LOCUS       NM_001730               3349 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens KLF transcription factor 5 (KLF5), transcript variant
            1, mRNA.
ACCESSION   NM_001730
VERSION     NM_001730.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3349)
  AUTHORS   Bhargava,D., Rusakow,D., Zheng,W., Awad,S. and Katz,J.P.
  TITLE     KLF5 inhibition initiates epithelial-mesenchymal transition in
            non-transformed human squamous epithelial cells
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1871 (7), 119789 (2024)
   PUBMED   38909912
  REMARK    GeneRIF: KLF5 inhibition initiates epithelial-mesenchymal
            transition in non-transformed human squamous epithelial cells.
REFERENCE   2  (bases 1 to 3349)
  AUTHORS   O'Reilly,M.E., Ho,S., Coronel,J., Zhu,L., Liu,W., Xue,C., Kim,E.,
            Cynn,E., Matias,C.V., Soni,R.K., Wang,C., Ionita-Laza,I.,
            Bauer,R.C., Ross,L., Zhang,Y., Corvera,S., Fried,S.K. and
            Reilly,M.P.
  TITLE     linc-ADAIN, a human adipose lincRNA, regulates adipogenesis by
            modulating KLF5 and IL-8 mRNA stability
  JOURNAL   Cell Rep 43 (5), 114240 (2024)
   PUBMED   38753486
  REMARK    GeneRIF: linc-ADAIN, a human adipose lincRNA, regulates
            adipogenesis by modulating KLF5 and IL-8 mRNA stability.
REFERENCE   3  (bases 1 to 3349)
  AUTHORS   Hu,J., Xin,F., Liu,W., Gong,Z., Zhang,Y. and Liu,S.
  TITLE     Downregulation of KLF5 by EBER1 via the ERK signaling pathway in
            EBV-positive nasopharyngeal carcinoma cells: implications for
            latent EBV infection
  JOURNAL   J Gen Virol 105 (5) (2024)
   PUBMED   38747699
  REMARK    GeneRIF: Downregulation of KLF5 by EBER1 via the ERK signaling
            pathway in EBV-positive nasopharyngeal carcinoma cells:
            implications for latent EBV infection.
REFERENCE   4  (bases 1 to 3349)
  AUTHORS   Camacho-Vanegas,O., Till,J., Miranda-Lorenzo,I., Ozturk,B.,
            Camacho,S.C. and Martignetti,J.A.
  TITLE     Shaking the family tree: identification of novel and biologically
            active alternatively spliced isoforms across the KLF family of
            transcription factors
  JOURNAL   FASEB J 27 (2), 432-436 (2013)
   PUBMED   23134681
REFERENCE   5  (bases 1 to 3349)
  AUTHORS   Dong,J.T. and Chen,C.
  TITLE     Essential role of KLF5 transcription factor in cell proliferation
            and differentiation and its implications for human diseases
  JOURNAL   Cell Mol Life Sci 66 (16), 2691-2706 (2009)
   PUBMED   19448973
  REMARK    GeneRIF: KLF5 mediates the signaling functions in cell
            proliferation, cell cycle, apoptosis, migration, differentiation,
            and stemness by regulating gene expression in response to
            environment stimuli. [review]
            Review article
REFERENCE   6  (bases 1 to 3349)
  AUTHORS   Hoshino,Y., Kurabayashi,M., Kanda,T., Hasegawa,A., Sakamoto,H.,
            Okamoto,E., Kowase,K., Watanabe,N., Manabe,I., Suzuki,T.,
            Nakano,A., Takase,S., Wilcox,J.N. and Nagai,R.
  TITLE     Regulated expression of the BTEB2 transcription factor in vascular
            smooth muscle cells: analysis of developmental and pathological
            expression profiles shows implications as a predictive factor for
            restenosis
  JOURNAL   Circulation 102 (20), 2528-2534 (2000)
   PUBMED   11076828
REFERENCE   7  (bases 1 to 3349)
  AUTHORS   Shi,H., Zhang,Z., Wang,X., Liu,S. and Teng,C.T.
