtgtg taaggagtat accatgagat gagatgacca ccaatcattt ccttgggggg
     1501 agggggtgtc tgcaccttag aaaaaaaaag aaaaatcaaa aaaacaaaaa aacaaaaaca
     1561 aaaaaagaag gaaaatcttg gagggtgggc gtgggaactc aggaccccag agtggcgagt
     1621 ggtgtgggga gggagagcct ctctccccct tttctgtgtg agaggaactc ttagtgtctg
     1681 gtgcagctat taaatgtgca atgtgtcaag tagcttgttt tacacgctac aacatagctc
     1741 atttgtaacc cattgtataa gctgtgtatt tacaaatata acacaacaat ttaacttttc
     1801 cttagaatac aaaaagtcat gcatggtctg gggaactata tgcttttcca tttttaagtc
     1861 aggactgcaa tactgattcc agttaatgag cagctaagat ccaatctgtc taatacagtg
     1921 accccctagc catccgggcc tggcaatata caattttttt tcccctccaa gtttgtaaca
     1981 ctccccttcc agaaaggcat tgtgcaacac aggattattt ttaaatgatt ctgaatttga
     2041 attaactttt tggagaattc tgtgatgccc ttagaagaaa ttggacacgt attgagtgtc
     2101 acaaagctgg ggctgggaat tgctggtcta atgtttcatt agacttaaga acctaaaatt
     2161 tttctcagtt gggtggataa aaccactaac gcttagaaac tgttttctca tgcagctatg
     2221 tttctcttat ttatgccttg aggactaatt tctggttttc tagctgttaa tgcactgttg
     2281 accttcataa tggtgcctta cgcaagcgat cccttctgtg ggggtctcat acaggggtgt
     2341 gggcgatgca tgctttatta aggctcttgt ttcacctggc agtgtactgt atcaacgtat
     2401 aatacagaaa aaaaatctct ttaaggtcct ccttcacaaa gacatagagt gaaactccct
     2461 ttacatgtca gtatttgttc aacactttag gcaacttgac tgtcagtgtt aaaatggaaa
     2521 acaggaaaat ggaaaaatct gaccaattct gccaccttga gactttcata tagaccttgc
     2581 acaacaattg tatagatcac acaccggctg tatttaatat gtaacatttt cacacatatt
     2641 aaagatacag aagtattaaa aaacccccaa tgttaatgta tttgcttaaa aggcacaagt
     2701 ttcacatatc tgtctagcta tctgttggta atacagaaag tatactactt ttttaaaaaa
     2761 gtgggcagaa ttcttgtgta tgtatatttg tgtgtacagt atgtgtatgt gtgtatatat
     2821 atatattata tatatagata atatataaat atttttttta aggagaaact agaatgttta
     2881 gctagaaaat tccacagcct gtgaagaaat atttcaaaat ggccataaag gaggtaaaaa
     2941 tgaaaaccat aacctaactt ttatagaggc tttatcttta atttaacgat gtgcggagga
     3001 ctttcttgct tgaatctgtt ccgggctgtc tgctctgtcc atcaaatggg caggtctgga
     3061 atggggcacc ttcggccgtt cagaagtggc ctgaacagaa tgctggaacc caggctggac
     3121 tcggacacac taaggttttg attttgaatt tcagccttat tagaagatct aacctaagag
     3181 taagctaacc acagggattc ttttgtagaa cactttttat gcagatgaag ctattttttc
     3241 cagcaagtag attcttccag tttttccaag gagtaatttc cccgaattgg cataccacgg
     3301 cgtggacagc tgatatttca cccagctgct ggcttgtggg tgtggctctt tgctttatat
     3361 atatatacac acatgtgagt ctggctgggc tggtattttg tttgatcttc ctggaaatga
     3421 gcagtgacta acgctcacat aactggtttt ttttttatct gggctgatga atacatttac
     3481 ctaagaaact catttcgttt tacttaagag gggaagtgca gttttctttt ggcagttcag
     3541 aatccaagca cttgatttgc tgggtttgga aaactccttt tttggccttc tatgtgctta
     3601 gccataacaa ttccattaag caagaaggta agcaaaagac aaaaaaaaaa aaaggaaaaa
     3661 aaaaaacttg cactggcttg tctcacttac gaaacatgtc ggagctgttt gcctgggtgg
     3721 ggctgggtac cgtacctgtc aatgcctgtg attttcataa ttagcacgta cataaagaag
     3781 tacattctgt tcaggtgata actgagcctc aatcaagcag aaactttttg cttgaaatta
     3841 aaaaaaaatt tctattagtg aaatttcttt tttttttttt tttggaagca ccctgttatc
     3901 taaagaatct ttgtaagatt tttgtaaaat tttgttttac aagattttat ttgaaattgt
     3961 tttttgcaag attgttatat ttctgtatga atgtattttt tattggaata acataaaaga
     4021 attcttatca gcatcttgag tctggttgtt ttttttgggg gaagggggtt gttggaacag
     4081 attcctcctg cattcatcac cctggcttcc tcctgggggc aaatcttcat tgagcaaccc
     4141 tgagaacaac tcaccgacct cagccccttc ctctttccac agcctgtcct gggagctgga
     4201 gaggatgtca gcgagcctga cattgccctc cctgaatgca tcaaatactc ttctccaagg
     4261 actgacaaaa acaacccccc ggctgtgggc acagtaggga accatgccgg tttgatcttc
     4321 cattgctcaa gccagggaat gcattgcaga ggcacctgca caacgacaaa cttgagtgtt
     4381 tccctgccac ttctgtgcct ccacagcctg ctccagttcc gcagctagag ctgggcctac
     4441 cttccccagc cagccctgcc acacacctgg ctgaggcatg tctgggaggg gtggaggagg
     4501 cagagggact ccaggccaga gggctgttct cacaacctca gcccactctc agtcaaggag
     4561 ggcagaaaat aaaagatgac atcactgcca
//