  TITLE     Isolation and characterization of a gene encoding human
            Kruppel-like factor 5 (IKLF): binding to the CAAT/GT box of the
            mouse lactoferrin gene promoter
  JOURNAL   Nucleic Acids Res 27 (24), 4807-4815 (1999)
   PUBMED   10572182
REFERENCE   8  (bases 1 to 3349)
  AUTHORS   Conkright,M.D., Wani,M.A., Anderson,K.P. and Lingrel,J.B.
  TITLE     A gene encoding an intestinal-enriched member of the Kruppel-like
            factor family expressed in intestinal epithelial cells
  JOURNAL   Nucleic Acids Res 27 (5), 1263-1270 (1999)
   PUBMED   9973612
REFERENCE   9  (bases 1 to 3349)
  AUTHORS   Kojima,S., Kobayashi,A., Gotoh,O., Ohkuma,Y., Fujii-Kuriyama,Y. and
            Sogawa,K.
  TITLE     Transcriptional activation domain of human BTEB2, a GC box-binding
            factor
  JOURNAL   J Biochem 121 (2), 389-396 (1997)
   PUBMED   9089417
REFERENCE   10 (bases 1 to 3349)
  AUTHORS   Sogawa,K., Imataka,H., Yamasaki,Y., Kusume,H., Abe,H. and
            Fujii-Kuriyama,Y.
  TITLE     cDNA cloning and transcriptional properties of a novel GC
            box-binding protein, BTEB2
  JOURNAL   Nucleic Acids Res 21 (7), 1527-1532 (1993)
   PUBMED   8479902
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF132818.1, BC007695.1,
            BC014302.2, AK131397.1 and BM982025.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001730.4.
            
            Summary: This gene encodes a member of the Kruppel-like factor
            subfamily of zinc finger proteins. The encoded protein is a
            transcriptional activator that binds directly to a specific
            recognition motif in the promoters of target genes. This protein
            acts downstream of multiple different signaling pathways and is
            regulated by post-translational modification. It may participate in
            both promoting and suppressing cell proliferation. Expression of
            this gene may be changed in a variety of different cancers and in
            cardiovascular disease. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Nov 2013].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF132818.1, SRR1660805.54979.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377687.6/ ENSP00000366915.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-583               AF132818.1         214-796
            584-1754            BC007695.1         575-1745
            1755-1784           BC014302.2         1742-1771
            1785-2211           AF132818.1         1999-2425
            2212-2290           AK131397.1         1817-1895
            2291-3348           AK131397.1         1897-2954
            3349-3349           BM982025.1         22-22               c
FEATURES             Location/Qualifiers
     source          1..3349
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q22.1"
     gene            1..3349
                     /gene="KLF5"
                     /gene_synonym="BTEB2; CKLF; IKLF"
                     /note="KLF transcription factor 5"
                     /db_xref="GeneID:688"
                     /db_xref="HGNC:HGNC:6349"
                     /db_xref="MIM:602903"
     exon            1..584
                     /gene="KLF5"
                     /gene_synonym="BTEB2; CKLF; IKLF"
                     /inference="alignment:Splign:2.1.0"
     CDS             324..1697
                     /gene="KLF5"
                     /gene_synonym="BTEB2; CKLF; IKLF"
                     /note="isoform 1 is encoded by transcript variant 1; GC
                     box binding protein 2; basic transcription element binding
                     protein 2; Kruppel like factor 5; intestinal-enriched
                     kruppel-like factor; colon kruppel-like factor;
                     transcription factor BTEB2; krueppel-like factor 5;
                     BTE-binding protein 2; intestinal-enriched krueppel-like
                     factor; colon krueppel-like factor; Kruppel-like factor 5
                     (intestinal); (intestinal Kruppel-like factor; epididymis
                     secretory sperm binding protein"
                     /codon_start=1
                     /product="Krueppel-like factor 5 isoform 1"
                     /protein_id="NP_001721.2"
                     /db_xref="CCDS:CCDS9448.1"
                     /db_xref="GeneID:688"
                     /db_xref="HGNC:HGNC:6349"
                     /db_xref="MIM:602903"
                     /translation="MATRVLSMSARLGPVPQPPAPQDEPVFAQLKPVLGAANPARDAA
                     LFPGEELKHAHHRPQAQPAPAQAPQPAQPPATGPRLPPEDLVQTRCEMEKYLTPQLPP
                     VPIIPEHKKYRRDSASVVDQFFTDTEGLPYSINMNVFLPDITHLRTGLYKSQRPCVTH
                     IKTEPVAIFSHQSETTAPPPAPTQALPEFTSIFSSHQTAAPEVNNIFIKQELPTPDLH
                     LSVPTQQGHLYQLLNTPDLDMPSSTNQTAAMDTLNVSMSAAMAGLNTHTSAVPQTAVK
                     QFQGMPPCTYTMPSQFLPQQATYFPPSPPSSEPGSPDRQAEMLQNLTPPPSYAATIAS
                     KLAIHNPNLPTTLPVNSQNIQPVRYNRRSNPDLEKRRIHYCDYPGCTKVYTKSSHLKA
                     HLRTHTGEKPYKCTWEGCDWRFARSDELTRHYRKHTGAKPFQCGVCNRSFSRSDHLAL
                     HMKRHQN"
     exon            585..1458
                     /gene="KLF5"
                     /gene_synonym="BTEB2; CKLF; IKLF"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1518
                     /gene="KLF5"
                     /gene_synonym="BTEB2; CKLF; IKLF"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..3349
                     /gene="KLF5"
                     /gene_synonym="BTEB2; CKLF; IKLF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3330..3335
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLF5"
                     /gene_synonym="BTEB2; CKLF; IKLF"
                     /note="hexamer: AATAAA"
     polyA_site      3349
                     /gene="KLF5"
                     /gene_synonym="BTEB2; CKLF; IKLF"
                     /note="major polyA site"
ORIGIN      
        1 agtcgcgggg caggtacgtg cgctcgcggt tctctcgcgg aggtcggcgg tggcgggagc
       61 gggctccgga gagcctgaga gcacggtggg gcggggcggg agaaagtggc cgcccggagg
      121 acgttggcgt ttacgtgtgg aagagcggaa gagttttgct tttcgtgcgc gccttcgaaa
      181 actgcctgcc gctgtctgag gagtccaccc gaaacctccc ctcctccgcc ggcagccccg
      241 cgctgagctc gccgacccaa gccagcgtgg gcgaggtggg aagtgcgccc gacccgcgcc
      301 tggagctgcg cccccgagtg cccatggcta caagggtgct gagcatgagc gcccgcctgg
      361 gacccgtgcc ccagccgccg gcgccgcagg acgagccggt gttcgcgcag ctcaagccgg
      421 tgctgggcgc cgcgaatccg gcccgcgacg cggcgctctt ccccggcgag gagctgaagc
      481 acgcgcacca ccgcccgcag gcgcagcccg cgcccgcgca ggccccgcag ccggcccagc
      541 cgcccgccac cggcccgcgg ctgcctccag aggacctggt ccagacaaga tgtgaaatgg
      601 agaagtatct gacacctcag cttcctccag ttcctataat tccagagcat aaaaagtata
      661 gacgagacag tgcctcagtc gtagaccagt tcttcactga cactgaaggg ttaccttaca
      721 gtatcaacat gaacgtcttc ctccctgaca tcactcacct gagaactggc ctctacaaat
      781 cccagagacc gtgcgtaaca cacatcaaga cagaacctgt tgccattttc agccaccaga
      841 gtgaaacgac tgcccctcct ccggccccga cccaggccct ccctgagttc accagtatat
      901 tcagctcaca ccagaccgca gctccagagg tgaacaatat tttcatcaaa caagaacttc
      961 ctacaccaga tcttcatctt tctgtcccta cccagcaggg ccacctgtac cagctactga
     1021 atacaccgga tctagatatg cccagttcta caaatcagac agcagcaatg gacactctta
     1081 atgtttctat gtcagctgcc atggcaggcc ttaacacaca cacctctgct gttccgcaga
     1141 ctgcagtgaa acaattccag ggcatgcccc cttgcacata cacaatgcca agtcagtttc
     1201 ttccacaaca ggccacttac tttcccccgt caccaccaag ctcagagcct ggaagtccag
     1261 atagacaagc agagatgctc cagaatttaa ccccacctcc atcctatgct gctacaattg
     1321 cttctaaact ggcaattcac aatccaaatt tacccaccac cctgccagtt aactcacaaa
     1381 acatccaacc tgtcagatac aatagaagga gtaaccccga tttggagaaa cgacgcatcc
     1441 actactgcga ttaccctggt tgcacaaaag tttataccaa gtcttctcat ttaaaagctc
     1501 acctgaggac tcacactggt gaaaagccat acaagtgtac ctgggaaggc tgcgactgga
     1561 ggttcgcgcg atcggatgag ctgacccgcc actaccggaa gcacacaggc gccaagccct
     1621 tccagtgcgg ggtgtgcaac cgcagcttct cgcgctctga ccacctggcc ctgcatatga
     1681 agaggcacca gaactgagca ctgcccgtgt gacccgttcc aggtcccctg ggctccctca
     1741 aatgacagac ctaactattc ctgtgtaaaa acaacaaaaa caaacaaaag caagaaaacc
     1801 acaactaaaa ctggaaatgt atattttgta tatttgagaa aacagggaat acattgtatt
     1861 aataccaaag tgtttggtca ttttaagaat ctggaatgct tgctgtaatg tatatggctt
     1921 tactcaagca gatctcatct catgacaggc agccacgtct caacatgggt aaggggtggg
     1981 ggtggagggg agtgtgtgca gcgtttttac ctaggcacca tcatttaatg tgacagtgtt
     2041 cagtaaacaa atcagttggc aggcaccaga agaagaatgg attgtatgtc aagattttac
     2101 ttggcattga gtagtttttt tcaatagtag gtaattcctt agagatacag tatacctggc
     2161 aattcacaaa tagccattga acaaatgtgt gggtttttaa aaattatata catatatgag
     2221 ttgcctatat ttgctattca aaattttgta aatatgcaaa tcagctttat aggtttatta
     2281 caagtttttt aggattcttt tggggaagag tcataattct tttgaaaata accatgaata
     2341 cacttacagt taggatttgt ggtaaggtac ctctcaacat taccaaaatc atttctttag
     2401 agggaaggaa taatcattca aatgaacttt aaaaaagcaa atttcatgca ctgattaaaa
     2461 taggattatt ttaaatacaa aaggcatttt atatgaatta taaactgaag agcttaaaga
     2521 tagttacaaa atacaaaagt tcaacctctt acaataagct aaacgcaatg tcatttttaa
     2581 aaagaaggac ttagggtgtc gttttcacat atgacaatgt tgcatttatg atgcagtttc
     2641 aagtaccaaa acgttgaatt gatgatgcag ttttcatata tcgagatgtt cgctcgtgca
     2701 gtactgttgg ttaaatgaca atttatgtgg attttgcatg taatacacag tgagacacag
     2761 taattttatc taaattacag tgcagtttag ttaatctatt aatactgact cagtgtctgc
     2821 ctttaaatat aaatgatatg ttgaaaactt aaggaagcaa atgctacata tatgcaatat
     2881 aaaatagtaa tgtgatgctg atgctgttaa ccaaagggca gaataaataa gcaaaatgcc
     2941 aaaaggggtc ttaattgaaa tgaaaattta attttgtttt taaaatattg tttatcttta
     3001 tttattttgt ggtaatatag taagtttttt tagaagacaa ttttcataac ttgataaatt
     3061 atagttttgt ttgttagaaa agttgctctt aaaagatgta aatagatgac aaacgatgta
     3121 aataattttg taagaggctt caaaatgttt atacgtggaa acacacctac atgaaaagca
     3181 gaaatcggtt gctgttttgc ttctttttcc ctcttatttt tgtattgtgg tcatttccta
     3241 tgcaaataat ggagcaaaca gctgtatagt tgtagaattt tttgagagaa tgagatgttt
     3301 atatattaac gacaattttt tttttggaaa ataaaaagtg cctaaaaga
//
